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Fusion gene ID: 41147 |
FusionGeneSummary for USP48_INA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: USP48_INA | Fusion gene ID: 41147 | Hgene | Tgene | Gene symbol | USP48 | INA | Gene ID | 84196 | 9118 |
| Gene name | ubiquitin specific peptidase 48 | internexin neuronal intermediate filament protein alpha | |
| Synonyms | RAP1GA1|USP31 | NEF5|NF-66|TXBP-1 | |
| Cytomap | 1p36.12 | 10q24.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin carboxyl-terminal hydrolase 48deubiquitinating enzyme 48ubiquitin specific protease 31ubiquitin thioesterase 48ubiquitin thiolesterase 48ubiquitin-specific-processing protease 48 | alpha-internexin66 kDa neurofilament proteinalpha-Inxneurofilament 5 (66kD)neurofilament-66, tax-binding protein | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q86UV5 | Q16352 | |
| Ensembl transtripts involved in fusion gene | ENST00000400301, ENST00000308271, ENST00000374732, ENST00000529637, ENST00000479177, ENST00000421625, | ENST00000369849, | |
| Fusion gene scores | * DoF score | 10 X 8 X 7=560 | 4 X 1 X 3=12 |
| # samples | 10 | 4 | |
| ** MAII score | log2(10/560*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: USP48 [Title/Abstract] AND INA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-AJ-A3BF-01A | USP48 | chr1 | 22109317 | - | INA | chr10 | 105046792 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000400301 | ENST00000369849 | USP48 | chr1 | 22109317 | - | INA | chr10 | 105046792 | + |
| In-frame | ENST00000308271 | ENST00000369849 | USP48 | chr1 | 22109317 | - | INA | chr10 | 105046792 | + |
| intron-3CDS | ENST00000374732 | ENST00000369849 | USP48 | chr1 | 22109317 | - | INA | chr10 | 105046792 | + |
| In-frame | ENST00000529637 | ENST00000369849 | USP48 | chr1 | 22109317 | - | INA | chr10 | 105046792 | + |
| intron-3CDS | ENST00000479177 | ENST00000369849 | USP48 | chr1 | 22109317 | - | INA | chr10 | 105046792 | + |
| In-frame | ENST00000421625 | ENST00000369849 | USP48 | chr1 | 22109317 | - | INA | chr10 | 105046792 | + |
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FusionProtFeatures for USP48_INA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| USP48 | INA |
| Class-IV neuronal intermediate filament that is able toself-assemble. It is involved in the morphogenesis of neurons. Itmay form an independent structural network without the involvementof other neurofilaments or it may cooperate with NF-L to form thefilamentous backbone to which NF-M and NF-H attach to form thecross-bridges. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >INA | chr1:22109317 | chr10:105046792 | ENST00000369849 | + | 0 | 3 | 449_454 | 355 | 500 | Compositional bias | Note=Poly-Glu |
| Tgene | >INA | chr1:22109317 | chr10:105046792 | ENST00000369849 | + | 0 | 3 | 409_499 | 355 | 500 | Region | Note=Tail |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >USP48 | chr1:22109317 | chr10:105046792 | ENST00000308271 | - | 1 | 27 | 460_554 | 44 | 1036 | Domain | DUSP 1 |
| Hgene | >USP48 | chr1:22109317 | chr10:105046792 | ENST00000308271 | - | 1 | 27 | 569_691 | 44 | 1036 | Domain | DUSP 2 |
| Hgene | >USP48 | chr1:22109317 | chr10:105046792 | ENST00000308271 | - | 1 | 27 | 711_824 | 44 | 1036 | Domain | DUSP 3 |
| Hgene | >USP48 | chr1:22109317 | chr10:105046792 | ENST00000308271 | - | 1 | 27 | 89_421 | 44 | 1036 | Domain | Note=USP |
| Hgene | >USP48 | chr1:22109317 | chr10:105046792 | ENST00000308271 | - | 1 | 27 | 929_1009 | 44 | 1036 | Domain | Ubiquitin-like |
| Hgene | >USP48 | chr1:22109317 | chr10:105046792 | ENST00000400301 | - | 1 | 26 | 460_554 | 44 | 984 | Domain | DUSP 1 |
| Hgene | >USP48 | chr1:22109317 | chr10:105046792 | ENST00000400301 | - | 1 | 26 | 569_691 | 44 | 984 | Domain | DUSP 2 |
| Hgene | >USP48 | chr1:22109317 | chr10:105046792 | ENST00000400301 | - | 1 | 26 | 711_824 | 44 | 984 | Domain | DUSP 3 |
| Hgene | >USP48 | chr1:22109317 | chr10:105046792 | ENST00000400301 | - | 1 | 26 | 89_421 | 44 | 984 | Domain | Note=USP |
| Hgene | >USP48 | chr1:22109317 | chr10:105046792 | ENST00000400301 | - | 1 | 26 | 929_1009 | 44 | 984 | Domain | Ubiquitin-like |
| Hgene | >USP48 | chr1:22109317 | chr10:105046792 | ENST00000421625 | - | 1 | 11 | 460_554 | 44 | 486 | Domain | DUSP 1 |
| Hgene | >USP48 | chr1:22109317 | chr10:105046792 | ENST00000421625 | - | 1 | 11 | 569_691 | 44 | 486 | Domain | DUSP 2 |
| Hgene | >USP48 | chr1:22109317 | chr10:105046792 | ENST00000421625 | - | 1 | 11 | 711_824 | 44 | 486 | Domain | DUSP 3 |
| Hgene | >USP48 | chr1:22109317 | chr10:105046792 | ENST00000421625 | - | 1 | 11 | 89_421 | 44 | 486 | Domain | Note=USP |
| Hgene | >USP48 | chr1:22109317 | chr10:105046792 | ENST00000421625 | - | 1 | 11 | 929_1009 | 44 | 486 | Domain | Ubiquitin-like |
| Tgene | INA | chr1:22109317 | chr10:105046792 | ENST00000369849 | + | 0 | 3 | 94_407 | 355 | 500 | Domain | IF rod |
| Tgene | INA | chr1:22109317 | chr10:105046792 | ENST00000369849 | + | 0 | 3 | 130_142 | 355 | 500 | Region | Note=Linker 1 |
| Tgene | INA | chr1:22109317 | chr10:105046792 | ENST00000369849 | + | 0 | 3 | 143_238 | 355 | 500 | Region | Note=Coil 1B |
| Tgene | INA | chr1:22109317 | chr10:105046792 | ENST00000369849 | + | 0 | 3 | 1_87 | 355 | 500 | Region | Note=Head |
| Tgene | INA | chr1:22109317 | chr10:105046792 | ENST00000369849 | + | 0 | 3 | 239_262 | 355 | 500 | Region | Note=Linker 2 |
| Tgene | INA | chr1:22109317 | chr10:105046792 | ENST00000369849 | + | 0 | 3 | 263_408 | 355 | 500 | Region | Note=Coil 2 |
| Tgene | INA | chr1:22109317 | chr10:105046792 | ENST00000369849 | + | 0 | 3 | 88_129 | 355 | 500 | Region | Note=Coil 1A |
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FusionGeneSequence for USP48_INA |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_USP48_ENST00000400301_chr1_22109317_-_INA_ENST00000369849_chr10_105046792_+_189aa MAPRLQLEKAAWRWAETVRPEEVSQEHIETAYRIWLEPCIRGVCRIALGSWRMIXGTPRVRWHATFGNTRTCSMSKWLLTLRXQLTGNCW KARRHVLAPVGXAFRGXIHFPIQVTCSHLESSVLQPPKSHPLGYHLRKRRRRRRHLRXPLRKPPRXGKVLKKYXRRQXYLLRKPRNQIXK >In-frame_USP48_ENST00000308271_chr1_22109317_-_INA_ENST00000369849_chr10_105046792_+_189aa MAPRLQLEKAAWRWAETVRPEEVSQEHIETAYRIWLEPCIRGVCRIALGSWRMIXGTPRVRWHATFGNTRTCSMSKWLLTLRXQLTGNCW KARRHVLAPVGXAFRGXIHFPIQVTCSHLESSVLQPPKSHPLGYHLRKRRRRRRHLRXPLRKPPRXGKVLKKYXRRQXYLLRKPRNQIXK >In-frame_USP48_ENST00000529637_chr1_22109317_-_INA_ENST00000369849_chr10_105046792_+_189aa MAPRLQLEKAAWRWAETVRPEEVSQEHIETAYRIWLEPCIRGVCRIALGSWRMIXGTPRVRWHATFGNTRTCSMSKWLLTLRXQLTGNCW KARRHVLAPVGXAFRGXIHFPIQVTCSHLESSVLQPPKSHPLGYHLRKRRRRRRHLRXPLRKPPRXGKVLKKYXRRQXYLLRKPRNQIXK >In-frame_USP48_ENST00000421625_chr1_22109317_-_INA_ENST00000369849_chr10_105046792_+_189aa MAPRLQLEKAAWRWAETVRPEEVSQEHIETAYRIWLEPCIRGVCRIALGSWRMIXGTPRVRWHATFGNTRTCSMSKWLLTLRXQLTGNCW KARRHVLAPVGXAFRGXIHFPIQVTCSHLESSVLQPPKSHPLGYHLRKRRRRRRHLRXPLRKPPRXGKVLKKYXRRQXYLLRKPRNQIXK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_USP48_ENST00000400301_chr1_22109317_-_INA_ENST00000369849_chr10_105046792_+_569nt ATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGCCTGGCGCTGGGCGGAGACGGTGCGGCCCGAGGAGGTGTCGCAGGAGCACATCGAGACC GCTTACCGCATCTGGCTGGAGCCCTGCATTCGCGGCGTGTGCAGGATAGCATTGGGCAGCTGGAGAATGATCTGAGGAACACCAAGAGTG AGATGGCACGCCACCTTCGGGAATACCAGGACTTGCTCAATGTCAAAATGGCTCTTGACATTGAGATAGCAGCTTACAGGAAACTGCTGG AAGGCGAGGAGACACGTTTTAGCACCAGTGGGTTAAGCATTTCGGGGCTGAATCCACTTCCCAATCCAAGTTACCTGCTCCCACCTAGAA TCCTCAGTGCTACAACCTCCAAAGTCTCATCCACTGGGCTATCACTTAAGAAAGAGGAGGAGGAGGAGGAGGCATCTAAGGTAGCCTCTA AGAAAACCTCCCAGATAGGGGAAAGTTTTGAAGAAATATTAGAGGAGACAGTAATATCTACTAAGAAAACCGAGAAATCAAATATAGAAG >In-frame_USP48_ENST00000308271_chr1_22109317_-_INA_ENST00000369849_chr10_105046792_+_569nt ATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGCCTGGCGCTGGGCGGAGACGGTGCGGCCCGAGGAGGTGTCGCAGGAGCACATCGAGACC GCTTACCGCATCTGGCTGGAGCCCTGCATTCGCGGCGTGTGCAGGATAGCATTGGGCAGCTGGAGAATGATCTGAGGAACACCAAGAGTG AGATGGCACGCCACCTTCGGGAATACCAGGACTTGCTCAATGTCAAAATGGCTCTTGACATTGAGATAGCAGCTTACAGGAAACTGCTGG AAGGCGAGGAGACACGTTTTAGCACCAGTGGGTTAAGCATTTCGGGGCTGAATCCACTTCCCAATCCAAGTTACCTGCTCCCACCTAGAA TCCTCAGTGCTACAACCTCCAAAGTCTCATCCACTGGGCTATCACTTAAGAAAGAGGAGGAGGAGGAGGAGGCATCTAAGGTAGCCTCTA AGAAAACCTCCCAGATAGGGGAAAGTTTTGAAGAAATATTAGAGGAGACAGTAATATCTACTAAGAAAACCGAGAAATCAAATATAGAAG >In-frame_USP48_ENST00000529637_chr1_22109317_-_INA_ENST00000369849_chr10_105046792_+_569nt ATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGCCTGGCGCTGGGCGGAGACGGTGCGGCCCGAGGAGGTGTCGCAGGAGCACATCGAGACC GCTTACCGCATCTGGCTGGAGCCCTGCATTCGCGGCGTGTGCAGGATAGCATTGGGCAGCTGGAGAATGATCTGAGGAACACCAAGAGTG AGATGGCACGCCACCTTCGGGAATACCAGGACTTGCTCAATGTCAAAATGGCTCTTGACATTGAGATAGCAGCTTACAGGAAACTGCTGG AAGGCGAGGAGACACGTTTTAGCACCAGTGGGTTAAGCATTTCGGGGCTGAATCCACTTCCCAATCCAAGTTACCTGCTCCCACCTAGAA TCCTCAGTGCTACAACCTCCAAAGTCTCATCCACTGGGCTATCACTTAAGAAAGAGGAGGAGGAGGAGGAGGCATCTAAGGTAGCCTCTA AGAAAACCTCCCAGATAGGGGAAAGTTTTGAAGAAATATTAGAGGAGACAGTAATATCTACTAAGAAAACCGAGAAATCAAATATAGAAG >In-frame_USP48_ENST00000421625_chr1_22109317_-_INA_ENST00000369849_chr10_105046792_+_569nt ATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGCCTGGCGCTGGGCGGAGACGGTGCGGCCCGAGGAGGTGTCGCAGGAGCACATCGAGACC GCTTACCGCATCTGGCTGGAGCCCTGCATTCGCGGCGTGTGCAGGATAGCATTGGGCAGCTGGAGAATGATCTGAGGAACACCAAGAGTG AGATGGCACGCCACCTTCGGGAATACCAGGACTTGCTCAATGTCAAAATGGCTCTTGACATTGAGATAGCAGCTTACAGGAAACTGCTGG AAGGCGAGGAGACACGTTTTAGCACCAGTGGGTTAAGCATTTCGGGGCTGAATCCACTTCCCAATCCAAGTTACCTGCTCCCACCTAGAA TCCTCAGTGCTACAACCTCCAAAGTCTCATCCACTGGGCTATCACTTAAGAAAGAGGAGGAGGAGGAGGAGGCATCTAAGGTAGCCTCTA AGAAAACCTCCCAGATAGGGGAAAGTTTTGAAGAAATATTAGAGGAGACAGTAATATCTACTAAGAAAACCGAGAAATCAAATATAGAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_USP48_ENST00000400301_chr1_22109317_-_INA_ENST00000369849_chr10_105046792_+_2489nt AACGTCCGCGGGCGCGGGGTGTGTCGGGTGTCGACGGCGGCGCTTTGCGGCCGGTCGTGCGGGTCGGGCGCGGGCGGGCGCGGCGGCAGT GGCGCGCACAGGTGATTGACTGGCCAGCTGCCTGAAGGAGCGCCAGGTCCTCCTTGCTGGCAGGTGGCGAAGCCCATTGGGGCGGCGGTG CAGACCGCGGCGGCGGCTGCGGCGGTCTGGCTCGGGAGGCGTTCCTGGGGCCAAGGCCATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGC CTGGCGCTGGGCGGAGACGGTGCGGCCCGAGGAGGTGTCGCAGGAGCACATCGAGACCGCTTACCGCATCTGGCTGGAGCCCTGCATTCG CGGCGTGTGCAGGATAGCATTGGGCAGCTGGAGAATGATCTGAGGAACACCAAGAGTGAGATGGCACGCCACCTTCGGGAATACCAGGAC TTGCTCAATGTCAAAATGGCTCTTGACATTGAGATAGCAGCTTACAGGAAACTGCTGGAAGGCGAGGAGACACGTTTTAGCACCAGTGGG TTAAGCATTTCGGGGCTGAATCCACTTCCCAATCCAAGTTACCTGCTCCCACCTAGAATCCTCAGTGCTACAACCTCCAAAGTCTCATCC ACTGGGCTATCACTTAAGAAAGAGGAGGAGGAGGAGGAGGCATCTAAGGTAGCCTCTAAGAAAACCTCCCAGATAGGGGAAAGTTTTGAA GAAATATTAGAGGAGACAGTAATATCTACTAAGAAAACCGAGAAATCAAATATAGAAGAAACCACCATTTCAAGCCAAAAAATATAATTC CATTGCTTTGAAAAAGTTAATGCTTAAGAGGGAATGATATGCATTTGACTTGTTAAACAGCCTATTCCTGAACTATAACACCTGCCACCA CTATAAAATGTCTTCAAGGCTTCAGTCTCATATTTAGTATTGAATACTTACATTCTCTAATAAGAAAACCACCCCTTAGATTGAAGTAAA CTGCAGTCCTGGAGCAATCACAGATGAGTTATCTAAGAATACAGCTTTCTGACCTTCAGCTCACGCTTCACAGTGATCGATGATTCAGGT GCAGAGGAAGTACAAACTAAGGTGCTAAATCTGCGATCATCGTCATTTGCTGTGAACTGAAATTAAAACTATTCATGCTACCCAGCCATT ACCCAGCTAAATAATCTTACTCTAGATACCTAAAACATAAGATCACTGCCAGAGATAAACTAATGGTCCACACCCAATTCCACTCTGATA GAATTATTTCACAAATAATAGGTGTTTGTTTAATGGACACTTTTCACCTCCTTCAATTCCATATATCCTTTTCTTCTATGTAGGAAAAAA ATAGTCTAGTGTAGTATTCTTCCCTTTTAAACACATTTTGGTTCTTCTCAAAAGAACTTACCCCCATTCGCGCTCTGCTCAGTGGGTAAA ATTAGATGCATGTTGACCATGTCTATGATTCGTGTAATTACTTATCCCTGCCCATTTCATATTCTTTCAATTCTGTAGGTTAAAAAAATG GCAGTGATGAATTTTAAGGGTTTCCCCCAACATATAAAATAATGCAAAGAATCCCTAGACTTTAGGCTTTCAGCTTACACAAATCTATTT AATTAGGAAAAAAACTATTAAGGATGTAGCTTTTCACCTTTACTTTAGAAGCACAGTAAATATCCCAAACTGTGATGAAGCCGACCTTAG ATTTAGTAGTGTAAGCTAGAAGAAGTGAGTGTTTCTATGAGTGGAAAAAGCCAAGGTGTCATTTATGTGTCAGTTCATTTGTGGTGATAT AGAATTAGCTTTTTCATCCCCTTACCCTTAGAATCCACGTATTCCCCTTCCCACTAGCCTAGGTCATAAAGAGGCGTTGCTTTCACTCTC CTATGCCTTTTACGAGTGCTAAGTGTAGGATATTTTGTCACCAGAACACAATGCTACCGCCCCAAAGTAAAAGAAACCACTTCTGGTCAA TCAACACTACCAGCGTATATATAAGAAAGACATCTTTCTCTTTTCTAAAAGACTTCCCTAACACTTACCCCATGGCTGCACAGTTGGTGG GGTCCTGCCGGAGAGGAAGAGACACTCAGACCAGAGAAGGGGTGTGCATGCGCCTACTCGCTTGCTAGAAGTAGATTCTGGACAGTCAGC TCTTCATCTGCCCAACTGTGTAGCATCTGCATTGCCCAGTCTTTCATGTGTGCCAAGGCTGATGCAGGATTTGTTCTCTGTCCAGCAGTC ACTTCGGCCAGAGCTGAAGAGTTGCCCCGTCTCTGTTCCATGTCTCCTTTAAGAGCTCTGGTGATAAGGACATGATGCTTTTACTGAACT TTCTTATCCTAGCACATGCTTCAATAGTTCAAGGAACTTGAAAAATACTTTTCCTTACCTTTACCCCATCCCTGTCTTTACTCCTCACAC >In-frame_USP48_ENST00000308271_chr1_22109317_-_INA_ENST00000369849_chr10_105046792_+_2900nt GCTCGGGAAAGGGGTTCGGAACCGGTCTAGGCTCAAGTTAAATCTCCCTCTAAAGAGCCAACACTGGTTTCTTTGGCGACTCGGTTTCTA CTCTAAACAGGTCCCGCTCCACAGTCTGGGCGGGCCTGTGTGTGCGTTGAGTAGCCTCTAGCGTGAAAACTTCATGGTTAAAAGGGAAGT ACCGGAGGCAAGAAATAGCTTTCGAGGCACTGGTTTGTTAGAGTAGTGGTACGTAGTGCGCCGCCCTGAACGGGGGCTGAGACGCTGCTT TTCCAGAAGTGCCAGTGAGGACGTGGCAAGACCGCCTCGGACGTACGCTTCCTCTACCTCAGCCCGTCGGGTTAGGGGCGCGGGAGGCGC AGAGGCTGCTGGGAACGCGCATGCGCTCAGCGCGGCGGGGAGTCCACCTTTAACGTCCGCGGGCGCGGGGTGTGTCGGGTGTCGACGGCG GCGCTTTGCGGCCGGTCGTGCGGGTCGGGCGCGGGCGGGCGCGGCGGCAGTGGCGCGCACAGGTGATTGACTGGCCAGCTGCCTGAAGGA GCGCCAGGTCCTCCTTGCTGGCAGGTGGCGAAGCCCATTGGGGCGGCGGTGCAGACCGCGGCGGCGGCTGCGGCGGTCTGGCTCGGGAGG CGTTCCTGGGGCCAAGGCCATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGCCTGGCGCTGGGCGGAGACGGTGCGGCCCGAGGAGGTGTC GCAGGAGCACATCGAGACCGCTTACCGCATCTGGCTGGAGCCCTGCATTCGCGGCGTGTGCAGGATAGCATTGGGCAGCTGGAGAATGAT CTGAGGAACACCAAGAGTGAGATGGCACGCCACCTTCGGGAATACCAGGACTTGCTCAATGTCAAAATGGCTCTTGACATTGAGATAGCA GCTTACAGGAAACTGCTGGAAGGCGAGGAGACACGTTTTAGCACCAGTGGGTTAAGCATTTCGGGGCTGAATCCACTTCCCAATCCAAGT TACCTGCTCCCACCTAGAATCCTCAGTGCTACAACCTCCAAAGTCTCATCCACTGGGCTATCACTTAAGAAAGAGGAGGAGGAGGAGGAG GCATCTAAGGTAGCCTCTAAGAAAACCTCCCAGATAGGGGAAAGTTTTGAAGAAATATTAGAGGAGACAGTAATATCTACTAAGAAAACC GAGAAATCAAATATAGAAGAAACCACCATTTCAAGCCAAAAAATATAATTCCATTGCTTTGAAAAAGTTAATGCTTAAGAGGGAATGATA TGCATTTGACTTGTTAAACAGCCTATTCCTGAACTATAACACCTGCCACCACTATAAAATGTCTTCAAGGCTTCAGTCTCATATTTAGTA TTGAATACTTACATTCTCTAATAAGAAAACCACCCCTTAGATTGAAGTAAACTGCAGTCCTGGAGCAATCACAGATGAGTTATCTAAGAA TACAGCTTTCTGACCTTCAGCTCACGCTTCACAGTGATCGATGATTCAGGTGCAGAGGAAGTACAAACTAAGGTGCTAAATCTGCGATCA TCGTCATTTGCTGTGAACTGAAATTAAAACTATTCATGCTACCCAGCCATTACCCAGCTAAATAATCTTACTCTAGATACCTAAAACATA AGATCACTGCCAGAGATAAACTAATGGTCCACACCCAATTCCACTCTGATAGAATTATTTCACAAATAATAGGTGTTTGTTTAATGGACA CTTTTCACCTCCTTCAATTCCATATATCCTTTTCTTCTATGTAGGAAAAAAATAGTCTAGTGTAGTATTCTTCCCTTTTAAACACATTTT GGTTCTTCTCAAAAGAACTTACCCCCATTCGCGCTCTGCTCAGTGGGTAAAATTAGATGCATGTTGACCATGTCTATGATTCGTGTAATT ACTTATCCCTGCCCATTTCATATTCTTTCAATTCTGTAGGTTAAAAAAATGGCAGTGATGAATTTTAAGGGTTTCCCCCAACATATAAAA TAATGCAAAGAATCCCTAGACTTTAGGCTTTCAGCTTACACAAATCTATTTAATTAGGAAAAAAACTATTAAGGATGTAGCTTTTCACCT TTACTTTAGAAGCACAGTAAATATCCCAAACTGTGATGAAGCCGACCTTAGATTTAGTAGTGTAAGCTAGAAGAAGTGAGTGTTTCTATG AGTGGAAAAAGCCAAGGTGTCATTTATGTGTCAGTTCATTTGTGGTGATATAGAATTAGCTTTTTCATCCCCTTACCCTTAGAATCCACG TATTCCCCTTCCCACTAGCCTAGGTCATAAAGAGGCGTTGCTTTCACTCTCCTATGCCTTTTACGAGTGCTAAGTGTAGGATATTTTGTC ACCAGAACACAATGCTACCGCCCCAAAGTAAAAGAAACCACTTCTGGTCAATCAACACTACCAGCGTATATATAAGAAAGACATCTTTCT CTTTTCTAAAAGACTTCCCTAACACTTACCCCATGGCTGCACAGTTGGTGGGGTCCTGCCGGAGAGGAAGAGACACTCAGACCAGAGAAG GGGTGTGCATGCGCCTACTCGCTTGCTAGAAGTAGATTCTGGACAGTCAGCTCTTCATCTGCCCAACTGTGTAGCATCTGCATTGCCCAG TCTTTCATGTGTGCCAAGGCTGATGCAGGATTTGTTCTCTGTCCAGCAGTCACTTCGGCCAGAGCTGAAGAGTTGCCCCGTCTCTGTTCC ATGTCTCCTTTAAGAGCTCTGGTGATAAGGACATGATGCTTTTACTGAACTTTCTTATCCTAGCACATGCTTCAATAGTTCAAGGAACTT GAAAAATACTTTTCCTTACCTTTACCCCATCCCTGTCTTTACTCCTCACACTTACTGTAAGACATTAGTAACATAATAAATTAAAAGTCA >In-frame_USP48_ENST00000529637_chr1_22109317_-_INA_ENST00000369849_chr10_105046792_+_2285nt GTCTGGCTCGGGAGGCGTTCCTGGGGCCAAGGCCATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGCCTGGCGCTGGGCGGAGACGGTGCG GCCCGAGGAGGTGTCGCAGGAGCACATCGAGACCGCTTACCGCATCTGGCTGGAGCCCTGCATTCGCGGCGTGTGCAGGATAGCATTGGG CAGCTGGAGAATGATCTGAGGAACACCAAGAGTGAGATGGCACGCCACCTTCGGGAATACCAGGACTTGCTCAATGTCAAAATGGCTCTT GACATTGAGATAGCAGCTTACAGGAAACTGCTGGAAGGCGAGGAGACACGTTTTAGCACCAGTGGGTTAAGCATTTCGGGGCTGAATCCA CTTCCCAATCCAAGTTACCTGCTCCCACCTAGAATCCTCAGTGCTACAACCTCCAAAGTCTCATCCACTGGGCTATCACTTAAGAAAGAG GAGGAGGAGGAGGAGGCATCTAAGGTAGCCTCTAAGAAAACCTCCCAGATAGGGGAAAGTTTTGAAGAAATATTAGAGGAGACAGTAATA TCTACTAAGAAAACCGAGAAATCAAATATAGAAGAAACCACCATTTCAAGCCAAAAAATATAATTCCATTGCTTTGAAAAAGTTAATGCT TAAGAGGGAATGATATGCATTTGACTTGTTAAACAGCCTATTCCTGAACTATAACACCTGCCACCACTATAAAATGTCTTCAAGGCTTCA GTCTCATATTTAGTATTGAATACTTACATTCTCTAATAAGAAAACCACCCCTTAGATTGAAGTAAACTGCAGTCCTGGAGCAATCACAGA TGAGTTATCTAAGAATACAGCTTTCTGACCTTCAGCTCACGCTTCACAGTGATCGATGATTCAGGTGCAGAGGAAGTACAAACTAAGGTG CTAAATCTGCGATCATCGTCATTTGCTGTGAACTGAAATTAAAACTATTCATGCTACCCAGCCATTACCCAGCTAAATAATCTTACTCTA GATACCTAAAACATAAGATCACTGCCAGAGATAAACTAATGGTCCACACCCAATTCCACTCTGATAGAATTATTTCACAAATAATAGGTG TTTGTTTAATGGACACTTTTCACCTCCTTCAATTCCATATATCCTTTTCTTCTATGTAGGAAAAAAATAGTCTAGTGTAGTATTCTTCCC TTTTAAACACATTTTGGTTCTTCTCAAAAGAACTTACCCCCATTCGCGCTCTGCTCAGTGGGTAAAATTAGATGCATGTTGACCATGTCT ATGATTCGTGTAATTACTTATCCCTGCCCATTTCATATTCTTTCAATTCTGTAGGTTAAAAAAATGGCAGTGATGAATTTTAAGGGTTTC CCCCAACATATAAAATAATGCAAAGAATCCCTAGACTTTAGGCTTTCAGCTTACACAAATCTATTTAATTAGGAAAAAAACTATTAAGGA TGTAGCTTTTCACCTTTACTTTAGAAGCACAGTAAATATCCCAAACTGTGATGAAGCCGACCTTAGATTTAGTAGTGTAAGCTAGAAGAA GTGAGTGTTTCTATGAGTGGAAAAAGCCAAGGTGTCATTTATGTGTCAGTTCATTTGTGGTGATATAGAATTAGCTTTTTCATCCCCTTA CCCTTAGAATCCACGTATTCCCCTTCCCACTAGCCTAGGTCATAAAGAGGCGTTGCTTTCACTCTCCTATGCCTTTTACGAGTGCTAAGT GTAGGATATTTTGTCACCAGAACACAATGCTACCGCCCCAAAGTAAAAGAAACCACTTCTGGTCAATCAACACTACCAGCGTATATATAA GAAAGACATCTTTCTCTTTTCTAAAAGACTTCCCTAACACTTACCCCATGGCTGCACAGTTGGTGGGGTCCTGCCGGAGAGGAAGAGACA CTCAGACCAGAGAAGGGGTGTGCATGCGCCTACTCGCTTGCTAGAAGTAGATTCTGGACAGTCAGCTCTTCATCTGCCCAACTGTGTAGC ATCTGCATTGCCCAGTCTTTCATGTGTGCCAAGGCTGATGCAGGATTTGTTCTCTGTCCAGCAGTCACTTCGGCCAGAGCTGAAGAGTTG CCCCGTCTCTGTTCCATGTCTCCTTTAAGAGCTCTGGTGATAAGGACATGATGCTTTTACTGAACTTTCTTATCCTAGCACATGCTTCAA TAGTTCAAGGAACTTGAAAAATACTTTTCCTTACCTTTACCCCATCCCTGTCTTTACTCCTCACACTTACTGTAAGACATTAGTAACATA >In-frame_USP48_ENST00000421625_chr1_22109317_-_INA_ENST00000369849_chr10_105046792_+_2900nt GCTCGGGAAAGGGGTTCGGAACCGGTCTAGGCTCAAGTTAAATCTCCCTCTAAAGAGCCAACACTGGTTTCTTTGGCGACTCGGTTTCTA CTCTAAACAGGTCCCGCTCCACAGTCTGGGCGGGCCTGTGTGTGCGTTGAGTAGCCTCTAGCGTGAAAACTTCATGGTTAAAAGGGAAGT ACCGGAGGCAAGAAATAGCTTTCGAGGCACTGGTTTGTTAGAGTAGTGGTACGTAGTGCGCCGCCCTGAACGGGGGCTGAGACGCTGCTT TTCCAGAAGTGCCAGTGAGGACGTGGCAAGACCGCCTCGGACGTACGCTTCCTCTACCTCAGCCCGTCGGGTTAGGGGCGCGGGAGGCGC AGAGGCTGCTGGGAACGCGCATGCGCTCAGCGCGGCGGGGAGTCCACCTTTAACGTCCGCGGGCGCGGGGTGTGTCGGGTGTCGACGGCG GCGCTTTGCGGCCGGTCGTGCGGGTCGGGCGCGGGCGGGCGCGGCGGCAGTGGCGCGCACAGGTGATTGACTGGCCAGCTGCCTGAAGGA GCGCCAGGTCCTCCTTGCTGGCAGGTGGCGAAGCCCATTGGGGCGGCGGTGCAGACCGCGGCGGCGGCTGCGGCGGTCTGGCTCGGGAGG CGTTCCTGGGGCCAAGGCCATGGCCCCGCGGCTGCAGCTGGAGAAGGCGGCCTGGCGCTGGGCGGAGACGGTGCGGCCCGAGGAGGTGTC GCAGGAGCACATCGAGACCGCTTACCGCATCTGGCTGGAGCCCTGCATTCGCGGCGTGTGCAGGATAGCATTGGGCAGCTGGAGAATGAT CTGAGGAACACCAAGAGTGAGATGGCACGCCACCTTCGGGAATACCAGGACTTGCTCAATGTCAAAATGGCTCTTGACATTGAGATAGCA GCTTACAGGAAACTGCTGGAAGGCGAGGAGACACGTTTTAGCACCAGTGGGTTAAGCATTTCGGGGCTGAATCCACTTCCCAATCCAAGT TACCTGCTCCCACCTAGAATCCTCAGTGCTACAACCTCCAAAGTCTCATCCACTGGGCTATCACTTAAGAAAGAGGAGGAGGAGGAGGAG GCATCTAAGGTAGCCTCTAAGAAAACCTCCCAGATAGGGGAAAGTTTTGAAGAAATATTAGAGGAGACAGTAATATCTACTAAGAAAACC GAGAAATCAAATATAGAAGAAACCACCATTTCAAGCCAAAAAATATAATTCCATTGCTTTGAAAAAGTTAATGCTTAAGAGGGAATGATA