FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 41093

FusionGeneSummary for USP34_WDR92

check button Fusion gene summary
Fusion gene informationFusion gene name: USP34_WDR92
Fusion gene ID: 41093
HgeneTgene
Gene symbol

USP34

WDR92

Gene ID

9736

116143

Gene nameubiquitin specific peptidase 34WD repeat domain 92
Synonyms--
Cytomap

2p15

2p14

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 34deubiquitinating enzyme 34ubiquitin specific protease 34ubiquitin thioesterase 34ubiquitin thiolesterase 34ubiquitin-specific-processing protease 34WD repeat-containing protein 92WD repeat-containing protein Monadmonadtesticular secretory protein Li 67
Modification date2018052320180523
UniProtAcc

Q70CQ2

Q96MX6

Ensembl transtripts involved in fusion geneENST00000398571, ENST00000472689, 
ENST00000492039, ENST00000295121, 
ENST00000406245, ENST00000409164, 
Fusion gene scores* DoF score18 X 14 X 10=25202 X 2 X 2=8
# samples 202
** MAII scorelog2(20/2520*10)=-3.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: USP34 [Title/Abstract] AND WDR92 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP34

GO:0016579

protein deubiquitination

14715245

HgeneUSP34

GO:0071108

protein K48-linked deubiquitination

21383061

HgeneUSP34

GO:0090263

positive regulation of canonical Wnt signaling pathway

21383061


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E2-A1II-01AUSP34chr2

61697785

-WDR92chr2

68374699

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000398571ENST00000492039USP34chr2

61697785

-WDR92chr2

68374699

-
5CDS-5UTRENST00000398571ENST00000295121USP34chr2

61697785

-WDR92chr2

68374699

-
5CDS-5UTRENST00000398571ENST00000406245USP34chr2

61697785

-WDR92chr2

68374699

-
5CDS-5UTRENST00000398571ENST00000409164USP34chr2

61697785

-WDR92chr2

68374699

-
intron-5UTRENST00000472689ENST00000492039USP34chr2

61697785

-WDR92chr2

68374699

-
intron-5UTRENST00000472689ENST00000295121USP34chr2

61697785

-WDR92chr2

68374699

-
intron-5UTRENST00000472689ENST00000406245USP34chr2

61697785

-WDR92chr2

68374699

-
intron-5UTRENST00000472689ENST00000409164USP34chr2

61697785

-WDR92chr2

68374699

-

Top

FusionProtFeatures for USP34_WDR92


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
USP34

Q70CQ2

WDR92

Q96MX6

Seems to act as a modulator of apoptosis.{ECO:0000269|PubMed:16487927}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for USP34_WDR92


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for USP34_WDR92


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
USP34ATM, SIRT7, UBE2C, UFC1, UFM1, ZRANB2, UBE2V2, SRXN1, STAM, AHCYL1, UBE4B, UBQLN1, UBXN7, UBA2, UBE2L3, UBE2V1, TTLL12, UCHL3, UBQLN2, UBXN1, ZFYVE19, SULT1A1, UBE2D1, UBQLN4, ATP6V1B2, LAGE3, SSSCA1, UBL7, USP9X, SEC24A, UNK, VPS4B, SOX2, CD2AP, ELP2, KIAA1033, SNRNP200, CSNK1A1, ZNF707, EIF3M, PCGF1, DPPA4, NANOG, POU5F1, EGFR, EPHA1, ZNF214, ZNF785, ZNF764, SUV39H1, ZNF669, ERMAP, ZNF550, LYPD4, TSPYL6, ZNF354C, ZNF211, RBM3, MTNR1A, MTNR1B, TRIM25WDR92PARD6A, RPAP3, ZNF316, PMVK, S100A10, PPP6R2, ATG7, PPP3CB, TERF2IP, THG1L, UBE3C, WDR12, WDR4, VPS25, AREG, EXOSC8, PIH1D1, CCT6B, CCT3, PPP1CC, PPP1CA, PPP1R3A, PFDN2, HERC2, OFD1, NPHP1, XPO1, PPP1CB, SEC16A, POLR1A, POLR3E, PPEF2, UXT, ASB7, PPP1R7, DNAAF2, RUVBL2, TBC1D7, TSC1, URI1, CCT2, CCT4, CCT5, CCT6A, CCT7, CCT8, CSNK1A1, CTU1, DPCD, ECD, EFTUD2, FAM83H, PDRG1, PFDN6, POLR1C, POLR2A, POLR2B, POLR2C, POLR2E, POLR2H, POLR2M, POLR3A, PRPF8, RPAP2, RUVBL1, SEC13, SNRNP200, SPAG1, TANGO6, TCP1, TELO2, TSC2, WDR92, ZNHIT2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for USP34_WDR92


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for USP34_WDR92


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource