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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 41064

FusionGeneSummary for USP32_SCPEP1

check button Fusion gene summary
Fusion gene informationFusion gene name: USP32_SCPEP1
Fusion gene ID: 41064
HgeneTgene
Gene symbol

USP32

SCPEP1

Gene ID

84669

59342

Gene nameubiquitin specific peptidase 32serine carboxypeptidase 1
SynonymsNY-REN-60|USP10HSCP1|RISC
Cytomap

17q23.1-q23.2

17q22

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32retinoid-inducible serine carboxypeptidaseserine carboxypeptidase 1 precursor protein
Modification date2018052320180526
UniProtAcc

Q8NFA0

Q9HB40

Ensembl transtripts involved in fusion geneENST00000300896, ENST00000592339, 
ENST00000393003, ENST00000586881, 
ENST00000262288, ENST00000571898, 
Fusion gene scores* DoF score28 X 15 X 9=37804 X 4 X 3=48
# samples 274
** MAII scorelog2(27/3780*10)=-3.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP32 [Title/Abstract] AND SCPEP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-C8-A275-01AUSP32chr17

58329742

-SCPEP1chr17

55075735

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000300896ENST00000262288USP32chr17

58329742

-SCPEP1chr17

55075735

+
5CDS-intronENST00000300896ENST00000571898USP32chr17

58329742

-SCPEP1chr17

55075735

+
5CDS-intronENST00000592339ENST00000262288USP32chr17

58329742

-SCPEP1chr17

55075735

+
5CDS-intronENST00000592339ENST00000571898USP32chr17

58329742

-SCPEP1chr17

55075735

+
5CDS-intronENST00000393003ENST00000262288USP32chr17

58329742

-SCPEP1chr17

55075735

+
5CDS-intronENST00000393003ENST00000571898USP32chr17

58329742

-SCPEP1chr17

55075735

+
intron-intronENST00000586881ENST00000262288USP32chr17

58329742

-SCPEP1chr17

55075735

+
intron-intronENST00000586881ENST00000571898USP32chr17

58329742

-SCPEP1chr17

55075735

+

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FusionProtFeatures for USP32_SCPEP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
USP32

Q8NFA0

SCPEP1

Q9HB40

May be involved in vascular wall and kidney homeostasis.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for USP32_SCPEP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for USP32_SCPEP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
USP32CDK1, FARSA, KRT8, KRT18, KRT19, ABCD3, YWHAB, TUBA1A, SMC1A, USP6, TRIP13, ERP44, UBXN1, MRPL39, VPS35, LRRC47, USP32P2, USP4, CUL3, CAND1, RBCK1, TRIM46, RNF144A, TRIM74, ZDHHC17, RAP1B, SORT1, SYNCRIP, BAG6, FDFT1, RAB6B, TPCN2, MANSC1, ENTPD7, ALDH3B1, CD83, NME4, HSPA12A, UBC, MTNR1A, TRIM25SCPEP1ALDH7A1, ASNS, STK26, PPP1CA, STK24, TBCB, TWF2, TUBA1A, TUBB, XPO1, YWHAE, CD2AP, PRDX6, IMPA1, IMPA2, PPA2, ZNF507


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for USP32_SCPEP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for USP32_SCPEP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource