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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 40764

FusionGeneSummary for ULK2_ACADVL

check button Fusion gene summary
Fusion gene informationFusion gene name: ULK2_ACADVL
Fusion gene ID: 40764
HgeneTgene
Gene symbol

ULK2

ACADVL

Gene ID

9706

37

Gene nameunc-51 like autophagy activating kinase 2acyl-CoA dehydrogenase very long chain
SynonymsATG1B|Unc51.2ACAD6|LCACD|VLCAD
Cytomap

17p11.2

17p13.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase ULK2very long-chain specific acyl-CoA dehydrogenase, mitochondrialacyl-Coenzyme A dehydrogenase, very long chain
Modification date2018052320180523
UniProtAcc

Q8IYT8

P49748

Ensembl transtripts involved in fusion geneENST00000361658, ENST00000395544, 
ENST00000580130, 		ENST00000543245, 
ENST00000356839, ENST00000350303, 
ENST00000581562, 
Fusion gene scores* DoF score6 X 5 X 4=1206 X 6 X 4=144
# samples 56
** MAII scorelog2(5/120*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ULK2 [Title/Abstract] AND ACADVL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneULK2

GO:0006914

autophagy

18936157

HgeneULK2

GO:0046777

protein autophosphorylation

18936157

TgeneACADVL

GO:0033539

fatty acid beta-oxidation using acyl-CoA dehydrogenase

7668252


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-95-A4VK-01AULK2chr17

19741814

-ACADVLchr17

7123441

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000361658ENST00000543245ULK2chr17

19741814

-ACADVLchr17

7123441

+
In-frameENST00000361658ENST00000356839ULK2chr17

19741814

-ACADVLchr17

7123441

+
In-frameENST00000361658ENST00000350303ULK2chr17

19741814

-ACADVLchr17

7123441

+
5CDS-3UTRENST00000361658ENST00000581562ULK2chr17

19741814

-ACADVLchr17

7123441

+
Frame-shiftENST00000395544ENST00000543245ULK2chr17

19741814

-ACADVLchr17

7123441

+
Frame-shiftENST00000395544ENST00000356839ULK2chr17

19741814

-ACADVLchr17

7123441

+
Frame-shiftENST00000395544ENST00000350303ULK2chr17

19741814

-ACADVLchr17

7123441

+
5CDS-3UTRENST00000395544ENST00000581562ULK2chr17

19741814

-ACADVLchr17

7123441

+
5UTR-3CDSENST00000580130ENST00000543245ULK2chr17

19741814

-ACADVLchr17

7123441

+
5UTR-3CDSENST00000580130ENST00000356839ULK2chr17

19741814

-ACADVLchr17

7123441

+
5UTR-3CDSENST00000580130ENST00000350303ULK2chr17

19741814

-ACADVLchr17

7123441

+
5UTR-3UTRENST00000580130ENST00000581562ULK2chr17

19741814

-ACADVLchr17

7123441

+

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FusionProtFeatures for ULK2_ACADVL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ULK2

Q8IYT8

ACADVL

P49748

Serine/threonine-protein kinase involved in autophagy inresponse to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, theprecursors of autophagosomes. Part of regulatory feedback loops inautophagy: acts both as a downstream effector and a negativeregulator of mammalian target of rapamycin complex 1 (mTORC1) viainteraction with RPTOR. Activated via phosphorylation by AMPK,also acts as a negative regulator of AMPK through phosphorylationof the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylateATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data needadditional evidences. Not involved in ammonia-induced autophagy orin autophagic response of cerebellar granule neurons (CGN) to lowpotassium concentration. Plays a role early in neuronaldifferentiation and is required for granule cell axon formation:may govern axon formation via Ras-like GTPase signaling andthrough regulation of the Rab5-mediated endocytic pathways withindeveloping axons. {ECO:0000269|PubMed:18936157,ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21460635,ECO:0000269|PubMed:21690395, ECO:0000269|PubMed:21795849}. Active toward esters of long-chain and very long chainfatty acids such as palmitoyl-CoA, myristoyl-CoA and stearoyl-CoA.Can accommodate substrate acyl chain lengths as long as 24carbons, but shows little activity for substrates of less than 12carbons. {ECO:0000269|PubMed:18227065}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneULK2chr17:19741814chr17:7123441ENST00000361658-102815_23262915Nucleotide bindingATP
HgeneULK2chr17:19741814chr17:7123441ENST00000395544-102715_232621037Nucleotide bindingATP
TgeneACADVLchr17:19741814chr17:7123441ENST00000350303+019214_22320634Nucleotide bindingNote=FAD
TgeneACADVLchr17:19741814chr17:7123441ENST00000350303+019249_25120634Nucleotide bindingNote=FAD
TgeneACADVLchr17:19741814chr17:7123441ENST00000350303+019435_43920634Nucleotide bindingFAD
TgeneACADVLchr17:19741814chr17:7123441ENST00000350303+019464_46620634Nucleotide bindingNote=FAD
TgeneACADVLchr17:19741814chr17:7123441ENST00000356839+020214_22320656Nucleotide bindingNote=FAD
TgeneACADVLchr17:19741814chr17:7123441ENST00000356839+020249_25120656Nucleotide bindingNote=FAD
TgeneACADVLchr17:19741814chr17:7123441ENST00000356839+020435_43920656Nucleotide bindingFAD
TgeneACADVLchr17:19741814chr17:7123441ENST00000356839+020464_46620656Nucleotide bindingNote=FAD
TgeneACADVLchr17:19741814chr17:7123441ENST00000543245+121214_22343679Nucleotide bindingNote=FAD
TgeneACADVLchr17:19741814chr17:7123441ENST00000543245+121249_25143679Nucleotide bindingNote=FAD
TgeneACADVLchr17:19741814chr17:7123441ENST00000543245+121435_43943679Nucleotide bindingFAD
TgeneACADVLchr17:19741814chr17:7123441ENST00000543245+121464_46643679Nucleotide bindingNote=FAD
TgeneACADVLchr17:19741814chr17:7123441ENST00000350303+019338_34120634RegionSubstrate binding
TgeneACADVLchr17:19741814chr17:7123441ENST00000350303+01941_48220634RegionNote=Catalytic
TgeneACADVLchr17:19741814chr17:7123441ENST00000350303+019462_46320634RegionNote=Substrate binding
TgeneACADVLchr17:19741814chr17:7123441ENST00000350303+019483_51620634RegionMembrane-anchoring
TgeneACADVLchr17:19741814chr17:7123441ENST00000356839+020338_34120656RegionSubstrate binding
TgeneACADVLchr17:19741814chr17:7123441ENST00000356839+02041_48220656RegionNote=Catalytic
TgeneACADVLchr17:19741814chr17:7123441ENST00000356839+020462_46320656RegionNote=Substrate binding
TgeneACADVLchr17:19741814chr17:7123441ENST00000356839+020483_51620656RegionMembrane-anchoring
TgeneACADVLchr17:19741814chr17:7123441ENST00000543245+121338_34143679RegionSubstrate binding
TgeneACADVLchr17:19741814chr17:7123441ENST00000543245+12141_48243679RegionNote=Catalytic
TgeneACADVLchr17:19741814chr17:7123441ENST00000543245+121462_46343679RegionNote=Substrate binding
TgeneACADVLchr17:19741814chr17:7123441ENST00000543245+121483_51643679RegionMembrane-anchoring

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneULK2chr17:19741814chr17:7123441ENST00000361658-10289_271262915DomainProtein kinase
HgeneULK2chr17:19741814chr17:7123441ENST00000395544-10279_2712621037DomainProtein kinase
HgeneULK2chr17:19741814chr17:7123441ENST00000361658-1028812_1036262915RegionNote=CTD-like region
HgeneULK2chr17:19741814chr17:7123441ENST00000395544-1027812_10362621037RegionNote=CTD-like region


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FusionGeneSequence for ULK2_ACADVL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ULK2_ENST00000361658_chr17_19741814_-_ACADVL_ENST00000543245_chr17_7123441_+_897aa
MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNG
GDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMY
MAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFARGSRRSW
GSPGPALPGGPMPGVPLSWLWTSQIPTPLTLXPGKNRPRRNLSPLLWECSKASSPQIRCSHTRPCSTKSRHSFLKSWWSLCPVSSRKXTI
PPRMTLWRWWRRPLGRASRSWGPLVCKCPVSWVVWAFATPSTPVWWRSWACMTLAWALPWGPIRASVSKASCSLAQRPRKKNTSPSWHLG
RLWPLSVXPSPQAGQMQPPSEPLLCPAPVENTIPSMEASFGSVMGAXQTSSRSLPRHQLQIQPQEPXRRRSQLLWWRGASGALPMGPLRR
RWASRLQTQQRCSLMEYGCHRRTCWVRLGVASRLPCTSSTMEGLAWLRPWQVPXEASLLRRXIMPLIVPSLGRKFTTLGXSRRSWHGWLC
CSMXLSPWLTWXVLTWTREPRTSRXRPPSAKSLARRQPGRXQMNASKSWGVWASXRNLEXSVCSEIFASSGSLRGQMTFFGCLWLCRAVW
TKERSSLGLAVLXRIPLGMLASCXERQANSXGGGQGWAAAXVSADLSTRSXVGVASWQYGLWSSLPLWWRPSXXNTRRGLSMNSFCCSGW

>In-frame_ULK2_ENST00000361658_chr17_19741814_-_ACADVL_ENST00000356839_chr17_7123441_+_897aa
MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNG
GDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMY
MAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFARGSRRSW
GSPGPALPGGPMPGVPLSWLWTSQIPTPLTLXPGKNRPRRNLSPLLWECSKASSPQIRCSHTRPCSTKSRHSFLKSWWSLCPVSSRKXTI
PPRMTLWRWWRRPLGRASRSWGPLVCKCPVSWVVWAFATPSTPVWWRSWACMTLAWALPWGPIRASVSKASCSLAQRPRKKNTSPSWHLG
RLWPLSVXPSPQAGQMQPPSEPLLCPAPVENTIPSMEASFGSVMGAXQTSSRSLPRHQLQIQPQEPXRRRSQLLWWRGASGALPMGPLRR
RWASRLQTQQRCSLMEYGCHRRTCWVRLGVASRLPCTSSTMEGLAWLRPWQVPXEASLLRRXIMPLIVPSLGRKFTTLGXSRRSWHGWLC
CSMXLSPWLTWXVLTWTREPRTSRXRPPSAKSLARRQPGRXQMNASKSWGVWASXRNLEXSVCSEIFASSGSLRGQMTFFGCLWLCRAVW
TKERSSLGLAVLXRIPLGMLASCXERQANSXGGGQGWAAAXVSADLSTRSXVGVASWQYGLWSSLPLWWRPSXXNTRRGLSMNSFCCSGW

>In-frame_ULK2_ENST00000361658_chr17_19741814_-_ACADVL_ENST00000350303_chr17_7123441_+_875aa
MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNG
GDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMY
MAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFARGSRRSW
GSPGPALPGGPMPGVPLRNLSPLLWECSKASSPQIRCSHTRPCSTKSRHSFLKSWWSLCPVSSRKXTIPPRMTLWRWWRRPLGRASRSWG
PLVCKCPVSWVVWAFATPSTPVWWRSWACMTLAWALPWGPIRASVSKASCSLAQRPRKKNTSPSWHLGRLWPLSVXPSPQAGQMQPPSEP
LLCPAPVENTIPSMEASFGSVMGAXQTSSRSLPRHQLQIQPQEPXRRRSQLLWWRGASGALPMGPLRRRWASRLQTQQRCSLMEYGCHRR
TCWVRLGVASRLPCTSSTMEGLAWLRPWQVPXEASLLRRXIMPLIVPSLGRKFTTLGXSRRSWHGWLCCSMXLSPWLTWXVLTWTREPRT
SRXRPPSAKSLARRQPGRXQMNASKSWGVWASXRNLEXSVCSEIFASSGSLRGQMTFFGCLWLCRAVWTKERSSLGLAVLXRIPLGMLAS
CXERQANSXGGGQGWAAAXVSADLSTRSXVGVASWQYGLWSSLPLWWRPSXXNTRRGLSMNSFCCSGWQTGPSTSMPWWWFSRGPQDPXV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ULK2_ENST00000361658_chr17_19741814_-_ACADVL_ENST00000543245_chr17_7123441_+_2693nt
ATGGAGGTGGTGGGTGACTTCGAGTACAGCAAGAGGGATCTCGTGGGACACGGGGCCTTCGCCGTGGTCTTCCGGGGGCGGCACCGCCAG
AAAACTGATTGGGAGGTAGCTATTAAAAGTATTAATAAAAAGAACTTGTCAAAATCACAAATACTGCTTGGAAAGGAAATTAAAATCTTA
AAGGAACTTCAGCATGAAAATATTGTAGCACTCTATGATGTTCAGGAATTACCCAACTCTGTCTTTTTGGTGATGGAGTATTGCAATGGT
GGAGACCTCGCAGATTATTTGCAAGCGAAAGGGACTCTCAGTGAAGACACGATCAGAGTGTTTCTGCATCAGATTGCTGCTGCCATGCGA
ATCCTGCACAGCAAAGGAATCATCCACAGAGATCTCAAACCACAGAACATCTTGCTGTCCTATGCCAATCGCAGAAAATCAAGTGTCAGT
GGTATTCGCATCAAAATAGCGGATTTTGGTTTTGCTCGTTACCTACATAGTAACATGATGGCTGCAACACTGTGTGGATCCCCGATGTAC
ATGGCTCCTGAGGTTATTATGTCTCAACATTATGATGCTAAGGCTGACTTGTGGAGCATAGGAACAGTGATATACCAATGCCTAGTTGGA
AAACCACCTTTTCAGGCCAATAGTCCTCAAGACTTAAGGATGTTTTATGAAAAAAACAGGAGCTTAATGCCTAGTATTCCCAGAGAAACA
TCACCTTATTTGGCTAATCTCCTTTTGGGTTTGCTTCAGAGAAACCAAAAAGATAGAATGGACTTTGCTCGCGGCTCACGGCGCTCCTGG
GGCAGCCCCGGCCCGGCCCTGCCCGGCGGCCCTATGCCGGGGGTGCCGCTCAGCTGGCTCTGGACAAGTCAGATTCCCACCCCTCTGACG
CTCTGACCAGGAAAAAACCGGCCAAGGCGGAATCTAAGTCCTTTGCTGTGGGAATGTTCAAAGGCCAGCTCACCACAGATCAGGTGTTCC
CATACCCGTCCGTGCTCAACGAAGAGCAGACACAGTTTCTTAAAGAGCTGGTGGAGCCTGTGTCCCGTTTCTTCGAGGAAGTGAACGATC
CCGCCAAGAATGACGCTCTGGAGATGGTGGAGGAGACCACTTGGCAGGGCCTCAAGGAGCTGGGGGCCTTTGGTCTGCAAGTGCCCAGTG
AGCTGGGTGGTGTGGGCCTTTGCAACACCCAGTACGCCCGTTTGGTGGAGATCGTGGGCATGCATGACCTTGGCGTGGGCATTACCCTGG
GGGCCCATCAGAGCATCGGTTTCAAAGGCATCCTGCTCTTTGGCACAAAGGCCCAGAAAGAAAAATACCTCCCCAAGCTGGCATCTGGGG
AGACTGTGGCCGCTTTCTGTCTAACCGAGCCCTCAAGCGGGTCAGATGCAGCCTCCATCCGAACCTCTGCTGTGCCCAGCCCCTGTGGAA
AATACTATACCCTCAATGGAAGCAAGCTTTGGATCAGTAATGGGGGCCTAGCAGACATCTTCACGGTCTTTGCCAAGACACCAGTTACAG
ATCCAGCCACAGGAGCCGTGAAGGAGAAGATCACAGCTTTTGTGGTGGAGAGGGGCTTCGGGGGCATTACCCATGGGCCCCCTGAGAAGA
AGATGGGCATCAAGGCTTCAAACACAGCAGAGGTGTTCTTTGATGGAGTACGGGTGCCATCGGAGAACGTGCTGGGTGAGGTTGGGAGTG
GCTTCAAGGTTGCCATGCACATCCTCAACAATGGAAGGTTTGGCATGGCTGCGGCCCTGGCAGGTACCATGAGAGGCATCATTGCTAAGG
CGGTAGATCATGCCACTAATCGTACCCAGTTTGGGGAGAAAATTCACAACTTTGGGCTGATCCAGGAGAAGCTGGCACGGATGGTTATGC
TGCAGTATGTAACTGAGTCCATGGCTTACATGGTGAGTGCTAACATGGACCAGGGAGCCACGGACTTCCAGATAGAGGCCGCCATCAGCA
AAATCTTTGGCTCGGAGGCAGCCTGGAAGGTGACAGATGAATGCATCCAAATCATGGGGGGTATGGGCTTCATGAAGGAACCTGGAGTAG
AGCGTGTGCTCCGAGATCTTCGCATCTTCCGGATCTTTGAGGGGACAAATGACATTCTTCGGCTGTTTGTGGCTCTGCAGGGCTGTATGG
ACAAAGGAAAGGAGCTCTCTGGGCTTGGCAGTGCTCTAAAGAATCCCTTTGGGAATGCTGGCCTCCTGCTAGGAGAGGCAGGCAAACAGC
TGAGGCGGCGGGCAGGGCTGGGCAGCGGCCTGAGTCTCAGCGGACTTGTCCACCCGGAGTTGAGTCGGAGTGGCGAGCTGGCAGTACGGG
CTCTGGAGCAGTTTGCCACTGTGGTGGAGGCCAAGCTGATAAAACACAAGAAGGGGATTGTCAATGAACAGTTTCTGCTGCAGCGGCTGG
CAGACGGGGCCATCGACCTCTATGCCATGGTGGTGGTTCTCTCGAGGGCCTCAAGATCCCTGAGTGAGGGCCACCCCACGGCCCAGCATG
AGAAAATGCTCTGTGACACCTGGTGTATCGAGGCTGCAGCTCGGATCCGAGAGGGCATGGCCGCCCTGCAGTCTGACCCCTGGCAGCAAG

>In-frame_ULK2_ENST00000361658_chr17_19741814_-_ACADVL_ENST00000356839_chr17_7123441_+_2693nt
ATGGAGGTGGTGGGTGACTTCGAGTACAGCAAGAGGGATCTCGTGGGACACGGGGCCTTCGCCGTGGTCTTCCGGGGGCGGCACCGCCAG
AAAACTGATTGGGAGGTAGCTATTAAAAGTATTAATAAAAAGAACTTGTCAAAATCACAAATACTGCTTGGAAAGGAAATTAAAATCTTA
AAGGAACTTCAGCATGAAAATATTGTAGCACTCTATGATGTTCAGGAATTACCCAACTCTGTCTTTTTGGTGATGGAGTATTGCAATGGT
GGAGACCTCGCAGATTATTTGCAAGCGAAAGGGACTCTCAGTGAAGACACGATCAGAGTGTTTCTGCATCAGATTGCTGCTGCCATGCGA
ATCCTGCACAGCAAAGGAATCATCCACAGAGATCTCAAACCACAGAACATCTTGCTGTCCTATGCCAATCGCAGAAAATCAAGTGTCAGT
GGTATTCGCATCAAAATAGCGGATTTTGGTTTTGCTCGTTACCTACATAGTAACATGATGGCTGCAACACTGTGTGGATCCCCGATGTAC
ATGGCTCCTGAGGTTATTATGTCTCAACATTATGATGCTAAGGCTGACTTGTGGAGCATAGGAACAGTGATATACCAATGCCTAGTTGGA
AAACCACCTTTTCAGGCCAATAGTCCTCAAGACTTAAGGATGTTTTATGAAAAAAACAGGAGCTTAATGCCTAGTATTCCCAGAGAAACA
TCACCTTATTTGGCTAATCTCCTTTTGGGTTTGCTTCAGAGAAACCAAAAAGATAGAATGGACTTTGCTCGCGGCTCACGGCGCTCCTGG
GGCAGCCCCGGCCCGGCCCTGCCCGGCGGCCCTATGCCGGGGGTGCCGCTCAGCTGGCTCTGGACAAGTCAGATTCCCACCCCTCTGACG
CTCTGACCAGGAAAAAACCGGCCAAGGCGGAATCTAAGTCCTTTGCTGTGGGAATGTTCAAAGGCCAGCTCACCACAGATCAGGTGTTCC
CATACCCGTCCGTGCTCAACGAAGAGCAGACACAGTTTCTTAAAGAGCTGGTGGAGCCTGTGTCCCGTTTCTTCGAGGAAGTGAACGATC
CCGCCAAGAATGACGCTCTGGAGATGGTGGAGGAGACCACTTGGCAGGGCCTCAAGGAGCTGGGGGCCTTTGGTCTGCAAGTGCCCAGTG
AGCTGGGTGGTGTGGGCCTTTGCAACACCCAGTACGCCCGTTTGGTGGAGATCGTGGGCATGCATGACCTTGGCGTGGGCATTACCCTGG
GGGCCCATCAGAGCATCGGTTTCAAAGGCATCCTGCTCTTTGGCACAAAGGCCCAGAAAGAAAAATACCTCCCCAAGCTGGCATCTGGGG
AGACTGTGGCCGCTTTCTGTCTAACCGAGCCCTCAAGCGGGTCAGATGCAGCCTCCATCCGAACCTCTGCTGTGCCCAGCCCCTGTGGAA
AATACTATACCCTCAATGGAAGCAAGCTTTGGATCAGTAATGGGGGCCTAGCAGACATCTTCACGGTCTTTGCCAAGACACCAGTTACAG
ATCCAGCCACAGGAGCCGTGAAGGAGAAGATCACAGCTTTTGTGGTGGAGAGGGGCTTCGGGGGCATTACCCATGGGCCCCCTGAGAAGA
AGATGGGCATCAAGGCTTCAAACACAGCAGAGGTGTTCTTTGATGGAGTACGGGTGCCATCGGAGAACGTGCTGGGTGAGGTTGGGAGTG
GCTTCAAGGTTGCCATGCACATCCTCAACAATGGAAGGTTTGGCATGGCTGCGGCCCTGGCAGGTACCATGAGAGGCATCATTGCTAAGG
CGGTAGATCATGCCACTAATCGTACCCAGTTTGGGGAGAAAATTCACAACTTTGGGCTGATCCAGGAGAAGCTGGCACGGATGGTTATGC
TGCAGTATGTAACTGAGTCCATGGCTTACATGGTGAGTGCTAACATGGACCAGGGAGCCACGGACTTCCAGATAGAGGCCGCCATCAGCA
AAATCTTTGGCTCGGAGGCAGCCTGGAAGGTGACAGATGAATGCATCCAAATCATGGGGGGTATGGGCTTCATGAAGGAACCTGGAGTAG
AGCGTGTGCTCCGAGATCTTCGCATCTTCCGGATCTTTGAGGGGACAAATGACATTCTTCGGCTGTTTGTGGCTCTGCAGGGCTGTATGG
ACAAAGGAAAGGAGCTCTCTGGGCTTGGCAGTGCTCTAAAGAATCCCTTTGGGAATGCTGGCCTCCTGCTAGGAGAGGCAGGCAAACAGC
TGAGGCGGCGGGCAGGGCTGGGCAGCGGCCTGAGTCTCAGCGGACTTGTCCACCCGGAGTTGAGTCGGAGTGGCGAGCTGGCAGTACGGG
CTCTGGAGCAGTTTGCCACTGTGGTGGAGGCCAAGCTGATAAAACACAAGAAGGGGATTGTCAATGAACAGTTTCTGCTGCAGCGGCTGG
CAGACGGGGCCATCGACCTCTATGCCATGGTGGTGGTTCTCTCGAGGGCCTCAAGATCCCTGAGTGAGGGCCACCCCACGGCCCAGCATG
AGAAAATGCTCTGTGACACCTGGTGTATCGAGGCTGCAGCTCGGATCCGAGAGGGCATGGCCGCCCTGCAGTCTGACCCCTGGCAGCAAG

>In-frame_ULK2_ENST00000361658_chr17_19741814_-_ACADVL_ENST00000350303_chr17_7123441_+_2627nt
ATGGAGGTGGTGGGTGACTTCGAGTACAGCAAGAGGGATCTCGTGGGACACGGGGCCTTCGCCGTGGTCTTCCGGGGGCGGCACCGCCAG
AAAACTGATTGGGAGGTAGCTATTAAAAGTATTAATAAAAAGAACTTGTCAAAATCACAAATACTGCTTGGAAAGGAAATTAAAATCTTA
AAGGAACTTCAGCATGAAAATATTGTAGCACTCTATGATGTTCAGGAATTACCCAACTCTGTCTTTTTGGTGATGGAGTATTGCAATGGT
GGAGACCTCGCAGATTATTTGCAAGCGAAAGGGACTCTCAGTGAAGACACGATCAGAGTGTTTCTGCATCAGATTGCTGCTGCCATGCGA
ATCCTGCACAGCAAAGGAATCATCCACAGAGATCTCAAACCACAGAACATCTTGCTGTCCTATGCCAATCGCAGAAAATCAAGTGTCAGT
GGTATTCGCATCAAAATAGCGGATTTTGGTTTTGCTCGTTACCTACATAGTAACATGATGGCTGCAACACTGTGTGGATCCCCGATGTAC
ATGGCTCCTGAGGTTATTATGTCTCAACATTATGATGCTAAGGCTGACTTGTGGAGCATAGGAACAGTGATATACCAATGCCTAGTTGGA
AAACCACCTTTTCAGGCCAATAGTCCTCAAGACTTAAGGATGTTTTATGAAAAAAACAGGAGCTTAATGCCTAGTATTCCCAGAGAAACA
TCACCTTATTTGGCTAATCTCCTTTTGGGTTTGCTTCAGAGAAACCAAAAAGATAGAATGGACTTTGCTCGCGGCTCACGGCGCTCCTGG
GGCAGCCCCGGCCCGGCCCTGCCCGGCGGCCCTATGCCGGGGGTGCCGCTCAGGAATCTAAGTCCTTTGCTGTGGGAATGTTCAAAGGCC
AGCTCACCACAGATCAGGTGTTCCCATACCCGTCCGTGCTCAACGAAGAGCAGACACAGTTTCTTAAAGAGCTGGTGGAGCCTGTGTCCC
GTTTCTTCGAGGAAGTGAACGATCCCGCCAAGAATGACGCTCTGGAGATGGTGGAGGAGACCACTTGGCAGGGCCTCAAGGAGCTGGGGG
CCTTTGGTCTGCAAGTGCCCAGTGAGCTGGGTGGTGTGGGCCTTTGCAACACCCAGTACGCCCGTTTGGTGGAGATCGTGGGCATGCATG
ACCTTGGCGTGGGCATTACCCTGGGGGCCCATCAGAGCATCGGTTTCAAAGGCATCCTGCTCTTTGGCACAAAGGCCCAGAAAGAAAAAT
ACCTCCCCAAGCTGGCATCTGGGGAGACTGTGGCCGCTTTCTGTCTAACCGAGCCCTCAAGCGGGTCAGATGCAGCCTCCATCCGAACCT
CTGCTGTGCCCAGCCCCTGTGGAAAATACTATACCCTCAATGGAAGCAAGCTTTGGATCAGTAATGGGGGCCTAGCAGACATCTTCACGG
TCTTTGCCAAGACACCAGTTACAGATCCAGCCACAGGAGCCGTGAAGGAGAAGATCACAGCTTTTGTGGTGGAGAGGGGCTTCGGGGGCA
TTACCCATGGGCCCCCTGAGAAGAAGATGGGCATCAAGGCTTCAAACACAGCAGAGGTGTTCTTTGATGGAGTACGGGTGCCATCGGAGA
ACGTGCTGGGTGAGGTTGGGAGTGGCTTCAAGGTTGCCATGCACATCCTCAACAATGGAAGGTTTGGCATGGCTGCGGCCCTGGCAGGTA
CCATGAGAGGCATCATTGCTAAGGCGGTAGATCATGCCACTAATCGTACCCAGTTTGGGGAGAAAATTCACAACTTTGGGCTGATCCAGG
AGAAGCTGGCACGGATGGTTATGCTGCAGTATGTAACTGAGTCCATGGCTTACATGGTGAGTGCTAACATGGACCAGGGAGCCACGGACT
TCCAGATAGAGGCCGCCATCAGCAAAATCTTTGGCTCGGAGGCAGCCTGGAAGGTGACAGATGAATGCATCCAAATCATGGGGGGTATGG
GCTTCATGAAGGAACCTGGAGTAGAGCGTGTGCTCCGAGATCTTCGCATCTTCCGGATCTTTGAGGGGACAAATGACATTCTTCGGCTGT
TTGTGGCTCTGCAGGGCTGTATGGACAAAGGAAAGGAGCTCTCTGGGCTTGGCAGTGCTCTAAAGAATCCCTTTGGGAATGCTGGCCTCC
TGCTAGGAGAGGCAGGCAAACAGCTGAGGCGGCGGGCAGGGCTGGGCAGCGGCCTGAGTCTCAGCGGACTTGTCCACCCGGAGTTGAGTC
GGAGTGGCGAGCTGGCAGTACGGGCTCTGGAGCAGTTTGCCACTGTGGTGGAGGCCAAGCTGATAAAACACAAGAAGGGGATTGTCAATG
AACAGTTTCTGCTGCAGCGGCTGGCAGACGGGGCCATCGACCTCTATGCCATGGTGGTGGTTCTCTCGAGGGCCTCAAGATCCCTGAGTG
AGGGCCACCCCACGGCCCAGCATGAGAAAATGCTCTGTGACACCTGGTGTATCGAGGCTGCAGCTCGGATCCGAGAGGGCATGGCCGCCC
TGCAGTCTGACCCCTGGCAGCAAGAGCTCTACCGCAACTTCAAAAGCATCTCCAAGGCCTTGGTGGAGCGGGGTGGTGTGGTCACCAGCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_ULK2_ENST00000361658_chr17_19741814_-_ACADVL_ENST00000543245_chr17_7123441_+_3381nt
AGTCGCGCGGGAGCGGGTAGCGCGCGCGAGGGCGTTGGGCGCCGCCGCGAGGCGGGGAAGCGCGGGGCCGCGGCGGTGCGGGTTCTAGGG
CGGCGGCCGTCGCCGTCGCAGCAGCGCCCCGAGCGGGGAGGGCCGAGGAGGCCCGACGAGCTGGGGATGGAGAGTACCGGGCCCCTCACT
GCCTCAGAGCGCGTGTGCGGCTCTGGGCGCGCACAGTGACGGTGACGGCACCCCTGGCCCGGCAGCGCCGAGGCCGCTTCGCCAGACAGC
CAGCGGCCGGCGGCAGGCCGGGCCATGAGCGGCAGGGGCCGGGCCGGGCCTCGCTGACCCTGGCTCCGCGCGGCAGCTTCCCCAGTTTCC
GCTCCGGTCTCTCGGCATGAGAGTCCGCCCGGGCCCGGGGCTGCGGCTGCCCCAGACCCGCCGCACGCTGGCGCGCTCCGGGCCCGCGGA
GCCGCGGTGCTGATACCTGCGCCGCACTGCGCCGCCCGCCCGTCCGCTGTGTGCCCCGGGGGCGCGGCCATGGAGGTGGTGGGTGACTTC
GAGTACAGCAAGAGGGATCTCGTGGGACACGGGGCCTTCGCCGTGGTCTTCCGGGGGCGGCACCGCCAGAAAACTGATTGGGAGGTAGCT
ATTAAAAGTATTAATAAAAAGAACTTGTCAAAATCACAAATACTGCTTGGAAAGGAAATTAAAATCTTAAAGGAACTTCAGCATGAAAAT
ATTGTAGCACTCTATGATGTTCAGGAATTACCCAACTCTGTCTTTTTGGTGATGGAGTATTGCAATGGTGGAGACCTCGCAGATTATTTG
CAAGCGAAAGGGACTCTCAGTGAAGACACGATCAGAGTGTTTCTGCATCAGATTGCTGCTGCCATGCGAATCCTGCACAGCAAAGGAATC
ATCCACAGAGATCTCAAACCACAGAACATCTTGCTGTCCTATGCCAATCGCAGAAAATCAAGTGTCAGTGGTATTCGCATCAAAATAGCG
GATTTTGGTTTTGCTCGTTACCTACATAGTAACATGATGGCTGCAACACTGTGTGGATCCCCGATGTACATGGCTCCTGAGGTTATTATG
TCTCAACATTATGATGCTAAGGCTGACTTGTGGAGCATAGGAACAGTGATATACCAATGCCTAGTTGGAAAACCACCTTTTCAGGCCAAT
AGTCCTCAAGACTTAAGGATGTTTTATGAAAAAAACAGGAGCTTAATGCCTAGTATTCCCAGAGAAACATCACCTTATTTGGCTAATCTC
CTTTTGGGTTTGCTTCAGAGAAACCAAAAAGATAGAATGGACTTTGCTCGCGGCTCACGGCGCTCCTGGGGCAGCCCCGGCCCGGCCCTG
CCCGGCGGCCCTATGCCGGGGGTGCCGCTCAGCTGGCTCTGGACAAGTCAGATTCCCACCCCTCTGACGCTCTGACCAGGAAAAAACCGG
CCAAGGCGGAATCTAAGTCCTTTGCTGTGGGAATGTTCAAAGGCCAGCTCACCACAGATCAGGTGTTCCCATACCCGTCCGTGCTCAACG
AAGAGCAGACACAGTTTCTTAAAGAGCTGGTGGAGCCTGTGTCCCGTTTCTTCGAGGAAGTGAACGATCCCGCCAAGAATGACGCTCTGG
AGATGGTGGAGGAGACCACTTGGCAGGGCCTCAAGGAGCTGGGGGCCTTTGGTCTGCAAGTGCCCAGTGAGCTGGGTGGTGTGGGCCTTT
GCAACACCCAGTACGCCCGTTTGGTGGAGATCGTGGGCATGCATGACCTTGGCGTGGGCATTACCCTGGGGGCCCATCAGAGCATCGGTT
TCAAAGGCATCCTGCTCTTTGGCACAAAGGCCCAGAAAGAAAAATACCTCCCCAAGCTGGCATCTGGGGAGACTGTGGCCGCTTTCTGTC
TAACCGAGCCCTCAAGCGGGTCAGATGCAGCCTCCATCCGAACCTCTGCTGTGCCCAGCCCCTGTGGAAAATACTATACCCTCAATGGAA
GCAAGCTTTGGATCAGTAATGGGGGCCTAGCAGACATCTTCACGGTCTTTGCCAAGACACCAGTTACAGATCCAGCCACAGGAGCCGTGA
AGGAGAAGATCACAGCTTTTGTGGTGGAGAGGGGCTTCGGGGGCATTACCCATGGGCCCCCTGAGAAGAAGATGGGCATCAAGGCTTCAA
ACACAGCAGAGGTGTTCTTTGATGGAGTACGGGTGCCATCGGAGAACGTGCTGGGTGAGGTTGGGAGTGGCTTCAAGGTTGCCATGCACA
TCCTCAACAATGGAAGGTTTGGCATGGCTGCGGCCCTGGCAGGTACCATGAGAGGCATCATTGCTAAGGCGGTAGATCATGCCACTAATC
GTACCCAGTTTGGGGAGAAAATTCACAACTTTGGGCTGATCCAGGAGAAGCTGGCACGGATGGTTATGCTGCAGTATGTAACTGAGTCCA
TGGCTTACATGGTGAGTGCTAACATGGACCAGGGAGCCACGGACTTCCAGATAGAGGCCGCCATCAGCAAAATCTTTGGCTCGGAGGCAG
CCTGGAAGGTGACAGATGAATGCATCCAAATCATGGGGGGTATGGGCTTCATGAAGGAACCTGGAGTAGAGCGTGTGCTCCGAGATCTTC
GCATCTTCCGGATCTTTGAGGGGACAAATGACATTCTTCGGCTGTTTGTGGCTCTGCAGGGCTGTATGGACAAAGGAAAGGAGCTCTCTG
GGCTTGGCAGTGCTCTAAAGAATCCCTTTGGGAATGCTGGCCTCCTGCTAGGAGAGGCAGGCAAACAGCTGAGGCGGCGGGCAGGGCTGG
GCAGCGGCCTGAGTCTCAGCGGACTTGTCCACCCGGAGTTGAGTCGGAGTGGCGAGCTGGCAGTACGGGCTCTGGAGCAGTTTGCCACTG
TGGTGGAGGCCAAGCTGATAAAACACAAGAAGGGGATTGTCAATGAACAGTTTCTGCTGCAGCGGCTGGCAGACGGGGCCATCGACCTCT
ATGCCATGGTGGTGGTTCTCTCGAGGGCCTCAAGATCCCTGAGTGAGGGCCACCCCACGGCCCAGCATGAGAAAATGCTCTGTGACACCT
GGTGTATCGAGGCTGCAGCTCGGATCCGAGAGGGCATGGCCGCCCTGCAGTCTGACCCCTGGCAGCAAGAGCTCTACCGCAACTTCAAAA
GCATCTCCAAGGCCTTGGTGGAGCGGGGTGGTGTGGTCACCAGCAACCCACTTGGCTTCTGAATACTCCCGGCCAGGGCCTGTCCCAGTT
ATGTGCCTTCCCTCAAGCCAAAGCCGAAGCCCCTTTCCTTAAGGCCCTGGTTTGTCCCGAAGGGGCCTAGTGTTCCCAGCACTGTGCCTG

>In-frame_ULK2_ENST00000361658_chr17_19741814_-_ACADVL_ENST00000356839_chr17_7123441_+_3388nt
AGTCGCGCGGGAGCGGGTAGCGCGCGCGAGGGCGTTGGGCGCCGCCGCGAGGCGGGGAAGCGCGGGGCCGCGGCGGTGCGGGTTCTAGGG
CGGCGGCCGTCGCCGTCGCAGCAGCGCCCCGAGCGGGGAGGGCCGAGGAGGCCCGACGAGCTGGGGATGGAGAGTACCGGGCCCCTCACT
GCCTCAGAGCGCGTGTGCGGCTCTGGGCGCGCACAGTGACGGTGACGGCACCCCTGGCCCGGCAGCGCCGAGGCCGCTTCGCCAGACAGC
CAGCGGCCGGCGGCAGGCCGGGCCATGAGCGGCAGGGGCCGGGCCGGGCCTCGCTGACCCTGGCTCCGCGCGGCAGCTTCCCCAGTTTCC
GCTCCGGTCTCTCGGCATGAGAGTCCGCCCGGGCCCGGGGCTGCGGCTGCCCCAGACCCGCCGCACGCTGGCGCGCTCCGGGCCCGCGGA
GCCGCGGTGCTGATACCTGCGCCGCACTGCGCCGCCCGCCCGTCCGCTGTGTGCCCCGGGGGCGCGGCCATGGAGGTGGTGGGTGACTTC
GAGTACAGCAAGAGGGATCTCGTGGGACACGGGGCCTTCGCCGTGGTCTTCCGGGGGCGGCACCGCCAGAAAACTGATTGGGAGGTAGCT
ATTAAAAGTATTAATAAAAAGAACTTGTCAAAATCACAAATACTGCTTGGAAAGGAAATTAAAATCTTAAAGGAACTTCAGCATGAAAAT
ATTGTAGCACTCTATGATGTTCAGGAATTACCCAACTCTGTCTTTTTGGTGATGGAGTATTGCAATGGTGGAGACCTCGCAGATTATTTG
CAAGCGAAAGGGACTCTCAGTGAAGACACGATCAGAGTGTTTCTGCATCAGATTGCTGCTGCCATGCGAATCCTGCACAGCAAAGGAATC
ATCCACAGAGATCTCAAACCACAGAACATCTTGCTGTCCTATGCCAATCGCAGAAAATCAAGTGTCAGTGGTATTCGCATCAAAATAGCG
GATTTTGGTTTTGCTCGTTACCTACATAGTAACATGATGGCTGCAACACTGTGTGGATCCCCGATGTACATGGCTCCTGAGGTTATTATG
TCTCAACATTATGATGCTAAGGCTGACTTGTGGAGCATAGGAACAGTGATATACCAATGCCTAGTTGGAAAACCACCTTTTCAGGCCAAT
AGTCCTCAAGACTTAAGGATGTTTTATGAAAAAAACAGGAGCTTAATGCCTAGTATTCCCAGAGAAACATCACCTTATTTGGCTAATCTC
CTTTTGGGTTTGCTTCAGAGAAACCAAAAAGATAGAATGGACTTTGCTCGCGGCTCACGGCGCTCCTGGGGCAGCCCCGGCCCGGCCCTG
CCCGGCGGCCCTATGCCGGGGGTGCCGCTCAGCTGGCTCTGGACAAGTCAGATTCCCACCCCTCTGACGCTCTGACCAGGAAAAAACCGG
CCAAGGCGGAATCTAAGTCCTTTGCTGTGGGAATGTTCAAAGGCCAGCTCACCACAGATCAGGTGTTCCCATACCCGTCCGTGCTCAACG
AAGAGCAGACACAGTTTCTTAAAGAGCTGGTGGAGCCTGTGTCCCGTTTCTTCGAGGAAGTGAACGATCCCGCCAAGAATGACGCTCTGG
AGATGGTGGAGGAGACCACTTGGCAGGGCCTCAAGGAGCTGGGGGCCTTTGGTCTGCAAGTGCCCAGTGAGCTGGGTGGTGTGGGCCTTT
GCAACACCCAGTACGCCCGTTTGGTGGAGATCGTGGGCATGCATGACCTTGGCGTGGGCATTACCCTGGGGGCCCATCAGAGCATCGGTT
TCAAAGGCATCCTGCTCTTTGGCACAAAGGCCCAGAAAGAAAAATACCTCCCCAAGCTGGCATCTGGGGAGACTGTGGCCGCTTTCTGTC
TAACCGAGCCCTCAAGCGGGTCAGATGCAGCCTCCATCCGAACCTCTGCTGTGCCCAGCCCCTGTGGAAAATACTATACCCTCAATGGAA
GCAAGCTTTGGATCAGTAATGGGGGCCTAGCAGACATCTTCACGGTCTTTGCCAAGACACCAGTTACAGATCCAGCCACAGGAGCCGTGA
AGGAGAAGATCACAGCTTTTGTGGTGGAGAGGGGCTTCGGGGGCATTACCCATGGGCCCCCTGAGAAGAAGATGGGCATCAAGGCTTCAA
ACACAGCAGAGGTGTTCTTTGATGGAGTACGGGTGCCATCGGAGAACGTGCTGGGTGAGGTTGGGAGTGGCTTCAAGGTTGCCATGCACA
TCCTCAACAATGGAAGGTTTGGCATGGCTGCGGCCCTGGCAGGTACCATGAGAGGCATCATTGCTAAGGCGGTAGATCATGCCACTAATC
GTACCCAGTTTGGGGAGAAAATTCACAACTTTGGGCTGATCCAGGAGAAGCTGGCACGGATGGTTATGCTGCAGTATGTAACTGAGTCCA
TGGCTTACATGGTGAGTGCTAACATGGACCAGGGAGCCACGGACTTCCAGATAGAGGCCGCCATCAGCAAAATCTTTGGCTCGGAGGCAG
CCTGGAAGGTGACAGATGAATGCATCCAAATCATGGGGGGTATGGGCTTCATGAAGGAACCTGGAGTAGAGCGTGTGCTCCGAGATCTTC
GCATCTTCCGGATCTTTGAGGGGACAAATGACATTCTTCGGCTGTTTGTGGCTCTGCAGGGCTGTATGGACAAAGGAAAGGAGCTCTCTG
GGCTTGGCAGTGCTCTAAAGAATCCCTTTGGGAATGCTGGCCTCCTGCTAGGAGAGGCAGGCAAACAGCTGAGGCGGCGGGCAGGGCTGG
GCAGCGGCCTGAGTCTCAGCGGACTTGTCCACCCGGAGTTGAGTCGGAGTGGCGAGCTGGCAGTACGGGCTCTGGAGCAGTTTGCCACTG
TGGTGGAGGCCAAGCTGATAAAACACAAGAAGGGGATTGTCAATGAACAGTTTCTGCTGCAGCGGCTGGCAGACGGGGCCATCGACCTCT
ATGCCATGGTGGTGGTTCTCTCGAGGGCCTCAAGATCCCTGAGTGAGGGCCACCCCACGGCCCAGCATGAGAAAATGCTCTGTGACACCT
GGTGTATCGAGGCTGCAGCTCGGATCCGAGAGGGCATGGCCGCCCTGCAGTCTGACCCCTGGCAGCAAGAGCTCTACCGCAACTTCAAAA
GCATCTCCAAGGCCTTGGTGGAGCGGGGTGGTGTGGTCACCAGCAACCCACTTGGCTTCTGAATACTCCCGGCCAGGGCCTGTCCCAGTT
ATGTGCCTTCCCTCAAGCCAAAGCCGAAGCCCCTTTCCTTAAGGCCCTGGTTTGTCCCGAAGGGGCCTAGTGTTCCCAGCACTGTGCCTG

>In-frame_ULK2_ENST00000361658_chr17_19741814_-_ACADVL_ENST00000350303_chr17_7123441_+_3313nt
AGTCGCGCGGGAGCGGGTAGCGCGCGCGAGGGCGTTGGGCGCCGCCGCGAGGCGGGGAAGCGCGGGGCCGCGGCGGTGCGGGTTCTAGGG
CGGCGGCCGTCGCCGTCGCAGCAGCGCCCCGAGCGGGGAGGGCCGAGGAGGCCCGACGAGCTGGGGATGGAGAGTACCGGGCCCCTCACT
GCCTCAGAGCGCGTGTGCGGCTCTGGGCGCGCACAGTGACGGTGACGGCACCCCTGGCCCGGCAGCGCCGAGGCCGCTTCGCCAGACAGC
CAGCGGCCGGCGGCAGGCCGGGCCATGAGCGGCAGGGGCCGGGCCGGGCCTCGCTGACCCTGGCTCCGCGCGGCAGCTTCCCCAGTTTCC
GCTCCGGTCTCTCGGCATGAGAGTCCGCCCGGGCCCGGGGCTGCGGCTGCCCCAGACCCGCCGCACGCTGGCGCGCTCCGGGCCCGCGGA
GCCGCGGTGCTGATACCTGCGCCGCACTGCGCCGCCCGCCCGTCCGCTGTGTGCCCCGGGGGCGCGGCCATGGAGGTGGTGGGTGACTTC
GAGTACAGCAAGAGGGATCTCGTGGGACACGGGGCCTTCGCCGTGGTCTTCCGGGGGCGGCACCGCCAGAAAACTGATTGGGAGGTAGCT
ATTAAAAGTATTAATAAAAAGAACTTGTCAAAATCACAAATACTGCTTGGAAAGGAAATTAAAATCTTAAAGGAACTTCAGCATGAAAAT
ATTGTAGCACTCTATGATGTTCAGGAATTACCCAACTCTGTCTTTTTGGTGATGGAGTATTGCAATGGTGGAGACCTCGCAGATTATTTG
CAAGCGAAAGGGACTCTCAGTGAAGACACGATCAGAGTGTTTCTGCATCAGATTGCTGCTGCCATGCGAATCCTGCACAGCAAAGGAATC
ATCCACAGAGATCTCAAACCACAGAACATCTTGCTGTCCTATGCCAATCGCAGAAAATCAAGTGTCAGTGGTATTCGCATCAAAATAGCG
GATTTTGGTTTTGCTCGTTACCTACATAGTAACATGATGGCTGCAACACTGTGTGGATCCCCGATGTACATGGCTCCTGAGGTTATTATG
TCTCAACATTATGATGCTAAGGCTGACTTGTGGAGCATAGGAACAGTGATATACCAATGCCTAGTTGGAAAACCACCTTTTCAGGCCAAT
AGTCCTCAAGACTTAAGGATGTTTTATGAAAAAAACAGGAGCTTAATGCCTAGTATTCCCAGAGAAACATCACCTTATTTGGCTAATCTC
CTTTTGGGTTTGCTTCAGAGAAACCAAAAAGATAGAATGGACTTTGCTCGCGGCTCACGGCGCTCCTGGGGCAGCCCCGGCCCGGCCCTG
CCCGGCGGCCCTATGCCGGGGGTGCCGCTCAGGAATCTAAGTCCTTTGCTGTGGGAATGTTCAAAGGCCAGCTCACCACAGATCAGGTGT
TCCCATACCCGTCCGTGCTCAACGAAGAGCAGACACAGTTTCTTAAAGAGCTGGTGGAGCCTGTGTCCCGTTTCTTCGAGGAAGTGAACG
ATCCCGCCAAGAATGACGCTCTGGAGATGGTGGAGGAGACCACTTGGCAGGGCCTCAAGGAGCTGGGGGCCTTTGGTCTGCAAGTGCCCA
GTGAGCTGGGTGGTGTGGGCCTTTGCAACACCCAGTACGCCCGTTTGGTGGAGATCGTGGGCATGCATGACCTTGGCGTGGGCATTACCC
TGGGGGCCCATCAGAGCATCGGTTTCAAAGGCATCCTGCTCTTTGGCACAAAGGCCCAGAAAGAAAAATACCTCCCCAAGCTGGCATCTG
GGGAGACTGTGGCCGCTTTCTGTCTAACCGAGCCCTCAAGCGGGTCAGATGCAGCCTCCATCCGAACCTCTGCTGTGCCCAGCCCCTGTG
GAAAATACTATACCCTCAATGGAAGCAAGCTTTGGATCAGTAATGGGGGCCTAGCAGACATCTTCACGGTCTTTGCCAAGACACCAGTTA
CAGATCCAGCCACAGGAGCCGTGAAGGAGAAGATCACAGCTTTTGTGGTGGAGAGGGGCTTCGGGGGCATTACCCATGGGCCCCCTGAGA
AGAAGATGGGCATCAAGGCTTCAAACACAGCAGAGGTGTTCTTTGATGGAGTACGGGTGCCATCGGAGAACGTGCTGGGTGAGGTTGGGA
GTGGCTTCAAGGTTGCCATGCACATCCTCAACAATGGAAGGTTTGGCATGGCTGCGGCCCTGGCAGGTACCATGAGAGGCATCATTGCTA
AGGCGGTAGATCATGCCACTAATCGTACCCAGTTTGGGGAGAAAATTCACAACTTTGGGCTGATCCAGGAGAAGCTGGCACGGATGGTTA
TGCTGCAGTATGTAACTGAGTCCATGGCTTACATGGTGAGTGCTAACATGGACCAGGGAGCCACGGACTTCCAGATAGAGGCCGCCATCA
GCAAAATCTTTGGCTCGGAGGCAGCCTGGAAGGTGACAGATGAATGCATCCAAATCATGGGGGGTATGGGCTTCATGAAGGAACCTGGAG
TAGAGCGTGTGCTCCGAGATCTTCGCATCTTCCGGATCTTTGAGGGGACAAATGACATTCTTCGGCTGTTTGTGGCTCTGCAGGGCTGTA
TGGACAAAGGAAAGGAGCTCTCTGGGCTTGGCAGTGCTCTAAAGAATCCCTTTGGGAATGCTGGCCTCCTGCTAGGAGAGGCAGGCAAAC
AGCTGAGGCGGCGGGCAGGGCTGGGCAGCGGCCTGAGTCTCAGCGGACTTGTCCACCCGGAGTTGAGTCGGAGTGGCGAGCTGGCAGTAC
GGGCTCTGGAGCAGTTTGCCACTGTGGTGGAGGCCAAGCTGATAAAACACAAGAAGGGGATTGTCAATGAACAGTTTCTGCTGCAGCGGC
TGGCAGACGGGGCCATCGACCTCTATGCCATGGTGGTGGTTCTCTCGAGGGCCTCAAGATCCCTGAGTGAGGGCCACCCCACGGCCCAGC
ATGAGAAAATGCTCTGTGACACCTGGTGTATCGAGGCTGCAGCTCGGATCCGAGAGGGCATGGCCGCCCTGCAGTCTGACCCCTGGCAGC
AAGAGCTCTACCGCAACTTCAAAAGCATCTCCAAGGCCTTGGTGGAGCGGGGTGGTGTGGTCACCAGCAACCCACTTGGCTTCTGAATAC
TCCCGGCCAGGGCCTGTCCCAGTTATGTGCCTTCCCTCAAGCCAAAGCCGAAGCCCCTTTCCTTAAGGCCCTGGTTTGTCCCGAAGGGGC


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FusionGenePPI for ULK2_ACADVL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ULK2SYNGAP1, POLA2, NASP, LUC7L2, SETDB1, RB1CC1, GABARAP, GABARAPL2, CBX6, SQSTM1, LNX1, ZNF32, DIXDC1ACADVLACADVL, ICT1, SOCS3, ATP5L, INTS9, EEF2K, CDH1, ATF2, RPSA, GPHN, CCDC8, SURF1, PPA2, HMGCL, HIBCH, MRM1, ECSIT, CYP1A1, C17orf105, OXLD1, NTRK1, IFI16, KIF2A, CKAP5, MCM2, DCUN1D5, NDUFA4, COQ9, VNN2, DHRS4, APC, PDE4DIP, FAM60A, CLASRP, NPPA, NDUFA13, IL31RA, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ULK2_ACADVL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ULK2_ACADVL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneULK2C0345967Malignant mesothelioma1CTD_human
TgeneACADVLC3887523Very long chain acyl-CoA dehydrogenase deficiency4CTD_human;ORPHANET;UNIPROT
TgeneACADVLC0242184Hypoxia1CTD_human