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Fusion gene ID: 40802 |
FusionGeneSummary for UNC45A_IQGAP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UNC45A_IQGAP1 | Fusion gene ID: 40802 | Hgene | Tgene | Gene symbol | UNC45A | IQGAP1 | Gene ID | 55898 | 8826 |
| Gene name | unc-45 myosin chaperone A | IQ motif containing GTPase activating protein 1 | |
| Synonyms | GC-UNC45|GCUNC-45|GCUNC45|IRO039700|SMAP-1|SMAP1|UNC-45A | HUMORFA01|SAR1|p195 | |
| Cytomap | 15q26.1 | 15q26.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein unc-45 homolog Ageneral cell UNC45smooth muscle cell associated protein-1unc-45 homolog A | ras GTPase-activating-like protein IQGAP1RasGAP-like with IQ motifs | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q9H3U1 | P46940 | |
| Ensembl transtripts involved in fusion gene | ENST00000394275, ENST00000418476, ENST00000553671, | ENST00000268182, ENST00000560738, ENST00000560020, | |
| Fusion gene scores | * DoF score | 5 X 3 X 5=75 | 7 X 7 X 4=196 |
| # samples | 6 | 7 | |
| ** MAII score | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: UNC45A [Title/Abstract] AND IQGAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | IQGAP1 | GO:0071277 | cellular response to calcium ion | 18567582 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | OV | TCGA-24-2023-01A | UNC45A | chr15 | 91483703 | + | IQGAP1 | chr15 | 91029262 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000394275 | ENST00000268182 | UNC45A | chr15 | 91483703 | + | IQGAP1 | chr15 | 91029262 | + |
| In-frame | ENST00000394275 | ENST00000560738 | UNC45A | chr15 | 91483703 | + | IQGAP1 | chr15 | 91029262 | + |
| 5CDS-intron | ENST00000394275 | ENST00000560020 | UNC45A | chr15 | 91483703 | + | IQGAP1 | chr15 | 91029262 | + |
| In-frame | ENST00000418476 | ENST00000268182 | UNC45A | chr15 | 91483703 | + | IQGAP1 | chr15 | 91029262 | + |
| In-frame | ENST00000418476 | ENST00000560738 | UNC45A | chr15 | 91483703 | + | IQGAP1 | chr15 | 91029262 | + |
| 5CDS-intron | ENST00000418476 | ENST00000560020 | UNC45A | chr15 | 91483703 | + | IQGAP1 | chr15 | 91029262 | + |
| 3UTR-3CDS | ENST00000553671 | ENST00000268182 | UNC45A | chr15 | 91483703 | + | IQGAP1 | chr15 | 91029262 | + |
| 3UTR-3CDS | ENST00000553671 | ENST00000560738 | UNC45A | chr15 | 91483703 | + | IQGAP1 | chr15 | 91029262 | + |
| 3UTR-intron | ENST00000553671 | ENST00000560020 | UNC45A | chr15 | 91483703 | + | IQGAP1 | chr15 | 91029262 | + |
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FusionProtFeatures for UNC45A_IQGAP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UNC45A | IQGAP1 |
| Acts as co-chaperone for HSP90. Prevents the stimulationof HSP90AB1 ATPase activity by AHSA1. Positive factor in promotingPGR function in the cell. May be necessary for proper folding ofmyosin (Potential). Necessary for normal cell proliferation.Necessary for normal myotube formation and myosin accumulationduring muscle cell development. May play a role in erythropoiesisin stroma cells in the spleen (By similarity). {ECO:0000250,ECO:0000269|PubMed:12119110, ECO:0000269|PubMed:16478993,ECO:0000305}. | Plays a crucial role in regulating the dynamics andassembly of the actin cytoskeleton. Binds to activated CDC42 butdoes not stimulate its GTPase activity. It associates withcalmodulin. Could serve as an assembly scaffold for theorganization of a multimolecular complex that would interfaceincoming signals to the reorganization of the actin cytoskeletonat the plasma membrane. May promote neurite outgrowth(PubMed:15695813). May play a possible role in cell cycleregulation by contributing to cell cycle progression after DNAreplication arrest (PubMed:20883816).{ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | UNC45A | chr15:91483703 | chr15:91029262 | ENST00000394275 | + | 9 | 23 | 21_54 | 214 | 930 | Repeat | Note=TPR 1 |
| Hgene | UNC45A | chr15:91483703 | chr15:91029262 | ENST00000394275 | + | 9 | 23 | 58_91 | 214 | 930 | Repeat | Note=TPR 2 |
| Hgene | UNC45A | chr15:91483703 | chr15:91029262 | ENST00000394275 | + | 9 | 23 | 92_125 | 214 | 930 | Repeat | Note=TPR 3 |
| Hgene | UNC45A | chr15:91483703 | chr15:91029262 | ENST00000418476 | + | 6 | 20 | 21_54 | 229 | 945 | Repeat | Note=TPR 1 |
| Hgene | UNC45A | chr15:91483703 | chr15:91029262 | ENST00000418476 | + | 6 | 20 | 58_91 | 229 | 945 | Repeat | Note=TPR 2 |
| Hgene | UNC45A | chr15:91483703 | chr15:91029262 | ENST00000418476 | + | 6 | 20 | 92_125 | 229 | 945 | Repeat | Note=TPR 3 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | IQGAP1 | chr15:91483703 | chr15:91029262 | ENST00000268182 | + | 29 | 38 | 1004_1237 | 1307 | 1658 | Domain | Ras-GAP |
| Tgene | IQGAP1 | chr15:91483703 | chr15:91029262 | ENST00000268182 | + | 29 | 38 | 44_159 | 1307 | 1658 | Domain | Calponin-homology (CH) |
| Tgene | IQGAP1 | chr15:91483703 | chr15:91029262 | ENST00000268182 | + | 29 | 38 | 679_712 | 1307 | 1658 | Domain | WW |
| Tgene | IQGAP1 | chr15:91483703 | chr15:91029262 | ENST00000268182 | + | 29 | 38 | 745_774 | 1307 | 1658 | Domain | IQ 1 |
| Tgene | IQGAP1 | chr15:91483703 | chr15:91029262 | ENST00000268182 | + | 29 | 38 | 775_804 | 1307 | 1658 | Domain | IQ 2 |
| Tgene | IQGAP1 | chr15:91483703 | chr15:91029262 | ENST00000268182 | + | 29 | 38 | 805_834 | 1307 | 1658 | Domain | IQ 3 |
| Tgene | IQGAP1 | chr15:91483703 | chr15:91029262 | ENST00000268182 | + | 29 | 38 | 835_864 | 1307 | 1658 | Domain | IQ 4 |
| Tgene | IQGAP1 | chr15:91483703 | chr15:91029262 | ENST00000268182 | + | 29 | 38 | 1276_1657 | 1307 | 1658 | Region | Note=C2 |
| Tgene | IQGAP1 | chr15:91483703 | chr15:91029262 | ENST00000268182 | + | 29 | 38 | 956_1274 | 1307 | 1658 | Region | Note=C1 |
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FusionGeneSequence for UNC45A_IQGAP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_UNC45A_ENST00000394275_chr15_91483703_+_IQGAP1_ENST00000268182_chr15_91029262_+_565aa MTASSVEQLRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETEASKAIEKDGGDVKALYRRSQALEKL GRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKVRYMSSTDAKVEQMFQILLDPEEKGTEKKQKASQNLVVLAREDAGAEKIFRSN GVQLLQRLLDMGETDLMLAALRTLVGICSEHQSRLLLDHQDAIAPEHNDPIHELLDDLGEVPTIESLIGESSGNLNDPNKEALAKTEVSL TLTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMKKSKSVKEDSNLTLQ EKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRKAELVKLQQTYAALNSKATFYGEQVDYYKSYIKTCLDNLASKGK VSKKPREMKGKKSKKISLKYTAARLHEKGVLLEIEDLQVNQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLHYQDLLQLQYEGVAVM >In-frame_UNC45A_ENST00000394275_chr15_91483703_+_IQGAP1_ENST00000560738_chr15_91029262_+_565aa MTASSVEQLRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETEASKAIEKDGGDVKALYRRSQALEKL GRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKVRYMSSTDAKVEQMFQILLDPEEKGTEKKQKASQNLVVLAREDAGAEKIFRSN GVQLLQRLLDMGETDLMLAALRTLVGICSEHQSRLLLDHQDAIAPEHNDPIHELLDDLGEVPTIESLIGESSGNLNDPNKEALAKTEVSL TLTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMKKSKSVKEDSNLTLQ EKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRKAELVKLQQTYAALNSKATFYGEQVDYYKSYIKTCLDNLASKGK VSKKPREMKGKKSKKISLKYTAARLHEKGVLLEIEDLQVNQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLHYQDLLQLQYEGVAVM >In-frame_UNC45A_ENST00000418476_chr15_91483703_+_IQGAP1_ENST00000268182_chr15_91029262_+_580aa MTVSGPGTPEPRPATPGASSVEQLRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETEASKAIEKDGG DVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKVRYMSSTDAKVEQMFQILLDPEEKGTEKKQKASQNLVV LAREDAGAEKIFRSNGVQLLQRLLDMGETDLMLAALRTLVGICSEHQSRLLLDHQDAIAPEHNDPIHELLDDLGEVPTIESLIGESSGNL NDPNKEALAKTEVSLTLTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKM KKSKSVKEDSNLTLQEKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRKAELVKLQQTYAALNSKATFYGEQVDYYK SYIKTCLDNLASKGKVSKKPREMKGKKSKKISLKYTAARLHEKGVLLEIEDLQVNQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLH >In-frame_UNC45A_ENST00000418476_chr15_91483703_+_IQGAP1_ENST00000560738_chr15_91029262_+_580aa MTVSGPGTPEPRPATPGASSVEQLRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYDKAETEASKAIEKDGG DVKALYRRSQALEKLGRLDQAVLDLQRCVSLEPKNKVFQEALRNIGGQIQEKVRYMSSTDAKVEQMFQILLDPEEKGTEKKQKASQNLVV LAREDAGAEKIFRSNGVQLLQRLLDMGETDLMLAALRTLVGICSEHQSRLLLDHQDAIAPEHNDPIHELLDDLGEVPTIESLIGESSGNL NDPNKEALAKTEVSLTLTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKM KKSKSVKEDSNLTLQEKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRKAELVKLQQTYAALNSKATFYGEQVDYYK SYIKTCLDNLASKGKVSKKPREMKGKKSKKISLKYTAARLHEKGVLLEIEDLQVNQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLH |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_UNC45A_ENST00000394275_chr15_91483703_+_IQGAP1_ENST00000268182_chr15_91029262_+_1695nt ATGACTGCCAGCTCAGTGGAGCAGCTGCGGAAGGAGGGCAATGAGCTGTTCAAATGTGGAGACTACGGGGGCGCCCTGGCGGCCTACACT CAGGCCCTGGGTCTGGACGCGACGCCCCAGGACCAGGCCGTTCTGCACCGGAACCGGGCCGCCTGCCACCTCAAGCTGGAAGATTACGAC AAAGCAGAAACAGAGGCATCCAAAGCCATTGAAAAGGATGGTGGGGATGTCAAAGCACTCTACCGGCGGAGCCAAGCCCTAGAGAAGCTG GGCCGCCTGGACCAGGCTGTCCTTGACCTGCAGAGATGTGTGAGCTTGGAGCCCAAGAACAAAGTTTTCCAGGAGGCCTTGCGGAACATC GGGGGCCAGATTCAGGAGAAGGTGCGATACATGTCCTCGACGGATGCCAAAGTGGAACAGATGTTTCAGATACTGTTGGACCCAGAAGAG AAGGGCACTGAGAAAAAGCAAAAGGCTTCTCAGAACCTGGTGGTGCTGGCCAGGGAGGATGCTGGAGCGGAGAAGATCTTCCGGAGTAAT GGGGTTCAGCTCTTGCAACGTTTACTGGACATGGGAGAGACTGACCTCATGCTGGCGGCTCTGCGTACGCTGGTTGGCATTTGCTCTGAG CATCAGTCACGGCTCCTGTTGGATCACCAGGATGCCATTGCTCCGGAGCACAATGATCCAATCCACGAACTGCTGGACGACCTCGGCGAG GTGCCCACCATCGAGTCCCTGATAGGGGAAAGCTCTGGCAATTTAAATGACCCAAATAAGGAGGCACTGGCTAAGACGGAAGTGTCTCTC ACCCTGACCAACAAGTTCGACGTGCCTGGAGATGAGAATGCAGAAATGGATGCTCGAACCATCTTACTGAATACAAAACGTTTAATTGTG GATGTCATCCGGTTCCAGCCAGGAGAGACCTTGACTGAAATCCTAGAAACACCAGCCACCAGTGAACAGGAAGCAGAACATCAGAGAGCC ATGCAGAGACGTGCTATCCGTGATGCCAAAACACCTGACAAGATGAAAAAGTCAAAATCTGTAAAGGAAGACAGCAACCTCACTCTTCAA GAGAAGAAAGAGAAGATCCAGACAGGTTTAAAGAAGCTAACAGAGCTTGGAACCGTGGACCCAAAGAACAAATACCAGGAACTGATCAAC GACATTGCCAGGGATATTCGGAATCAGCGGAGGTACCGACAGAGGAGAAAGGCCGAACTAGTGAAACTGCAACAGACATACGCTGCTCTG AACTCTAAGGCCACCTTTTATGGGGAGCAGGTGGATTACTATAAAAGCTATATCAAAACCTGCTTGGATAACTTAGCCAGCAAGGGCAAA GTCTCCAAAAAGCCTAGGGAAATGAAAGGAAAGAAAAGCAAAAAGATTTCTCTGAAATATACAGCAGCAAGACTACATGAAAAAGGAGTT CTTCTGGAAATTGAGGACCTGCAAGTGAATCAGTTTAAAAATGTTATATTTGAAATCAGTCCAACAGAAGAAGTTGGAGACTTCGAAGTG AAAGCCAAATTCATGGGAGTTCAAATGGAGACTTTTATGTTACATTATCAGGACCTGCTGCAGCTACAGTATGAAGGAGTTGCAGTCATG >In-frame_UNC45A_ENST00000394275_chr15_91483703_+_IQGAP1_ENST00000560738_chr15_91029262_+_1695nt ATGACTGCCAGCTCAGTGGAGCAGCTGCGGAAGGAGGGCAATGAGCTGTTCAAATGTGGAGACTACGGGGGCGCCCTGGCGGCCTACACT CAGGCCCTGGGTCTGGACGCGACGCCCCAGGACCAGGCCGTTCTGCACCGGAACCGGGCCGCCTGCCACCTCAAGCTGGAAGATTACGAC AAAGCAGAAACAGAGGCATCCAAAGCCATTGAAAAGGATGGTGGGGATGTCAAAGCACTCTACCGGCGGAGCCAAGCCCTAGAGAAGCTG GGCCGCCTGGACCAGGCTGTCCTTGACCTGCAGAGATGTGTGAGCTTGGAGCCCAAGAACAAAGTTTTCCAGGAGGCCTTGCGGAACATC GGGGGCCAGATTCAGGAGAAGGTGCGATACATGTCCTCGACGGATGCCAAAGTGGAACAGATGTTTCAGATACTGTTGGACCCAGAAGAG AAGGGCACTGAGAAAAAGCAAAAGGCTTCTCAGAACCTGGTGGTGCTGGCCAGGGAGGATGCTGGAGCGGAGAAGATCTTCCGGAGTAAT GGGGTTCAGCTCTTGCAACGTTTACTGGACATGGGAGAGACTGACCTCATGCTGGCGGCTCTGCGTACGCTGGTTGGCATTTGCTCTGAG CATCAGTCACGGCTCCTGTTGGATCACCAGGATGCCATTGCTCCGGAGCACAATGATCCAATCCACGAACTGCTGGACGACCTCGGCGAG GTGCCCACCATCGAGTCCCTGATAGGGGAAAGCTCTGGCAATTTAAATGACCCAAATAAGGAGGCACTGGCTAAGACGGAAGTGTCTCTC ACCCTGACCAACAAGTTCGACGTGCCTGGAGATGAGAATGCAGAAATGGATGCTCGAACCATCTTACTGAATACAAAACGTTTAATTGTG GATGTCATCCGGTTCCAGCCAGGAGAGACCTTGACTGAAATCCTAGAAACACCAGCCACCAGTGAACAGGAAGCAGAACATCAGAGAGCC ATGCAGAGACGTGCTATCCGTGATGCCAAAACACCTGACAAGATGAAAAAGTCAAAATCTGTAAAGGAAGACAGCAACCTCACTCTTCAA GAGAAGAAAGAGAAGATCCAGACAGGTTTAAAGAAGCTAACAGAGCTTGGAACCGTGGACCCAAAGAACAAATACCAGGAACTGATCAAC GACATTGCCAGGGATATTCGGAATCAGCGGAGGTACCGACAGAGGAGAAAGGCCGAACTAGTGAAACTGCAACAGACATACGCTGCTCTG AACTCTAAGGCCACCTTTTATGGGGAGCAGGTGGATTACTATAAAAGCTATATCAAAACCTGCTTGGATAACTTAGCCAGCAAGGGCAAA GTCTCCAAAAAGCCTAGGGAAATGAAAGGAAAGAAAAGCAAAAAGATTTCTCTGAAATATACAGCAGCAAGACTACATGAAAAAGGAGTT CTTCTGGAAATTGAGGACCTGCAAGTGAATCAGTTTAAAAATGTTATATTTGAAATCAGTCCAACAGAAGAAGTTGGAGACTTCGAAGTG AAAGCCAAATTCATGGGAGTTCAAATGGAGACTTTTATGTTACATTATCAGGACCTGCTGCAGCTACAGTATGAAGGAGTTGCAGTCATG >In-frame_UNC45A_ENST00000418476_chr15_91483703_+_IQGAP1_ENST00000268182_chr15_91029262_+_1740nt ATGACTGTGAGTGGTCCAGGGACCCCCGAGCCCCGGCCGGCCACCCCCGGGGCCAGCTCAGTGGAGCAGCTGCGGAAGGAGGGCAATGAG CTGTTCAAATGTGGAGACTACGGGGGCGCCCTGGCGGCCTACACTCAGGCCCTGGGTCTGGACGCGACGCCCCAGGACCAGGCCGTTCTG CACCGGAACCGGGCCGCCTGCCACCTCAAGCTGGAAGATTACGACAAAGCAGAAACAGAGGCATCCAAAGCCATTGAAAAGGATGGTGGG GATGTCAAAGCACTCTACCGGCGGAGCCAAGCCCTAGAGAAGCTGGGCCGCCTGGACCAGGCTGTCCTTGACCTGCAGAGATGTGTGAGC TTGGAGCCCAAGAACAAAGTTTTCCAGGAGGCCTTGCGGAACATCGGGGGCCAGATTCAGGAGAAGGTGCGATACATGTCCTCGACGGAT GCCAAAGTGGAACAGATGTTTCAGATACTGTTGGACCCAGAAGAGAAGGGCACTGAGAAAAAGCAAAAGGCTTCTCAGAACCTGGTGGTG CTGGCCAGGGAGGATGCTGGAGCGGAGAAGATCTTCCGGAGTAATGGGGTTCAGCTCTTGCAACGTTTACTGGACATGGGAGAGACTGAC CTCATGCTGGCGGCTCTGCGTACGCTGGTTGGCATTTGCTCTGAGCATCAGTCACGGCTCCTGTTGGATCACCAGGATGCCATTGCTCCG GAGCACAATGATCCAATCCACGAACTGCTGGACGACCTCGGCGAGGTGCCCACCATCGAGTCCCTGATAGGGGAAAGCTCTGGCAATTTA AATGACCCAAATAAGGAGGCACTGGCTAAGACGGAAGTGTCTCTCACCCTGACCAACAAGTTCGACGTGCCTGGAGATGAGAATGCAGAA ATGGATGCTCGAACCATCTTACTGAATACAAAACGTTTAATTGTGGATGTCATCCGGTTCCAGCCAGGAGAGACCTTGACTGAAATCCTA GAAACACCAGCCACCAGTGAACAGGAAGCAGAACATCAGAGAGCCATGCAGAGACGTGCTATCCGTGATGCCAAAACACCTGACAAGATG AAAAAGTCAAAATCTGTAAAGGAAGACAGCAACCTCACTCTTCAAGAGAAGAAAGAGAAGATCCAGACAGGTTTAAAGAAGCTAACAGAG CTTGGAACCGTGGACCCAAAGAACAAATACCAGGAACTGATCAACGACATTGCCAGGGATATTCGGAATCAGCGGAGGTACCGACAGAGG AGAAAGGCCGAACTAGTGAAACTGCAACAGACATACGCTGCTCTGAACTCTAAGGCCACCTTTTATGGGGAGCAGGTGGATTACTATAAA AGCTATATCAAAACCTGCTTGGATAACTTAGCCAGCAAGGGCAAAGTCTCCAAAAAGCCTAGGGAAATGAAAGGAAAGAAAAGCAAAAAG ATTTCTCTGAAATATACAGCAGCAAGACTACATGAAAAAGGAGTTCTTCTGGAAATTGAGGACCTGCAAGTGAATCAGTTTAAAAATGTT ATATTTGAAATCAGTCCAACAGAAGAAGTTGGAGACTTCGAAGTGAAAGCCAAATTCATGGGAGTTCAAATGGAGACTTTTATGTTACAT TATCAGGACCTGCTGCAGCTACAGTATGAAGGAGTTGCAGTCATGAAATTATTTGATAGAGCTAAAGTAAATGTCAACCTCCTGATCTTC >In-frame_UNC45A_ENST00000418476_chr15_91483703_+_IQGAP1_ENST00000560738_chr15_91029262_+_1740nt ATGACTGTGAGTGGTCCAGGGACCCCCGAGCCCCGGCCGGCCACCCCCGGGGCCAGCTCAGTGGAGCAGCTGCGGAAGGAGGGCAATGAG CTGTTCAAATGTGGAGACTACGGGGGCGCCCTGGCGGCCTACACTCAGGCCCTGGGTCTGGACGCGACGCCCCAGGACCAGGCCGTTCTG CACCGGAACCGGGCCGCCTGCCACCTCAAGCTGGAAGATTACGACAAAGCAGAAACAGAGGCATCCAAAGCCATTGAAAAGGATGGTGGG GATGTCAAAGCACTCTACCGGCGGAGCCAAGCCCTAGAGAAGCTGGGCCGCCTGGACCAGGCTGTCCTTGACCTGCAGAGATGTGTGAGC TTGGAGCCCAAGAACAAAGTTTTCCAGGAGGCCTTGCGGAACATCGGGGGCCAGATTCAGGAGAAGGTGCGATACATGTCCTCGACGGAT GCCAAAGTGGAACAGATGTTTCAGATACTGTTGGACCCAGAAGAGAAGGGCACTGAGAAAAAGCAAAAGGCTTCTCAGAACCTGGTGGTG CTGGCCAGGGAGGATGCTGGAGCGGAGAAGATCTTCCGGAGTAATGGGGTTCAGCTCTTGCAACGTTTACTGGACATGGGAGAGACTGAC CTCATGCTGGCGGCTCTGCGTACGCTGGTTGGCATTTGCTCTGAGCATCAGTCACGGCTCCTGTTGGATCACCAGGATGCCATTGCTCCG GAGCACAATGATCCAATCCACGAACTGCTGGACGACCTCGGCGAGGTGCCCACCATCGAGTCCCTGATAGGGGAAAGCTCTGGCAATTTA AATGACCCAAATAAGGAGGCACTGGCTAAGACGGAAGTGTCTCTCACCCTGACCAACAAGTTCGACGTGCCTGGAGATGAGAATGCAGAA ATGGATGCTCGAACCATCTTACTGAATACAAAACGTTTAATTGTGGATGTCATCCGGTTCCAGCCAGGAGAGACCTTGACTGAAATCCTA GAAACACCAGCCACCAGTGAACAGGAAGCAGAACATCAGAGAGCCATGCAGAGACGTGCTATCCGTGATGCCAAAACACCTGACAAGATG AAAAAGTCAAAATCTGTAAAGGAAGACAGCAACCTCACTCTTCAAGAGAAGAAAGAGAAGATCCAGACAGGTTTAAAGAAGCTAACAGAG CTTGGAACCGTGGACCCAAAGAACAAATACCAGGAACTGATCAACGACATTGCCAGGGATATTCGGAATCAGCGGAGGTACCGACAGAGG AGAAAGGCCGAACTAGTGAAACTGCAACAGACATACGCTGCTCTGAACTCTAAGGCCACCTTTTATGGGGAGCAGGTGGATTACTATAAA AGCTATATCAAAACCTGCTTGGATAACTTAGCCAGCAAGGGCAAAGTCTCCAAAAAGCCTAGGGAAATGAAAGGAAAGAAAAGCAAAAAG ATTTCTCTGAAATATACAGCAGCAAGACTACATGAAAAAGGAGTTCTTCTGGAAATTGAGGACCTGCAAGTGAATCAGTTTAAAAATGTT ATATTTGAAATCAGTCCAACAGAAGAAGTTGGAGACTTCGAAGTGAAAGCCAAATTCATGGGAGTTCAAATGGAGACTTTTATGTTACAT TATCAGGACCTGCTGCAGCTACAGTATGAAGGAGTTGCAGTCATGAAATTATTTGATAGAGCTAAAGTAAATGTCAACCTCCTGATCTTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_UNC45A_ENST00000394275_chr15_91483703_+_IQGAP1_ENST00000268182_chr15_91029262_+_4665nt ACTTAACAACCGAAGTAACCCGCAATGCGGAAGGGCGAGGGGATTGCGAGTCACCGAGTTTCCCGCGCGGCTTGAGTCACGGCCTAGAAA GAGAGATGTTGGGGTTCCCAGGACCAGGACAGAGGTGGTAGTGAACTCTCATGGGCATCCAGAGAAGGTCAGGCCCCTTGCTGACAGGCC TATCTGTGGGGCTACTGCTGCTCTTCAGCTGGGTGACCCTTGTCCAGCCAACCTCTCTCTCAGCTCTGGTCCACCACCCTCACTTGTGCC AGACCACCCGGGATGTCCATGGCCGTCACTACCCTGGTTTCTTTTGCCCTCGTCTGTCTGATTCTCCAGAGGAAGCCTACTGCTGCCACC TGCAGGCTGCAGGGGGCTCCTGCTGCACCCGGGCTGAATTTGAGGCCCTGTACCAAGTCAATCTGTCCGCTCTTCCGCCCCCGCCCATCC TCAGGGGCCCAGGCCCGCTCCTAGTGCTGGGCCTCTACAACCTACTGGTTGTGACCCTGATGACCGTAGACCTCGTGCACTTCTGCTGCG GTCGGGGCCGGAGTCTGGGCTGGAGCCACCGCAGGCCTCCCTCTGGGTCCTCCGCCGCGAGCTCCCTGCAGGTCTCTGCGGGGACAGCTT AGGTGCGCCCGGAGCTTGCCTGCACCTGCGATCCAGAGCCAAGCGCCCCGCCCCTGCCCGGGCGCGCTCCCTCCTTAGCCCTGCCCCTCT CTGACCCCACCTCCGACGCAAGAGTGGGGCGGGGCAGCTGCCGGTGGCGTCCCGAACCCAGACTCGCCCCGCCCCAGAGACTGCGCCTGC GCGGGCACGAGACAACCTCTCCGCGATGACTGCCAGCTCAGTGGAGCAGCTGCGGAAGGAGGGCAATGAGCTGTTCAAATGTGGAGACTA CGGGGGCGCCCTGGCGGCCTACACTCAGGCCCTGGGTCTGGACGCGACGCCCCAGGACCAGGCCGTTCTGCACCGGAACCGGGCCGCCTG CCACCTCAAGCTGGAAGATTACGACAAAGCAGAAACAGAGGCATCCAAAGCCATTGAAAAGGATGGTGGGGATGTCAAAGCACTCTACCG GCGGAGCCAAGCCCTAGAGAAGCTGGGCCGCCTGGACCAGGCTGTCCTTGACCTGCAGAGATGTGTGAGCTTGGAGCCCAAGAACAAAGT TTTCCAGGAGGCCTTGCGGAACATCGGGGGCCAGATTCAGGAGAAGGTGCGATACATGTCCTCGACGGATGCCAAAGTGGAACAGATGTT TCAGATACTGTTGGACCCAGAAGAGAAGGGCACTGAGAAAAAGCAAAAGGCTTCTCAGAACCTGGTGGTGCTGGCCAGGGAGGATGCTGG AGCGGAGAAGATCTTCCGGAGTAATGGGGTTCAGCTCTTGCAACGTTTACTGGACATGGGAGAGACTGACCTCATGCTGGCGGCTCTGCG TACGCTGGTTGGCATTTGCTCTGAGCATCAGTCACGGCTCCTGTTGGATCACCAGGATGCCATTGCTCCGGAGCACAATGATCCAATCCA CGAACTGCTGGACGACCTCGGCGAGGTGCCCACCATCGAGTCCCTGATAGGGGAAAGCTCTGGCAATTTAAATGACCCAAATAAGGAGGC ACTGGCTAAGACGGAAGTGTCTCTCACCCTGACCAACAAGTTCGACGTGCCTGGAGATGAGAATGCAGAAATGGATGCTCGAACCATCTT ACTGAATACAAAACGTTTAATTGTGGATGTCATCCGGTTCCAGCCAGGAGAGACCTTGACTGAAATCCTAGAAACACCAGCCACCAGTGA ACAGGAAGCAGAACATCAGAGAGCCATGCAGAGACGTGCTATCCGTGATGCCAAAACACCTGACAAGATGAAAAAGTCAAAATCTGTAAA GGAAGACAGCAACCTCACTCTTCAAGAGAAGAAAGAGAAGATCCAGACAGGTTTAAAGAAGCTAACAGAGCTTGGAACCGTGGACCCAAA GAACAAATACCAGGAACTGATCAACGACATTGCCAGGGATATTCGGAATCAGCGGAGGTACCGACAGAGGAGAAAGGCCGAACTAGTGAA ACTGCAACAGACATACGCTGCTCTGAACTCTAAGGCCACCTTTTATGGGGAGCAGGTGGATTACTATAAAAGCTATATCAAAACCTGCTT GGATAACTTAGCCAGCAAGGGCAAAGTCTCCAAAAAGCCTAGGGAAATGAAAGGAAAGAAAAGCAAAAAGATTTCTCTGAAATATACAGC AGCAAGACTACATGAAAAAGGAGTTCTTCTGGAAATTGAGGACCTGCAAGTGAATCAGTTTAAAAATGTTATATTTGAAATCAGTCCAAC AGAAGAAGTTGGAGACTTCGAAGTGAAAGCCAAATTCATGGGAGTTCAAATGGAGACTTTTATGTTACATTATCAGGACCTGCTGCAGCT ACAGTATGAAGGAGTTGCAGTCATGAAATTATTTGATAGAGCTAAAGTAAATGTCAACCTCCTGATCTTCCTTCTCAACAAAAAGTTCTA CGGGAAGTAATTGATCGTTTGCTGCCAGCCCAGAAGGATGAAGGAAAGAAGCACCTCACAGCTCCTTTCTAGGTCCTTCTTTCCTCATTG GAAGCAAAGACCTAGCCAACAACAGCACCTCAATCTGATACACTCCCGATGCCACATTTTTAACTCCTCTCGCTCTGATGGGACATTTGT TACCCTTTTTTCATAGTGAAATTGTGTTTCAGGCTTAGTCTGACCTTTCTGGTTTCTTCATTTTCTTCCATTACTTAGGAAAGAGTGGAA ACTCCACTAAAATTTCTCTGTGTTGTTACAGTCTTAGAGGTTGCAGTACTATATTGTAAGCTTTGGTGTTTGTTTAATTAGCAATAGGGA TGGTAGGATTCAAATGTGTGTCATTTAGAAGTGGAAGCTATTAGCACCAATGACATAAATACATACAAGACACACAACTAAAATGTCATG TTATTAACAGTTATTAGGTTGTCATTTAAAAATAAAGTTCCTTTATATTTCTGTCCCATCAGGAAAACTGAAGGATATGGGGAATCATTG GTTATCTTCCATTGTGTTTTTCTTTATGGACAGGAGCTAATGGAAGTGACAGTCATGTTCAAAGGAAGCATTTCTAGAAAAAAGGAGATA ATGTTTTTAAATTTCATTATCAAACTTGGGCAATTCTGTTTGTGTAACTCCCCGACTAGTGGATGGGAGAGTCCCATTGCTAAAATTCAG CTACTCAGATAAATTCAGAATGGGTCAAGGCACCTGCCTGTTTTTGTTGGTGCACAGAGATTGACTTGATTCAGAGAGACAATTCACTCC ATCCCTATGGCAGAGGAATGGGTTAGCCCTAATGTAGAATGTCATTGTTTTTAAAACTGTTTTATATCTTAAGAGTGCCTTATTAAAGTA TAGATGTATGTCTTAAAATGTGGGTGATAGGAATTTTAAAGATTTATATAATGCATCAAAAGCCTTAGAATAAGAAAAGCTTTTTTTAAA TTGCTTTATCTGTATATCTGAACTCTTGAAACTTATAGCTAAAACACTAGGATTTATCTGCAGTGTTCAGGGAGATAATTCTGCCTTTAA TTGTCTAAAACAAAAACAAAACCAGCCAACCTATGTTACACGTGAGATTAAAACCAATTTTTTCCCCATTTTTTCTCCTTTTTTCTCTTG CTGCCCACATTGTGCCTTTATTTTATGAGCCCCAGTTTTCTGGGCTTAGTTTAAAAAAAAAATCAAGTCTAAACATTGCATTTAGAAAGC TTTTGTTCTTGGATAAAAAGTCATACACTTTAAAAAAAAAAAAAACTTTTTCCAGGAAAATATATTGAAATCATGCTGCTGAGCCTCTAT TTTCTTTCTTTGATGTTTTGATTCAGTATTCTTTTATCATAAATTTTTAGCATTTAAAAATTCACTGATGTACATTAAGCCAATAAACTG CTTTAATGAATAACAAACTATGTAGTGTGTCCCTATTATAAATGCATTGGAGAAGTATTTTTATGAGACTCTTTACTCAGGTGCATGGTT ACAGCCCACAGGGAGGCATGGAGTGCCATGGAAGGATTCGCCACTACCCAGACCTTGTTTTTTGTTGTATTTTGGAAGACAGGTTTTTTA AAGAAACATTTTCCTCAGATTAAAAGATGATGCTATTACAACTAGCATTGCCTCAAAAACTGGGACCAACCAAAGTGTGTCAACCCTGTT TCCTTAAAAGAGGCTATGAATCCCAAAGGCCACATCCAAGACAGGCAATAATGAGCAGAGTTTACAGCTCCTTTAATAAAATGTGTCAGT AATTTTAAGGTTTATAGTTCCCTCAACACAATTGCTAATGCAGAATAGTGTAAAATGCGCTTCAAGAATGTTGATGATGATGATATAGAA TTGTGGCTTTAGTAGCACAGAGGATGCCCCAACAAACTCATGGCGTTGAAACCACACAGTTCTCATTACTGTTATTTATTAGCTGTAGCA TTCTCTGTCTCCTCTCTCTCCTCCTTTGACCTTCTCCTCGACCAGCCATCATGACATTTACCATGAATTTACTTCCTCCCAAGAGTTTGG >In-frame_UNC45A_ENST00000394275_chr15_91483703_+_IQGAP1_ENST00000560738_chr15_91029262_+_2793nt ACTTAACAACCGAAGTAACCCGCAATGCGGAAGGGCGAGGGGATTGCGAGTCACCGAGTTTCCCGCGCGGCTTGAGTCACGGCCTAGAAA GAGAGATGTTGGGGTTCCCAGGACCAGGACAGAGGTGGTAGTGAACTCTCATGGGCATCCAGAGAAGGTCAGGCCCCTTGCTGACAGGCC TATCTGTGGGGCTACTGCTGCTCTTCAGCTGGGTGACCCTTGTCCAGCCAACCTCTCTCTCAGCTCTGGTCCACCACCCTCACTTGTGCC AGACCACCCGGGATGTCCATGGCCGTCACTACCCTGGTTTCTTTTGCCCTCGTCTGTCTGATTCTCCAGAGGAAGCCTACTGCTGCCACC TGCAGGCTGCAGGGGGCTCCTGCTGCACCCGGGCTGAATTTGAGGCCCTGTACCAAGTCAATCTGTCCGCTCTTCCGCCCCCGCCCATCC TCAGGGGCCCAGGCCCGCTCCTAGTGCTGGGCCTCTACAACCTACTGGTTGTGACCCTGATGACCGTAGACCTCGTGCACTTCTGCTGCG GTCGGGGCCGGAGTCTGGGCTGGAGCCACCGCAGGCCTCCCTCTGGGTCCTCCGCCGCGAGCTCCCTGCAGGTCTCTGCGGGGACAGCTT AGGTGCGCCCGGAGCTTGCCTGCACCTGCGATCCAGAGCCAAGCGCCCCGCCCCTGCCCGGGCGCGCTCCCTCCTTAGCCCTGCCCCTCT CTGACCCCACCTCCGACGCAAGAGTGGGGCGGGGCAGCTGCCGGTGGCGTCCCGAACCCAGACTCGCCCCGCCCCAGAGACTGCGCCTGC GCGGGCACGAGACAACCTCTCCGCGATGACTGCCAGCTCAGTGGAGCAGCTGCGGAAGGAGGGCAATGAGCTGTTCAAATGTGGAGACTA CGGGGGCGCCCTGGCGGCCTACACTCAGGCCCTGGGTCTGGACGCGACGCCCCAGGACCAGGCCGTTCTGCACCGGAACCGGGCCGCCTG CCACCTCAAGCTGGAAGATTACGACAAAGCAGAAACAGAGGCATCCAAAGCCATTGAAAAGGATGGTGGGGATGTCAAAGCACTCTACCG GCGGAGCCAAGCCCTAGAGAAGCTGGGCCGCCTGGACCAGGCTGTCCTTGACCTGCAGAGATGTGTGAGCTTGGAGCCCAAGAACAAAGT TTTCCAGGAGGCCTTGCGGAACATCGGGGGCCAGATTCAGGAGAAGGTGCGATACATGTCCTCGACGGATGCCAAAGTGGAACAGATGTT TCAGATACTGTTGGACCCAGAAGAGAAGGGCACTGAGAAAAAGCAAAAGGCTTCTCAGAACCTGGTGGTGCTGGCCAGGGAGGATGCTGG AGCGGAGAAGATCTTCCGGAGTAATGGGGTTCAGCTCTTGCAACGTTTACTGGACATGGGAGAGACTGACCTCATGCTGGCGGCTCTGCG TACGCTGGTTGGCATTTGCTCTGAGCATCAGTCACGGCTCCTGTTGGATCACCAGGATGCCATTGCTCCGGAGCACAATGATCCAATCCA CGAACTGCTGGACGACCTCGGCGAGGTGCCCACCATCGAGTCCCTGATAGGGGAAAGCTCTGGCAATTTAAATGACCCAAATAAGGAGGC ACTGGCTAAGACGGAAGTGTCTCTCACCCTGACCAACAAGTTCGACGTGCCTGGAGATGAGAATGCAGAAATGGATGCTCGAACCATCTT ACTGAATACAAAACGTTTAATTGTGGATGTCATCCGGTTCCAGCCAGGAGAGACCTTGACTGAAATCCTAGAAACACCAGCCACCAGTGA ACAGGAAGCAGAACATCAGAGAGCCATGCAGAGACGTGCTATCCGTGATGCCAAAACACCTGACAAGATGAAAAAGTCAAAATCTGTAAA GGAAGACAGCAACCTCACTCTTCAAGAGAAGAAAGAGAAGATCCAGACAGGTTTAAAGAAGCTAACAGAGCTTGGAACCGTGGACCCAAA GAACAAATACCAGGAACTGATCAACGACATTGCCAGGGATATTCGGAATCAGCGGAGGTACCGACAGAGGAGAAAGGCCGAACTAGTGAA ACTGCAACAGACATACGCTGCTCTGAACTCTAAGGCCACCTTTTATGGGGAGCAGGTGGATTACTATAAAAGCTATATCAAAACCTGCTT GGATAACTTAGCCAGCAAGGGCAAAGTCTCCAAAAAGCCTAGGGAAATGAAAGGAAAGAAAAGCAAAAAGATTTCTCTGAAATATACAGC AGCAAGACTACATGAAAAAGGAGTTCTTCTGGAAATTGAGGACCTGCAAGTGAATCAGTTTAAAAATGTTATATTTGAAATCAGTCCAAC AGAAGAAGTTGGAGACTTCGAAGTGAAAGCCAAATTCATGGGAGTTCAAATGGAGACTTTTATGTTACATTATCAGGACCTGCTGCAGCT ACAGTATGAAGGAGTTGCAGTCATGAAATTATTTGATAGAGCTAAAGTAAATGTCAACCTCCTGATCTTCCTTCTCAACAAAAAGTTCTA CGGGAAGTAATTGATCGTTTGCTGCCAGCCCAGAAGGATGAAGGAAAGAAGCACCTCACAGCTCCTTTCTAGGTCCTTCTTTCCTCATTG GAAGCAAAGACCTAGCCAACAACAGCACCTCAATCTGATACACTCCCGATGCCACATTTTTAACTCCTCTCGCTCTGATGGGACATTTGT TACCCTTTTTTCATAGTGAAATTGTGTTTCAGGCTTAGTCTGACCTTTCTGGTTTCTTCATTTTCTTCCATTACTTAGGAAAGAGTGGAA >In-frame_UNC45A_ENST00000418476_chr15_91483703_+_IQGAP1_ENST00000268182_chr15_91029262_+_3915nt AGAGACTGCGCCTGCGCGGGCACGAGACAACCTCTCCGCGATGACTGTGAGTGGTCCAGGGACCCCCGAGCCCCGGCCGGCCACCCCCGG GGCCAGCTCAGTGGAGCAGCTGCGGAAGGAGGGCAATGAGCTGTTCAAATGTGGAGACTACGGGGGCGCCCTGGCGGCCTACACTCAGGC CCTGGGTCTGGACGCGACGCCCCAGGACCAGGCCGTTCTGCACCGGAACCGGGCCGCCTGCCACCTCAAGCTGGAAGATTACGACAAAGC AGAAACAGAGGCATCCAAAGCCATTGAAAAGGATGGTGGGGATGTCAAAGCACTCTACCGGCGGAGCCAAGCCCTAGAGAAGCTGGGCCG CCTGGACCAGGCTGTCCTTGACCTGCAGAGATGTGTGAGCTTGGAGCCCAAGAACAAAGTTTTCCAGGAGGCCTTGCGGAACATCGGGGG CCAGATTCAGGAGAAGGTGCGATACATGTCCTCGACGGATGCCAAAGTGGAACAGATGTTTCAGATACTGTTGGACCCAGAAGAGAAGGG CACTGAGAAAAAGCAAAAGGCTTCTCAGAACCTGGTGGTGCTGGCCAGGGAGGATGCTGGAGCGGAGAAGATCTTCCGGAGTAATGGGGT TCAGCTCTTGCAACGTTTACTGGACATGGGAGAGACTGACCTCATGCTGGCGGCTCTGCGTACGCTGGTTGGCATTTGCTCTGAGCATCA GTCACGGCTCCTGTTGGATCACCAGGATGCCATTGCTCCGGAGCACAATGATCCAATCCACGAACTGCTGGACGACCTCGGCGAGGTGCC CACCATCGAGTCCCTGATAGGGGAAAGCTCTGGCAATTTAAATGACCCAAATAAGGAGGCACTGGCTAAGACGGAAGTGTCTCTCACCCT GACCAACAAGTTCGACGTGCCTGGAGATGAGAATGCAGAAATGGATGCTCGAACCATCTTACTGAATACAAAACGTTTAATTGTGGATGT CATCCGGTTCCAGCCAGGAGAGACCTTGACTGAAATCCTAGAAACACCAGCCACCAGTGAACAGGAAGCAGAACATCAGAGAGCCATGCA GAGACGTGCTATCCGTGATGCCAAAACACCTGACAAGATGAAAAAGTCAAAATCTGTAAAGGAAGACAGCAACCTCACTCTTCAAGAGAA GAAAGAGAAGATCCAGACAGGTTTAAAGAAGCTAACAGAGCTTGGAACCGTGGACCCAAAGAACAAATACCAGGAACTGATCAACGACAT TGCCAGGGATATTCGGAATCAGCGGAGGTACCGACAGAGGAGAAAGGCCGAACTAGTGAAACTGCAACAGACATACGCTGCTCTGAACTC TAAGGCCACCTTTTATGGGGAGCAGGTGGATTACTATAAAAGCTATATCAAAACCTGCTTGGATAACTTAGCCAGCAAGGGCAAAGTCTC CAAAAAGCCTAGGGAAATGAAAGGAAAGAAAAGCAAAAAGATTTCTCTGAAATATACAGCAGCAAGACTACATGAAAAAGGAGTTCTTCT GGAAATTGAGGACCTGCAAGTGAATCAGTTTAAAAATGTTATATTTGAAATCAGTCCAACAGAAGAAGTTGGAGACTTCGAAGTGAAAGC CAAATTCATGGGAGTTCAAATGGAGACTTTTATGTTACATTATCAGGACCTGCTGCAGCTACAGTATGAAGGAGTTGCAGTCATGAAATT ATTTGATAGAGCTAAAGTAAATGTCAACCTCCTGATCTTCCTTCTCAACAAAAAGTTCTACGGGAAGTAATTGATCGTTTGCTGCCAGCC CAGAAGGATGAAGGAAAGAAGCACCTCACAGCTCCTTTCTAGGTCCTTCTTTCCTCATTGGAAGCAAAGACCTAGCCAACAACAGCACCT CAATCTGATACACTCCCGATGCCACATTTTTAACTCCTCTCGCTCTGATGGGACATTTGTTACCCTTTTTTCATAGTGAAATTGTGTTTC AGGCTTAGTCTGACCTTTCTGGTTTCTTCATTTTCTTCCATTACTTAGGAAAGAGTGGAAACTCCACTAAAATTTCTCTGTGTTGTTACA GTCTTAGAGGTTGCAGTACTATATTGTAAGCTTTGGTGTTTGTTTAATTAGCAATAGGGATGGTAGGATTCAAATGTGTGTCATTTAGAA GTGGAAGCTATTAGCACCAATGACATAAATACATACAAGACACACAACTAAAATGTCATGTTATTAACAGTTATTAGGTTGTCATTTAAA AATAAAGTTCCTTTATATTTCTGTCCCATCAGGAAAACTGAAGGATATGGGGAATCATTGGTTATCTTCCATTGTGTTTTTCTTTATGGA CAGGAGCTAATGGAAGTGACAGTCATGTTCAAAGGAAGCATTTCTAGAAAAAAGGAGATAATGTTTTTAAATTTCATTATCAAACTTGGG CAATTCTGTTTGTGTAACTCCCCGACTAGTGGATGGGAGAGTCCCATTGCTAAAATTCAGCTACTCAGATAAATTCAGAATGGGTCAAGG CACCTGCCTGTTTTTGTTGGTGCACAGAGATTGACTTGATTCAGAGAGACAATTCACTCCATCCCTATGGCAGAGGAATGGGTTAGCCCT AATGTAGAATGTCATTGTTTTTAAAACTGTTTTATATCTTAAGAGTGCCTTATTAAAGTATAGATGTATGTCTTAAAATGTGGGTGATAG GAATTTTAAAGATTTATATAATGCATCAAAAGCCTTAGAATAAGAAAAGCTTTTTTTAAATTGCTTTATCTGTATATCTGAACTCTTGAA ACTTATAGCTAAAACACTAGGATTTATCTGCAGTGTTCAGGGAGATAATTCTGCCTTTAATTGTCTAAAACAAAAACAAAACCAGCCAAC CTATGTTACACGTGAGATTAAAACCAATTTTTTCCCCATTTTTTCTCCTTTTTTCTCTTGCTGCCCACATTGTGCCTTTATTTTATGAGC CCCAGTTTTCTGGGCTTAGTTTAAAAAAAAAATCAAGTCTAAACATTGCATTTAGAAAGCTTTTGTTCTTGGATAAAAAGTCATACACTT TAAAAAAAAAAAAAACTTTTTCCAGGAAAATATATTGAAATCATGCTGCTGAGCCTCTATTTTCTTTCTTTGATGTTTTGATTCAGTATT CTTTTATCATAAATTTTTAGCATTTAAAAATTCACTGATGTACATTAAGCCAATAAACTGCTTTAATGAATAACAAACTATGTAGTGTGT CCCTATTATAAATGCATTGGAGAAGTATTTTTATGAGACTCTTTACTCAGGTGCATGGTTACAGCCCACAGGGAGGCATGGAGTGCCATG GAAGGATTCGCCACTACCCAGACCTTGTTTTTTGTTGTATTTTGGAAGACAGGTTTTTTAAAGAAACATTTTCCTCAGATTAAAAGATGA TGCTATTACAACTAGCATTGCCTCAAAAACTGGGACCAACCAAAGTGTGTCAACCCTGTTTCCTTAAAAGAGGCTATGAATCCCAAAGGC CACATCCAAGACAGGCAATAATGAGCAGAGTTTACAGCTCCTTTAATAAAATGTGTCAGTAATTTTAAGGTTTATAGTTCCCTCAACACA ATTGCTAATGCAGAATAGTGTAAAATGCGCTTCAAGAATGTTGATGATGATGATATAGAATTGTGGCTTTAGTAGCACAGAGGATGCCCC AACAAACTCATGGCGTTGAAACCACACAGTTCTCATTACTGTTATTTATTAGCTGTAGCATTCTCTGTCTCCTCTCTCTCCTCCTTTGAC CTTCTCCTCGACCAGCCATCATGACATTTACCATGAATTTACTTCCTCCCAAGAGTTTGGACTGCCCGTCAGATTGTTGCTGCACATAGT >In-frame_UNC45A_ENST00000418476_chr15_91483703_+_IQGAP1_ENST00000560738_chr15_91029262_+_2043nt AGAGACTGCGCCTGCGCGGGCACGAGACAACCTCTCCGCGATGACTGTGAGTGGTCCAGGGACCCCCGAGCCCCGGCCGGCCACCCCCGG GGCCAGCTCAGTGGAGCAGCTGCGGAAGGAGGGCAATGAGCTGTTCAAATGTGGAGACTACGGGGGCGCCCTGGCGGCCTACACTCAGGC CCTGGGTCTGGACGCGACGCCCCAGGACCAGGCCGTTCTGCACCGGAACCGGGCCGCCTGCCACCTCAAGCTGGAAGATTACGACAAAGC AGAAACAGAGGCATCCAAAGCCATTGAAAAGGATGGTGGGGATGTCAAAGCACTCTACCGGCGGAGCCAAGCCCTAGAGAAGCTGGGCCG CCTGGACCAGGCTGTCCTTGACCTGCAGAGATGTGTGAGCTTGGAGCCCAAGAACAAAGTTTTCCAGGAGGCCTTGCGGAACATCGGGGG CCAGATTCAGGAGAAGGTGCGATACATGTCCTCGACGGATGCCAAAGTGGAACAGATGTTTCAGATACTGTTGGACCCAGAAGAGAAGGG CACTGAGAAAAAGCAAAAGGCTTCTCAGAACCTGGTGGTGCTGGCCAGGGAGGATGCTGGAGCGGAGAAGATCTTCCGGAGTAATGGGGT TCAGCTCTTGCAACGTTTACTGGACATGGGAGAGACTGACCTCATGCTGGCGGCTCTGCGTACGCTGGTTGGCATTTGCTCTGAGCATCA GTCACGGCTCCTGTTGGATCACCAGGATGCCATTGCTCCGGAGCACAATGATCCAATCCACGAACTGCTGGACGACCTCGGCGAGGTGCC CACCATCGAGTCCCTGATAGGGGAAAGCTCTGGCAATTTAAATGACCCAAATAAGGAGGCACTGGCTAAGACGGAAGTGTCTCTCACCCT GACCAACAAGTTCGACGTGCCTGGAGATGAGAATGCAGAAATGGATGCTCGAACCATCTTACTGAATACAAAACGTTTAATTGTGGATGT CATCCGGTTCCAGCCAGGAGAGACCTTGACTGAAATCCTAGAAACACCAGCCACCAGTGAACAGGAAGCAGAACATCAGAGAGCCATGCA GAGACGTGCTATCCGTGATGCCAAAACACCTGACAAGATGAAAAAGTCAAAATCTGTAAAGGAAGACAGCAACCTCACTCTTCAAGAGAA GAAAGAGAAGATCCAGACAGGTTTAAAGAAGCTAACAGAGCTTGGAACCGTGGACCCAAAGAACAAATACCAGGAACTGATCAACGACAT TGCCAGGGATATTCGGAATCAGCGGAGGTACCGACAGAGGAGAAAGGCCGAACTAGTGAAACTGCAACAGACATACGCTGCTCTGAACTC TAAGGCCACCTTTTATGGGGAGCAGGTGGATTACTATAAAAGCTATATCAAAACCTGCTTGGATAACTTAGCCAGCAAGGGCAAAGTCTC CAAAAAGCCTAGGGAAATGAAAGGAAAGAAAAGCAAAAAGATTTCTCTGAAATATACAGCAGCAAGACTACATGAAAAAGGAGTTCTTCT GGAAATTGAGGACCTGCAAGTGAATCAGTTTAAAAATGTTATATTTGAAATCAGTCCAACAGAAGAAGTTGGAGACTTCGAAGTGAAAGC CAAATTCATGGGAGTTCAAATGGAGACTTTTATGTTACATTATCAGGACCTGCTGCAGCTACAGTATGAAGGAGTTGCAGTCATGAAATT ATTTGATAGAGCTAAAGTAAATGTCAACCTCCTGATCTTCCTTCTCAACAAAAAGTTCTACGGGAAGTAATTGATCGTTTGCTGCCAGCC CAGAAGGATGAAGGAAAGAAGCACCTCACAGCTCCTTTCTAGGTCCTTCTTTCCTCATTGGAAGCAAAGACCTAGCCAACAACAGCACCT CAATCTGATACACTCCCGATGCCACATTTTTAACTCCTCTCGCTCTGATGGGACATTTGTTACCCTTTTTTCATAGTGAAATTGTGTTTC |
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FusionGenePPI for UNC45A_IQGAP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| UNC45A | USP19, CLN3, FBXO25, USP14, UBXN1, TWF1, CSE1L, UBE3A, USP1, TXNDC5, WDR5, PSMD13, UFD1L, RPA3, UCHL5, ESR1, HSP90AA1, SMAD9, UGGT1, ACBD3, CSNK1A1, CSNK1E, CDC37, FAM83H, HUWE1, MAX, MEOX2, MID2, MARCH10, KRTAP10-3, ATP6V1A, NAPA, PPME1, RAP1GDS1, RNF20, PLCG1, NTRK1, NUP85, AHI1, OFD1, MKS1, CC2D2A, CCP110, CEP170, KIAA0753, CEP162, CEP120, FGFR1OP, CEP128, CEP89, FBF1, NIN, NPHP1, SCLT1, CEP19, EVC2, NEK8, SASS6, POC1A, POC1B, RPGRIP1, RPGR, STIL, CENPJ, CAPZA2, MYH9, MYO1C, XRCC3, MYO19, SNW1, CDC5L, FAF2, HSP90AB1, ZNF746, CDH1, CDK17, MYH14, SLC27A2, MYO1E, CYLD, LMNA, TES | IQGAP1 | ARF6, PRKACA, AKAP5, GRB2, CALM1, S100B, CDC42, RAC1, CLIP1, EZR, CTNNB1, CDH1, USP46, KBTBD7, PPARGC1A, MYL6B, RPTOR, AKT1, SIRT7, NRD1, TSG101, ISG15, FBXO25, CDK2, KDR, SRC, WHSC1, INPPL1, CBL, UBASH3B, PIK3R2, SHC1, EPS15, AP2M1, ACTB, CYBB, MYH10, HSPA5, SDHB, MAPK3, MAPK1, CD44, LRRK2, NFATC2, VCAM1, FN1, PEX14, TGFBR2, ITGA4, MEN1, BRAF, MAPK14, YWHAQ, GAPVD1, AIMP1, AIMP2, CCT2, DNAJA1, EEF1E1, EIF2S3, EIF4G1, HNRNPA1, CCAR2, LRRC47, PRPSAP2, PSMA1, PTBP1, QARS, RPLP0, SYNCRIP, RUVBL1, RPA3, RPA2, RPA1, LGR4, LRP6, DVL2, MAP2K1, MAP2K2, PTK2, WASL, PXN, DIAPH1, STAU1, CEP57, CEP76, TP53, TUBGCP3, VCP, PDLIM7, NXF1, CUL7, OBSL1, CCDC8, UBE2I, RNF2, MYL1, ABCE1, MYL10, HOXB5, MAGEA4, GGPS1, ECH1, PARVA, DDX19B, PPP2R2C, CYP1A1, NAP1L5, RPS6KB2, ANXA5, NDUFA9, TRAP1, UQCRQ, USP7, WDR3, NTRK1, OFD1, NPHP1, PPME1, ACTG1, ACTN4, ACTN1, ADD1, AP2A1, AP2A2, ANXA2, DST, CAMK2G, CAPZA2, CAPZB, CDK4, CDKN2A, CFL1, CFL2, CLIC1, CLTA, CLTB, CLTC, DAB2, DAPK3, DBN1, DSG1, DSG2, CTTN, FLII, FLNA, FLNB, GSN, HSP90AB1, ABLIM1, LMO7, MYO1B, MYL6, MYO1C, MYO1E, MYO5A, MYO5B, PPP1R12A, PPP1R12B, PIK3C2A, PLEC, PPP1CA, PPP1CB, PPP1CC, TWF1, RAP1A, SIPA1, SPTAN1, SPTBN1, SPTBN2, SSFA2, SVIL, TMOD1, TPM1, TPM2, TPM3, TPM4, CORO2A, LUZP1, SORBS2, MYH9, SMC3, LIMA1, MYO19, LRRFIP1, LRRFIP2, TJP2, CLINT1, ARHGAP11A, ARHGEF17, SEC16A, WDR1, ARPC4, ARPC3, ACTR3, ACTR2, ARPC2, CEPT1, BASP1, GAS2L1, ASCC3, TRIOBP, AKAP2, SYNPO, LIMCH1, SIPA1L3, MPRIP, COBL, SPECC1L, CORO1C, ZDHHC5, PLEKHG3, SIPA1L1, RAI14, TES, ZBTB20, RPS6KC1, GOLIM4, PACSIN3, TMOD3, KCTD3, GTSE1, NCKIPSD, OXR1, BMP2K, MYO5C, CORO1B, CGN, ARHGAP21, AFAP1, INF2, CYBRD1, ARPC5L, LZTS2, PPP1R9B, SSH2, NEXN, SPECC1, MISP, PTGR2, PPP1R18, TPRN, MYO18A, MROH6, RCC2, MCM2, SNW1, CDC5L, EID1, U2AF2, EGFR, AHSA1, C1orf131, HECTD1, MYL3, PPP2R2D, CDK15, TRPC4AP, DNM1L, SOD1, TRIM25, BRCA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UNC45A_IQGAP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | IQGAP1 | P46940 | DB11638 | Artenimol | Ras GTPase-activating-like protein IQGAP1 | small molecule | approved|investigational |
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RelatedDiseases for UNC45A_IQGAP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | IQGAP1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | IQGAP1 | C0043094 | Weight Gain | 1 | CTD_human |
| Tgene | IQGAP1 | C2239176 | Liver carcinoma | 1 | CTD_human |
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