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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40684

FusionGeneSummary for UFD1L_GUCY1B2

check button Fusion gene summary
Fusion gene informationFusion gene name: UFD1L_GUCY1B2
Fusion gene ID: 40684
HgeneTgene
Gene symbol

UFD1L

GUCY1B2

Gene ID

2974

Gene nameguanylate cyclase 1 soluble subunit beta 2 (pseudogene)
SynonymsGC-SB2
Cytomap

13q14.3

Type of genepseudo
Descriptionguanylate cyclase 1 solube subunit beta 2 (pseudogene)guanylate cyclase 1, soluble, beta 2 (pseudogene)
Modification date20180329
UniProtAcc

Ensembl transtripts involved in fusion geneENST00000263202, ENST00000360834, 
ENST00000399523, ENST00000484101, 
ENST00000493639, 
Fusion gene scores* DoF score6 X 6 X 2=721 X 1 X 1=1
# samples 71
** MAII scorelog2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: UFD1L [Title/Abstract] AND GUCY1B2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-WE-A8ZR-06AUFD1Lchr22

19462591

-GUCY1B2chr13

51622450

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000263202ENST00000493639UFD1Lchr22

19462591

-GUCY1B2chr13

51622450

-
intron-5UTRENST00000360834ENST00000493639UFD1Lchr22

19462591

-GUCY1B2chr13

51622450

-
5CDS-5UTRENST00000399523ENST00000493639UFD1Lchr22

19462591

-GUCY1B2chr13

51622450

-
5UTR-5UTRENST00000484101ENST00000493639UFD1Lchr22

19462591

-GUCY1B2chr13

51622450

-

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FusionProtFeatures for UFD1L_GUCY1B2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UFD1L

GUCY1B2

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UFD1L_GUCY1B2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UFD1L_GUCY1B2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UFD1LNPLOC4, VIMP, HMOX1, VCP, AMFR, SVIP, USP13, VCPIP1, RAE1, UBL4A, BIRC5, PSMD2, SKP2, NSFL1C, FAF2, FAF1, UBXN7, UBXN1, UBXN8, UBXN10, ASPSCR1, PIK3CA, A2M, TAF1C, F13A1, TP53, PPHLN1, ANAPC2, NGFR, MASP1, TIAM2, SNX1, IGHM, ITPR1, ERLIN2, UBXN6, GZMK, SPRTN, TXLNA, VPS33B, UBE2N, UBE3A, PSMD7, UNC45A, UBC, ADRB2, NUB1, CAV1, NFKBIA, PDCD4, BTRC, SHFM1, YOD1, HUWE1, MOV10, EZH2, SUZ12, MAP3K1, DEGS1, KCNK16, TMEM62, CHMP2A, HSPB1, ARMC1, ARPC5L, ASNS, CAP1, CD2AP, DHX15, DPH5, FUS, GARS, MTMR12, PAPOLA, RTCB, SH3KBP1, STIP1, SUMO3, TTC27, CFL1, DCUN1D1, FLNB, LDHA, PTPRF, IFT74, TTC26, NUBPL, UBAC2, HMGB1, PLS3, RDX, SLC17A2, SV2C, ATG9A, FAM189BGUCY1B2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UFD1L_GUCY1B2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UFD1L_GUCY1B2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource