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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40982

FusionGeneSummary for USP15_PCBP2

check button Fusion gene summary
Fusion gene informationFusion gene name: USP15_PCBP2
Fusion gene ID: 40982
HgeneTgene
Gene symbol

USP15

PCBP2

Gene ID

9958

5094

Gene nameubiquitin specific peptidase 15poly(rC) binding protein 2
SynonymsUNPH-2|UNPH4HNRNPE2|HNRPE2|hnRNP-E2
Cytomap

12q14.1

12q13.13

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 15deubiquitinating enzyme 15ubiquitin thioesterase 15ubiquitin thiolesterase 15ubiquitin-specific-processing protease 15poly(rC)-binding protein 2alpha-CP2heterogeneous nuclear ribonucleoprotein E2heterogenous nuclear ribonucleoprotein E2hnRNP E2
Modification date2018052320180522
UniProtAcc

Q9Y4E8

Q15366

Ensembl transtripts involved in fusion geneENST00000353364, ENST00000280377, 
ENST00000393654, ENST00000550632, 
ENST00000312635, 
ENST00000359282, 
ENST00000603815, ENST00000437231, 
ENST00000447282, ENST00000549863, 
ENST00000359462, ENST00000546463, 
ENST00000552296, ENST00000552819, 
ENST00000455667, ENST00000439930, 
ENST00000548933, ENST00000541275, 
Fusion gene scores* DoF score13 X 7 X 6=54614 X 14 X 7=1372
# samples 1315
** MAII scorelog2(13/546*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/1372*10)=-3.19324607567693
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USP15 [Title/Abstract] AND PCBP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUSP15

GO:0007179

transforming growth factor beta receptor signaling pathway

21947082

HgeneUSP15

GO:0016579

protein deubiquitination

16005295|22344298|27368102

HgeneUSP15

GO:0030509

BMP signaling pathway

21947082

HgeneUSP15

GO:0035520

monoubiquitinated protein deubiquitination

21947082

HgeneUSP15

GO:0035616

histone H2B conserved C-terminal lysine deubiquitination

24526689

TgenePCBP2

GO:0039694

viral RNA genome replication

12414943

TgenePCBP2

GO:0075522

IRES-dependent viral translational initiation

12414943


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-41-2571-01AUSP15chr12

62654284

+PCBP2chr12

53848510

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000353364ENST00000359282USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000353364ENST00000603815USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000353364ENST00000437231USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000353364ENST00000447282USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000353364ENST00000549863USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000353364ENST00000359462USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000353364ENST00000546463USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000353364ENST00000552296USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-intronENST00000353364ENST00000552819USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-intronENST00000353364ENST00000455667USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-intronENST00000353364ENST00000439930USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-intronENST00000353364ENST00000548933USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000353364ENST00000541275USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000280377ENST00000359282USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000280377ENST00000603815USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000280377ENST00000437231USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000280377ENST00000447282USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000280377ENST00000549863USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000280377ENST00000359462USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000280377ENST00000546463USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000280377ENST00000552296USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-intronENST00000280377ENST00000552819USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-intronENST00000280377ENST00000455667USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-intronENST00000280377ENST00000439930USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-intronENST00000280377ENST00000548933USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000280377ENST00000541275USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000393654ENST00000359282USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000393654ENST00000603815USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000393654ENST00000437231USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000393654ENST00000447282USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000393654ENST00000549863USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000393654ENST00000359462USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000393654ENST00000546463USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000393654ENST00000552296USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-intronENST00000393654ENST00000552819USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-intronENST00000393654ENST00000455667USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-intronENST00000393654ENST00000439930USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-intronENST00000393654ENST00000548933USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000393654ENST00000541275USP15chr12

62654284

+PCBP2chr12

53848510

+
3UTR-5UTRENST00000550632ENST00000359282USP15chr12

62654284

+PCBP2chr12

53848510

+
3UTR-5UTRENST00000550632ENST00000603815USP15chr12

62654284

+PCBP2chr12

53848510

+
3UTR-5UTRENST00000550632ENST00000437231USP15chr12

62654284

+PCBP2chr12

53848510

+
3UTR-5UTRENST00000550632ENST00000447282USP15chr12

62654284

+PCBP2chr12

53848510

+
3UTR-5UTRENST00000550632ENST00000549863USP15chr12

62654284

+PCBP2chr12

53848510

+
3UTR-5UTRENST00000550632ENST00000359462USP15chr12

62654284

+PCBP2chr12

53848510

+
3UTR-5UTRENST00000550632ENST00000546463USP15chr12

62654284

+PCBP2chr12

53848510

+
3UTR-5UTRENST00000550632ENST00000552296USP15chr12

62654284

+PCBP2chr12

53848510

+
3UTR-intronENST00000550632ENST00000552819USP15chr12

62654284

+PCBP2chr12

53848510

+
3UTR-intronENST00000550632ENST00000455667USP15chr12

62654284

+PCBP2chr12

53848510

+
3UTR-intronENST00000550632ENST00000439930USP15chr12

62654284

+PCBP2chr12

53848510

+
3UTR-intronENST00000550632ENST00000548933USP15chr12

62654284

+PCBP2chr12

53848510

+
3UTR-5UTRENST00000550632ENST00000541275USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000312635ENST00000359282USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000312635ENST00000603815USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000312635ENST00000437231USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000312635ENST00000447282USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000312635ENST00000549863USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000312635ENST00000359462USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000312635ENST00000546463USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000312635ENST00000552296USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-intronENST00000312635ENST00000552819USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-intronENST00000312635ENST00000455667USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-intronENST00000312635ENST00000439930USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-intronENST00000312635ENST00000548933USP15chr12

62654284

+PCBP2chr12

53848510

+
5CDS-5UTRENST00000312635ENST00000541275USP15chr12

62654284

+PCBP2chr12

53848510

+

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FusionProtFeatures for USP15_PCBP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
USP15

Q9Y4E8

PCBP2

Q15366

Hydrolase that removes conjugated ubiquitin from targetproteins and regulates various pathways such as the TGF-betareceptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways(PubMed:21947082, PubMed:22344298, PubMed:24852371,PubMed:16005295, PubMed:17318178, PubMed:19826004,PubMed:19576224). Acts as a key regulator of TGF-beta receptorsignaling pathway, but the precise mechanism is still unclear:according to a report, acts by promoting deubiquitination ofmonoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), therebyalleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports,regulates the TGF-beta receptor signaling pathway by mediatingdeubiquitination and stabilization of TGFBR1, leading to anenhanced TGF-beta signal (PubMed:22344298). Able to mediatedeubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them againstproteasomal degradation. May also regulate gene expression and/orDNA repair through the deubiquitination of histone H2B(PubMed:24526689). Acts as an inhibitor of mitophagy bycounteracting the action of parkin (PRKN): hydrolyzes cleavage of'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached byparkin on target proteins such as MFN2, thereby reducing parkin'sability to drive mitophagy (PubMed:24852371). Acts as anassociated component of COP9 signalosome complex (CSN) andregulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA anddeubiquitinates substrates bound to VCP (PubMed:16005295,PubMed:17318178, PubMed:19826004, PubMed:19576224). Involved inendosome organization by mediating deubiquitination of SQSTM1:ubiquitinated SQSTM1 forms a molecular bridge that restrainscognate vesicles in the perinuclear region and itsdeubiquitination releases target vesicles for fast transport intothe cell periphery (PubMed:27368102).{ECO:0000269|PubMed:16005295, ECO:0000269|PubMed:17318178,ECO:0000269|PubMed:19576224, ECO:0000269|PubMed:19826004,ECO:0000269|PubMed:21947082, ECO:0000269|PubMed:22344298,ECO:0000269|PubMed:24526689, ECO:0000269|PubMed:24852371,ECO:0000269|PubMed:27368102}. (Microbial infection) Protects APC and humanpapillomavirus type 16 protein E6 against degradation via theubiquitin proteasome pathway. {ECO:0000269|PubMed:19553310}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for USP15_PCBP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for USP15_PCBP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
USP15CD40, PHB2, UBE2G2, DFFA, ADSL, ALDOA, CALML3, CKB, CSTF1, FABP4, KRT31, KRT33B, KRT34, KRT35, KRT81, KRT85, LGALS7, MYH2, MYH4, PGAM2, PSMD11, SELENBP1, PRPF4, PRPF3, RNF40, PPIH, LSM6, LSM4, PRPF31, LSM8, MEPCE, LSM2, TUT1, LRRC15, VSIG8, SART3, PSMD7, USP11, UBC, TERF2, USP15, SMAD1, SMAD2, SMAD3, SMAD4, UBE2S, TRAF6, FHL1, USP4, SMAD7, SMURF2, TGFBR1, CUL3, CUL4B, COPS5, CAND1, STK33, GRK5, SHC1, TRIM63, TRIM54, USP21, USP20, USP51, USP7, OTUB1, JOSD1, UCHL3, USP8, USP33, SENP8, USP14, STAM, BAP1, YOD1, UCHL1, SENP3, USP28, WAPAL, USP10, ZC3H13, HMG20B, ZMYM2, NOTCH1, BRAP, TRIM21, RBCK1, TRIM17, PHF7, RNF126, TRIM46, TRIM5, RNF144B, TRIM74, SMURF1, FN1, BIRC2, BIRC3, NPM1, SOX2, LMNA, NUSAP1, PLOD2, UGP2, HIST2H2BE, HIST2H2AC, RNF20, TRIM25, TRAF4, SMAD6, BMPR1A, ACVR1, BMPR1B, SHFM1, HUWE1, PLA2G2A, MAD1L1, SPDL1, CARD9, CCDC57, NXF1, ECHS1, BCAT1, EEF2KMT, SNUPN, OBFC1, TRPV5, PSMB9, DDX58, NTRK1, MED4, MKNK2, ID1, SORT1, ATL3, SGTB, TMEM132A, TCEAL4, FERMT3, BAG6, POU5F1, CTNNB1, ANAPC1, AXIN1, BTRC, GLTSCR2, TP53, MDM2, NFE2L1, WWP2, RORC, COPS7A, COPS7B, KEAP1, IRS2, CDH1, UBE2E3, UBE2E2, RNF19B, RHPN1, SPAG9, MCM2, MCM4, MCM6, IVNS1ABP, EPS15L1, GTF3C4, SMC1A, GAPVD1, ANK3, SBNO1, SMC3, CDK11A, SOX4, BCR, PPP4R2, HSF1, KIAA1468, MCM7, PLK1, ATG2B, SMEK1, WEE1, GTF3C2, CYLD, RNF26, YAP1PCBP2PCBP2, PTBP1, HNRNPK, HNRNPL, MEPCE, CDK9, RUVBL1, RUVBL2, POLR3H, KAT2A, H2AFX, UBC, HDAC5, PSMA3, HNRNPD, PABPC1, ELAVL1, MAVS, ITCH, IFIH1, CUL3, CUL2, CDK2, CUL1, COPS5, QKI, PCBP1, FBXO6, EEF1A1, PPIB, BARD1, PAXIP1, FN1, VCAM1, SF3B2, SLU7, WDR83, WDR77, NKAP, NOS2, PRPF40A, BRCA1, UBL4A, ITGA4, CD81, IGSF8, HMGA1, HMGA2, ADRB2, CASK, TARDBP, CEP250, HUWE1, FUS, SNRPA, PHF6, CUL7, OBSL1, CCDC8, EED, FTH1, HNRNPA1, ACAT2, ANXA2, ARF4, ARF5, CCDC58, DAZAP1, FUBP1, FUBP3, GBA, GNB2L1, GNPNAT1, KIF2C, LGALS1, LGALS3, MAGI3, PIN1, SCYL2, STIP1, TIA1, TIAL1, TRIP6, UBE2M, NTRK1, MCM2, CDC5L, CDH1, CYLD, URI1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for USP15_PCBP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for USP15_PCBP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource