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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40713

FusionGeneSummary for UGGT2_UGGT2

check button Fusion gene summary
Fusion gene informationFusion gene name: UGGT2_UGGT2
Fusion gene ID: 40713
HgeneTgene
Gene symbol

UGGT2

UGGT2

Gene ID

55757

55757

Gene nameUDP-glucose glycoprotein glucosyltransferase 2UDP-glucose glycoprotein glucosyltransferase 2
SynonymsHUGT2|UGCGL2|UGT2HUGT2|UGCGL2|UGT2
Cytomap

13q32.1

13q32.1

Type of geneprotein-codingprotein-coding
DescriptionUDP-glucose:glycoprotein glucosyltransferase 2UDP-Glc:glycoprotein glucosyltransferase 2UDP-glucose ceramide glucosyltransferase-like 1UDP-glucose ceramide glucosyltransferase-like 2UDP-glucose:glycoprotein glucosyltransferase 2UDP-Glc:glycoprotein glucosyltransferase 2UDP-glucose ceramide glucosyltransferase-like 1UDP-glucose ceramide glucosyltransferase-like 2
Modification date2018052320180523
UniProtAcc

Q9NYU1

Q9NYU1

Ensembl transtripts involved in fusion geneENST00000376747, ENST00000376714, 
ENST00000397618, ENST00000467305, 
ENST00000376712, 
ENST00000376747, 
ENST00000376714, ENST00000397618, 
ENST00000467305, ENST00000376712, 
Fusion gene scores* DoF score6 X 6 X 4=1442 X 3 X 3=18
# samples 63
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: UGGT2 [Title/Abstract] AND UGGT2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA335867UGGT2chr13

96622366

-UGGT2chr13

96651562

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000376747ENST00000376747UGGT2chr13

96622366

-UGGT2chr13

96651562

-
In-frameENST00000376747ENST00000376714UGGT2chr13

96622366

-UGGT2chr13

96651562

-
In-frameENST00000376747ENST00000397618UGGT2chr13

96622366

-UGGT2chr13

96651562

-
5CDS-5UTRENST00000376747ENST00000467305UGGT2chr13

96622366

-UGGT2chr13

96651562

-
5CDS-5UTRENST00000376747ENST00000376712UGGT2chr13

96622366

-UGGT2chr13

96651562

-
intron-3CDSENST00000376714ENST00000376747UGGT2chr13

96622366

-UGGT2chr13

96651562

-
intron-3CDSENST00000376714ENST00000376714UGGT2chr13

96622366

-UGGT2chr13

96651562

-
intron-3CDSENST00000376714ENST00000397618UGGT2chr13

96622366

-UGGT2chr13

96651562

-
intron-5UTRENST00000376714ENST00000467305UGGT2chr13

96622366

-UGGT2chr13

96651562

-
intron-5UTRENST00000376714ENST00000376712UGGT2chr13

96622366

-UGGT2chr13

96651562

-
intron-3CDSENST00000397618ENST00000376747UGGT2chr13

96622366

-UGGT2chr13

96651562

-
intron-3CDSENST00000397618ENST00000376714UGGT2chr13

96622366

-UGGT2chr13

96651562

-
intron-3CDSENST00000397618ENST00000397618UGGT2chr13

96622366

-UGGT2chr13

96651562

-
intron-5UTRENST00000397618ENST00000467305UGGT2chr13

96622366

-UGGT2chr13

96651562

-
intron-5UTRENST00000397618ENST00000376712UGGT2chr13

96622366

-UGGT2chr13

96651562

-
intron-3CDSENST00000467305ENST00000376747UGGT2chr13

96622366

-UGGT2chr13

96651562

-
intron-3CDSENST00000467305ENST00000376714UGGT2chr13

96622366

-UGGT2chr13

96651562

-
intron-3CDSENST00000467305ENST00000397618UGGT2chr13

96622366

-UGGT2chr13

96651562

-
intron-5UTRENST00000467305ENST00000467305UGGT2chr13

96622366

-UGGT2chr13

96651562

-
intron-5UTRENST00000467305ENST00000376712UGGT2chr13

96622366

-UGGT2chr13

96651562

-
intron-3CDSENST00000376712ENST00000376747UGGT2chr13

96622366

-UGGT2chr13

96651562

-
intron-3CDSENST00000376712ENST00000376714UGGT2chr13

96622366

-UGGT2chr13

96651562

-
intron-3CDSENST00000376712ENST00000397618UGGT2chr13

96622366

-UGGT2chr13

96651562

-
intron-5UTRENST00000376712ENST00000467305UGGT2chr13

96622366

-UGGT2chr13

96651562

-
intron-5UTRENST00000376712ENST00000376712UGGT2chr13

96622366

-UGGT2chr13

96651562

-

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FusionProtFeatures for UGGT2_UGGT2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UGGT2

Q9NYU1

UGGT2

Q9NYU1

Recognizes glycoproteins with minor folding defects.Reglucosylates single N-glycans near the misfolded part of theprotein, thus providing quality control for protein folding in theendoplasmic reticulum. Reglucosylated proteins are recognized bycalreticulin for recycling to the endoplasmic reticulum andrefolding or degradation (By similarity). {ECO:0000250}. Recognizes glycoproteins with minor folding defects.Reglucosylates single N-glycans near the misfolded part of theprotein, thus providing quality control for protein folding in theendoplasmic reticulum. Reglucosylated proteins are recognized bycalreticulin for recycling to the endoplasmic reticulum andrefolding or degradation (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUGGT2chr13:96622366chr13:96651562ENST00000376747-4391513_15162201517MotifPrevents secretion from ER
TgeneUGGT2chr13:96622366chr13:96651562ENST00000376747-4391220_15162201517RegionNote=Glucosyltransferase

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUGGT2chr13:96622366chr13:96651562ENST00000376747-12391513_15164451517MotifPrevents secretion from ER
HgeneUGGT2chr13:96622366chr13:96651562ENST00000376747-12391220_15164451517RegionNote=Glucosyltransferase


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FusionGeneSequence for UGGT2_UGGT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UGGT2_UGGT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UGGT2BRE, BABAM1, APP, OS9, METTL23, FBXO6, APPBP2, TCTN1, SORT1, BIRC6, ITIH2, AGMATUGGT2BRE, BABAM1, APP, OS9, METTL23, FBXO6, APPBP2, TCTN1, SORT1, BIRC6, ITIH2, AGMAT


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UGGT2_UGGT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UGGT2_UGGT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource