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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40868

FusionGeneSummary for UQCC1_FER1L4

check button Fusion gene summary
Fusion gene informationFusion gene name: UQCC1_FER1L4
Fusion gene ID: 40868
HgeneTgene
Gene symbol

UQCC1

FER1L4

Gene ID

55245

80307

Gene nameubiquinol-cytochrome c reductase complex assembly factor 1fer-1 like family member 4, pseudogene
SynonymsBFZB|C20orf44|CBP3|UQCCC20orf124
Cytomap

20q11.22

20q11.22

Type of geneprotein-codingpseudo
Descriptionubiquinol-cytochrome-c reductase complex assembly factor 1bFGF-repressed Zic-binding proteinbasic FGF-repressed Zic-binding proteincytochrome B protein synthesis 3 homologubiquinol-cytochrome c reductase complex chaperone CBP3 homologfer-1 like family member 4, pseudogene (functional)fer-1-like 4, pseudogene (functional)
Modification date2018051920180429
UniProtAcc

Q9NVA1

Ensembl transtripts involved in fusion geneENST00000349714, ENST00000359226, 
ENST00000374384, ENST00000374380, 
ENST00000374385, ENST00000374377, 
ENST00000397556, ENST00000407996, 
ENST00000540457, ENST00000542501, 
ENST00000397554, ENST00000491125, 
ENST00000430275, 
Fusion gene scores* DoF score13 X 8 X 10=10404 X 3 X 4=48
# samples 134
** MAII scorelog2(13/1040*10)=-3
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UQCC1 [Title/Abstract] AND FER1L4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUQCC1

GO:0034551

mitochondrial respiratory chain complex III assembly

24385928

HgeneUQCC1

GO:0070131

positive regulation of mitochondrial translation

24385928


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-BC-A10T-01AUQCC1chr20

33954360

-FER1L4chr20

34167036

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000349714ENST00000430275UQCC1chr20

33954360

-FER1L4chr20

34167036

-
intron-intronENST00000359226ENST00000430275UQCC1chr20

33954360

-FER1L4chr20

34167036

-
5CDS-intronENST00000374384ENST00000430275UQCC1chr20

33954360

-FER1L4chr20

34167036

-
5CDS-intronENST00000374380ENST00000430275UQCC1chr20

33954360

-FER1L4chr20

34167036

-
5CDS-intronENST00000374385ENST00000430275UQCC1chr20

33954360

-FER1L4chr20

34167036

-
5CDS-intronENST00000374377ENST00000430275UQCC1chr20

33954360

-FER1L4chr20

34167036

-
5CDS-intronENST00000397556ENST00000430275UQCC1chr20

33954360

-FER1L4chr20

34167036

-
intron-intronENST00000407996ENST00000430275UQCC1chr20

33954360

-FER1L4chr20

34167036

-
intron-intronENST00000540457ENST00000430275UQCC1chr20

33954360

-FER1L4chr20

34167036

-
intron-intronENST00000542501ENST00000430275UQCC1chr20

33954360

-FER1L4chr20

34167036

-
5CDS-intronENST00000397554ENST00000430275UQCC1chr20

33954360

-FER1L4chr20

34167036

-
5UTR-intronENST00000491125ENST00000430275UQCC1chr20

33954360

-FER1L4chr20

34167036

-

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FusionProtFeatures for UQCC1_FER1L4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UQCC1

Q9NVA1

FER1L4

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UQCC1_FER1L4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UQCC1_FER1L4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UQCC1BRCA2, UQCC2, ECHDC2, LRRC46, MRM1, COX20, LPAR1, OXLD1, TRUB2, NDUFA4, SBF1, TM2D2, P3H1, CSNK1E, FADS1, MRPL10, CDH13, YARS2, FECH, CLPP, NDUFA13, CDIPT, SLX1A, C3AR1, CDR2, TRIM25FER1L4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UQCC1_FER1L4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UQCC1_FER1L4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource