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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40688

FusionGeneSummary for UFL1_HNRNPA1

check button Fusion gene summary
Fusion gene informationFusion gene name: UFL1_HNRNPA1
Fusion gene ID: 40688
HgeneTgene
Gene symbol

UFL1

HNRNPA1

Gene ID

23376

3178

Gene nameUFM1 specific ligase 1heterogeneous nuclear ribonucleoprotein A1
SynonymsKIAA0776|Maxer|NLBP|RCADALS19|ALS20|HNRPA1|HNRPA1L3|IBMPFD3|UP 1|hnRNP A1|hnRNP-A1
Cytomap

6q16.1

12q13.13

Type of geneprotein-codingprotein-coding
DescriptionE3 UFM1-protein ligase 1E3 UFM1-protein transferase 1LZAP-binding proteinRegulator of CDK5RAP3 and DDRGK1novel LZAP-binding proteinregulator of C53/LZAP and DDRGK1heterogeneous nuclear ribonucleoprotein A1helix-destabilizing proteinheterogeneous nuclear ribonucleoprotein A1B proteinheterogeneous nuclear ribonucleoprotein B2 proteinheterogeneous nuclear ribonucleoprotein core protein A1hnRNP core protein A1-lik
Modification date2018052220180523
UniProtAcc

O94874

P09651

Ensembl transtripts involved in fusion geneENST00000369278, ENST00000461673, 
ENST00000546500, ENST00000340913, 
ENST00000330752, ENST00000547276, 
ENST00000551803, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 5 X 4=100
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UFL1 [Title/Abstract] AND HNRNPA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUFL1

GO:0031397

negative regulation of protein ubiquitination

20164180

HgeneUFL1

GO:0033146

regulation of intracellular estrogen receptor signaling pathway

25219498

HgeneUFL1

GO:0034976

response to endoplasmic reticulum stress

23152784

HgeneUFL1

GO:0071569

protein ufmylation

20018847

HgeneUFL1

GO:1990592

protein K69-linked ufmylation

25219498

TgeneHNRNPA1

GO:0032212

positive regulation of telomere maintenance via telomerase

23935072

TgeneHNRNPA1

GO:0051168

nuclear export

8521471

TgeneHNRNPA1

GO:0051170

import into nucleus

8521471

TgeneHNRNPA1

GO:1903936

cellular response to sodium arsenite

27694260


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDKIRCTCGA-CJ-4878-01AUFL1chr6

96969826

+HNRNPA1chr12

54675579

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000369278ENST00000546500UFL1chr6

96969826

+HNRNPA1chr12

54675579

+
Frame-shitENST00000369278ENST00000340913UFL1chr6

96969826

+HNRNPA1chr12

54675579

+
Frame-shitENST00000369278ENST00000330752UFL1chr6

96969826

+HNRNPA1chr12

54675579

+
Frame-shitENST00000369278ENST00000547276UFL1chr6

96969826

+HNRNPA1chr12

54675579

+
5CDS-intronENST00000369278ENST00000551803UFL1chr6

96969826

+HNRNPA1chr12

54675579

+
3UTR-3CDSENST00000461673ENST00000546500UFL1chr6

96969826

+HNRNPA1chr12

54675579

+
3UTR-3CDSENST00000461673ENST00000340913UFL1chr6

96969826

+HNRNPA1chr12

54675579

+
3UTR-3CDSENST00000461673ENST00000330752UFL1chr6

96969826

+HNRNPA1chr12

54675579

+
3UTR-3CDSENST00000461673ENST00000547276UFL1chr6

96969826

+HNRNPA1chr12

54675579

+
3UTR-intronENST00000461673ENST00000551803UFL1chr6

96969826

+HNRNPA1chr12

54675579

+

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FusionProtFeatures for UFL1_HNRNPA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UFL1

O94874

HNRNPA1

P09651

E3 protein ligase that mediates ufmylation, the covalentattachment of the ubiquitin-like modifier UFM1 to substrateproteins, a post-translational modification on lysine residues ofproteins that may play a crucial role in a number of cellularprocesses. Mediates DDRGK1 ufmylation and may regulate theproteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulatingNF-kappa-B signaling (PubMed:20018847, PubMed:20164180,PubMed:20228063, PubMed:25219498). May also through TRIP4ufmylation play a role in nuclear receptors-mediated transcription(PubMed:25219498). May play a role in the unfolded proteinresponse, mediating the ufmylation of multiple proteins inresponse to endoplasmic reticulum stress (PubMed:23152784).{ECO:0000269|PubMed:20018847, ECO:0000269|PubMed:20164180,ECO:0000269|PubMed:20228063, ECO:0000269|PubMed:23152784,ECO:0000269|PubMed:25219498}. Involved in the packaging of pre-mRNA into hnRNPparticles, transport of poly(A) mRNA from the nucleus to thecytoplasm and may modulate splice site selection(PubMed:17371836). May bind to specific miRNA hairpins(PubMed:28431233). {ECO:0000269|PubMed:17371836,ECO:0000269|PubMed:28431233}. (Microbial infection) May play a role in HCV RNAreplication. {ECO:0000269|PubMed:17229681}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UFL1_HNRNPA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UFL1_HNRNPA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UFL1CASP4, CDK5RAP3, ZNF622, FUS, CCDC8, EGFR, ABCE1, BSG, DDRGK1, TNF, NTRK1, TCTN3, AHSA1, FOXB1, FOXL1, FOXS1, SENP3, TMEM206, APLNRHNRNPA1PRRC2A, FEN1, PRMT1, KHSRP, HNRNPA1, NFKBIA, SAFB, RRP1B, MEPCE, CDK9, DDX17, DDX5, HSP90AB1, IGF2BP1, IGF2BP3, UBR2, HNRNPA2B1, HNRNPH1, HNRNPK, HNRNPR, ILF2, ILF3, SYNCRIP, KHDRBS2, RPAP1, HNRNPUL2, IGF2BP2, LARP7, HNRNPM, RBMX, HNRNPC, HSPA9, SRP72, MRPS27, PABPC1, CCNT1, ZFR, YTHDF2, RBM39, HSPA2, GTF2E2, KIAA0368, ARHGAP23, SYTL2, ARID2, HNRNPAB, PABPC4, PRMT8, HNRNPCL2, TARDBP, UBR1, GTF2A1, PLOD3, PURA, MOV10, HNRNPA1P70, HNRNPDL, PLOD2, ROCK1, CENPC, CAPN2, HNRNPL, MRPL37, FRMD4A, NNT, SAP25, SRRM2, TOPORS, H2AFX, SMN1, CD4, HDAC5, NOP56, NR3C1, TOP1, PSMA3, VHL, SREK1, ELAVL1, SF3A2, ARRB1, ARRB2, XRN2, PTBP1, FIP1L1, NONO, CPSF2, NUDT21, SFPQ, CPSF6, CSTF3, CSTF1, SNRNP200, PUF60, PRPF8, SUGP2, SRSF4, PRPF4, SRSF1, CDC5L, PNN, SRSF6, PRPF19, SNRPD1, SNRPD2, SNRPD3, AQR, XAB2, HNRNPD, HNRNPH2, HNRNPF, HNRNPH3, DDX1, DHX15, DDX21, DDX28, DDX23, DHX30, DHX9, EWSR1, RBM26, ADAR, RBM12, RBM7, RBM14, AKAP8, LMNB1, NUP205, NCBP1, ALYREF, MLLT4, WDR82, NFATC1, NFATC2, NKRF, MEF2A, RAD50, G3BP1, BRINP1, WDR33, PTCD1, PTCD3, GADD45GIP1, ZNF326, ACIN1, CARF, XRCC6, PPIA, LRPPRC, XRCC5, SRRT, PRKDC, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, DCUN1D1, CAND1, NEDD8, RN7SK, BRCA1, RNF14, XIAP, HIPK3, SRSF7, APP, HNRNPU, SF3B6, PHF5A, RPS8, RPS3A, RPS6, RPSA, CPSF7, RPLP2, RPS5, RPS21, RPS3, HSP90AA1, CLIC4, RBM3, PPP5C, ESR1, LIG4, SMURF1, CTNNB1, VCP, FN1, VCAM1, PPIL1, TRA2B, IFIT2, IFIT3, NOS2, ITGA4, PRMT2, PRMT3, CARM1, PAN2, CD81, IGSF8, ICAM1, HMGA1, LMNA, CSF2, NR0B2, TFEC, XRN1, SRPK1, YWHAQ, FBXO6, PARK2, AIMP2, HIST1H2AB, CCAR2, QARS, RPL27A, RPL38, IQGAP1, ZC3HC1, RPA1, RPA2, RPA3, ERG, ASB2, HSPA5, PSMD9, CHUK, TNF, PSMB4, IVNS1ABP, STAU1, AURKA, AURKB, NEDD1, TP53, TUBGCP3, HIST3H3, CUL7, OBSL1, CCDC8, EED, RNF2, FBXW11, MRPL16, MRPL28, MRPS18A, MRPL4, RPL26, RPS27A, MTERF3, FAM120A, STRBP, NGRN, UPF1, PDCD11, YARS2, RPS7, MRPS23, HNRNPA1L2, TRUB2, MRPL9, MRPL32, MRPL3, ZCCHC3, MRPS10, DAP3, MRPL1, LARP1, LARP1B, FASTKD2, MRPS5, MRPS7, MRPS22, MRPL10, RPS15, MRPL44, MRPS9, PAIP2, PAIP2B, PRKRIR, MRPL27, MALSU1, DHX36, MRPL47, DUSP11, MRPS24, YTHDC1, RALY, RBMS1, MRPL15, MRPL21, MRPL13, MCAT, FARS2, ICT1, DNTTIP2, MRPS18C, RPUSD3, MRPL57, SUPV3L1, MRPL52, RPS6KB2, PDCD4, BCL2L1, YWHAE, YWHAZ, A2ML1, ACTB, ADA, AKR1B10, ALB, ALDOA, ANGEL2, ANXA1, ANXA2, ARF3, ARG1, ASPRV1, ATP5A1, ATP5B, STRAP, C14orf166, C1orf68, RTCB, C3, CALML3, CALML5, CANX, CAPRIN1, CDKN2AIP, CFL1, CKMT1A, CLTC, YBX3, CTSD, DCD, DDX3X, DDX6, DIMT1, DNAJC10, DSG1, DSP, EEF1A1, EEF1G, EEF2, EIF2B1, EIF2B3, EIF3H, EIF4A2, EIF4A3, ENO1, EPPK1, FAM120C, FAM35A, FAM98B, FLG, FLG2, FLNA, FUS, G3BP2, GADD45A, GAPDH, GDE1, GM2A, GNB2L1, GSN, GSTP1, GTF2I, H1FX, H3F3A, HAL, HIST1H1E, HNRNPA0, HNRNPA3, HNRNPUL1, HRNR, HSPA1A, HSPA8, HSPB1, HSPD1, IL36G, IVL, JUP, KPRP, KRT1, KRT10, KRT14, KRT15, KRT16, KRT17, KRT2, KRT33A, KRT34, KRT5, KRT6A, KRT6B, KRT6C, KRT78, KRT79, KRT80, KRT83, KRT9, LAMP1, SSB, LCN2, LDHA, LGALS7, LTV1, MARK2, MATR3, MRPL11, MRPL18, MRPL19, MRPL22, MRPL24, MRPL38, MRPL39, MRPL43, MRPL45, MRPL46, MRPL48, MRPS15, MRPS18B, MRPS2, MRPS28, MRPS30, MRPS31, MRPS35, MX1, MYH9, MYL12A, NAMPT, NCCRP1, NCL, NSUN5, NXF1, P4HB, PCBP2, PFN1, PGK1, PHB2, PICALM, PKM, PKP1, PLOD1, PNO1, PNP, POF1B, POLDIP3, PPL, PPP2R1A, PRDX1, PRPF31, PRSS3, MAEL, AASDHPPT, ACAA2, ANXA5, CARS, CDC42, CYB5B, EIF4EBP1, FDPS, HMBS, ATP5F1, CRIP1, DUT, GART, GLO1, KAT8, MSN, PAPOLA, PHGDH, PROSC, PRRC1, RAB1A, UBE2I, UBE2K, ITPA, MSI2, SEC31A, NTRK1, SCARNA22, SRPK2, CLK1, XPO1, AHSA1, ADARB1, CIRBP, GTF2F1, SEC16A, ZWINT, EXOSC4, PARD6B, TAF15, TNK1, FUBP3, APOBEC3B, SAFB2, RBM6, KHDRBS1, ZNF638, YLPM1, NCOA5, NBEAL1, SCAI, RBM12B, GAN, UBQLN2, MCM2, MCM5, SNW1, U2AF2, MRPL35, RPS15A, C17orf89, CYLD, COX15, PDHA1, SDHA, TRIM25, HEY1, MTF1, HIST1H3A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UFL1_HNRNPA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UFL1_HNRNPA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHNRNPA1C3715156AMYOTROPHIC LATERAL SCLEROSIS 202UNIPROT
TgeneHNRNPA1C3809469INCLUSION BODY MYOPATHY WITH EARLY-ONSET PAGET DISEASE WITH OR WITHOUT FRONTOTEMPORAL DEMENTIA 32UNIPROT
TgeneHNRNPA1C0024667Animal Mammary Neoplasms1CTD_human
TgeneHNRNPA1C0024668Mammary Neoplasms, Experimental1CTD_human