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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40878

FusionGeneSummary for UQCR10_PXN

check button Fusion gene summary
Fusion gene informationFusion gene name: UQCR10_PXN
Fusion gene ID: 40878
HgeneTgene
Gene symbol

UQCR10

PXN

Gene ID

29796

7837

Gene nameubiquinol-cytochrome c reductase, complex III subunit Xperoxidasin
SynonymsHSPC051|HSPC119|HSPC151|QCR9|UCCR7.2|UCRCASGD7|COPOA|D2S448|D2S448E|MG50|PRG2|PXN|VPO
Cytomap

22q12.2

2p25.3

Type of geneprotein-codingprotein-coding
Descriptioncytochrome b-c1 complex subunit 9cytochrome C1, nonheme 7kDa proteincytochrome c1 non-heme 7 kDa proteinubiquinol-cytochrome c reductase complex (7.2 kD)ubiquinol-cytochrome c reductase complex 7.2 kDa proteinubiquinol-cytochrome c reductase, complexperoxidasin homologmelanoma-associated antigen MG50p53-responsive gene 2 proteinvascular peroxidase 1
Modification date2018052320180523
UniProtAcc

Q9UDW1

P49023

Ensembl transtripts involved in fusion geneENST00000330029, ENST00000401406, 
ENST00000458477, ENST00000228307, 
ENST00000424649, ENST00000397506, 
ENST00000536957, ENST00000267257, 
ENST00000538144, 
Fusion gene scores* DoF score2 X 2 X 2=88 X 8 X 2=128
# samples 28
** MAII scorelog2(2/8*10)=1.32192809488736log2(8/128*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UQCR10 [Title/Abstract] AND PXN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePXN

GO:0030198

extracellular matrix organization

19590037

TgenePXN

GO:0042744

hydrogen peroxide catabolic process

18929642

TgenePXN

GO:0055114

oxidation-reduction process

18929642


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW371242UQCR10chr22

30165810

-PXNchr12

120694339

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000330029ENST00000458477UQCR10chr22

30165810

-PXNchr12

120694339

+
3UTR-intronENST00000330029ENST00000228307UQCR10chr22

30165810

-PXNchr12

120694339

+
3UTR-intronENST00000330029ENST00000424649UQCR10chr22

30165810

-PXNchr12

120694339

+
3UTR-intronENST00000330029ENST00000397506UQCR10chr22

30165810

-PXNchr12

120694339

+
3UTR-intronENST00000330029ENST00000536957UQCR10chr22

30165810

-PXNchr12

120694339

+
3UTR-intronENST00000330029ENST00000267257UQCR10chr22

30165810

-PXNchr12

120694339

+
3UTR-intronENST00000330029ENST00000538144UQCR10chr22

30165810

-PXNchr12

120694339

+
3UTR-intronENST00000401406ENST00000458477UQCR10chr22

30165810

-PXNchr12

120694339

+
3UTR-intronENST00000401406ENST00000228307UQCR10chr22

30165810

-PXNchr12

120694339

+
3UTR-intronENST00000401406ENST00000424649UQCR10chr22

30165810

-PXNchr12

120694339

+
3UTR-intronENST00000401406ENST00000397506UQCR10chr22

30165810

-PXNchr12

120694339

+
3UTR-intronENST00000401406ENST00000536957UQCR10chr22

30165810

-PXNchr12

120694339

+
3UTR-intronENST00000401406ENST00000267257UQCR10chr22

30165810

-PXNchr12

120694339

+
3UTR-intronENST00000401406ENST00000538144UQCR10chr22

30165810

-PXNchr12

120694339

+

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FusionProtFeatures for UQCR10_PXN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UQCR10

Q9UDW1

PXN

P49023

This is a component of the ubiquinol-cytochrome creductase complex (complex III or cytochrome b-c1 complex), whichis part of the mitochondrial respiratory chain. This subunitinteracts with cytochrome c1 (By similarity). {ECO:0000250}. Cytoskeletal protein involved in actin-membraneattachment at sites of cell adhesion to the extracellular matrix(focal adhesion).

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UQCR10_PXN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UQCR10_PXN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UQCR10_PXN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UQCR10_PXN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePXNC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgenePXNC0025205Melanoma, Experimental1CTD_human
TgenePXNC0027627Neoplasm Metastasis1CTD_human