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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40903

FusionGeneSummary for URGCP_UPP1

check button Fusion gene summary
Fusion gene informationFusion gene name: URGCP_UPP1
Fusion gene ID: 40903
HgeneTgene
Gene symbol

URGCP

UPP1

Gene ID

55665

7378

Gene nameupregulator of cell proliferationuridine phosphorylase 1
SynonymsURG4UDRPASE|UP|UPASE|UPP
Cytomap

7p13

7p12.3

Type of geneprotein-codingprotein-coding
Descriptionup-regulator of cell proliferationHBV X protein up-regulated gene 4 proteinHBxAg up-regulated gene 4 proteinup-regulated gene 4uridine phosphorylase 1UPase 1urdPase 1
Modification date2018051920180519
UniProtAcc

Q8TCY9

Q16831

Ensembl transtripts involved in fusion geneENST00000497914, ENST00000223341, 
ENST00000336086, ENST00000402306, 
ENST00000443736, ENST00000453200, 
ENST00000447717, ENST00000446958, 
ENST00000331803, ENST00000341253, 
ENST00000395564, ENST00000482015, 
ENST00000429491, 
Fusion gene scores* DoF score3 X 2 X 3=182 X 3 X 2=12
# samples 33
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: URGCP [Title/Abstract] AND UPP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-O2-A52N-01AURGCPchr7

43965731

-UPP1chr7

48134360

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000497914ENST00000331803URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000497914ENST00000341253URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000497914ENST00000395564URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-3UTRENST00000497914ENST00000482015URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000497914ENST00000429491URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000223341ENST00000331803URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000223341ENST00000341253URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000223341ENST00000395564URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-3UTRENST00000223341ENST00000482015URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000223341ENST00000429491URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000336086ENST00000331803URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000336086ENST00000341253URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000336086ENST00000395564URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-3UTRENST00000336086ENST00000482015URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000336086ENST00000429491URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000402306ENST00000331803URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000402306ENST00000341253URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000402306ENST00000395564URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-3UTRENST00000402306ENST00000482015URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000402306ENST00000429491URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000443736ENST00000331803URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000443736ENST00000341253URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000443736ENST00000395564URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-3UTRENST00000443736ENST00000482015URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000443736ENST00000429491URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000453200ENST00000331803URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000453200ENST00000341253URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000453200ENST00000395564URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-3UTRENST00000453200ENST00000482015URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000453200ENST00000429491URGCPchr7

43965731

-UPP1chr7

48134360

+
5UTR-5UTRENST00000447717ENST00000331803URGCPchr7

43965731

-UPP1chr7

48134360

+
5UTR-5UTRENST00000447717ENST00000341253URGCPchr7

43965731

-UPP1chr7

48134360

+
5UTR-5UTRENST00000447717ENST00000395564URGCPchr7

43965731

-UPP1chr7

48134360

+
5UTR-3UTRENST00000447717ENST00000482015URGCPchr7

43965731

-UPP1chr7

48134360

+
5UTR-5UTRENST00000447717ENST00000429491URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000446958ENST00000331803URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000446958ENST00000341253URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000446958ENST00000395564URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-3UTRENST00000446958ENST00000482015URGCPchr7

43965731

-UPP1chr7

48134360

+
intron-5UTRENST00000446958ENST00000429491URGCPchr7

43965731

-UPP1chr7

48134360

+

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FusionProtFeatures for URGCP_UPP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
URGCP

Q8TCY9

UPP1

Q16831

May be involved in cell cycle progression through theregulation of cyclin D1 expression. May participate in thedevelopment of hepatocellular carcinoma (HCC) by promotinghepatocellular growth and survival. May play an important role indevelopment of gastric cancer. {ECO:0000269|PubMed:12082552,ECO:0000269|PubMed:17217616}. Catalyzes the reversible phosphorylytic cleavage ofuridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate (PubMed:7488099). The produced molecules are thenutilized as carbon and energy sources or in the rescue ofpyrimidine bases for nucleotide synthesis.{ECO:0000269|PubMed:7488099, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for URGCP_UPP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for URGCP_UPP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
URGCPCHMP5, VIM, NTRK1, DNAJC7, PLEC, AAK1, PPIP5K2, SEC24B, CCDC88A, EYA4UPP1VIM, WBP2, UCK2, WDR45B, YRDC, UBE2D1, MPST, CTDP1, GPD1L, RPE, VPS18, MCM2, CUTA, LRRC45


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for URGCP_UPP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for URGCP_UPP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneUPP1C0035228Respiratory Hypersensitivity1CTD_human
TgeneUPP1C0162820Dermatitis, Allergic Contact1CTD_human