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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41123

FusionGeneSummary for USP3_MYO1D

check button Fusion gene summary
Fusion gene informationFusion gene name: USP3_MYO1D
Fusion gene ID: 41123
HgeneTgene
Gene symbol

USP3

MYO1D

Gene ID

9960

4642

Gene nameubiquitin specific peptidase 3myosin ID
SynonymsSIH003|UBPPPP1R108|myr4
Cytomap

15q22.31

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 3deubiquitinating enzyme 3ubiquitin thioesterase 3ubiquitin thiolesterase 3ubiquitin-specific-processing protease 3unconventional myosin-Idmyosin-I gammaprotein phosphatase 1, regulatory subunit 108
Modification date2018052320180519
UniProtAcc

Q9Y6I4

O94832

Ensembl transtripts involved in fusion geneENST00000540797, ENST00000380324, 
ENST00000268049, ENST00000536001, 
ENST00000539772, ENST00000558285, 
ENST00000559711, ENST00000558218, 
ENST00000318217, ENST00000394649, 
ENST00000579584, ENST00000584232, 
ENST00000583621, 
Fusion gene scores* DoF score5 X 5 X 4=10015 X 9 X 8=1080
# samples 615
** MAII scorelog2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/1080*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP3 [Title/Abstract] AND MYO1D [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP3

GO:0016578

histone deubiquitination

17980597

HgeneUSP3

GO:0031647

regulation of protein stability

17980597

TgeneMYO1D

GO:0010923

negative regulation of phosphatase activity

19389623


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-HF-7131-01AUSP3chr15

63829355

+MYO1Dchr17

30821933

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000540797ENST00000318217USP3chr15

63829355

+MYO1Dchr17

30821933

-
intron-3CDSENST00000540797ENST00000394649USP3chr15

63829355

+MYO1Dchr17

30821933

-
intron-intronENST00000540797ENST00000579584USP3chr15

63829355

+MYO1Dchr17

30821933

-
intron-intronENST00000540797ENST00000584232USP3chr15

63829355

+MYO1Dchr17

30821933

-
intron-intronENST00000540797ENST00000583621USP3chr15

63829355

+MYO1Dchr17

30821933

-
Frame-shiftENST00000380324ENST00000318217USP3chr15

63829355

+MYO1Dchr17

30821933

-
Frame-shiftENST00000380324ENST00000394649USP3chr15

63829355

+MYO1Dchr17

30821933

-
5CDS-intronENST00000380324ENST00000579584USP3chr15

63829355

+MYO1Dchr17

30821933

-
5CDS-intronENST00000380324ENST00000584232USP3chr15

63829355

+MYO1Dchr17

30821933

-
5CDS-intronENST00000380324ENST00000583621USP3chr15

63829355

+MYO1Dchr17

30821933

-
Frame-shiftENST00000268049ENST00000318217USP3chr15

63829355

+MYO1Dchr17

30821933

-
Frame-shiftENST00000268049ENST00000394649USP3chr15

63829355

+MYO1Dchr17

30821933

-
5CDS-intronENST00000268049ENST00000579584USP3chr15

63829355

+MYO1Dchr17

30821933

-
5CDS-intronENST00000268049ENST00000584232USP3chr15

63829355

+MYO1Dchr17

30821933

-
5CDS-intronENST00000268049ENST00000583621USP3chr15

63829355

+MYO1Dchr17

30821933

-
Frame-shiftENST00000536001ENST00000318217USP3chr15

63829355

+MYO1Dchr17

30821933

-
Frame-shiftENST00000536001ENST00000394649USP3chr15

63829355

+MYO1Dchr17

30821933

-
5CDS-intronENST00000536001ENST00000579584USP3chr15

63829355

+MYO1Dchr17

30821933

-
5CDS-intronENST00000536001ENST00000584232USP3chr15

63829355

+MYO1Dchr17

30821933

-
5CDS-intronENST00000536001ENST00000583621USP3chr15

63829355

+MYO1Dchr17

30821933

-
intron-3CDSENST00000539772ENST00000318217USP3chr15

63829355

+MYO1Dchr17

30821933

-
intron-3CDSENST00000539772ENST00000394649USP3chr15

63829355

+MYO1Dchr17

30821933

-
intron-intronENST00000539772ENST00000579584USP3chr15

63829355

+MYO1Dchr17

30821933

-
intron-intronENST00000539772ENST00000584232USP3chr15

63829355

+MYO1Dchr17

30821933

-
intron-intronENST00000539772ENST00000583621USP3chr15

63829355

+MYO1Dchr17

30821933

-
Frame-shiftENST00000558285ENST00000318217USP3chr15

63829355

+MYO1Dchr17

30821933

-
Frame-shiftENST00000558285ENST00000394649USP3chr15

63829355

+MYO1Dchr17

30821933

-
5CDS-intronENST00000558285ENST00000579584USP3chr15

63829355

+MYO1Dchr17

30821933

-
5CDS-intronENST00000558285ENST00000584232USP3chr15

63829355

+MYO1Dchr17

30821933

-
5CDS-intronENST00000558285ENST00000583621USP3chr15

63829355

+MYO1Dchr17

30821933

-
intron-3CDSENST00000559711ENST00000318217USP3chr15

63829355

+MYO1Dchr17

30821933

-
intron-3CDSENST00000559711ENST00000394649USP3chr15

63829355

+MYO1Dchr17

30821933

-
intron-intronENST00000559711ENST00000579584USP3chr15

63829355

+MYO1Dchr17

30821933

-
intron-intronENST00000559711ENST00000584232USP3chr15

63829355

+MYO1Dchr17

30821933

-
intron-intronENST00000559711ENST00000583621USP3chr15

63829355

+MYO1Dchr17

30821933

-
intron-3CDSENST00000558218ENST00000318217USP3chr15

63829355

+MYO1Dchr17

30821933

-
intron-3CDSENST00000558218ENST00000394649USP3chr15

63829355

+MYO1Dchr17

30821933

-
intron-intronENST00000558218ENST00000579584USP3chr15

63829355

+MYO1Dchr17

30821933

-
intron-intronENST00000558218ENST00000584232USP3chr15

63829355

+MYO1Dchr17

30821933

-
intron-intronENST00000558218ENST00000583621USP3chr15

63829355

+MYO1Dchr17

30821933

-

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FusionProtFeatures for USP3_MYO1D


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
USP3

Q9Y6I4

MYO1D

O94832

Hydrolase that deubiquitinates monoubiquitinated targetproteins such as histone H2A and H2B. Required for properprogression through S phase and subsequent mitotic entry. Mayregulate the DNA damage response (DDR) checkpoint throughdeubiquitination of H2A at DNA damage sites. Associates with thechromatin. {ECO:0000269|PubMed:17980597}. Myosins are actin-based motor molecules with ATPaseactivity. Unconventional myosins serve in intracellular movements.Their highly divergent tails are presumed to bind to membranouscompartments, which would be moved relative to actin filaments (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for USP3_MYO1D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for USP3_MYO1D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
USP3UBC, CBR3, EIF4G1, GNAL, LRP1, PKLR, EIF3A, EIF3B, EIF3C, EIF3D, EIF3F, EIF3G, EIF3H, EIF3I, GNA13, WDTC1, RIMBP2, NXN, PRRC2B, TOR1AIP2, ELAVL1, TXNDC17, TXLNG, ZFAND6, SH3BGRL3, ATP6V1H, DDX58, IFIH1, HIST1H2AB, HIST1H2BB, ISLR, RSU1, DHX15, HIST1H3A, TMEM173, GPC1, NT5E, PDZK1MYO1DILK, PELO, SIRT7, FBXO25, CUL1, LRRK2, UBASH3B, SHC1, ATP6V1B1, ECT2, MDC1, PAXIP1, PAN2, CCDC8, EGFR, DAPK1, PEX19, VSIG4, UBB, TBC1D9B, PTEN, ZNF746, SSH1, SSH2, PSMC4, DKK3, FBXO40, TOR1AIP2, BTD, HAVCR2, EID1, NEXN, SCN3B, SSSCA1, CDH5, DNAI2, PPP6R2, LSP1, BBS7, COX15, DLST, PDHA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for USP3_MYO1D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for USP3_MYO1D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMYO1DC0004352Autistic Disorder1CTD_human