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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40680

FusionGeneSummary for UFC1_NPIPB7

check button Fusion gene summary
Fusion gene informationFusion gene name: UFC1_NPIPB7
Fusion gene ID: 40680
HgeneTgene
Gene symbol

UFC1

NPIPB7

Gene ID

51506

440350

Gene nameubiquitin-fold modifier conjugating enzyme 1nuclear pore complex interacting protein family member B7
SynonymsHSPC155A-575C2.4|A-761H5.5|NPIPL1
Cytomap

1q23.3

16p12.1

Type of geneprotein-codingpseudo
Descriptionubiquitin-fold modifier-conjugating enzyme 1Ufm1-conjugating enzyme 1nuclear pore complex-interacting protein-like 1
Modification date2018052320180329
UniProtAcc

Q9Y3C8

O75200

Ensembl transtripts involved in fusion geneENST00000368003, ENST00000473766, 
ENST00000452313, 
Fusion gene scores* DoF score3 X 3 X 2=1816 X 18 X 1=288
# samples 319
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(19/288*10)=-0.600069393111365
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UFC1 [Title/Abstract] AND NPIPB7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUFC1

GO:0034976

response to endoplasmic reticulum stress

23152784

HgeneUFC1

GO:0071569

protein ufmylation

15071506

HgeneUFC1

GO:1990592

protein K69-linked ufmylation

25219498


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW628133UFC1chr1

161128577

-NPIPB7chr16

28975536

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000368003ENST00000452313UFC1chr1

161128577

-NPIPB7chr16

28975536

-
intron-intronENST00000473766ENST00000452313UFC1chr1

161128577

-NPIPB7chr16

28975536

-

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FusionProtFeatures for UFC1_NPIPB7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UFC1

Q9Y3C8

NPIPB7

O75200

E2-like enzyme which forms an intermediate with UFM1 viaa thioester linkage. {ECO:0000269|PubMed:15071506}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UFC1_NPIPB7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UFC1_NPIPB7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UFC1_NPIPB7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UFC1_NPIPB7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource