FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 41179

FusionGeneSummary for USP54_PSMA6

check button Fusion gene summary
Fusion gene informationFusion gene name: USP54_PSMA6
Fusion gene ID: 41179
HgeneTgene
Gene symbol

USP54

PSMA6

Gene ID

159195

5687

Gene nameubiquitin specific peptidase 54proteasome subunit alpha 6
SynonymsC10orf29|bA137L10.3|bA137L10.4IOTA|PROS27|p27K
Cytomap

10q22.2

14q13.2

Type of geneprotein-codingprotein-coding
Descriptioninactive ubiquitin carboxyl-terminal hydrolase 54inactive ubiquitin-specific peptidase 54ubiquitin specific protease 54ubiquitin specific proteinase 54proteasome subunit alpha type-627 kDa prosomal proteinPROS-27macropain iota chainmacropain subunit iotamulticatalytic endopeptidase complex iota chainprosomal P27K proteinproteasome (prosome, macropain) subunit, alpha type, 6proteasome iota chain
Modification date2018051920180523
UniProtAcc

Q70EL1

P60900

Ensembl transtripts involved in fusion geneENST00000339859, ENST00000408019, 
ENST00000428547, ENST00000394811, 
ENST00000497106, ENST00000422491, 
ENST00000319786, 		ENST00000540871, 
ENST00000261479, ENST00000553809, 
ENST00000555764, ENST00000556506, 
Fusion gene scores* DoF score13 X 9 X 7=8195 X 3 X 4=60
# samples 145
** MAII scorelog2(14/819*10)=-2.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP54 [Title/Abstract] AND PSMA6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-B5-A5OD-01AUSP54chr10

75331179

-PSMA6chr14

35786455

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000339859ENST00000540871USP54chr10

75331179

-PSMA6chr14

35786455

+
Frame-shiftENST00000339859ENST00000261479USP54chr10

75331179

-PSMA6chr14

35786455

+
Frame-shiftENST00000339859ENST00000553809USP54chr10

75331179

-PSMA6chr14

35786455

+
In-frameENST00000339859ENST00000555764USP54chr10

75331179

-PSMA6chr14

35786455

+
Frame-shiftENST00000339859ENST00000556506USP54chr10

75331179

-PSMA6chr14

35786455

+
Frame-shiftENST00000408019ENST00000540871USP54chr10

75331179

-PSMA6chr14

35786455

+
In-frameENST00000408019ENST00000261479USP54chr10

75331179

-PSMA6chr14

35786455

+
Frame-shiftENST00000408019ENST00000553809USP54chr10

75331179

-PSMA6chr14

35786455

+
Frame-shiftENST00000408019ENST00000555764USP54chr10

75331179

-PSMA6chr14

35786455

+
In-frameENST00000408019ENST00000556506USP54chr10

75331179

-PSMA6chr14

35786455

+
Frame-shiftENST00000428547ENST00000540871USP54chr10

75331179

-PSMA6chr14

35786455

+
In-frameENST00000428547ENST00000261479USP54chr10

75331179

-PSMA6chr14

35786455

+
Frame-shiftENST00000428547ENST00000553809USP54chr10

75331179

-PSMA6chr14

35786455

+
Frame-shiftENST00000428547ENST00000555764USP54chr10

75331179

-PSMA6chr14

35786455

+
In-frameENST00000428547ENST00000556506USP54chr10

75331179

-PSMA6chr14

35786455

+
5UTR-3CDSENST00000394811ENST00000540871USP54chr10

75331179

-PSMA6chr14

35786455

+
5UTR-3CDSENST00000394811ENST00000261479USP54chr10

75331179

-PSMA6chr14

35786455

+
5UTR-3CDSENST00000394811ENST00000553809USP54chr10

75331179

-PSMA6chr14

35786455

+
5UTR-3CDSENST00000394811ENST00000555764USP54chr10

75331179

-PSMA6chr14

35786455

+
5UTR-3CDSENST00000394811ENST00000556506USP54chr10

75331179

-PSMA6chr14

35786455

+
intron-3CDSENST00000497106ENST00000540871USP54chr10

75331179

-PSMA6chr14

35786455

+
intron-3CDSENST00000497106ENST00000261479USP54chr10

75331179

-PSMA6chr14

35786455

+
intron-3CDSENST00000497106ENST00000553809USP54chr10

75331179

-PSMA6chr14

35786455

+
intron-3CDSENST00000497106ENST00000555764USP54chr10

75331179

-PSMA6chr14

35786455

+
intron-3CDSENST00000497106ENST00000556506USP54chr10

75331179

-PSMA6chr14

35786455

+
intron-3CDSENST00000422491ENST00000540871USP54chr10

75331179

-PSMA6chr14

35786455

+
intron-3CDSENST00000422491ENST00000261479USP54chr10

75331179

-PSMA6chr14

35786455

+
intron-3CDSENST00000422491ENST00000553809USP54chr10

75331179

-PSMA6chr14

35786455

+
intron-3CDSENST00000422491ENST00000555764USP54chr10

75331179

-PSMA6chr14

35786455

+
intron-3CDSENST00000422491ENST00000556506USP54chr10

75331179

-PSMA6chr14

35786455

+
In-frameENST00000319786ENST00000540871USP54chr10

75331179

-PSMA6chr14

35786455

+
Frame-shiftENST00000319786ENST00000261479USP54chr10

75331179

-PSMA6chr14

35786455

+
In-frameENST00000319786ENST00000553809USP54chr10

75331179

-PSMA6chr14

35786455

+
Frame-shiftENST00000319786ENST00000555764USP54chr10

75331179

-PSMA6chr14

35786455

+
Frame-shiftENST00000319786ENST00000556506USP54chr10

75331179

-PSMA6chr14

35786455

+

Top

FusionProtFeatures for USP54_PSMA6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
USP54

Q70EL1

PSMA6

P60900

Component of the 20S core proteasome complex involved inthe proteolytic degradation of most intracellular proteins. Thiscomplex plays numerous essential roles within the cell byassociating with different regulatory particles. Associated withtwo 19S regulatory particles, forms the 26S proteasome and thusparticipates in the ATP-dependent degradation of ubiquitinatedproteins. The 26S proteasome plays a key role in the maintenanceof protein homeostasis by removing misfolded or damaged proteinsthat could impair cellular functions, and by removing proteinswhose functions are no longer required. Associated with the PA200or PA28, the 20S proteasome mediates ubiquitin-independent proteindegradation. This type of proteolysis is required in severalpathways including spermatogenesis (20S-PA200 complex) orgeneration of a subset of MHC class I-presented antigenic peptides(20S-PA28 complex). {ECO:0000269|PubMed:15244466,ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for USP54_PSMA6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_USP54_ENST00000339859_chr10_75331179_-_PSMA6_ENST00000555764_chr14_35786455_+_99aa
MSWKRNYFSGGRGSVQGMFAPRSSTSIAPSKGLSNEPGQNSCFLNSALQVLWHLDIFRRSFRQLTTHKCMGDSCIFCALKDSYRSRDXCS

>In-frame_USP54_ENST00000408019_chr10_75331179_-_PSMA6_ENST00000261479_chr14_35786455_+_99aa
MSWKRNYFSGGRGSVQGMFAPRSSTSIAPSKGLSNEPGQNSCFLNSALQVLWHLDIFRRSFRQLTTHKCMGDSCIFCALKDSYRSRDXCS

>In-frame_USP54_ENST00000408019_chr10_75331179_-_PSMA6_ENST00000556506_chr14_35786455_+_88aa

>In-frame_USP54_ENST00000428547_chr10_75331179_-_PSMA6_ENST00000261479_chr14_35786455_+_99aa
MSWKRNYFSGGRGSVQGMFAPRSSTSIAPSKGLSNEPGQNSCFLNSALQVLWHLDIFRRSFRQLTTHKCMGDSCIFCALKDSYRSRDXCS

>In-frame_USP54_ENST00000428547_chr10_75331179_-_PSMA6_ENST00000556506_chr14_35786455_+_88aa

>In-frame_USP54_ENST00000319786_chr10_75331179_-_PSMA6_ENST00000540871_chr14_35786455_+_99aa
MSWKRNYFSGGRGSVQGMFAPRSSTSIAPSKGLSNEPGQNSCFLNSALQVLWHLDIFRRSFRQLTTHKCMGDSCIFCALKDSYRSRDXCS

>In-frame_USP54_ENST00000319786_chr10_75331179_-_PSMA6_ENST00000553809_chr14_35786455_+_99aa
MSWKRNYFSGGRGSVQGMFAPRSSTSIAPSKGLSNEPGQNSCFLNSALQVLWHLDIFRRSFRQLTTHKCMGDSCIFCALKDSYRSRDXCS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_USP54_ENST00000339859_chr10_75331179_-_PSMA6_ENST00000555764_chr14_35786455_+_298nt
ATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTTTGCACCTCGAAGCTCAACCTCCATAGCCCCCAGC
AAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCAGGTTTTGTGGCACTTGGATATCTTCCGACGTAGC
TTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCTCAAGGATTCTTACAGAAGCAGAGATTGATGCTCA

>In-frame_USP54_ENST00000408019_chr10_75331179_-_PSMA6_ENST00000261479_chr14_35786455_+_298nt
ATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTTTGCACCTCGAAGCTCAACCTCCATAGCCCCCAGC
AAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCAGGTTTTGTGGCACTTGGATATCTTCCGACGTAGC
TTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCTCAAGGATTCTTACAGAAGCAGAGATTGATGCTCA

>In-frame_USP54_ENST00000408019_chr10_75331179_-_PSMA6_ENST00000556506_chr14_35786455_+_264nt
ATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTTTGCACCTCGAAGCTCAACCTCCATAGCCCCCAGC
AAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCAGGTTTTGTGGCACTTGGATATCTTCCGACGTAGC

>In-frame_USP54_ENST00000428547_chr10_75331179_-_PSMA6_ENST00000261479_chr14_35786455_+_298nt
ATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTTTGCACCTCGAAGCTCAACCTCCATAGCCCCCAGC
AAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCAGGTTTTGTGGCACTTGGATATCTTCCGACGTAGC
TTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCTCAAGGATTCTTACAGAAGCAGAGATTGATGCTCA

>In-frame_USP54_ENST00000428547_chr10_75331179_-_PSMA6_ENST00000556506_chr14_35786455_+_264nt
ATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTTTGCACCTCGAAGCTCAACCTCCATAGCCCCCAGC
AAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCAGGTTTTGTGGCACTTGGATATCTTCCGACGTAGC

>In-frame_USP54_ENST00000319786_chr10_75331179_-_PSMA6_ENST00000540871_chr14_35786455_+_298nt
ATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTTTGCACCTCGAAGCTCAACCTCCATAGCCCCCAGC
AAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCAGGTTTTGTGGCACTTGGATATCTTCCGACGTAGC
TTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCTCAAGGATTCTTACAGAAGCAGAGATTGATGCTCA

>In-frame_USP54_ENST00000319786_chr10_75331179_-_PSMA6_ENST00000553809_chr14_35786455_+_298nt
ATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTTTGCACCTCGAAGCTCAACCTCCATAGCCCCCAGC
AAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCAGGTTTTGTGGCACTTGGATATCTTCCGACGTAGC
TTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCTCAAGGATTCTTACAGAAGCAGAGATTGATGCTCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_USP54_ENST00000339859_chr10_75331179_-_PSMA6_ENST00000555764_chr14_35786455_+_586nt
GTTTACGGAGACTCGGAACTGGATAAAGGGACCAGGCTACATTGGGAAAGAAGTGGGAAGAAATGGGGTACAGCGACGAGGAGGGCTAAA
TGTGAACAATAATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTTTGCACCTCGAAGCTCAACCTCCA
TAGCCCCCAGCAAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCAGGTTTTGTGGCACTTGGATATCT
TCCGACGTAGCTTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCTCAAGGATTCTTACAGAAGCAGAG
ATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCCGTGATGCCACTTACCTGTGTGTTTGG
TAACAACAAACCAACATCATGGAGGTCCCTGGATTGAAAAAGGAGCCTCTCCCACTCCTCCTACCACCGAAGTGGTTAGGACTCTATATA

>In-frame_USP54_ENST00000408019_chr10_75331179_-_PSMA6_ENST00000261479_chr14_35786455_+_483nt
GCTAAATGTGAACAATAATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTTTGCACCTCGAAGCTCAA
CCTCCATAGCCCCCAGCAAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCAGGTTTTGTGGCACTTGG
ATATCTTCCGACGTAGCTTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCTCAAGGATTCTTACAGAA
GCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCCGTGATGCCACTTACCTGTGT
GTTTGGTAACAACAAACCAACATCATGGAGGTCCCTGGATTGAAAAAGGAGCCTCTCCCACTCCTCCTACCACCGAAGTGGTTAGGACTC

>In-frame_USP54_ENST00000408019_chr10_75331179_-_PSMA6_ENST00000556506_chr14_35786455_+_428nt
GCTAAATGTGAACAATAATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTTTGCACCTCGAAGCTCAA
CCTCCATAGCCCCCAGCAAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCAGGTTTTGTGGCACTTGG
ATATCTTCCGACGTAGCTTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCTCAAGGATTCTTACAGAA
GCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCCGTGATGCCACTTACCTGTGT

>In-frame_USP54_ENST00000428547_chr10_75331179_-_PSMA6_ENST00000261479_chr14_35786455_+_483nt
GCTAAATGTGAACAATAATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTTTGCACCTCGAAGCTCAA
CCTCCATAGCCCCCAGCAAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCAGGTTTTGTGGCACTTGG
ATATCTTCCGACGTAGCTTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCTCAAGGATTCTTACAGAA
GCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCCGTGATGCCACTTACCTGTGT
GTTTGGTAACAACAAACCAACATCATGGAGGTCCCTGGATTGAAAAAGGAGCCTCTCCCACTCCTCCTACCACCGAAGTGGTTAGGACTC

>In-frame_USP54_ENST00000428547_chr10_75331179_-_PSMA6_ENST00000556506_chr14_35786455_+_428nt
GCTAAATGTGAACAATAATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTTTGCACCTCGAAGCTCAA
CCTCCATAGCCCCCAGCAAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCAGGTTTTGTGGCACTTGG
ATATCTTCCGACGTAGCTTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCTCAAGGATTCTTACAGAA
GCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCCGTGATGCCACTTACCTGTGT

>In-frame_USP54_ENST00000319786_chr10_75331179_-_PSMA6_ENST00000540871_chr14_35786455_+_1303nt
AACTTTGTCATGAATTGTCAGTGCTGAGTTCCTGGTAGTTGGTAAAAAGAATTGCCTTCTCTCTGATATCCTGTTCTGCGGGAAGTCCTT
GTGGTTTAGATTCACAGTTTCTCATTGTTGCTAGCTACAGTCGTCTCCTCCCTCCTAGCCTTCCCTCCCCACAGCTCTAGCTATTCCCAT
ATCCCTCCCCATTCTTGTATCACTTGCCCCACAGATACCCTCGTGATTAGAGGTCTTTTGCTGGAGGTTGACTGTGCTGTCTGCTCTCTG
ACACAGCTGGCTATTCTAGTCCCAGAAGAAAGAGGAGAGACTTGCTGAAGATCTGGATGGGACAATAGAAGTTTGGGGCACATTAAAAAG
AAGCAGCAAGAACATCAACAAAAACCTCAGATGATTCAAACAGGCTTCTTCTTGGCTTTGTGGAACCTTTTGCAGTTGCTCAGAATTTGA
GTTTTTGCTTCAGAGGATGATGAGACAAGGCAATAGAGGGTGAGGAGGATCATGTTGGATTCTTGCTTCTCTGTCTGCCTCTCCTTCCAG
TTGGAAAAATCTTCAGTCCATAAGAAGCATTATCAACAAGCCTGAAGAACACATCTTACCCTGATCCTGGATGCTGTTGGAGTTGAGAAT
TACATCCACTTCACCAGGACTTTATGGAGGCTGTTCAAGAAAAATAGAAGGAAGCAATACTTAAGGATTTCTCTGTTTGCATTAGTCCTG
TGCCATGTTACATTTTGGAGATTGTTTGGAACAAGTGAGGGAGGGCTCTGTCATCTTGATCTAGGAGGATACCTGAGTCCCTTGACTACA
CAGATGATATTTGGAAGGCTAAATGTGAACAATAATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTT
TGCACCTCGAAGCTCAACCTCCATAGCCCCCAGCAAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCA
GGTTTTGTGGCACTTGGATATCTTCCGACGTAGCTTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCT
CAAGGATTCTTACAGAAGCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCCGTG
ATGCCACTTACCTGTGTGTTTGGTAACAACAAACCAACATCATGGAGGTCCCTGGATTGAAAAAGGAGCCTCTCCCACTCCTCCTACCAC

>In-frame_USP54_ENST00000319786_chr10_75331179_-_PSMA6_ENST00000553809_chr14_35786455_+_1183nt
AACTTTGTCATGAATTGTCAGTGCTGAGTTCCTGGTAGTTGGTAAAAAGAATTGCCTTCTCTCTGATATCCTGTTCTGCGGGAAGTCCTT
GTGGTTTAGATTCACAGTTTCTCATTGTTGCTAGCTACAGTCGTCTCCTCCCTCCTAGCCTTCCCTCCCCACAGCTCTAGCTATTCCCAT
ATCCCTCCCCATTCTTGTATCACTTGCCCCACAGATACCCTCGTGATTAGAGGTCTTTTGCTGGAGGTTGACTGTGCTGTCTGCTCTCTG
ACACAGCTGGCTATTCTAGTCCCAGAAGAAAGAGGAGAGACTTGCTGAAGATCTGGATGGGACAATAGAAGTTTGGGGCACATTAAAAAG
AAGCAGCAAGAACATCAACAAAAACCTCAGATGATTCAAACAGGCTTCTTCTTGGCTTTGTGGAACCTTTTGCAGTTGCTCAGAATTTGA
GTTTTTGCTTCAGAGGATGATGAGACAAGGCAATAGAGGGTGAGGAGGATCATGTTGGATTCTTGCTTCTCTGTCTGCCTCTCCTTCCAG
TTGGAAAAATCTTCAGTCCATAAGAAGCATTATCAACAAGCCTGAAGAACACATCTTACCCTGATCCTGGATGCTGTTGGAGTTGAGAAT
TACATCCACTTCACCAGGACTTTATGGAGGCTGTTCAAGAAAAATAGAAGGAAGCAATACTTAAGGATTTCTCTGTTTGCATTAGTCCTG
TGCCATGTTACATTTTGGAGATTGTTTGGAACAAGTGAGGGAGGGCTCTGTCATCTTGATCTAGGAGGATACCTGAGTCCCTTGACTACA
CAGATGATATTTGGAAGGCTAAATGTGAACAATAATGTCTTGGAAGAGAAATTATTTTTCAGGGGGTCGTGGTAGTGTACAAGGGATGTT
TGCACCTCGAAGCTCAACCTCCATAGCCCCCAGCAAAGGCCTCAGCAATGAGCCAGGGCAAAACAGCTGCTTCCTCAACAGTGCCCTGCA
GGTTTTGTGGCACTTGGATATCTTCCGACGTAGCTTTAGGCAGCTTACAACTCACAAGTGCATGGGAGATTCCTGCATCTTTTGCGCTCT
CAAGGATTCTTACAGAAGCAGAGATTGATGCTCACCTTGTTGCTCTAGCAGAGAGAGACTAAACATTGTCGTTAGTTTACCAGATCCGTG


Top

FusionGenePPI for USP54_PSMA6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
USP54CHMP1B, CHMP2A, CHMP4C, CHMP2B, ATN1, ATXN1, ATXN1L, LATS2, YWHAB, LGR4, FBXW11, EIF4E2, NXT2, MLST8, SKAP1, CARD8, CLEC11A, OLFM4, CCNJL, BTRC, PLK4, CEP128, CEP135, NINL, PIGT, VPS39, CDC16, P4HA2, SIRT6, ASB3, PDDC1, KIAA1683, IL17RA, THSD4, PRSS50, LGALS3BP, OLFM2, BBS7, CELA1, CRYL1, ZEB1, TRIM25PSMA6PSMD13, PSMA3, PLK1, UBQLN2, USP14, USP53, SLX1B, CUL1, RBX1, PSMA4, PSMA2, RNF185, UBC, XBP1, UBD, PSMD4, PSMD14, ADRM1, PSMD1, TXNL1, RAD23A, SHFM1, PSME1, PSMA7, PSMA1, PPP3CA, CCND1, CCNE1, CCNA2, CCNB1, CDK4, CDK1, CDK2, CCNF, GPS1, COPS5, PSMD6, PSMC1, FKBP8, NEDD8, DNAJB2, KIAA0368, COPS2, UCHL5, POMP, PSMB6, PSMB5, PSMB8, USP4, PSMA5, PSMB1, PSMB2, PSMB3, PSMB4, PSMB7, PSMC6, PSMC3, PSMC4, PSMC2, PSMD2, PSMD3, PSMD8, PSMC5, PSMD12, PSMD11, PSMD7, PSMD5, PSME2, PSME3, PSMA8, SF3A1, CCT5, SNRPA1, TPM4, CCT4, CCT3, EEF1A1, CCT8, TARDBP, BRCA1, ECT2, LIG4, PAXIP1, FN1, VCAM1, IQCB1, NOS2, ITGA4, PARK2, BAG3, CAST, HNRNPA2B1, PYCRL, RPP30, RPP38, PSMG1, PSMG3, PSMG2, AURKA, HUWE1, CADM1, ZBTB44, TRIM39, C19orf57, LIMD2, RNF170, KRTAP4-2, RTP5, RNF2, AMFR, SYVN1, BUB1B, VCP, UBQLN1, UBXN4, PSMB9, HSPB1, AMBRA1, ACTN4, CAND2, CAPZA1, ELP6, EXOSC4, EXOSC6, EXOSC9, ISY1-RAB43, ISY1, NELFE, PGK1, POLR2A, DNAJA2, EXOSC5, TPM3, WDR11, NTRK1, FBXO7, MID1, CEP85, PSMA6, DERL1, CYLD, SOD1, MAP1LC3B, SQSTM1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for USP54_PSMA6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for USP54_PSMA6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePSMA6C0019693HIV Infections1CTD_human
TgenePSMA6C0027051Myocardial Infarction1CTD_human