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Fusion gene ID: 4105 |
FusionGeneSummary for BDH1_C7orf60 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BDH1_C7orf60 | Fusion gene ID: 4105 | Hgene | Tgene | Gene symbol | BDH1 | C7orf60 | Gene ID | 622 | 154743 |
| Gene name | 3-hydroxybutyrate dehydrogenase 1 | base methyltransferase of 25S rRNA 2 homolog | |
| Synonyms | BDH|SDR9C1 | C7orf60|SAMTOR | |
| Cytomap | 3q29 | 7q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | D-beta-hydroxybutyrate dehydrogenase, mitochondrial(R)-3-hydroxybutyrate dehydrogenase3-hydroxybutyrate dehydrogenase (heart, mitochondrial)3-hydroxybutyrate dehydrogenase, type 1short chain dehydrogenase/reductase family 9C member 1 | S-adenosylmethionine sensor upstream of mTORC1UPF0532 protein C7orf60probable methyltransferase BMT2 homologprobable methyltransferase BTM2 homolog | |
| Modification date | 20180519 | 20180526 | |
| UniProtAcc | Q02338 | ||
| Ensembl transtripts involved in fusion gene | ENST00000392379, ENST00000392378, ENST00000358186, ENST00000441275, ENST00000476764, | ENST00000297145, ENST00000485446, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: BDH1 [Title/Abstract] AND C7orf60 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | C7orf60 | GO:0034198 | cellular response to amino acid starvation | 29123071 |
| Tgene | C7orf60 | GO:1904262 | negative regulation of TORC1 signaling | 29123071 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-XF-AAMX-01A | BDH1 | chr3 | 197273232 | - | C7orf60 | chr7 | 112472730 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000392379 | ENST00000297145 | BDH1 | chr3 | 197273232 | - | C7orf60 | chr7 | 112472730 | - |
| 5CDS-5UTR | ENST00000392379 | ENST00000485446 | BDH1 | chr3 | 197273232 | - | C7orf60 | chr7 | 112472730 | - |
| In-frame | ENST00000392378 | ENST00000297145 | BDH1 | chr3 | 197273232 | - | C7orf60 | chr7 | 112472730 | - |
| 5CDS-5UTR | ENST00000392378 | ENST00000485446 | BDH1 | chr3 | 197273232 | - | C7orf60 | chr7 | 112472730 | - |
| In-frame | ENST00000358186 | ENST00000297145 | BDH1 | chr3 | 197273232 | - | C7orf60 | chr7 | 112472730 | - |
| 5CDS-5UTR | ENST00000358186 | ENST00000485446 | BDH1 | chr3 | 197273232 | - | C7orf60 | chr7 | 112472730 | - |
| intron-3CDS | ENST00000441275 | ENST00000297145 | BDH1 | chr3 | 197273232 | - | C7orf60 | chr7 | 112472730 | - |
| intron-5UTR | ENST00000441275 | ENST00000485446 | BDH1 | chr3 | 197273232 | - | C7orf60 | chr7 | 112472730 | - |
| intron-3CDS | ENST00000476764 | ENST00000297145 | BDH1 | chr3 | 197273232 | - | C7orf60 | chr7 | 112472730 | - |
| intron-5UTR | ENST00000476764 | ENST00000485446 | BDH1 | chr3 | 197273232 | - | C7orf60 | chr7 | 112472730 | - |
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FusionProtFeatures for BDH1_C7orf60 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BDH1 | C7orf60 |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BDH1_C7orf60 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_BDH1_ENST00000392378_chr3_197273232_-_C7orf60_ENST00000297145_chr7_112472730_-_276aa MLATRLSRPLSRLPGKTLSACDRENGARLLQASGKIRLLDVGSCFNPFLKFEEFLTVGIDIVPAVESVYKCDFLNLQLQQPLQLAQDAID AFLKQLKNPIDSLPGELFHVVVFSLLLSYFPSPYQRWICCKKAHELLVLNGLLLIITPDSSHQNRHAMMMKSWKIAIESLGFKRFKYSKF SHMHLMAFRKISLKTTSDLVSRNYPGMLYIPQDFNSIEDEEYSNPSCYVRSDIEDEQLAYGFTELPDAPYDSDSGESQASSIPFYELEDP >In-frame_BDH1_ENST00000358186_chr3_197273232_-_C7orf60_ENST00000297145_chr7_112472730_-_276aa MLATRLSRPLSRLPGKTLSACDRENGARLLQASGKIRLLDVGSCFNPFLKFEEFLTVGIDIVPAVESVYKCDFLNLQLQQPLQLAQDAID AFLKQLKNPIDSLPGELFHVVVFSLLLSYFPSPYQRWICCKKAHELLVLNGLLLIITPDSSHQNRHAMMMKSWKIAIESLGFKRFKYSKF SHMHLMAFRKISLKTTSDLVSRNYPGMLYIPQDFNSIEDEEYSNPSCYVRSDIEDEQLAYGFTELPDAPYDSDSGESQASSIPFYELEDP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_BDH1_ENST00000392378_chr3_197273232_-_C7orf60_ENST00000297145_chr7_112472730_-_828nt ATGCTGGCCACCCGCCTCTCCAGACCCCTGTCACGGCTCCCAGGAAAAACCCTAAGTGCCTGTGATAGAGAAAATGGAGCAAGGTTGCTA CAAGCCTCAGGAAAAATCAGATTACTTGATGTTGGCAGCTGCTTTAACCCATTTCTGAAGTTTGAAGAATTTCTAACTGTTGGCATAGAT ATTGTACCTGCTGTAGAGAGTGTCTATAAATGTGATTTCCTGAACTTACAGCTTCAGCAACCACTCCAGCTTGCACAGGATGCTATAGAT GCTTTTTTGAAGCAGCTGAAAAACCCTATTGATTCTCTTCCTGGAGAGCTTTTCCATGTGGTTGTTTTCTCTCTCCTTCTTTCTTATTTT CCATCTCCTTACCAGCGATGGATTTGCTGCAAGAAAGCCCATGAACTGTTAGTGTTAAATGGTTTATTACTAATCATCACACCTGATTCC TCCCATCAGAACCGTCATGCTATGATGATGAAAAGCTGGAAGATTGCTATAGAGTCCCTGGGCTTTAAACGCTTCAAGTACTCAAAATTT TCACATATGCATCTGATGGCATTTAGGAAAATCTCTCTAAAAACCACAAGTGACTTGGTTAGTAGGAACTACCCAGGAATGTTATATATT CCTCAAGATTTCAACAGTATAGAAGATGAGGAATATTCTAACCCTTCCTGCTATGTTCGATCAGATATAGAAGATGAACAACTAGCATAT GGTTTCACAGAACTCCCTGATGCGCCATATGACTCAGATTCTGGAGAAAGTCAAGCCAGCTCTATTCCTTTCTATGAGCTAGAAGACCCC >In-frame_BDH1_ENST00000358186_chr3_197273232_-_C7orf60_ENST00000297145_chr7_112472730_-_828nt ATGCTGGCCACCCGCCTCTCCAGACCCCTGTCACGGCTCCCAGGAAAAACCCTAAGTGCCTGTGATAGAGAAAATGGAGCAAGGTTGCTA CAAGCCTCAGGAAAAATCAGATTACTTGATGTTGGCAGCTGCTTTAACCCATTTCTGAAGTTTGAAGAATTTCTAACTGTTGGCATAGAT ATTGTACCTGCTGTAGAGAGTGTCTATAAATGTGATTTCCTGAACTTACAGCTTCAGCAACCACTCCAGCTTGCACAGGATGCTATAGAT GCTTTTTTGAAGCAGCTGAAAAACCCTATTGATTCTCTTCCTGGAGAGCTTTTCCATGTGGTTGTTTTCTCTCTCCTTCTTTCTTATTTT CCATCTCCTTACCAGCGATGGATTTGCTGCAAGAAAGCCCATGAACTGTTAGTGTTAAATGGTTTATTACTAATCATCACACCTGATTCC TCCCATCAGAACCGTCATGCTATGATGATGAAAAGCTGGAAGATTGCTATAGAGTCCCTGGGCTTTAAACGCTTCAAGTACTCAAAATTT TCACATATGCATCTGATGGCATTTAGGAAAATCTCTCTAAAAACCACAAGTGACTTGGTTAGTAGGAACTACCCAGGAATGTTATATATT CCTCAAGATTTCAACAGTATAGAAGATGAGGAATATTCTAACCCTTCCTGCTATGTTCGATCAGATATAGAAGATGAACAACTAGCATAT GGTTTCACAGAACTCCCTGATGCGCCATATGACTCAGATTCTGGAGAAAGTCAAGCCAGCTCTATTCCTTTCTATGAGCTAGAAGACCCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_BDH1_ENST00000392378_chr3_197273232_-_C7orf60_ENST00000297145_chr7_112472730_-_3736nt GGAGGAGGCGGCTCGGCGGCCCCCCGACAGCCACGCCGCCGTGAGCCCCGCCCAGCGTAGCCCCAGCGCGCGCTTCGCGTGTAGAAGCGT CCGGGTGGCGGAGGCCGCAGGCCGCAGGAGTGCTGGTGGAGGGGCTTCCAGAAAGACCCTGCGGCAGCGCCCCCCCTCGGCTCTCCCCGC AGGAGAGCGGGCACCTGCGCGGCGCCGGGTGAAGGCGAGAGCCTCGGCGAGCCCTCTGCAGCGGAGCCCCCTGCCCATTTGGTTTTGGAA CCACCGGGAGGAACTGGGCCATTCTAACACCCGTTGCTACCATGCTGGCCACCCGCCTCTCCAGACCCCTGTCACGGCTCCCAGGAAAAA CCCTAAGTGCCTGTGATAGAGAAAATGGAGCAAGGTTGCTACAAGCCTCAGGAAAAATCAGATTACTTGATGTTGGCAGCTGCTTTAACC CATTTCTGAAGTTTGAAGAATTTCTAACTGTTGGCATAGATATTGTACCTGCTGTAGAGAGTGTCTATAAATGTGATTTCCTGAACTTAC AGCTTCAGCAACCACTCCAGCTTGCACAGGATGCTATAGATGCTTTTTTGAAGCAGCTGAAAAACCCTATTGATTCTCTTCCTGGAGAGC TTTTCCATGTGGTTGTTTTCTCTCTCCTTCTTTCTTATTTTCCATCTCCTTACCAGCGATGGATTTGCTGCAAGAAAGCCCATGAACTGT TAGTGTTAAATGGTTTATTACTAATCATCACACCTGATTCCTCCCATCAGAACCGTCATGCTATGATGATGAAAAGCTGGAAGATTGCTA TAGAGTCCCTGGGCTTTAAACGCTTCAAGTACTCAAAATTTTCACATATGCATCTGATGGCATTTAGGAAAATCTCTCTAAAAACCACAA GTGACTTGGTTAGTAGGAACTACCCAGGAATGTTATATATTCCTCAAGATTTCAACAGTATAGAAGATGAGGAATATTCTAACCCTTCCT GCTATGTTCGATCAGATATAGAAGATGAACAACTAGCATATGGTTTCACAGAACTCCCTGATGCGCCATATGACTCAGATTCTGGAGAAA GTCAAGCCAGCTCTATTCCTTTCTATGAGCTAGAAGACCCCATATTACTTTTAAGTTAATATAGAAGCAAAAAGCCCCTTTCAGTCCAGG CTCCTAAACTAATTGCTTACACCAATTGGAAATACTAACATGAACTCAGTACTGAAAACCTGGTTTGCATAAAAGAAATGCAGAGGTTTA