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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40896

FusionGeneSummary for UQCRQ_FGF14

check button Fusion gene summary
Fusion gene informationFusion gene name: UQCRQ_FGF14
Fusion gene ID: 40896
HgeneTgene
Gene symbol

UQCRQ

FGF14

Gene ID

27089

2259

Gene nameubiquinol-cytochrome c reductase complex III subunit VIIfibroblast growth factor 14
SynonymsMC3DN4|QCR8|QP-C|QPC|UQCR7FGF-14|FHF-4|FHF4|SCA27
Cytomap

5q31.1

13q33.1

Type of geneprotein-codingprotein-coding
Descriptioncytochrome b-c1 complex subunit 8complex III subunit 8complex III subunit VIIIlow molecular mass ubiquinone-binding protein (9.5kD)ubiquinol-cytochrome c reductase complex 9.5 kDa proteinubiquinol-cytochrome c reductase complex ubiquinone-binding profibroblast growth factor 14bA397O8.2fibroblast growth factor homologous factor 4
Modification date2018052320180519
UniProtAcc

O14949

Q92915

Ensembl transtripts involved in fusion geneENST00000378670, ENST00000378667, 
ENST00000496429, ENST00000378665, 
ENST00000376131, ENST00000376143, 
ENST00000468052, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 3 X 4=48
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UQCRQ [Title/Abstract] AND FGF14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AV742377UQCRQchr5

132203379

+FGF14chr13

103018966

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000378670ENST00000376131UQCRQchr5

132203379

+FGF14chr13

103018966

+
3UTR-intronENST00000378670ENST00000376143UQCRQchr5

132203379

+FGF14chr13

103018966

+
3UTR-intronENST00000378670ENST00000468052UQCRQchr5

132203379

+FGF14chr13

103018966

+
5CDS-intronENST00000378667ENST00000376131UQCRQchr5

132203379

+FGF14chr13

103018966

+
5CDS-intronENST00000378667ENST00000376143UQCRQchr5

132203379

+FGF14chr13

103018966

+
5CDS-intronENST00000378667ENST00000468052UQCRQchr5

132203379

+FGF14chr13

103018966

+
3UTR-intronENST00000496429ENST00000376131UQCRQchr5

132203379

+FGF14chr13

103018966

+
3UTR-intronENST00000496429ENST00000376143UQCRQchr5

132203379

+FGF14chr13

103018966

+
3UTR-intronENST00000496429ENST00000468052UQCRQchr5

132203379

+FGF14chr13

103018966

+
5CDS-intronENST00000378665ENST00000376131UQCRQchr5

132203379

+FGF14chr13

103018966

+
5CDS-intronENST00000378665ENST00000376143UQCRQchr5

132203379

+FGF14chr13

103018966

+
5CDS-intronENST00000378665ENST00000468052UQCRQchr5

132203379

+FGF14chr13

103018966

+

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FusionProtFeatures for UQCRQ_FGF14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UQCRQ

O14949

FGF14

Q92915

This is a component of the ubiquinol-cytochrome creductase complex (complex III or cytochrome b-c1 complex), whichis part of the mitochondrial respiratory chain. This subunit,together with cytochrome b, binds to ubiquinone. Probably involved in nervous system development andfunction.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UQCRQ_FGF14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UQCRQ_FGF14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UQCRQ_FGF14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UQCRQ_FGF14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUQCRQC3554607MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 41UNIPROT
TgeneFGF14C1836383SPINOCEREBELLAR ATAXIA 272CTD_human;ORPHANET;UNIPROT
TgeneFGF14C0007302Cartilage Diseases1CTD_human
TgeneFGF14C0009241Cognition Disorders1CTD_human