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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41158

FusionGeneSummary for USP49_GSTA1

check button Fusion gene summary
Fusion gene informationFusion gene name: USP49_GSTA1
Fusion gene ID: 41158
HgeneTgene
Gene symbol

USP49

GSTA1

Gene ID

25862

2938

Gene nameubiquitin specific peptidase 49glutathione S-transferase alpha 1
Synonyms-GST-epsilon|GST2|GSTA1-1|GTH1
Cytomap

6p21.1

6p12.2

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 49deubiquitinating enzyme 49ubiquitin specific protease 49ubiquitin thioesterase 49ubiquitin thiolesterase 49ubiquitin-specific-processing protease 49glutathione S-transferase A1GST HA subunit 1GST class-alpha member 1S-(hydroxyalkyl)glutathione lyase A1glutathione S-alkyltransferase A1glutathione S-aryltransferase A1glutathione S-transferase 2glutathione S-transferase Ha subunit 1testicular ti
Modification date2018052320180519
UniProtAcc

Q70CQ1

P08263

Ensembl transtripts involved in fusion geneENST00000394253, ENST00000373010, 
ENST00000373006, ENST00000297229, 
ENST00000373009, 
ENST00000493331, 
ENST00000334575, 
Fusion gene scores* DoF score5 X 3 X 4=602 X 2 X 2=8
# samples 42
** MAII scorelog2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: USP49 [Title/Abstract] AND GSTA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP49

GO:0016579

protein deubiquitination

14715245

HgeneUSP49

GO:0035616

histone H2B conserved C-terminal lysine deubiquitination

23824326

TgeneGSTA1

GO:0006749

glutathione metabolic process

11851347|20606271

TgeneGSTA1

GO:0043651

linoleic acid metabolic process

16624487


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-KB-A93J-01AUSP49chr6

41859532

-GSTA1chr6

52668676

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000394253ENST00000493331USP49chr6

41859532

-GSTA1chr6

52668676

-
intron-5UTRENST00000394253ENST00000334575USP49chr6

41859532

-GSTA1chr6

52668676

-
intron-intronENST00000373010ENST00000493331USP49chr6

41859532

-GSTA1chr6

52668676

-
intron-5UTRENST00000373010ENST00000334575USP49chr6

41859532

-GSTA1chr6

52668676

-
5UTR-intronENST00000373006ENST00000493331USP49chr6

41859532

-GSTA1chr6

52668676

-
5UTR-5UTRENST00000373006ENST00000334575USP49chr6

41859532

-GSTA1chr6

52668676

-
intron-intronENST00000297229ENST00000493331USP49chr6

41859532

-GSTA1chr6

52668676

-
intron-5UTRENST00000297229ENST00000334575USP49chr6

41859532

-GSTA1chr6

52668676

-
intron-intronENST00000373009ENST00000493331USP49chr6

41859532

-GSTA1chr6

52668676

-
intron-5UTRENST00000373009ENST00000334575USP49chr6

41859532

-GSTA1chr6

52668676

-

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FusionProtFeatures for USP49_GSTA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
USP49

Q70CQ1

GSTA1

P08263

Specifically deubiquitinates histone H2B at 'Lys-120'(H2BK120Ub). H2BK120Ub is a specific tag for epigenetictranscriptional activation and acts as a regulator of mRNAsplicing. Deubiquitination is required for efficientcotranscriptional splicing of a large set of exons.{ECO:0000269|PubMed:23824326}. Conjugation of reduced glutathione to a wide number ofexogenous and endogenous hydrophobic electrophiles.{ECO:0000269|PubMed:20606271}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for USP49_GSTA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for USP49_GSTA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
USP49CETN1, CETN2, CETN3, COPA, F7, FKBP5, HADHA, MCM6, PDCD2, PPM1G, PPP5C, PRKACA, RPN1, SLC39A7, PPP6R2, HUWE1, LRPPRC, IPO7, STIP1, KRR1, PPP6R1, ANKRD28, DICER1, STAMBPL1, YARS2, UBR5, PPP6R3, IPO9, SHCBP1, NUP85, USP44, SHPRH, ANKRD52, TRIM35, RBCK1, HIST2H2BE, RUVBL1, PSMC5, TMEM173GSTA1GSTA1, APP, BAG3, LSM3, PPP2CB, ST3GAL1, YWHAE, RPAIN, GSTA3, ZBTB21, SPDL1, ACOX1, GSTA4, GAR1, GGTLC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for USP49_GSTA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGSTA1P08263DB00143GlutathioneGlutathione S-transferase A1small moleculeapproved|investigational|nutraceutical

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RelatedDiseases for USP49_GSTA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGSTA1C0036341Schizophrenia2PSYGENET
TgeneGSTA1C0033578Prostatic Neoplasms1CTD_human
TgeneGSTA1C0033975Psychotic Disorders1PSYGENET
TgeneGSTA1C0151744Myocardial Ischemia1CTD_human
TgeneGSTA1C0400966Non-alcoholic Fatty Liver Disease1CTD_human