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Fusion gene ID: 40745 |
FusionGeneSummary for UHRF1_KDM4B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UHRF1_KDM4B | Fusion gene ID: 40745 | Hgene | Tgene | Gene symbol | UHRF1 | KDM4B | Gene ID | 29128 | 23030 |
| Gene name | ubiquitin like with PHD and ring finger domains 1 | lysine demethylase 4B | |
| Synonyms | ICBP90|Np95|RNF106|TDRD22|hNP95|hUHRF1|huNp95 | JMJD2B|TDRD14B | |
| Cytomap | 19p13.3 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase UHRF1RING finger protein 106RING-type E3 ubiquitin transferase UHRF1inverted CCAAT box-binding protein of 90 kDanuclear phosphoprotein 95nuclear protein 95nuclear zinc finger protein Np95transcription factor ICBP90ubiqu | lysine-specific demethylase 4BjmjC domain-containing histone demethylation protein 3Bjumonji domain containing 2Bjumonji domain-containing protein 2Blysine (K)-specific demethylase 4Btudor domain containing 14B | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O94953 | ||
| Ensembl transtripts involved in fusion gene | ENST00000592666, | ENST00000159111, ENST00000381759, ENST00000536461, ENST00000592175, | |
| Fusion gene scores | * DoF score | 3 X 5 X 4=60 | 9 X 9 X 9=729 |
| # samples | 5 | 12 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/729*10)=-2.60288440871842 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: UHRF1 [Title/Abstract] AND KDM4B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UHRF1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 21777816 |
| Hgene | UHRF1 | GO:0006511 | ubiquitin-dependent protein catabolic process | 22945642 |
| Hgene | UHRF1 | GO:0016574 | histone ubiquitination | 17967883 |
| Hgene | UHRF1 | GO:0032270 | positive regulation of cellular protein metabolic process | 10646863 |
| Hgene | UHRF1 | GO:0051865 | protein autoubiquitination | 17967883|21745816 |
| Tgene | KDM4B | GO:0033169 | histone H3-K9 demethylation | 21914792 |
| Tgene | KDM4B | GO:0070544 | histone H3-K36 demethylation | 21914792 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | DLBC | TCGA-FA-A7DS-01A | UHRF1 | chr19 | 4941943 | + | KDM4B | chr19 | 5047487 | + |
| TCGA | LD | LUAD | TCGA-95-8494-01A | UHRF1 | chr19 | 4932968 | + | KDM4B | chr19 | 5071021 | + |
| TCGA | LD | SARC | TCGA-DX-A48R-01A | UHRF1 | chr19 | 4951008 | + | KDM4B | chr19 | 5077378 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000592666 | ENST00000159111 | UHRF1 | chr19 | 4941943 | + | KDM4B | chr19 | 5047487 | + |
| 3UTR-3CDS | ENST00000592666 | ENST00000381759 | UHRF1 | chr19 | 4941943 | + | KDM4B | chr19 | 5047487 | + |
| 3UTR-3CDS | ENST00000592666 | ENST00000536461 | UHRF1 | chr19 | 4941943 | + | KDM4B | chr19 | 5047487 | + |
| 3UTR-3UTR | ENST00000592666 | ENST00000592175 | UHRF1 | chr19 | 4941943 | + | KDM4B | chr19 | 5047487 | + |
| 3UTR-3CDS | ENST00000592666 | ENST00000159111 | UHRF1 | chr19 | 4932968 | + | KDM4B | chr19 | 5071021 | + |
| 3UTR-3CDS | ENST00000592666 | ENST00000381759 | UHRF1 | chr19 | 4932968 | + | KDM4B | chr19 | 5071021 | + |
| 3UTR-3CDS | ENST00000592666 | ENST00000536461 | UHRF1 | chr19 | 4932968 | + | KDM4B | chr19 | 5071021 | + |
| 3UTR-3UTR | ENST00000592666 | ENST00000592175 | UHRF1 | chr19 | 4932968 | + | KDM4B | chr19 | 5071021 | + |
| 3UTR-3CDS | ENST00000592666 | ENST00000159111 | UHRF1 | chr19 | 4951008 | + | KDM4B | chr19 | 5077378 | + |
| 3UTR-3CDS | ENST00000592666 | ENST00000381759 | UHRF1 | chr19 | 4951008 | + | KDM4B | chr19 | 5077378 | + |
| 3UTR-3CDS | ENST00000592666 | ENST00000536461 | UHRF1 | chr19 | 4951008 | + | KDM4B | chr19 | 5077378 | + |
| 3UTR-3UTR | ENST00000592666 | ENST00000592175 | UHRF1 | chr19 | 4951008 | + | KDM4B | chr19 | 5077378 | + |
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FusionProtFeatures for UHRF1_KDM4B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UHRF1 | KDM4B |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does notdemethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', witha weaker activity than KDM4A, KDM4C and KDM4D. Demethylation ofLys residue generates formaldehyde and succinate.{ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UHRF1_KDM4B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UHRF1_KDM4B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| UHRF1 | DNMT1, HDAC1, EHMT2, DNMT3A, DNMT3B, KAT5, UHRF1BP1, USP7, HIST1H3A, TRIM28, RNF4, USP11, UHRF2, ELAVL1, SUZ12, EZH2, SUV39H1, HIST2H3C, PML, HIST2H3A, HIST2H3D, PRKACA, HIST3H3, RB1, ZPR1, UHRF1, BTRC, CUL1, MPG, PARP1, PARP2, MBD4, OBSL1, CCDC8, RNF2, TRPV5, TCEAL1, WIPI1, UQCRB, CCNDBP1, MUS81, ERCC1, ERCC4, EME1, TOP2A, NTRK1, HIST1H2BG, AHSA1, DBN1, HNRNPU, PCNA, RPL10, AOC4P, FBXW11, UBE2D3, TP53, PRMT5, NFATC2, HSPA1A, HSP90AA1, ZNF18, ARIH1, TMCC2, RNMTL1, HBS1L, ERG, LASP1, FOXA1 | KDM4B | KMT2D, ASH2L, RBBP5, WDR5, HNRNPU, HSPA4, ESR1, KMT2C, SMU1, HSP90AA2P, HSP90B1, H3F3C, ZNF414, DDX3X, NHP2L1, HIST1H2BG, CHORDC1, KDM4A, CCT3, CCT4, CCT6B, CCT2, CCT7, CCDC85C, CCT5, TCP1, CCT6A, CCT8, TRIM25, UHRF2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UHRF1_KDM4B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UHRF1_KDM4B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | UHRF1 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Tgene | KDM4B | C0025149 | Medulloblastoma | 1 | CTD_human |
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