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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41175

FusionGeneSummary for USP54_MLLT10

check button Fusion gene summary
Fusion gene informationFusion gene name: USP54_MLLT10
Fusion gene ID: 41175
HgeneTgene
Gene symbol

USP54

MLLT10

Gene ID

159195

8028

Gene nameubiquitin specific peptidase 54MLLT10, histone lysine methyltransferase DOT1L cofactor
SynonymsC10orf29|bA137L10.3|bA137L10.4AF10
Cytomap

10q22.2

10p12.31

Type of geneprotein-codingprotein-coding
Descriptioninactive ubiquitin carboxyl-terminal hydrolase 54inactive ubiquitin-specific peptidase 54ubiquitin specific protease 54ubiquitin specific proteinase 54protein AF-10ALL1-fused gene from chromosome 10 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10type I AF10 proteintype III AF10 prot
Modification date2018051920180522
UniProtAcc

Q70EL1

P55197

Ensembl transtripts involved in fusion geneENST00000339859, ENST00000408019, 
ENST00000428547, ENST00000394811, 
ENST00000497106, ENST00000422491, 
ENST00000319786, 
ENST00000446906, 
ENST00000377072, ENST00000307729, 
ENST00000377059, ENST00000495130, 
ENST00000377100, ENST00000377091, 
Fusion gene scores* DoF score13 X 9 X 7=8195 X 15 X 3=225
# samples 1420
** MAII scorelog2(14/819*10)=-2.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(20/225*10)=-0.169925001442312
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP54 [Title/Abstract] AND MLLT10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMLLT10

GO:0045944

positive regulation of transcription by RNA polymerase II

17868029


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1M79063USP54chr10

75350706

+MLLT10chr10

21945338

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000339859ENST00000446906USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000339859ENST00000377072USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000339859ENST00000307729USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000339859ENST00000377059USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000339859ENST00000495130USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000339859ENST00000377100USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000339859ENST00000377091USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000408019ENST00000446906USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000408019ENST00000377072USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000408019ENST00000307729USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000408019ENST00000377059USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000408019ENST00000495130USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000408019ENST00000377100USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000408019ENST00000377091USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000428547ENST00000446906USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000428547ENST00000377072USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000428547ENST00000307729USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000428547ENST00000377059USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000428547ENST00000495130USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000428547ENST00000377100USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000428547ENST00000377091USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000394811ENST00000446906USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000394811ENST00000377072USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000394811ENST00000307729USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000394811ENST00000377059USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000394811ENST00000495130USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000394811ENST00000377100USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000394811ENST00000377091USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000497106ENST00000446906USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000497106ENST00000377072USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000497106ENST00000307729USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000497106ENST00000377059USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000497106ENST00000495130USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000497106ENST00000377100USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000497106ENST00000377091USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000422491ENST00000446906USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000422491ENST00000377072USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000422491ENST00000307729USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000422491ENST00000377059USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000422491ENST00000495130USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000422491ENST00000377100USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000422491ENST00000377091USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000319786ENST00000446906USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000319786ENST00000377072USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000319786ENST00000307729USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000319786ENST00000377059USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000319786ENST00000495130USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000319786ENST00000377100USP54chr10

75350706

+MLLT10chr10

21945338

+
intron-intronENST00000319786ENST00000377091USP54chr10

75350706

+MLLT10chr10

21945338

+

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FusionProtFeatures for USP54_MLLT10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
USP54

Q70EL1

MLLT10

P55197

Probably involved in transcriptional regulation. Invitro or as fusion protein with KMT2A/MLL1 has transactivationactivity. Binds to cruciform DNA. In cells, binding to unmodifiedhistone H3 regulates DOT1L functions including histone H3 'Lys-79'dimethylation (H3K79me2) and gene activation (PubMed:26439302).{ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for USP54_MLLT10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for USP54_MLLT10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for USP54_MLLT10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for USP54_MLLT10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMLLT10C0007134Renal Cell Carcinoma1CTD_human
TgeneMLLT10C0025202melanoma1CTD_human
TgeneMLLT10C0025286Meningioma1CTD_human