	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 41126

FusionGeneSummary for USP3_USP3

Fusion gene summary

Fusion gene information	Fusion gene name: USP3_USP3
	Fusion gene ID: 41126
		Hgene	Tgene
	Gene symbol	USP3	USP3
	Gene ID	9960	9960
	Gene name	ubiquitin specific peptidase 3	ubiquitin specific peptidase 3
	Synonyms	SIH003\|UBP	SIH003\|UBP
	Cytomap	15q22.31	15q22.31
	Type of gene	protein-coding	protein-coding
	Description	ubiquitin carboxyl-terminal hydrolase 3deubiquitinating enzyme 3ubiquitin thioesterase 3ubiquitin thiolesterase 3ubiquitin-specific-processing protease 3	ubiquitin carboxyl-terminal hydrolase 3deubiquitinating enzyme 3ubiquitin thioesterase 3ubiquitin thiolesterase 3ubiquitin-specific-processing protease 3
	Modification date	20180523	20180523
	UniProtAcc	Q9Y6I4	Q9Y6I4
	Ensembl transtripts involved in fusion gene	ENST00000540797, ENST00000380324, ENST00000268049, ENST00000536001, ENST00000539772, ENST00000558285, ENST00000559711, ENST00000558218,	ENST00000540797, ENST00000380324, ENST00000268049, ENST00000536001, ENST00000539772, ENST00000558285, ENST00000559711, ENST00000558218,
Fusion gene scores	* DoF score	5 X 5 X 4=100	4 X 5 X 3=60
	# samples	6	5
	** MAII score	log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: USP3 [Title/Abstract] AND USP3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	USP3	GO:0016578	histone deubiquitination	17980597
Hgene	USP3	GO:0031647	regulation of protein stability	17980597
Tgene	USP3	GO:0016578	histone deubiquitination	17980597
Tgene	USP3	GO:0031647	regulation of protein stability	17980597

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BE080252	USP3	chr15	63824842	-	USP3	chr15	63855207	-
ChiTaRS3.1			AK024198	USP3	chr15	63838251	+	USP3	chr15	63835698	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000540797	ENST00000540797	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000540797	ENST00000380324	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000540797	ENST00000268049	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000540797	ENST00000536001	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000540797	ENST00000539772	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000540797	ENST00000558285	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000540797	ENST00000559711	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000540797	ENST00000558218	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000380324	ENST00000540797	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000380324	ENST00000380324	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000380324	ENST00000268049	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000380324	ENST00000536001	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000380324	ENST00000539772	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000380324	ENST00000558285	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000380324	ENST00000559711	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000380324	ENST00000558218	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000268049	ENST00000540797	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000268049	ENST00000380324	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000268049	ENST00000268049	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000268049	ENST00000536001	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000268049	ENST00000539772	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000268049	ENST00000558285	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000268049	ENST00000559711	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000268049	ENST00000558218	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000536001	ENST00000540797	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000536001	ENST00000380324	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000536001	ENST00000268049	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000536001	ENST00000536001	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000536001	ENST00000539772	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000536001	ENST00000558285	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000536001	ENST00000559711	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000536001	ENST00000558218	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000539772	ENST00000540797	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000539772	ENST00000380324	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000539772	ENST00000268049	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000539772	ENST00000536001	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000539772	ENST00000539772	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000539772	ENST00000558285	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000539772	ENST00000559711	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000539772	ENST00000558218	USP3	chr15	63824842	-	USP3	chr15	63855207	-
5CDS-intron	ENST00000558285	ENST00000540797	USP3	chr15	63824842	-	USP3	chr15	63855207	-
5CDS-intron	ENST00000558285	ENST00000380324	USP3	chr15	63824842	-	USP3	chr15	63855207	-
5CDS-intron	ENST00000558285	ENST00000268049	USP3	chr15	63824842	-	USP3	chr15	63855207	-
5CDS-intron	ENST00000558285	ENST00000536001	USP3	chr15	63824842	-	USP3	chr15	63855207	-
5CDS-intron	ENST00000558285	ENST00000539772	USP3	chr15	63824842	-	USP3	chr15	63855207	-
5CDS-intron	ENST00000558285	ENST00000558285	USP3	chr15	63824842	-	USP3	chr15	63855207	-
5CDS-intron	ENST00000558285	ENST00000559711	USP3	chr15	63824842	-	USP3	chr15	63855207	-
5CDS-intron	ENST00000558285	ENST00000558218	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000559711	ENST00000540797	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000559711	ENST00000380324	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000559711	ENST00000268049	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000559711	ENST00000536001	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000559711	ENST00000539772	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000559711	ENST00000558285	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000559711	ENST00000559711	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000559711	ENST00000558218	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000558218	ENST00000540797	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000558218	ENST00000380324	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000558218	ENST00000268049	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000558218	ENST00000536001	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000558218	ENST00000539772	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000558218	ENST00000558285	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000558218	ENST00000559711	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000558218	ENST00000558218	USP3	chr15	63824842	-	USP3	chr15	63855207	-
intron-intron	ENST00000540797	ENST00000540797	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000540797	ENST00000380324	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000540797	ENST00000268049	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000540797	ENST00000536001	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000540797	ENST00000539772	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000540797	ENST00000558285	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000540797	ENST00000559711	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000540797	ENST00000558218	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000380324	ENST00000540797	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000380324	ENST00000380324	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000380324	ENST00000268049	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000380324	ENST00000536001	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000380324	ENST00000539772	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000380324	ENST00000558285	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000380324	ENST00000559711	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000380324	ENST00000558218	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000268049	ENST00000540797	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000268049	ENST00000380324	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000268049	ENST00000268049	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000268049	ENST00000536001	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000268049	ENST00000539772	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000268049	ENST00000558285	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000268049	ENST00000559711	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000268049	ENST00000558218	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000536001	ENST00000540797	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000536001	ENST00000380324	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000536001	ENST00000268049	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000536001	ENST00000536001	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000536001	ENST00000539772	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000536001	ENST00000558285	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000536001	ENST00000559711	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000536001	ENST00000558218	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000539772	ENST00000540797	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000539772	ENST00000380324	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000539772	ENST00000268049	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000539772	ENST00000536001	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000539772	ENST00000539772	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000539772	ENST00000558285	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000539772	ENST00000559711	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000539772	ENST00000558218	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000558285	ENST00000540797	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000558285	ENST00000380324	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000558285	ENST00000268049	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000558285	ENST00000536001	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000558285	ENST00000539772	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000558285	ENST00000558285	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000558285	ENST00000559711	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000558285	ENST00000558218	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000559711	ENST00000540797	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000559711	ENST00000380324	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000559711	ENST00000268049	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000559711	ENST00000536001	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000559711	ENST00000539772	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000559711	ENST00000558285	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000559711	ENST00000559711	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000559711	ENST00000558218	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000558218	ENST00000540797	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000558218	ENST00000380324	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000558218	ENST00000268049	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000558218	ENST00000536001	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000558218	ENST00000539772	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000558218	ENST00000558285	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000558218	ENST00000559711	USP3	chr15	63838251	+	USP3	chr15	63835698	+
intron-intron	ENST00000558218	ENST00000558218	USP3	chr15	63838251	+	USP3	chr15	63835698	+

Top

FusionProtFeatures for USP3_USP3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
USP3 Q9Y6I4	USP3 Q9Y6I4
Hydrolase that deubiquitinates monoubiquitinated targetproteins such as histone H2A and H2B. Required for properprogression through S phase and subsequent mitotic entry. Mayregulate the DNA damage response (DDR) checkpoint throughdeubiquitination of H2A at DNA damage sites. Associates with thechromatin. {ECO:0000269\|PubMed:17980597}.	Hydrolase that deubiquitinates monoubiquitinated targetproteins such as histone H2A and H2B. Required for properprogression through S phase and subsequent mitotic entry. Mayregulate the DNA damage response (DDR) checkpoint throughdeubiquitination of H2A at DNA damage sites. Associates with thechromatin. {ECO:0000269\|PubMed:17980597}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

FusionGeneSequence for USP3_USP3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for USP3_USP3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

RelatedDrugs for USP3_USP3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for USP3_USP3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 41126

FusionGeneSummary for USP3_USP3

FusionProtFeatures for USP3_USP3

FusionGeneSequence for USP3_USP3

FusionGenePPI for USP3_USP3

RelatedDrugs for USP3_USP3

RelatedDiseases for USP3_USP3