CAGAGTTTGCTATTTTTTTCTACTTCTCAATTTTAAAATTTATTCTTATATAGAAAGCTTAAAGTTTCATGCAGAGTGACTCATGTCATA GCAGAAACTACTGTTACTTTAGCATTTAGCACTATCATAGAAAGGTACCTTTTTCTCTTTAGTGCTATTGTGAAAACAAGCATAATTTGC TATATGTTTTCCTTTTCAACTTTTCAGTGTTGACTATAAACCATTGAATGGAAAACTTTAAGATGTAGAAAGCTGTAGATTGCACTTTGA TGACTCACAAGTTAAATGTGATACAGAAAAATAGATCGGTTAGTTGTTTTGTGATGCACTTATCTTTTTCTTTTTTCTAACTAAAATTGT GATGTTACAGAAAGTCATTTTATGTTCCTTTTTTGTCTGATGATCCAATATTTACTGAACTTTTTGTAATTGGTGATAATTCTTTTTATT TCTTCCTTATATTAAAAGCTCATTTGACAGCATCAGACATTGGGGGAGAGATGTCCCCCAAAGTGTGTATTCTAATTTTATTAGCCCTAT CCAATAAACACCATTGCCAAAGTAGTATTTTCATAACTTTCTTGTTGATTTGGGCCTTGGTGTGAAGTATATTTACCTGAGAGTTCACTT TTACTTTTCTTAAACTTAGGCTTCATTTACAAAATGTTTTATTTAAGCAAGGAACAATGTAATACTCAATAATGACCTAAAACACCTTTT TGAAAGGGTTTGCACTTGGAAGAGAGTTTATGTTCTGTTGAAACCAACTTTGATAGGGTCCTCACCTTTCCGTTAAGGAGGTGCCGCACT ACAAGTTTCAAATTATATGGAAAAACCTAAAATTAACCCTCTGTTGGTGATCTCATAAAATGGTTTTGACCTTTTGGTATCTTAATTTCT ATCTAAACTTTATCAGAAAATTTTCTTTGAATATATCAATTAGTTGGCTGTGGGAATTTTCCCTTTCCACATTAATAAATGCCTTTCTGT GTTTCTGAATCAGAAGCAAATGATTAGGGAAAAATATATGTCCAAACAAGACAAGATTAGTTTAAACAGTTAAGAACATTTAGTCCACAT TGTCTTGTCAGCCAGCAATTGTCATGGAAGCTATCATTTTTAAGAGTGCCACTGTGTGGATTTTTTTTTCAAGTGGTTATTACATTAAAA TTACCTCATACTGAGGTTTTTGCACTGAAATATCACAGTTTCAGATTTCATGGTTAATGTTGTGCGTATGTTTGTATGTTTTTAAAGGAA ACTTGCATTTTCAATAGTTGATCCTAAATTTCATAAACTGCACTTCTTTACTCTGGTAAAGCTGATGTTTTTGTGCTTATTGTGAATTGC CGTAGTACCTTTGAATGTCAAACTTTATTTAGAAATATAAAACTTATCCTTTATGATATAAATGGTTGAGTGTATGTACCCAGTATTTCT AATTAAATTTCACATGCTAAATTAATGAAAGTAACAAGATTGTAATTTTTTAAAGTCAGTTGATTAAATGCAATAAATATTGGTTGCTCA AATATGCCACAAATAACTCGAAATTTTTCATTTACTTTCAACAGCATAAGATTCTTTAATATTTAGGATTGACTGTTCTTTCCAGTTAAG CACTGAAGGATTATGTCTTGTAGCTTCCCCAAGAGAAGGGGAAGGAAAAAAAAGCACTATGTTAAGGATAATACAGAACTCTTTTGAACT ATTTTGGTAGTACCTTTTACCATACTGTTTGCTTTTTGATTTGGGTAAATATCTTAAGAGCAAAGAAAACAATACACCAAATGAAAATGC TTTGAAAGTAAATGAAAACAGCGCTTTTGAAAGGCTGGTATAGTATGACCCTGGAGTCAGCCTTTGTGTTACAGCGAAAATGTTGGTGCT ATAAATTCTGATTGTTTACAGATGTTGATTCTGCTTATGCTCCAAAGTGTGCATGATGTATTTTACGTAGTACTCTGAGGAAGTCTCTTT ATAAAACCTACTACCACTTAGTATAAATTTGTTTGAATTTATATCATTTGTTACTGTAAATTCAGCTTATTCCAATTAGGTTGGCACAGA TTTAAACTGATACACATTCCACAAAAACCAATTCAGTGTATAAGTATTGAAGTATAAGCAGTCATTGCAGCTTGATGCCAGATCATGTAT GTAATAACAAGTGGAAGTTAATAGGGCCTTCTAATACTGTATGGGTACTCCTAAGAATTATTTCATTTTGGATATAAAGAAGTTATGAGG CCTCCTGTCACATTCACAGCTGGTTCTCCAAAATAATTTGGTTGTTTCAAAAACAAATGGTAATCATTTGGTTGGATTCTTCAGTATCAT GACTAGATCATGTGGTTTTACCATAGTTGCCAAGTGGTGGGAGGTAGCATACCTGAAAATGTACGTGTGTGTTTGTTGTATTTTTTCACA >In-frame_BDH1_ENST00000358186_chr3_197273232_-_C7orf60_ENST00000297145_chr7_112472730_-_3611nt ATTGAAAGAATACACAGAAAGCCTGGAAAAGGTTTCCAGGGGTGTCAATACGCCCTGTCAACTGAGAATTAAGAGGATCCGGCTGGTCAC TTGCCTGGAGAGGATCCTGCATGCTGATAGTGCTGAGGCACCTGCCAGCTAAGAACCACCGGGAGGAACTGGGCCATTCTAACACCCGTT GCTACCATGCTGGCCACCCGCCTCTCCAGACCCCTGTCACGGCTCCCAGGAAAAACCCTAAGTGCCTGTGATAGAGAAAATGGAGCAAGG TTGCTACAAGCCTCAGGAAAAATCAGATTACTTGATGTTGGCAGCTGCTTTAACCCATTTCTGAAGTTTGAAGAATTTCTAACTGTTGGC ATAGATATTGTACCTGCTGTAGAGAGTGTCTATAAATGTGATTTCCTGAACTTACAGCTTCAGCAACCACTCCAGCTTGCACAGGATGCT ATAGATGCTTTTTTGAAGCAGCTGAAAAACCCTATTGATTCTCTTCCTGGAGAGCTTTTCCATGTGGTTGTTTTCTCTCTCCTTCTTTCT TATTTTCCATCTCCTTACCAGCGATGGATTTGCTGCAAGAAAGCCCATGAACTGTTAGTGTTAAATGGTTTATTACTAATCATCACACCT GATTCCTCCCATCAGAACCGTCATGCTATGATGATGAAAAGCTGGAAGATTGCTATAGAGTCCCTGGGCTTTAAACGCTTCAAGTACTCA AAATTTTCACATATGCATCTGATGGCATTTAGGAAAATCTCTCTAAAAACCACAAGTGACTTGGTTAGTAGGAACTACCCAGGAATGTTA TATATTCCTCAAGATTTCAACAGTATAGAAGATGAGGAATATTCTAACCCTTCCTGCTATGTTCGATCAGATATAGAAGATGAACAACTA GCATATGGTTTCACAGAACTCCCTGATGCGCCATATGACTCAGATTCTGGAGAAAGTCAAGCCAGCTCTATTCCTTTCTATGAGCTAGAA GACCCCATATTACTTTTAAGTTAATATAGAAGCAAAAAGCCCCTTTCAGTCCAGGCTCCTAAACTAATTGCTTACACCAATTGGAAATAC TAACATGAACTCAGTACTGAAAACCTGGTTTGCATAAAAGAAATGCAGAGGTTTACAGAGTTTGCTATTTTTTTCTACTTCTCAATTTTA AAATTTATTCTTATATAGAAAGCTTAAAGTTTCATGCAGAGTGACTCATGTCATAGCAGAAACTACTGTTACTTTAGCATTTAGCACTAT CATAGAAAGGTACCTTTTTCTCTTTAGTGCTATTGTGAAAACAAGCATAATTTGCTATATGTTTTCCTTTTCAACTTTTCAGTGTTGACT ATAAACCATTGAATGGAAAACTTTAAGATGTAGAAAGCTGTAGATTGCACTTTGATGACTCACAAGTTAAATGTGATACAGAAAAATAGA TCGGTTAGTTGTTTTGTGATGCACTTATCTTTTTCTTTTTTCTAACTAAAATTGTGATGTTACAGAAAGTCATTTTATGTTCCTTTTTTG TCTGATGATCCAATATTTACTGAACTTTTTGTAATTGGTGATAATTCTTTTTATTTCTTCCTTATATTAAAAGCTCATTTGACAGCATCA GACATTGGGGGAGAGATGTCCCCCAAAGTGTGTATTCTAATTTTATTAGCCCTATCCAATAAACACCATTGCCAAAGTAGTATTTTCATA ACTTTCTTGTTGATTTGGGCCTTGGTGTGAAGTATATTTACCTGAGAGTTCACTTTTACTTTTCTTAAACTTAGGCTTCATTTACAAAAT GTTTTATTTAAGCAAGGAACAATGTAATACTCAATAATGACCTAAAACACCTTTTTGAAAGGGTTTGCACTTGGAAGAGAGTTTATGTTC TGTTGAAACCAACTTTGATAGGGTCCTCACCTTTCCGTTAAGGAGGTGCCGCACTACAAGTTTCAAATTATATGGAAAAACCTAAAATTA ACCCTCTGTTGGTGATCTCATAAAATGGTTTTGACCTTTTGGTATCTTAATTTCTATCTAAACTTTATCAGAAAATTTTCTTTGAATATA TCAATTAGTTGGCTGTGGGAATTTTCCCTTTCCACATTAATAAATGCCTTTCTGTGTTTCTGAATCAGAAGCAAATGATTAGGGAAAAAT ATATGTCCAAACAAGACAAGATTAGTTTAAACAGTTAAGAACATTTAGTCCACATTGTCTTGTCAGCCAGCAATTGTCATGGAAGCTATC ATTTTTAAGAGTGCCACTGTGTGGATTTTTTTTTCAAGTGGTTATTACATTAAAATTACCTCATACTGAGGTTTTTGCACTGAAATATCA CAGTTTCAGATTTCATGGTTAATGTTGTGCGTATGTTTGTATGTTTTTAAAGGAAACTTGCATTTTCAATAGTTGATCCTAAATTTCATA AACTGCACTTCTTTACTCTGGTAAAGCTGATGTTTTTGTGCTTATTGTGAATTGCCGTAGTACCTTTGAATGTCAAACTTTATTTAGAAA TATAAAACTTATCCTTTATGATATAAATGGTTGAGTGTATGTACCCAGTATTTCTAATTAAATTTCACATGCTAAATTAATGAAAGTAAC AAGATTGTAATTTTTTAAAGTCAGTTGATTAAATGCAATAAATATTGGTTGCTCAAATATGCCACAAATAACTCGAAATTTTTCATTTAC TTTCAACAGCATAAGATTCTTTAATATTTAGGATTGACTGTTCTTTCCAGTTAAGCACTGAAGGATTATGTCTTGTAGCTTCCCCAAGAG AAGGGGAAGGAAAAAAAAGCACTATGTTAAGGATAATACAGAACTCTTTTGAACTATTTTGGTAGTACCTTTTACCATACTGTTTGCTTT TTGATTTGGGTAAATATCTTAAGAGCAAAGAAAACAATACACCAAATGAAAATGCTTTGAAAGTAAATGAAAACAGCGCTTTTGAAAGGC TGGTATAGTATGACCCTGGAGTCAGCCTTTGTGTTACAGCGAAAATGTTGGTGCTATAAATTCTGATTGTTTACAGATGTTGATTCTGCT TATGCTCCAAAGTGTGCATGATGTATTTTACGTAGTACTCTGAGGAAGTCTCTTTATAAAACCTACTACCACTTAGTATAAATTTGTTTG AATTTATATCATTTGTTACTGTAAATTCAGCTTATTCCAATTAGGTTGGCACAGATTTAAACTGATACACATTCCACAAAAACCAATTCA GTGTATAAGTATTGAAGTATAAGCAGTCATTGCAGCTTGATGCCAGATCATGTATGTAATAACAAGTGGAAGTTAATAGGGCCTTCTAAT ACTGTATGGGTACTCCTAAGAATTATTTCATTTTGGATATAAAGAAGTTATGAGGCCTCCTGTCACATTCACAGCTGGTTCTCCAAAATA ATTTGGTTGTTTCAAAAACAAATGGTAATCATTTGGTTGGATTCTTCAGTATCATGACTAGATCATGTGGTTTTACCATAGTTGCCAAGT GGTGGGAGGTAGCATACCTGAAAATGTACGTGTGTGTTTGTTGTATTTTTTCACATTTTGTGAACAAAGCACATTTATTAAAAATTTTAA |
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FusionGenePPI for BDH1_C7orf60 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| BDH1 | APP, HDAC6, HDAC11, SPACA1, MAGEA1, LPAR6, ERGIC3, TMPRSS5, TNF, THBS3, COQ9, LAMP2, APLNR, SLC15A1, C1orf85, SLC39A9, IL13RA2, SLC18A1, CD79A, LPAR4, PGM3, QTRTD1, MARC1, ACSL1 | C7orf60 | DEPDC5, SZT2, C12orf66, NPRL2, NPRL3, ACAD11, ITFG2, KPTN, REN, PER1, MIF4GD, GRN, MGEA5, TSR3, TGFBRAP1, CSNK1E, VPS11, SHMT1, POLR2A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BDH1_C7orf60 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BDH1_C7orf60 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | BDH1 | C0023893 | Liver Cirrhosis, Experimental | 2 | CTD_human |
| Hgene | BDH1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
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