TGCATTTGACTTGTTAAACAGCCTATTCCTGAACTATAACACCTGCCACCACTATAAAATGTCTTCAAGGCTTCAGTCTCATATTTAGTA TTGAATACTTACATTCTCTAATAAGAAAACCACCCCTTAGATTGAAGTAAACTGCAGTCCTGGAGCAATCACAGATGAGTTATCTAAGAA TACAGCTTTCTGACCTTCAGCTCACGCTTCACAGTGATCGATGATTCAGGTGCAGAGGAAGTACAAACTAAGGTGCTAAATCTGCGATCA TCGTCATTTGCTGTGAACTGAAATTAAAACTATTCATGCTACCCAGCCATTACCCAGCTAAATAATCTTACTCTAGATACCTAAAACATA AGATCACTGCCAGAGATAAACTAATGGTCCACACCCAATTCCACTCTGATAGAATTATTTCACAAATAATAGGTGTTTGTTTAATGGACA CTTTTCACCTCCTTCAATTCCATATATCCTTTTCTTCTATGTAGGAAAAAAATAGTCTAGTGTAGTATTCTTCCCTTTTAAACACATTTT GGTTCTTCTCAAAAGAACTTACCCCCATTCGCGCTCTGCTCAGTGGGTAAAATTAGATGCATGTTGACCATGTCTATGATTCGTGTAATT ACTTATCCCTGCCCATTTCATATTCTTTCAATTCTGTAGGTTAAAAAAATGGCAGTGATGAATTTTAAGGGTTTCCCCCAACATATAAAA TAATGCAAAGAATCCCTAGACTTTAGGCTTTCAGCTTACACAAATCTATTTAATTAGGAAAAAAACTATTAAGGATGTAGCTTTTCACCT TTACTTTAGAAGCACAGTAAATATCCCAAACTGTGATGAAGCCGACCTTAGATTTAGTAGTGTAAGCTAGAAGAAGTGAGTGTTTCTATG AGTGGAAAAAGCCAAGGTGTCATTTATGTGTCAGTTCATTTGTGGTGATATAGAATTAGCTTTTTCATCCCCTTACCCTTAGAATCCACG TATTCCCCTTCCCACTAGCCTAGGTCATAAAGAGGCGTTGCTTTCACTCTCCTATGCCTTTTACGAGTGCTAAGTGTAGGATATTTTGTC ACCAGAACACAATGCTACCGCCCCAAAGTAAAAGAAACCACTTCTGGTCAATCAACACTACCAGCGTATATATAAGAAAGACATCTTTCT CTTTTCTAAAAGACTTCCCTAACACTTACCCCATGGCTGCACAGTTGGTGGGGTCCTGCCGGAGAGGAAGAGACACTCAGACCAGAGAAG GGGTGTGCATGCGCCTACTCGCTTGCTAGAAGTAGATTCTGGACAGTCAGCTCTTCATCTGCCCAACTGTGTAGCATCTGCATTGCCCAG TCTTTCATGTGTGCCAAGGCTGATGCAGGATTTGTTCTCTGTCCAGCAGTCACTTCGGCCAGAGCTGAAGAGTTGCCCCGTCTCTGTTCC ATGTCTCCTTTAAGAGCTCTGGTGATAAGGACATGATGCTTTTACTGAACTTTCTTATCCTAGCACATGCTTCAATAGTTCAAGGAACTT GAAAAATACTTTTCCTTACCTTTACCCCATCCCTGTCTTTACTCCTCACACTTACTGTAAGACATTAGTAACATAATAAATTAAAAGTCA |
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FusionGenePPI for USP48_INA |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| USP48 | USP21, EEF1B2P5, APP, UCHL3, ZC3HAV1, ZFR, UBA6, UACA, VPS35, UBC, PSAP, SEC24D, BRAT1, DRD3, SLC9A3, SIRT6, GPS1, CSNK2A1, DYNC1LI1, NCBP2, NUP188, NTRK1, HIST1H2BG, HIST1H3A, SNW1, NDUFAF7, NR1D2, RNF123, UBB, HIST1H2BJ, PXK, UBAC1, ZNF232 | INA | SQSTM1, ARRB1, SIRT7, PPP1CA, PAN2, PARK2, STAU1, CUL7, OBSL1, CCDC183, CENPP, ERGIC1, PRMT8, MAB21L2, CTBP1, NTRK1, CNTROB, ODF2, GAN, NEFM, VIM, SYNC, CCDC120, RSPRY1, NEFH, GFAP, MIPEP, CAPN1, VSIG8, VWA3B, BFSP2, BMP1, GJB7, BAZ2B, KLHL36, TIAL1, DLST, PDHA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for USP48_INA |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for USP48_INA |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | USP48 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
| Tgene | INA | C0524851 | Neurodegenerative Disorders | 1 | CTD_human |
| Tgene | INA | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |
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