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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41113

FusionGeneSummary for USP39_CD8B

check button Fusion gene summary
Fusion gene informationFusion gene name: USP39_CD8B
Fusion gene ID: 41113
HgeneTgene
Gene symbol

USP39

CD8B

Gene ID

10713

926

Gene nameubiquitin specific peptidase 39CD8b molecule
Synonyms65K|CGI-21|HSPC332|SAD1|SNRNP65CD8B1|LEU2|LY3|LYT3|P37
Cytomap

2p11.2

2p11.2

Type of geneprotein-codingprotein-coding
DescriptionU4/U6.U5 tri-snRNP-associated protein 2SAD1 homologSnRNP assembly defective 1 homologU4/U6.U5 tri-snRNP-associated 65 kDa proteininactive ubiquitin-specific peptidase 39small nuclear ribonucleoprotein 65kDa (U4/U6.U5)ubiquitin specific protease 39T-cell surface glycoprotein CD8 beta chainCD8 antigen, beta polypeptide 1 (p37)T lymphocyte surface glycoprotein beta chain
Modification date2018052220180519
UniProtAcc

Q53GS9

P10966

Ensembl transtripts involved in fusion geneENST00000459775, ENST00000450066, 
ENST00000409025, ENST00000409470, 
ENST00000323701, ENST00000409766, 
ENST00000393761, ENST00000393759, 
ENST00000349455, ENST00000331469, 
ENST00000390655, ENST00000431506, 
Fusion gene scores* DoF score9 X 8 X 7=5041 X 1 X 1=1
# samples 101
** MAII scorelog2(10/504*10)=-2.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: USP39 [Title/Abstract] AND CD8B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CV-7421-01AUSP39chr2

85848702

+CD8Bchr2

87049497

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000459775ENST00000393761USP39chr2

85848702

+CD8Bchr2

87049497

-
3UTR-intronENST00000459775ENST00000393759USP39chr2

85848702

+CD8Bchr2

87049497

-
3UTR-intronENST00000459775ENST00000349455USP39chr2

85848702

+CD8Bchr2

87049497

-
3UTR-intronENST00000459775ENST00000331469USP39chr2

85848702

+CD8Bchr2

87049497

-
3UTR-intronENST00000459775ENST00000390655USP39chr2

85848702

+CD8Bchr2

87049497

-
3UTR-intronENST00000459775ENST00000431506USP39chr2

85848702

+CD8Bchr2

87049497

-
intron-intronENST00000450066ENST00000393761USP39chr2

85848702

+CD8Bchr2

87049497

-
intron-intronENST00000450066ENST00000393759USP39chr2

85848702

+CD8Bchr2

87049497

-
intron-intronENST00000450066ENST00000349455USP39chr2

85848702

+CD8Bchr2

87049497

-
intron-intronENST00000450066ENST00000331469USP39chr2

85848702

+CD8Bchr2

87049497

-
intron-intronENST00000450066ENST00000390655USP39chr2

85848702

+CD8Bchr2

87049497

-
intron-intronENST00000450066ENST00000431506USP39chr2

85848702

+CD8Bchr2

87049497

-
5CDS-intronENST00000409025ENST00000393761USP39chr2

85848702

+CD8Bchr2

87049497

-
5CDS-intronENST00000409025ENST00000393759USP39chr2

85848702

+CD8Bchr2

87049497

-
5CDS-intronENST00000409025ENST00000349455USP39chr2

85848702

+CD8Bchr2

87049497

-
5CDS-intronENST00000409025ENST00000331469USP39chr2

85848702

+CD8Bchr2

87049497

-
5CDS-intronENST00000409025ENST00000390655USP39chr2

85848702

+CD8Bchr2

87049497

-
5CDS-intronENST00000409025ENST00000431506USP39chr2

85848702

+CD8Bchr2

87049497

-
5CDS-intronENST00000409470ENST00000393761USP39chr2

85848702

+CD8Bchr2

87049497

-
5CDS-intronENST00000409470ENST00000393759USP39chr2

85848702

+CD8Bchr2

87049497

-
5CDS-intronENST00000409470ENST00000349455USP39chr2

85848702

+CD8Bchr2

87049497

-
5CDS-intronENST00000409470ENST00000331469USP39chr2

85848702

+CD8Bchr2

87049497

-
5CDS-intronENST00000409470ENST00000390655USP39chr2

85848702

+CD8Bchr2

87049497

-
5CDS-intronENST00000409470ENST00000431506USP39chr2

85848702

+CD8Bchr2

87049497

-
5CDS-intronENST00000323701ENST00000393761USP39chr2

85848702

+CD8Bchr2

87049497

-
5CDS-intronENST00000323701ENST00000393759USP39chr2

85848702

+CD8Bchr2

87049497

-
5CDS-intronENST00000323701ENST00000349455USP39chr2

85848702

+CD8Bchr2

87049497

-
5CDS-intronENST00000323701ENST00000331469USP39chr2

85848702

+CD8Bchr2

87049497

-
5CDS-intronENST00000323701ENST00000390655USP39chr2

85848702

+CD8Bchr2

87049497

-
5CDS-intronENST00000323701ENST00000431506USP39chr2

85848702

+CD8Bchr2

87049497

-
5CDS-intronENST00000409766ENST00000393761USP39chr2

85848702

+CD8Bchr2

87049497

-
5CDS-intronENST00000409766ENST00000393759USP39chr2

85848702

+CD8Bchr2

87049497

-
5CDS-intronENST00000409766ENST00000349455USP39chr2

85848702

+CD8Bchr2

87049497

-
5CDS-intronENST00000409766ENST00000331469USP39chr2

85848702

+CD8Bchr2

87049497

-
5CDS-intronENST00000409766ENST00000390655USP39chr2

85848702

+CD8Bchr2

87049497

-
5CDS-intronENST00000409766ENST00000431506USP39chr2

85848702

+CD8Bchr2

87049497

-

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FusionProtFeatures for USP39_CD8B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
USP39

Q53GS9

CD8B

P10966


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for USP39_CD8B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for USP39_CD8B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
USP39CD2BP2, PA2G4, TP53, PRPF4B, SART1, PRPF4, PRPF3, EFTUD2, ZRANB2, SNRNP40, DDX23, DHX38, PRPF8, USP12, TXNL4A, SNRNP27, SNRNP200, RRP8, PRPF6, PRPF31, LSM8, GAR1, TRMT10C, RNMTL1, COPRS, DDX24, NOC3L, TSR2, RPL22L1, MEPCE, SART3, CAND1, RNU4ATAC, RNU6ATAC, APP, SF3B6, SRSF11, SF3A1, SRSF3, SRSF5, SF3B1, RBM39, DHX9, SRSF7, HNRNPC, HNRNPU, NCSTN, SON, GTF3C1, SAFB, TPBG, TRIM55, ZC3H18, SRSF10, VTN, SUPT16H, CETN2, TRAF6, TRIM25, TRIM26, TRIM39, TRIM8, TRIM5, FN1, MMS19, SP1, SRPK1, WWOX, PTEN, SAE1, CUL7, OBSL1, CCDC8, ADARB1, CSNK1E, LGALS9, NSUN2, PCNA, APEH, ARF1, HSPA4, HSPH1, NCAPD3, PRPF19, RUVBL2, NTRK1, SCARNA22, SRPK2, CDC5L, NCL, EAPP, ZNHIT2CD8BCD8A, ELAVL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for USP39_CD8B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for USP39_CD8B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCD8BC3495559Juvenile arthritis1CTD_human