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Fusion gene ID: 40995 |
FusionGeneSummary for USP18_BAG6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: USP18_BAG6 | Fusion gene ID: 40995 | Hgene | Tgene | Gene symbol | USP18 | BAG6 | Gene ID | 11274 | 7917 |
| Gene name | ubiquitin specific peptidase 18 | BCL2 associated athanogene 6 | |
| Synonyms | ISG43|PTORCH2|UBP43 | BAG-6|BAT3|D6S52E|G3 | |
| Cytomap | 22q11.21 | 6p21.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubl carboxyl-terminal hydrolase 1843 kDa ISG15-specific proteaseISG15-specific-processing proteasehUBP43ubiquitin specific protease 18ubl thioesterase 18ubl thiolesterase 18 | large proline-rich protein BAG6BAG family molecular chaperone regulator 6HLA-B-associated transcript 3large proline-rich protein BAT3protein G3protein Scythescythe | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UMW8 | P46379 | |
| Ensembl transtripts involved in fusion gene | ENST00000215794, | ENST00000375976, ENST00000211379, ENST00000439687, ENST00000404765, ENST00000375964, ENST00000362049, ENST00000470875, ENST00000442479, ENST00000449450, ENST00000417144, ENST00000551350, ENST00000497694, ENST00000422756, ENST00000425649, ENST00000434446, ENST00000552467, ENST00000463220, ENST00000413922, ENST00000454478, ENST00000412012, ENST00000546462, ENST00000460147, ENST00000383446, ENST00000361076, ENST00000383448, ENST00000552605, ENST00000471376, ENST00000415373, ENST00000444402, ENST00000415345, ENST00000550393, ENST00000461852, ENST00000443182, ENST00000451932, ENST00000419847, ENST00000552116, ENST00000460429, | |
| Fusion gene scores | * DoF score | 4 X 5 X 4=80 | 5 X 5 X 3=75 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/80*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: USP18 [Title/Abstract] AND BAG6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | BAG6 | GO:0002429 | immune response-activating cell surface receptor signaling pathway | 18852879 |
| Tgene | BAG6 | GO:0006915 | apoptotic process | 14960581 |
| Tgene | BAG6 | GO:0018393 | internal peptidyl-lysine acetylation | 17403783 |
| Tgene | BAG6 | GO:0030101 | natural killer cell activation | 18852879 |
| Tgene | BAG6 | GO:0030433 | ubiquitin-dependent ERAD pathway | 23129660|24981174 |
| Tgene | BAG6 | GO:0071712 | ER-associated misfolded protein catabolic process | 23129660|24981174 |
| Tgene | BAG6 | GO:0071816 | tail-anchored membrane protein insertion into ER membrane | 20676083 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-24-1424-01A | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000215794 | ENST00000375976 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| Frame-shift | ENST00000215794 | ENST00000211379 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| Frame-shift | ENST00000215794 | ENST00000439687 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| Frame-shift | ENST00000215794 | ENST00000404765 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| Frame-shift | ENST00000215794 | ENST00000375964 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| Frame-shift | ENST00000215794 | ENST00000362049 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000470875 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000442479 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000449450 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000417144 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000551350 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000497694 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000422756 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000425649 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000434446 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000552467 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000463220 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000413922 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000454478 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000412012 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000546462 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000460147 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000383446 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000361076 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000383448 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000552605 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000471376 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000415373 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000444402 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000415345 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000550393 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000461852 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000443182 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000451932 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000419847 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000552116 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
| 5CDS-intron | ENST00000215794 | ENST00000460429 | USP18 | chr22 | 18640587 | + | BAG6 | chr6 | 31607003 | - |
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FusionProtFeatures for USP18_BAG6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| USP18 | BAG6 |
| Involved in the regulation of inflammatory response tointerferon type 1 (PubMed:27325888). Can efficiently cleave onlyISG15 fusions including native ISG15 conjugates linked viaisopeptide bonds. Necessary to maintain a critical cellularbalance of ISG15-conjugated proteins in both healthy and stressedorganisms. {ECO:0000269|PubMed:27325888}. Isoform 2: Has enzymatic activity similar to isoform 1and interferes with type I interferon signaling. MajordeISGylation enzyme for nuclear proteins (PubMed:22170061).{ECO:0000269|PubMed:22170061}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for USP18_BAG6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for USP18_BAG6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| USP18 | ISG15, MYL6, NME1, KDM3B, USP41, SKP2, IFNAR2, TRIM54, PCNA, MOV10, NXF1, ZDHHC17, HERC1, BECN1, ATG14, PIK3C3, UVRAG, TMEM14A, TAB1, MAP3K7, CHUK, IKBKB, IKBKG, CARD11, TAB2, TMEM173 | BAG6 | XRN1, EFEMP2, KLHL12, TSC22D1, MAGED1, WRAP73, PPP4C, RCN2, C19orf10, CTSE, IQCG, DPT, EDN1, FKBP2, LPPR3, IGFBP5, NDUFA6, PPAP2C, PRNP, RAB8A, TDGF1, B2M, CHN2, CTSB, DNAJB11, PELP1, NOMO1, PTH, REG1B, S100A4, TAC1, IMMT, CDK4, FAM173A, SMN1, STX5, ARPC3, IKBKAP, SETDB1, CSTF2, TOMM20, HSPA1A, NBL1, UBL4A, RPAP1, GTF2F2, CTCFL, INSIG2, MAVS, CDK5, GSK3B, MEST, PLA2G2A, RAC1, CSNK2B, SERPINH1, FZD4, TK1, MAPK6, CDKN1A, PLK1, RCC1, NDUFB11, PIN1, TTR, SRGN, NR1H2, ANXA7, CTSL, GADD45A, IGF2, PCK1, EP300, APLP2, DOT1L, HIST2H3C, TSG101, SPP1, DERL2, AMFR, VCP, TRA, SEC61B, SEC61A1, VAMP2, AIFM1, SGTA, ICK, UBQLN4, ATN1, ATXN2, FAF2, FN1, PRPF40A, ZFYVE9, PTPN12, FAM46A, HAVCR2, METTL21B, METTL23, GET4, BAG6, FAS, CLU, SERPING1, C1QA, CXCL8, LBP, NPY, POLR2J, PTN, SDC2, HSPA13, TP63, CD93, ACVR1B, CDK18, PRMT2, ASNA1, EEF1D, WDHD1, HLA-A, ZFAND2B, PASK, SHFM1, LCK, VAPB, FAF1, NCR3, EFEMP1, TFCP2, RNF126, FAM9B, CUL7, USP13, NTRK1, RFXANK, RPN1, MED4, MED20, MED23, EWSR1, SERPINI2, BLMH, CALU, CAST, CDKN2A, CRY1, ECHS1, ETF1, FANCD2, MTOR, GOLGA1, HEXA, ITGB4, MAPT, MAP3K4, NHS, NOP2, YBX1, FURIN, PDCL, PHKA2, PI4KA, PRIM2, PTMA, PWP2, RET, SRSF2, UAP1, TARBP1, TCOF1, ICAM5, TLN1, USP1, ATM, CDK8, MKNK2, HNRNPD, HSPA5, KIF2A, LLGL2, MAPK3, RB1, VPS26A, KIF21B, SGTB, CCDC88A, CERK, CDCA5, IP6K3, KLC3, CEP170P1, RAD54L, KCNAB2, EIF3H, MTA1, PTTG1, TRIP10, GTF2IRD1, C2CD5, URB1, OSBPL2, OXSR1, USP15, CEBPZ, TCIRG1, TUBB3, LAMTOR5, POLR3F, CNTRL, TRIOBP, FNDC3A, PDCD11, WDFY3, CNOT1, RRP1B, SIRT5, MACF1, MYOF, WDR91, PNPLA8, CHMP5, SIRT6, PPIL3, PALMD, UHRF1BP1, UACA, CEP55, DNAJA4, PLXNA3, BAIAP2L1, SMEK2, ZNF286A, UVSSA, ENOPH1, MRPL17, PDF, IPO4, TSEN2, SBF2, ASCC2, WDR83, MYPN, USP32, ACTR8, RAVER1, MRPL55, PDE12, REEP3, SYVN1, PSMD14, UBXN1, VCAM1, OTUB1, POU5F1, HUWE1, UBR5, UBR3, UBR2, RNF123, WWP2, HECTD3, RLIM, TRAFD1, TRIM27, TRIM21, TRIM11, FANCL, STUB1, CCNB1IP1, RNF5, RNF115, HSPA2, CDKN3, FUZ, IL17RC, FAM58A, MTNR1A, TRIM25, TES, UBQLN1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for USP18_BAG6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for USP18_BAG6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | USP18 | C0023269 | leiomyosarcoma | 1 | CTD_human |
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