|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 41056 |
FusionGeneSummary for USP32_MAP3K3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: USP32_MAP3K3 | Fusion gene ID: 41056 | Hgene | Tgene | Gene symbol | USP32 | MAP3K3 | Gene ID | 84669 | 4215 |
| Gene name | ubiquitin specific peptidase 32 | mitogen-activated protein kinase kinase kinase 3 | |
| Synonyms | NY-REN-60|USP10 | MAPKKK3|MEKK3 | |
| Cytomap | 17q23.1-q23.2 | 17q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32 | mitogen-activated protein kinase kinase kinase 3MAP/ERK kinase kinase 3MAPK/ERK kinase kinase 3MEK kinase 3MEKK 3 | |
| Modification date | 20180523 | 20180529 | |
| UniProtAcc | Q8NFA0 | Q99759 | |
| Ensembl transtripts involved in fusion gene | ENST00000300896, ENST00000592339, ENST00000393003, ENST00000586881, | ENST00000579585, ENST00000584573, ENST00000361733, ENST00000361357, ENST00000577395, ENST00000577784, | |
| Fusion gene scores | * DoF score | 28 X 15 X 9=3780 | 8 X 6 X 3=144 |
| # samples | 27 | 9 | |
| ** MAII score | log2(27/3780*10)=-3.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/144*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: USP32 [Title/Abstract] AND MAP3K3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MAP3K3 | GO:0035556 | intracellular signal transduction | 15001576 |
| Tgene | MAP3K3 | GO:0046777 | protein autophosphorylation | 15001576 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A0DZ-01A | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000300896 | ENST00000579585 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| In-frame | ENST00000300896 | ENST00000584573 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| Frame-shift | ENST00000300896 | ENST00000361733 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| In-frame | ENST00000300896 | ENST00000361357 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| Frame-shift | ENST00000300896 | ENST00000577395 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| 5CDS-intron | ENST00000300896 | ENST00000577784 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| intron-3CDS | ENST00000592339 | ENST00000579585 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| intron-3CDS | ENST00000592339 | ENST00000584573 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| intron-3CDS | ENST00000592339 | ENST00000361733 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| intron-3CDS | ENST00000592339 | ENST00000361357 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| intron-3CDS | ENST00000592339 | ENST00000577395 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| intron-intron | ENST00000592339 | ENST00000577784 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| Frame-shift | ENST00000393003 | ENST00000579585 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| In-frame | ENST00000393003 | ENST00000584573 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| Frame-shift | ENST00000393003 | ENST00000361733 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| In-frame | ENST00000393003 | ENST00000361357 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| Frame-shift | ENST00000393003 | ENST00000577395 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| 5CDS-intron | ENST00000393003 | ENST00000577784 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| intron-3CDS | ENST00000586881 | ENST00000579585 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| intron-3CDS | ENST00000586881 | ENST00000584573 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| intron-3CDS | ENST00000586881 | ENST00000361733 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| intron-3CDS | ENST00000586881 | ENST00000361357 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| intron-3CDS | ENST00000586881 | ENST00000577395 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
| intron-intron | ENST00000586881 | ENST00000577784 | USP32 | chr17 | 58422842 | - | MAP3K3 | chr17 | 61770909 | + |
Top |
FusionProtFeatures for USP32_MAP3K3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| USP32 | MAP3K3 |
| Component of a protein kinase signal transductioncascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3transcriptional regulators. {ECO:0000269|PubMed:12912994,ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216,ECO:0000269|PubMed:9006902}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for USP32_MAP3K3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_USP32_ENST00000300896_chr17_58422842_-_MAP3K3_ENST00000584573_chr17_61770909_+_138aa MGAKESRIGFLSYEEALRRVTDVELKRLKDAFKRTCGLSYYMGQHCFIREVLGDGVPPKVAEEPGLHCGGDADRETTVGRVXSYGRHLQD >In-frame_USP32_ENST00000300896_chr17_58422842_-_MAP3K3_ENST00000361357_chr17_61770909_+_138aa MGAKESRIGFLSYEEALRRVTDVELKRLKDAFKRTCGLSYYMGQHCFIREVLGDGVPPKVAEEPGLHCGGDADRETTVGRVXSYGRHLQD >In-frame_USP32_ENST00000393003_chr17_58422842_-_MAP3K3_ENST00000584573_chr17_61770909_+_138aa MGAKESRIGFLSYEEALRRVTDVELKRLKDAFKRTCGLSYYMGQHCFIREVLGDGVPPKVAEEPGLHCGGDADRETTVGRVXSYGRHLQD >In-frame_USP32_ENST00000393003_chr17_58422842_-_MAP3K3_ENST00000361357_chr17_61770909_+_138aa MGAKESRIGFLSYEEALRRVTDVELKRLKDAFKRTCGLSYYMGQHCFIREVLGDGVPPKVAEEPGLHCGGDADRETTVGRVXSYGRHLQD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_USP32_ENST00000300896_chr17_58422842_-_MAP3K3_ENST00000584573_chr17_61770909_+_415nt ATGGGTGCCAAGGAGTCACGGATCGGATTCCTCAGCTACGAGGAGGCGCTGAGGAGAGTTACAGATGTAGAGCTAAAACGACTGAAGGAT GCTTTCAAGAGGACCTGTGGACTCTCATATTACATGGGCCAGCACTGCTTCATCCGGGAAGTGCTTGGGGATGGAGTGCCTCCAAAGGTT GCTGAGGAGCCTGGGCTGCACTGTGGTGGAGATGCTGACAGAGAAACCACCGTGGGCAGAGTATGAAGCTATGGCCGCCATCTTCAAGAT TGCCACCCAGCCCACCAATCCTCAGCTGCCCTCCCACATCTCTGAACATGGCCGGGACTTCCTGAGGCGCATTTTTGTGGAGGCTCGCCA >In-frame_USP32_ENST00000300896_chr17_58422842_-_MAP3K3_ENST00000361357_chr17_61770909_+_415nt ATGGGTGCCAAGGAGTCACGGATCGGATTCCTCAGCTACGAGGAGGCGCTGAGGAGAGTTACAGATGTAGAGCTAAAACGACTGAAGGAT GCTTTCAAGAGGACCTGTGGACTCTCATATTACATGGGCCAGCACTGCTTCATCCGGGAAGTGCTTGGGGATGGAGTGCCTCCAAAGGTT GCTGAGGAGCCTGGGCTGCACTGTGGTGGAGATGCTGACAGAGAAACCACCGTGGGCAGAGTATGAAGCTATGGCCGCCATCTTCAAGAT TGCCACCCAGCCCACCAATCCTCAGCTGCCCTCCCACATCTCTGAACATGGCCGGGACTTCCTGAGGCGCATTTTTGTGGAGGCTCGCCA >In-frame_USP32_ENST00000393003_chr17_58422842_-_MAP3K3_ENST00000584573_chr17_61770909_+_415nt ATGGGTGCCAAGGAGTCACGGATCGGATTCCTCAGCTACGAGGAGGCGCTGAGGAGAGTTACAGATGTAGAGCTAAAACGACTGAAGGAT GCTTTCAAGAGGACCTGTGGACTCTCATATTACATGGGCCAGCACTGCTTCATCCGGGAAGTGCTTGGGGATGGAGTGCCTCCAAAGGTT GCTGAGGAGCCTGGGCTGCACTGTGGTGGAGATGCTGACAGAGAAACCACCGTGGGCAGAGTATGAAGCTATGGCCGCCATCTTCAAGAT TGCCACCCAGCCCACCAATCCTCAGCTGCCCTCCCACATCTCTGAACATGGCCGGGACTTCCTGAGGCGCATTTTTGTGGAGGCTCGCCA >In-frame_USP32_ENST00000393003_chr17_58422842_-_MAP3K3_ENST00000361357_chr17_61770909_+_415nt ATGGGTGCCAAGGAGTCACGGATCGGATTCCTCAGCTACGAGGAGGCGCTGAGGAGAGTTACAGATGTAGAGCTAAAACGACTGAAGGAT GCTTTCAAGAGGACCTGTGGACTCTCATATTACATGGGCCAGCACTGCTTCATCCGGGAAGTGCTTGGGGATGGAGTGCCTCCAAAGGTT GCTGAGGAGCCTGGGCTGCACTGTGGTGGAGATGCTGACAGAGAAACCACCGTGGGCAGAGTATGAAGCTATGGCCGCCATCTTCAAGAT TGCCACCCAGCCCACCAATCCTCAGCTGCCCTCCCACATCTCTGAACATGGCCGGGACTTCCTGAGGCGCATTTTTGTGGAGGCTCGCCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_USP32_ENST00000300896_chr17_58422842_-_MAP3K3_ENST00000584573_chr17_61770909_+_793nt ACGTGATCCGGCATGGAGGCGGTGGCGGCGACCGGGAGGAGCCGCCGGGGCAGAAGCCGCACTTGTTAGTGTGGGGGGAGGTGGGGGCGG GGGACGCCGACACCGTCACCGTCACCCAGGGACGCCGAGGAGAAGGCGGGAGGGGGGTGGGGGCGAGATCAGGCTCCGACCCCCCGCCGA GGGGATGAGGGGAGCATGGGTGCCAAGGAGTCACGGATCGGATTCCTCAGCTACGAGGAGGCGCTGAGGAGAGTTACAGATGTAGAGCTA AAACGACTGAAGGATGCTTTCAAGAGGACCTGTGGACTCTCATATTACATGGGCCAGCACTGCTTCATCCGGGAAGTGCTTGGGGATGGA GTGCCTCCAAAGGTTGCTGAGGAGCCTGGGCTGCACTGTGGTGGAGATGCTGACAGAGAAACCACCGTGGGCAGAGTATGAAGCTATGGC CGCCATCTTCAAGATTGCCACCCAGCCCACCAATCCTCAGCTGCCCTCCCACATCTCTGAACATGGCCGGGACTTCCTGAGGCGCATTTT TGTGGAGGCTCGCCAGAGACCTTCAGCTGAGGAGCTGCTCACACACCACTTTGCACAGCTCATGTACTGAGCTCTCACGGCCACACAGCT GCCGGTCGCCCTTTGCTGCATGGCAGGGGGCTGCTGCTGGGCTCAGTGAAGTTGCTGCTTCTCCCAGGCAAGGCTGTGGACCATGGAGTG >In-frame_USP32_ENST00000300896_chr17_58422842_-_MAP3K3_ENST00000361357_chr17_61770909_+_3136nt ACGTGATCCGGCATGGAGGCGGTGGCGGCGACCGGGAGGAGCCGCCGGGGCAGAAGCCGCACTTGTTAGTGTGGGGGGAGGTGGGGGCGG GGGACGCCGACACCGTCACCGTCACCCAGGGACGCCGAGGAGAAGGCGGGAGGGGGGTGGGGGCGAGATCAGGCTCCGACCCCCCGCCGA GGGGATGAGGGGAGCATGGGTGCCAAGGAGTCACGGATCGGATTCCTCAGCTACGAGGAGGCGCTGAGGAGAGTTACAGATGTAGAGCTA AAACGACTGAAGGATGCTTTCAAGAGGACCTGTGGACTCTCATATTACATGGGCCAGCACTGCTTCATCCGGGAAGTGCTTGGGGATGGA GTGCCTCCAAAGGTTGCTGAGGAGCCTGGGCTGCACTGTGGTGGAGATGCTGACAGAGAAACCACCGTGGGCAGAGTATGAAGCTATGGC CGCCATCTTCAAGATTGCCACCCAGCCCACCAATCCTCAGCTGCCCTCCCACATCTCTGAACATGGCCGGGACTTCCTGAGGCGCATTTT TGTGGAGGCTCGCCAGAGACCTTCAGCTGAGGAGCTGCTCACACACCACTTTGCACAGCTCATGTACTGAGCTCTCACGGCCACACAGCT GCCGGTCGCCCTTTGCTGCATGGCAGGGGGCTGCTGCTGGGCTCAGTGAAGTTGCTGCTTCTCCCAGGCAAGGCTGTGGACCATGGAGTG GCAGCCCAGCCAGCGTCGGTCTGTGCCCCTTCCGCCACTGGGGCTCAGAGCCGGGGTGGGGTGGCTGCAGCCTCAGGACTGGGAGCCCCC AGCCTGTCAGATCCAGGAGCTCCAGTGTCCTGAGCTCAGCGTGGAGGGGTAGGGGCTGGGAACAGTGTGCAAGGCAGCCGTGGGCCCCAC CCTCGGGGATGTGTCCTGACACTGCAATTGGCACCGAAGCCCAGAGGGTCTGGGGGCACAAGACTGACGCCAGGGTATGAAGAGTGTTAT TTTCATTCAAAGTGTTATTTTGTTTTTCCTTCCAATGTCTGGAGACCACCAGGGCATCTCTGGGCTGGATGAGCTCCCACAAGCCTGAGG GAAAGGCCAGCACTCGCTAGCAGTGGCAGGCAGAGGCCCAGGCTGCCGTCCCCTAGAGTCCCAGGTTGGCTCTGCCAGTCCTGTCCTTTA CCAAAGATGAATGAAGCAAATGTCATGCTGCCTTATTCAGGGAAGGAGGAGCCTGTCCTGCCTGTGGCCATGACCCTGCCTCTCCCAGGC AGGGGCCCGCGATGTGGAACTGCTGCCACTGAGGGGGGATCCAGTTTTGTCAATGCAGTTGTCTCTGTTTTACAAGTTGGAGTCACTCTT ATGCTGTACCCAGTTTCTAAACTGGAGACTGTGTGTGCCCTCTGGGCTCTGAGTACCCCTGCTTTGGGCTTGGGCCTAGGCTGCATTGAA AAGAGCTGAAGGTTGTGGCCTTTGCGCTCCTGGCCCAGCCTTTGTTCCCCACTGGAGCAGAAGGGGAGATGGACGACACGGTCGGGGCAT CTGGCCTGGCCAGTGCCCTGATCCCAGAGAGCCCGAGGAGGTGTCTCAGGCTGCCTGAGTCGTGACCTGCTAGGCCAGAGCCCACTCCAT CTGGTAGAAGGGAAAGCCCATATGCTACCACCAGCTGTGTCCAAAACCGCCAGCTCTGTTCTTCCTCAGCCAGCCTCGCCCATCCCCTTG AGGTCTCAGCCCCTTTCCCTTGTAGCTCCTCCCCTGGAGGGGGAATGGCAGCAGGGGTTGGGGAAACAGCATCTCCAAGCAGCTTAGAGT TGGCCATATTTACCTCAGCCTGGGCGCTGGTCCTTTCTTCCGGCCCCTCCCCTCCAAAATGTGCCTATTGCTAGAGCTCCTCCCTCTCAA CACCCAGTTTCCTTGGGAGTTGTCATTAAAGGAAAAAAAAAAAAAAAAAAGCCAGTGCCCAGGGATGGGCATCTCCAGGGAGCTGGGGAT TAGTGCCAGGCAGCCCTGCCAGCCATGCCTACATCCCCATGGGCACAGAACAAGCCAAAGCCTTCGTTGTATGTTGACGATGCACTTTTA TGAATGTAGTTTCTATCGCTGTTTTTAGCCTTTTCACATCATGTAATGTGAGGCCTTGTACTTGTTAATTTATATCTCAGATCATATTTG ATGGTTTTTATATATATCAATTCTAGACTGTTACAGGTGACGGACGCCTCAAGAGAGAGAAGAGAAAATGAAAGCAGCTGGTTTTGCAGA AGTGTGTGTCGCATGCGCCAGTTGGGCCTGGACCCTCCTGTGTCCATCCCTGTTCCCCCAGGGGCTCTATCAGCCCCTGTACCCCACACT GCCCTCTGAAGACAACACAGGCTCCTGCTTCCACCTCGGCCCTTGCCCAGGGTGGGGCCTGGCCCTCATCTTGACCAAAGCTGCTGTGTG GCAGCTCGGCCTCTCTACGACCCCATCTTGGTGGCTGCACACTCTTCCTGGCCCGCACCCCCATCCCCAGTCCCTGTTCCCCAAGAGGAT ACAGAGCACGGTGCTGGCTGACTCAACTGTGCGTCCCAGGTTCAGGGTCTTACAGAGCTCCACCCCCTGGGGTCTTACCTCACTGGGAAT GTGTTTTGAAAATGAATTTGAAGACAAGCCAACAAACCCTGCACTCCAAAAAAGCAAAACAGACCCTAATTTTTTTGTGCCAAAAACTGT GGACATGCTGGCTCAGCATCCTCAGGACCAAGTTGTTGCTTAATTTATTGTTTTTTAATAACTAATCCAGATAAAAAGTTGTGGGGCTTC AGGGTGACCTGGGCCCAAAGGTTCTGAAGGGCAGTTCCTGGCAGCCCCAGGCTTGCTGTGGGAAGGGGCCGTGCCGTCACTTTCTCATCA TTCCATGGGGTGTGTCTGCCTGGGCCAACTCTGCATGGAGAGGCCAGGGCTGGGGACAGTCCGCACTCTGCCACCCTCCTGCCCCTTCCA CCCACCCCAGCTCTATGTCTGTGTCTGAATTGTGGATCGTGCAGCCATGGTTATTGTGGAACTGTGGAACCTGCAGCCATAGTTATTTGA >In-frame_USP32_ENST00000393003_chr17_58422842_-_MAP3K3_ENST00000584573_chr17_61770909_+_634nt CAGGCTCCGACCCCCCGCCGAGGGGATGAGGGGAGCATGGGTGCCAAGGAGTCACGGATCGGATTCCTCAGCTACGAGGAGGCGCTGAGG AGAGTTACAGATGTAGAGCTAAAACGACTGAAGGATGCTTTCAAGAGGACCTGTGGACTCTCATATTACATGGGCCAGCACTGCTTCATC CGGGAAGTGCTTGGGGATGGAGTGCCTCCAAAGGTTGCTGAGGAGCCTGGGCTGCACTGTGGTGGAGATGCTGACAGAGAAACCACCGTG GGCAGAGTATGAAGCTATGGCCGCCATCTTCAAGATTGCCACCCAGCCCACCAATCCTCAGCTGCCCTCCCACATCTCTGAACATGGCCG GGACTTCCTGAGGCGCATTTTTGTGGAGGCTCGCCAGAGACCTTCAGCTGAGGAGCTGCTCACACACCACTTTGCACAGCTCATGTACTG AGCTCTCACGGCCACACAGCTGCCGGTCGCCCTTTGCTGCATGGCAGGGGGCTGCTGCTGGGCTCAGTGAAGTTGCTGCTTCTCCCAGGC AAGGCTGTGGACCATGGAGTGGCAGCCCAGCCAGCGTCGGTCTGTGCCCCTTCCGCCACTGGGGCTCAGAGCCGGGGTGGGGTGGCTGCA >In-frame_USP32_ENST00000393003_chr17_58422842_-_MAP3K3_ENST00000361357_chr17_61770909_+_2977nt CAGGCTCCGACCCCCCGCCGAGGGGATGAGGGGAGCATGGGTGCCAAGGAGTCACGGATCGGATTCCTCAGCTACGAGGAGGCGCTGAGG AGAGTTACAGATGTAGAGCTAAAACGACTGAAGGATGCTTTCAAGAGGACCTGTGGACTCTCATATTACATGGGCCAGCACTGCTTCATC CGGGAAGTGCTTGGGGATGGAGTGCCTCCAAAGGTTGCTGAGGAGCCTGGGCTGCACTGTGGTGGAGATGCTGACAGAGAAACCACCGTG GGCAGAGTATGAAGCTATGGCCGCCATCTTCAAGATTGCCACCCAGCCCACCAATCCTCAGCTGCCCTCCCACATCTCTGAACATGGCCG GGACTTCCTGAGGCGCATTTTTGTGGAGGCTCGCCAGAGACCTTCAGCTGAGGAGCTGCTCACACACCACTTTGCACAGCTCATGTACTG AGCTCTCACGGCCACACAGCTGCCGGTCGCCCTTTGCTGCATGGCAGGGGGCTGCTGCTGGGCTCAGTGAAGTTGCTGCTTCTCCCAGGC AAGGCTGTGGACCATGGAGTGGCAGCCCAGCCAGCGTCGGTCTGTGCCCCTTCCGCCACTGGGGCTCAGAGCCGGGGTGGGGTGGCTGCA GCCTCAGGACTGGGAGCCCCCAGCCTGTCAGATCCAGGAGCTCCAGTGTCCTGAGCTCAGCGTGGAGGGGTAGGGGCTGGGAACAGTGTG CAAGGCAGCCGTGGGCCCCACCCTCGGGGATGTGTCCTGACACTGCAATTGGCACCGAAGCCCAGAGGGTCTGGGGGCACAAGACTGACG CCAGGGTATGAAGAGTGTTATTTTCATTCAAAGTGTTATTTTGTTTTTCCTTCCAATGTCTGGAGACCACCAGGGCATCTCTGGGCTGGA TGAGCTCCCACAAGCCTGAGGGAAAGGCCAGCACTCGCTAGCAGTGGCAGGCAGAGGCCCAGGCTGCCGTCCCCTAGAGTCCCAGGTTGG CTCTGCCAGTCCTGTCCTTTACCAAAGATGAATGAAGCAAATGTCATGCTGCCTTATTCAGGGAAGGAGGAGCCTGTCCTGCCTGTGGCC ATGACCCTGCCTCTCCCAGGCAGGGGCCCGCGATGTGGAACTGCTGCCACTGAGGGGGGATCCAGTTTTGTCAATGCAGTTGTCTCTGTT TTACAAGTTGGAGTCACTCTTATGCTGTACCCAGTTTCTAAACTGGAGACTGTGTGTGCCCTCTGGGCTCTGAGTACCCCTGCTTTGGGC TTGGGCCTAGGCTGCATTGAAAAGAGCTGAAGGTTGTGGCCTTTGCGCTCCTGGCCCAGCCTTTGTTCCCCACTGGAGCAGAAGGGGAGA TGGACGACACGGTCGGGGCATCTGGCCTGGCCAGTGCCCTGATCCCAGAGAGCCCGAGGAGGTGTCTCAGGCTGCCTGAGTCGTGACCTG CTAGGCCAGAGCCCACTCCATCTGGTAGAAGGGAAAGCCCATATGCTACCACCAGCTGTGTCCAAAACCGCCAGCTCTGTTCTTCCTCAG CCAGCCTCGCCCATCCCCTTGAGGTCTCAGCCCCTTTCCCTTGTAGCTCCTCCCCTGGAGGGGGAATGGCAGCAGGGGTTGGGGAAACAG CATCTCCAAGCAGCTTAGAGTTGGCCATATTTACCTCAGCCTGGGCGCTGGTCCTTTCTTCCGGCCCCTCCCCTCCAAAATGTGCCTATT GCTAGAGCTCCTCCCTCTCAACACCCAGTTTCCTTGGGAGTTGTCATTAAAGGAAAAAAAAAAAAAAAAAAGCCAGTGCCCAGGGATGGG CATCTCCAGGGAGCTGGGGATTAGTGCCAGGCAGCCCTGCCAGCCATGCCTACATCCCCATGGGCACAGAACAAGCCAAAGCCTTCGTTG TATGTTGACGATGCACTTTTATGAATGTAGTTTCTATCGCTGTTTTTAGCCTTTTCACATCATGTAATGTGAGGCCTTGTACTTGTTAAT TTATATCTCAGATCATATTTGATGGTTTTTATATATATCAATTCTAGACTGTTACAGGTGACGGACGCCTCAAGAGAGAGAAGAGAAAAT GAAAGCAGCTGGTTTTGCAGAAGTGTGTGTCGCATGCGCCAGTTGGGCCTGGACCCTCCTGTGTCCATCCCTGTTCCCCCAGGGGCTCTA TCAGCCCCTGTACCCCACACTGCCCTCTGAAGACAACACAGGCTCCTGCTTCCACCTCGGCCCTTGCCCAGGGTGGGGCCTGGCCCTCAT CTTGACCAAAGCTGCTGTGTGGCAGCTCGGCCTCTCTACGACCCCATCTTGGTGGCTGCACACTCTTCCTGGCCCGCACCCCCATCCCCA GTCCCTGTTCCCCAAGAGGATACAGAGCACGGTGCTGGCTGACTCAACTGTGCGTCCCAGGTTCAGGGTCTTACAGAGCTCCACCCCCTG GGGTCTTACCTCACTGGGAATGTGTTTTGAAAATGAATTTGAAGACAAGCCAACAAACCCTGCACTCCAAAAAAGCAAAACAGACCCTAA TTTTTTTGTGCCAAAAACTGTGGACATGCTGGCTCAGCATCCTCAGGACCAAGTTGTTGCTTAATTTATTGTTTTTTAATAACTAATCCA GATAAAAAGTTGTGGGGCTTCAGGGTGACCTGGGCCCAAAGGTTCTGAAGGGCAGTTCCTGGCAGCCCCAGGCTTGCTGTGGGAAGGGGC CGTGCCGTCACTTTCTCATCATTCCATGGGGTGTGTCTGCCTGGGCCAACTCTGCATGGAGAGGCCAGGGCTGGGGACAGTCCGCACTCT GCCACCCTCCTGCCCCTTCCACCCACCCCAGCTCTATGTCTGTGTCTGAATTGTGGATCGTGCAGCCATGGTTATTGTGGAACTGTGGAA CCTGCAGCCATAGTTATTTGACTATATCTTGACCGAGGGCTTGCAGTGCAAAGCCAGGCCAGTGTTGCGCATTACTTACAATAAAAGGGA |
Top |
FusionGenePPI for USP32_MAP3K3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| USP32 | CDK1, FARSA, KRT8, KRT18, KRT19, ABCD3, YWHAB, TUBA1A, SMC1A, USP6, TRIP13, ERP44, UBXN1, MRPL39, VPS35, LRRC47, USP32P2, USP4, CUL3, CAND1, RBCK1, TRIM46, RNF144A, TRIM74, ZDHHC17, RAP1B, SORT1, SYNCRIP, BAG6, FDFT1, RAB6B, TPCN2, MANSC1, ENTPD7, ALDH3B1, CD83, NME4, HSPA12A, UBC, MTNR1A, TRIM25 | MAP3K3 | MAP2K5, YWHAG, PDRG1, CDC37, HSPA4, HSP90AA2P, MARK2, PFDN2, TRAF7, BRCA1, ZBTB16, SPAG9, YWHAE, GAB1, VWF, COPS5, HSP90AA1, SQSTM1, TRAF6, NEDD4, TOM1L1, NEDD4L, SMURF1, MAP3K7, PPP2CA, RIPK1, MAP3K3, MAP2K4, MAP2K3, IRAK1, GTF2I, XIAP, BIRC2, MBP, MAP3K2, MAP2K7, FUS, GLRX3, EGFR, NBR1, XPO1, KIFC3, IP6K3, FLNA, CHUK, PRKACA, MTOR, CBY1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for USP32_MAP3K3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for USP32_MAP3K3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | MAP3K3 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|