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Fusion gene ID: 40926 |
FusionGeneSummary for URM1_ARPC2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: URM1_ARPC2 | Fusion gene ID: 40926 | Hgene | Tgene | Gene symbol | URM1 | ARPC2 | Gene ID | 81605 | 10109 |
| Gene name | ubiquitin related modifier 1 | actin related protein 2/3 complex subunit 2 | |
| Synonyms | C9orf74 | ARC34|PNAS-139|PRO2446|p34-Arc | |
| Cytomap | 9q34.11 | 2q35 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin-related modifier 1ubiquitin-related modifier 1 homolog | actin-related protein 2/3 complex subunit 2ARP2/3 protein complex subunit 34actin related protein 2/3 complex, subunit 2, 34kDaarp2/3 complex 34 kDa subunittestis tissue sperm-binding protein Li 53e | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9BTM9 | O15144 | |
| Ensembl transtripts involved in fusion gene | ENST00000372853, ENST00000452446, ENST00000372850, ENST00000372847, ENST00000483206, | ENST00000315717, ENST00000295685, ENST00000477992, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 9 X 10 X 4=360 |
| # samples | 3 | 11 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: URM1 [Title/Abstract] AND ARPC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ARPC2 | GO:0034314 | Arp2/3 complex-mediated actin nucleation | 11741539 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF840371 | URM1 | chr9 | 131140385 | + | ARPC2 | chr2 | 219114087 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000372853 | ENST00000315717 | URM1 | chr9 | 131140385 | + | ARPC2 | chr2 | 219114087 | + |
| In-frame | ENST00000372853 | ENST00000295685 | URM1 | chr9 | 131140385 | + | ARPC2 | chr2 | 219114087 | + |
| 5CDS-3UTR | ENST00000372853 | ENST00000477992 | URM1 | chr9 | 131140385 | + | ARPC2 | chr2 | 219114087 | + |
| In-frame | ENST00000452446 | ENST00000315717 | URM1 | chr9 | 131140385 | + | ARPC2 | chr2 | 219114087 | + |
| In-frame | ENST00000452446 | ENST00000295685 | URM1 | chr9 | 131140385 | + | ARPC2 | chr2 | 219114087 | + |
| 5CDS-3UTR | ENST00000452446 | ENST00000477992 | URM1 | chr9 | 131140385 | + | ARPC2 | chr2 | 219114087 | + |
| In-frame | ENST00000372850 | ENST00000315717 | URM1 | chr9 | 131140385 | + | ARPC2 | chr2 | 219114087 | + |
| In-frame | ENST00000372850 | ENST00000295685 | URM1 | chr9 | 131140385 | + | ARPC2 | chr2 | 219114087 | + |
| 5CDS-3UTR | ENST00000372850 | ENST00000477992 | URM1 | chr9 | 131140385 | + | ARPC2 | chr2 | 219114087 | + |
| Frame-shift | ENST00000372847 | ENST00000315717 | URM1 | chr9 | 131140385 | + | ARPC2 | chr2 | 219114087 | + |
| Frame-shift | ENST00000372847 | ENST00000295685 | URM1 | chr9 | 131140385 | + | ARPC2 | chr2 | 219114087 | + |
| 5CDS-3UTR | ENST00000372847 | ENST00000477992 | URM1 | chr9 | 131140385 | + | ARPC2 | chr2 | 219114087 | + |
| 3UTR-3CDS | ENST00000483206 | ENST00000315717 | URM1 | chr9 | 131140385 | + | ARPC2 | chr2 | 219114087 | + |
| 3UTR-3CDS | ENST00000483206 | ENST00000295685 | URM1 | chr9 | 131140385 | + | ARPC2 | chr2 | 219114087 | + |
| 3UTR-3UTR | ENST00000483206 | ENST00000477992 | URM1 | chr9 | 131140385 | + | ARPC2 | chr2 | 219114087 | + |
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FusionProtFeatures for URM1_ARPC2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| URM1 | ARPC2 |
| Acts as a sulfur carrier required for 2-thiolation ofmcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys),tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein(UBL) that is covalently conjugated via an isopeptide bond tolysine residues of target proteins such as MOCS3, ATPBD3, CTU2,USP15 and CAS. The thiocarboxylated form serves as substrate forconjugation and oxidative stress specifically induces theformation of UBL-protein conjugates. {ECO:0000255|HAMAP-Rule:MF_03048, ECO:0000269|PubMed:19017811,ECO:0000269|PubMed:21209336}. | Functions as actin-binding component of the Arp2/3complex which is involved in regulation of actin polymerizationand together with an activating nucleation-promoting factor (NPF)mediates the formation of branched actin networks. Seems tocontact the mother actin filament. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for URM1_ARPC2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_URM1_ENST00000372853_chr9_131140385_+_ARPC2_ENST00000315717_chr2_219114087_+_111aa MAAPLSVEVEFGGGAELLFDGIKKHRVTLPGQEEPLLFPRHTNASARDNTINLIHTFRDYLHYHIKCSKAYIHTRMRAKTSDFLKVLNRA >In-frame_URM1_ENST00000372853_chr9_131140385_+_ARPC2_ENST00000295685_chr2_219114087_+_111aa MAAPLSVEVEFGGGAELLFDGIKKHRVTLPGQEEPLLFPRHTNASARDNTINLIHTFRDYLHYHIKCSKAYIHTRMRAKTSDFLKVLNRA >In-frame_URM1_ENST00000452446_chr9_131140385_+_ARPC2_ENST00000315717_chr2_219114087_+_111aa MAAPLSVEVEFGGGAELLFDGIKKHRVTLPGQEEPLLFPRHTNASARDNTINLIHTFRDYLHYHIKCSKAYIHTRMRAKTSDFLKVLNRA >In-frame_URM1_ENST00000452446_chr9_131140385_+_ARPC2_ENST00000295685_chr2_219114087_+_111aa MAAPLSVEVEFGGGAELLFDGIKKHRVTLPGQEEPLLFPRHTNASARDNTINLIHTFRDYLHYHIKCSKAYIHTRMRAKTSDFLKVLNRA >In-frame_URM1_ENST00000372850_chr9_131140385_+_ARPC2_ENST00000315717_chr2_219114087_+_111aa MAAPLSVEVEFGGGAELLFDGIKKHRVTLPGQEEPLLFPRHTNASARDNTINLIHTFRDYLHYHIKCSKAYIHTRMRAKTSDFLKVLNRA >In-frame_URM1_ENST00000372850_chr9_131140385_+_ARPC2_ENST00000295685_chr2_219114087_+_111aa MAAPLSVEVEFGGGAELLFDGIKKHRVTLPGQEEPLLFPRHTNASARDNTINLIHTFRDYLHYHIKCSKAYIHTRMRAKTSDFLKVLNRA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_URM1_ENST00000372853_chr9_131140385_+_ARPC2_ENST00000315717_chr2_219114087_+_333nt ATGGCTGCGCCCTTGTCAGTGGAGGTGGAGTTCGGAGGTGGTGCGGAGCTCCTGTTTGACGGTATTAAGAAACATCGAGTCACTTTGCCT GGACAGGAGGAACCCTTGCTGTTCCCTCGTCACACCAATGCCAGTGCTCGAGACAACACCATCAACCTGATCCACACGTTCCGGGACTAC CTGCACTACCACATCAAGTGCTCTAAGGCCTATATTCACACACGTATGCGGGCGAAAACGTCTGACTTCCTCAAGGTGCTGAACCGCGCA >In-frame_URM1_ENST00000372853_chr9_131140385_+_ARPC2_ENST00000295685_chr2_219114087_+_333nt ATGGCTGCGCCCTTGTCAGTGGAGGTGGAGTTCGGAGGTGGTGCGGAGCTCCTGTTTGACGGTATTAAGAAACATCGAGTCACTTTGCCT GGACAGGAGGAACCCTTGCTGTTCCCTCGTCACACCAATGCCAGTGCTCGAGACAACACCATCAACCTGATCCACACGTTCCGGGACTAC CTGCACTACCACATCAAGTGCTCTAAGGCCTATATTCACACACGTATGCGGGCGAAAACGTCTGACTTCCTCAAGGTGCTGAACCGCGCA >In-frame_URM1_ENST00000452446_chr9_131140385_+_ARPC2_ENST00000315717_chr2_219114087_+_333nt ATGGCTGCGCCCTTGTCAGTGGAGGTGGAGTTCGGAGGTGGTGCGGAGCTCCTGTTTGACGGTATTAAGAAACATCGAGTCACTTTGCCT GGACAGGAGGAACCCTTGCTGTTCCCTCGTCACACCAATGCCAGTGCTCGAGACAACACCATCAACCTGATCCACACGTTCCGGGACTAC CTGCACTACCACATCAAGTGCTCTAAGGCCTATATTCACACACGTATGCGGGCGAAAACGTCTGACTTCCTCAAGGTGCTGAACCGCGCA >In-frame_URM1_ENST00000452446_chr9_131140385_+_ARPC2_ENST00000295685_chr2_219114087_+_333nt ATGGCTGCGCCCTTGTCAGTGGAGGTGGAGTTCGGAGGTGGTGCGGAGCTCCTGTTTGACGGTATTAAGAAACATCGAGTCACTTTGCCT GGACAGGAGGAACCCTTGCTGTTCCCTCGTCACACCAATGCCAGTGCTCGAGACAACACCATCAACCTGATCCACACGTTCCGGGACTAC CTGCACTACCACATCAAGTGCTCTAAGGCCTATATTCACACACGTATGCGGGCGAAAACGTCTGACTTCCTCAAGGTGCTGAACCGCGCA >In-frame_URM1_ENST00000372850_chr9_131140385_+_ARPC2_ENST00000315717_chr2_219114087_+_333nt ATGGCTGCGCCCTTGTCAGTGGAGGTGGAGTTCGGAGGTGGTGCGGAGCTCCTGTTTGACGGTATTAAGAAACATCGAGTCACTTTGCCT GGACAGGAGGAACCCTTGCTGTTCCCTCGTCACACCAATGCCAGTGCTCGAGACAACACCATCAACCTGATCCACACGTTCCGGGACTAC CTGCACTACCACATCAAGTGCTCTAAGGCCTATATTCACACACGTATGCGGGCGAAAACGTCTGACTTCCTCAAGGTGCTGAACCGCGCA >In-frame_URM1_ENST00000372850_chr9_131140385_+_ARPC2_ENST00000295685_chr2_219114087_+_333nt ATGGCTGCGCCCTTGTCAGTGGAGGTGGAGTTCGGAGGTGGTGCGGAGCTCCTGTTTGACGGTATTAAGAAACATCGAGTCACTTTGCCT GGACAGGAGGAACCCTTGCTGTTCCCTCGTCACACCAATGCCAGTGCTCGAGACAACACCATCAACCTGATCCACACGTTCCGGGACTAC CTGCACTACCACATCAAGTGCTCTAAGGCCTATATTCACACACGTATGCGGGCGAAAACGTCTGACTTCCTCAAGGTGCTGAACCGCGCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_URM1_ENST00000372853_chr9_131140385_+_ARPC2_ENST00000315717_chr2_219114087_+_828nt CCGGAAATTTGCGGGCGCGCCGGAAGTTGAGGGGAGTTTCCTGCGAGCTCGGCTTCCTCAACATGGCTGCGCCCTTGTCAGTGGAGGTGG AGTTCGGAGGTGGTGCGGAGCTCCTGTTTGACGGTATTAAGAAACATCGAGTCACTTTGCCTGGACAGGAGGAACCCTTGCTGTTCCCTC GTCACACCAATGCCAGTGCTCGAGACAACACCATCAACCTGATCCACACGTTCCGGGACTACCTGCACTACCACATCAAGTGCTCTAAGG CCTATATTCACACACGTATGCGGGCGAAAACGTCTGACTTCCTCAAGGTGCTGAACCGCGCACGCCCAGATGCCGAGAAAAAAGAAATGA AAACAATCACGGGGAAGACGTTTTCATCCCGCTAATCTTGGGAATAAGAGGAGGAAGCGGCTGGCAACTGAAGGCTGGAACACTTGCTAC TGGATAATCGTAGCTTTTAATGTTGCGCCTCTTCAGGTTCTTAAGGGATTCTCCGTTTTGGTTCCATTTTGTACACGTTTGGAAAATAAT CTGCAGAAACGAGCTGTGCTTGCAAAGACTTCATAGTTCCCAAGAATTAAAAAAAAAAAAAAAAGAATTCCACTTGATCAACTTAATTCC TTTTCTTTATCTTCCCTCCCTCACTTCCCTTTTCTCCCACCCTCTTTTCCAAGCTGTTTCGCTTTGCAATATATTACTGGTAATGAGTTG CAGGATAATGCAGTCATAACTTGTTTTCTCCTAAGTATTTGAGTTCAAAACTCCTGTATCTAAAGAAATACGGTTGGGGTCATTAATAAA >In-frame_URM1_ENST00000372853_chr9_131140385_+_ARPC2_ENST00000295685_chr2_219114087_+_836nt CCGGAAATTTGCGGGCGCGCCGGAAGTTGAGGGGAGTTTCCTGCGAGCTCGGCTTCCTCAACATGGCTGCGCCCTTGTCAGTGGAGGTGG AGTTCGGAGGTGGTGCGGAGCTCCTGTTTGACGGTATTAAGAAACATCGAGTCACTTTGCCTGGACAGGAGGAACCCTTGCTGTTCCCTC GTCACACCAATGCCAGTGCTCGAGACAACACCATCAACCTGATCCACACGTTCCGGGACTACCTGCACTACCACATCAAGTGCTCTAAGG CCTATATTCACACACGTATGCGGGCGAAAACGTCTGACTTCCTCAAGGTGCTGAACCGCGCACGCCCAGATGCCGAGAAAAAAGAAATGA AAACAATCACGGGGAAGACGTTTTCATCCCGCTAATCTTGGGAATAAGAGGAGGAAGCGGCTGGCAACTGAAGGCTGGAACACTTGCTAC TGGATAATCGTAGCTTTTAATGTTGCGCCTCTTCAGGTTCTTAAGGGATTCTCCGTTTTGGTTCCATTTTGTACACGTTTGGAAAATAAT CTGCAGAAACGAGCTGTGCTTGCAAAGACTTCATAGTTCCCAAGAATTAAAAAAAAAAAAAAAAGAATTCCACTTGATCAACTTAATTCC TTTTCTTTATCTTCCCTCCCTCACTTCCCTTTTCTCCCACCCTCTTTTCCAAGCTGTTTCGCTTTGCAATATATTACTGGTAATGAGTTG CAGGATAATGCAGTCATAACTTGTTTTCTCCTAAGTATTTGAGTTCAAAACTCCTGTATCTAAAGAAATACGGTTGGGGTCATTAATAAA >In-frame_URM1_ENST00000452446_chr9_131140385_+_ARPC2_ENST00000315717_chr2_219114087_+_828nt CCGGAAATTTGCGGGCGCGCCGGAAGTTGAGGGGAGTTTCCTGCGAGCTCGGCTTCCTCAACATGGCTGCGCCCTTGTCAGTGGAGGTGG AGTTCGGAGGTGGTGCGGAGCTCCTGTTTGACGGTATTAAGAAACATCGAGTCACTTTGCCTGGACAGGAGGAACCCTTGCTGTTCCCTC GTCACACCAATGCCAGTGCTCGAGACAACACCATCAACCTGATCCACACGTTCCGGGACTACCTGCACTACCACATCAAGTGCTCTAAGG CCTATATTCACACACGTATGCGGGCGAAAACGTCTGACTTCCTCAAGGTGCTGAACCGCGCACGCCCAGATGCCGAGAAAAAAGAAATGA AAACAATCACGGGGAAGACGTTTTCATCCCGCTAATCTTGGGAATAAGAGGAGGAAGCGGCTGGCAACTGAAGGCTGGAACACTTGCTAC TGGATAATCGTAGCTTTTAATGTTGCGCCTCTTCAGGTTCTTAAGGGATTCTCCGTTTTGGTTCCATTTTGTACACGTTTGGAAAATAAT CTGCAGAAACGAGCTGTGCTTGCAAAGACTTCATAGTTCCCAAGAATTAAAAAAAAAAAAAAAAGAATTCCACTTGATCAACTTAATTCC TTTTCTTTATCTTCCCTCCCTCACTTCCCTTTTCTCCCACCCTCTTTTCCAAGCTGTTTCGCTTTGCAATATATTACTGGTAATGAGTTG CAGGATAATGCAGTCATAACTTGTTTTCTCCTAAGTATTTGAGTTCAAAACTCCTGTATCTAAAGAAATACGGTTGGGGTCATTAATAAA >In-frame_URM1_ENST00000452446_chr9_131140385_+_ARPC2_ENST00000295685_chr2_219114087_+_836nt CCGGAAATTTGCGGGCGCGCCGGAAGTTGAGGGGAGTTTCCTGCGAGCTCGGCTTCCTCAACATGGCTGCGCCCTTGTCAGTGGAGGTGG AGTTCGGAGGTGGTGCGGAGCTCCTGTTTGACGGTATTAAGAAACATCGAGTCACTTTGCCTGGACAGGAGGAACCCTTGCTGTTCCCTC GTCACACCAATGCCAGTGCTCGAGACAACACCATCAACCTGATCCACACGTTCCGGGACTACCTGCACTACCACATCAAGTGCTCTAAGG CCTATATTCACACACGTATGCGGGCGAAAACGTCTGACTTCCTCAAGGTGCTGAACCGCGCACGCCCAGATGCCGAGAAAAAAGAAATGA AAACAATCACGGGGAAGACGTTTTCATCCCGCTAATCTTGGGAATAAGAGGAGGAAGCGGCTGGCAACTGAAGGCTGGAACACTTGCTAC TGGATAATCGTAGCTTTTAATGTTGCGCCTCTTCAGGTTCTTAAGGGATTCTCCGTTTTGGTTCCATTTTGTACACGTTTGGAAAATAAT CTGCAGAAACGAGCTGTGCTTGCAAAGACTTCATAGTTCCCAAGAATTAAAAAAAAAAAAAAAAGAATTCCACTTGATCAACTTAATTCC TTTTCTTTATCTTCCCTCCCTCACTTCCCTTTTCTCCCACCCTCTTTTCCAAGCTGTTTCGCTTTGCAATATATTACTGGTAATGAGTTG CAGGATAATGCAGTCATAACTTGTTTTCTCCTAAGTATTTGAGTTCAAAACTCCTGTATCTAAAGAAATACGGTTGGGGTCATTAATAAA >In-frame_URM1_ENST00000372850_chr9_131140385_+_ARPC2_ENST00000315717_chr2_219114087_+_786nt GCGAGCTCGGCTTCCTCAACATGGCTGCGCCCTTGTCAGTGGAGGTGGAGTTCGGAGGTGGTGCGGAGCTCCTGTTTGACGGTATTAAGA AACATCGAGTCACTTTGCCTGGACAGGAGGAACCCTTGCTGTTCCCTCGTCACACCAATGCCAGTGCTCGAGACAACACCATCAACCTGA TCCACACGTTCCGGGACTACCTGCACTACCACATCAAGTGCTCTAAGGCCTATATTCACACACGTATGCGGGCGAAAACGTCTGACTTCC TCAAGGTGCTGAACCGCGCACGCCCAGATGCCGAGAAAAAAGAAATGAAAACAATCACGGGGAAGACGTTTTCATCCCGCTAATCTTGGG AATAAGAGGAGGAAGCGGCTGGCAACTGAAGGCTGGAACACTTGCTACTGGATAATCGTAGCTTTTAATGTTGCGCCTCTTCAGGTTCTT AAGGGATTCTCCGTTTTGGTTCCATTTTGTACACGTTTGGAAAATAATCTGCAGAAACGAGCTGTGCTTGCAAAGACTTCATAGTTCCCA AGAATTAAAAAAAAAAAAAAAAGAATTCCACTTGATCAACTTAATTCCTTTTCTTTATCTTCCCTCCCTCACTTCCCTTTTCTCCCACCC TCTTTTCCAAGCTGTTTCGCTTTGCAATATATTACTGGTAATGAGTTGCAGGATAATGCAGTCATAACTTGTTTTCTCCTAAGTATTTGA >In-frame_URM1_ENST00000372850_chr9_131140385_+_ARPC2_ENST00000295685_chr2_219114087_+_794nt GCGAGCTCGGCTTCCTCAACATGGCTGCGCCCTTGTCAGTGGAGGTGGAGTTCGGAGGTGGTGCGGAGCTCCTGTTTGACGGTATTAAGA AACATCGAGTCACTTTGCCTGGACAGGAGGAACCCTTGCTGTTCCCTCGTCACACCAATGCCAGTGCTCGAGACAACACCATCAACCTGA TCCACACGTTCCGGGACTACCTGCACTACCACATCAAGTGCTCTAAGGCCTATATTCACACACGTATGCGGGCGAAAACGTCTGACTTCC TCAAGGTGCTGAACCGCGCACGCCCAGATGCCGAGAAAAAAGAAATGAAAACAATCACGGGGAAGACGTTTTCATCCCGCTAATCTTGGG AATAAGAGGAGGAAGCGGCTGGCAACTGAAGGCTGGAACACTTGCTACTGGATAATCGTAGCTTTTAATGTTGCGCCTCTTCAGGTTCTT AAGGGATTCTCCGTTTTGGTTCCATTTTGTACACGTTTGGAAAATAATCTGCAGAAACGAGCTGTGCTTGCAAAGACTTCATAGTTCCCA AGAATTAAAAAAAAAAAAAAAAGAATTCCACTTGATCAACTTAATTCCTTTTCTTTATCTTCCCTCCCTCACTTCCCTTTTCTCCCACCC TCTTTTCCAAGCTGTTTCGCTTTGCAATATATTACTGGTAATGAGTTGCAGGATAATGCAGTCATAACTTGTTTTCTCCTAAGTATTTGA |
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FusionGenePPI for URM1_ARPC2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| URM1 | ASCC2, CTU1, PRDX2, SEC23IP, USP5, DSTN, VCL, PRDX1, TXNL1, PTGES3, XPO1, ATP6V1A, MOV10, NXF1, GDPGP1, TRIM25 | ARPC2 | ACTR3B, ARPC3, ACTR3, ARPC4, CDH1, CTTN, UBE2Q2, CEP97, CCP110, CDK2, WAS, LRRK2, ARPC1B, AURKA, ACTR2, ARPC5, ARPC1A, ARPC5L, VCP, BAG3, AARSD1, ANP32B, CALU, LAP3, METTL1, NIF3L1, PFDN5, PPP1R12A, PPP2R5D, PUS1, SH3GL1, SUMO1, TNPO3, TOM1L1, FUBP1, MTR, NSUN2, PRKACA, PRKACB, RANGAP1, RPA1, RPA2, SH3GLB1, THG1L, TPD52L2, TPRKB, CUL7, OBSL1, UNK, ARHGAP17, ARPC4-TTLL3, CAPZA1, CAPZA2, CAPZB, EFHD2, EEF2, NTRK1, KRAS, XPO1, DBN1, MYH9, PPP1CB, IQGAP1, PDLIM7, SYNPO, ANLN, MYO5C, MYO19, GLI1, TMEM165, FOXA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for URM1_ARPC2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for URM1_ARPC2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | URM1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Tgene | ARPC2 | C0009324 | Ulcerative Colitis | 1 | CTD_human |
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