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Fusion gene ID: 40672 |
FusionGeneSummary for UCKL1_TXN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UCKL1_TXN | Fusion gene ID: 40672 | Hgene | Tgene | Gene symbol | UCKL1 | TXN | Gene ID | 54963 | 25828 |
| Gene name | uridine-cytidine kinase 1 like 1 | thioredoxin 2 | |
| Synonyms | UCK1L|URKL1 | COXPD29|MT-TRX|MTRX|TRX2|TXN | |
| Cytomap | 20q13.33 | 22q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | uridine-cytidine kinase-like 1UCK1-LIKE | thioredoxin, mitochondrialmitochondrial thioredoxin | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q9NWZ5 | P10599 | |
| Ensembl transtripts involved in fusion gene | ENST00000354216, ENST00000369892, ENST00000358711, ENST00000369908, ENST00000492660, | ENST00000374515, ENST00000374517, ENST00000487892, | |
| Fusion gene scores | * DoF score | 2 X 3 X 3=18 | 3 X 3 X 3=27 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: UCKL1 [Title/Abstract] AND TXN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-C8-A12K-01A | UCKL1 | chr20 | 62587613 | - | TXN | chr9 | 113013742 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000354216 | ENST00000374515 | UCKL1 | chr20 | 62587613 | - | TXN | chr9 | 113013742 | - |
| In-frame | ENST00000354216 | ENST00000374517 | UCKL1 | chr20 | 62587613 | - | TXN | chr9 | 113013742 | - |
| 5CDS-intron | ENST00000354216 | ENST00000487892 | UCKL1 | chr20 | 62587613 | - | TXN | chr9 | 113013742 | - |
| In-frame | ENST00000369892 | ENST00000374515 | UCKL1 | chr20 | 62587613 | - | TXN | chr9 | 113013742 | - |
| In-frame | ENST00000369892 | ENST00000374517 | UCKL1 | chr20 | 62587613 | - | TXN | chr9 | 113013742 | - |
| 5CDS-intron | ENST00000369892 | ENST00000487892 | UCKL1 | chr20 | 62587613 | - | TXN | chr9 | 113013742 | - |
| In-frame | ENST00000358711 | ENST00000374515 | UCKL1 | chr20 | 62587613 | - | TXN | chr9 | 113013742 | - |
| In-frame | ENST00000358711 | ENST00000374517 | UCKL1 | chr20 | 62587613 | - | TXN | chr9 | 113013742 | - |
| 5CDS-intron | ENST00000358711 | ENST00000487892 | UCKL1 | chr20 | 62587613 | - | TXN | chr9 | 113013742 | - |
| intron-3CDS | ENST00000369908 | ENST00000374515 | UCKL1 | chr20 | 62587613 | - | TXN | chr9 | 113013742 | - |
| intron-3CDS | ENST00000369908 | ENST00000374517 | UCKL1 | chr20 | 62587613 | - | TXN | chr9 | 113013742 | - |
| intron-intron | ENST00000369908 | ENST00000487892 | UCKL1 | chr20 | 62587613 | - | TXN | chr9 | 113013742 | - |
| intron-3CDS | ENST00000492660 | ENST00000374515 | UCKL1 | chr20 | 62587613 | - | TXN | chr9 | 113013742 | - |
| intron-3CDS | ENST00000492660 | ENST00000374517 | UCKL1 | chr20 | 62587613 | - | TXN | chr9 | 113013742 | - |
| intron-intron | ENST00000492660 | ENST00000487892 | UCKL1 | chr20 | 62587613 | - | TXN | chr9 | 113013742 | - |
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FusionProtFeatures for UCKL1_TXN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UCKL1 | TXN |
| May contribute to UTP accumulation needed for blasttransformation and proliferation. {ECO:0000269|PubMed:12199906}. | Participates in various redox reactions through thereversible oxidation of its active center dithiol to a disulfideand catalyzes dithiol-disulfide exchange reactions. Plays a rolein the reversible S-nitrosylation of cysteine residues in targetproteins, and thereby contributes to the response to intracellularnitric oxide. Nitrosylates the active site Cys of CASP3 inresponse to nitric oxide (NO), and thereby inhibits caspase-3activity. Induces the FOS/JUN AP-1 DNA-binding activity inionizing radiation (IR) cells through its oxidation/reductionstatus and stimulates AP-1 transcriptional activity. ADF augments the expression of the interleukin-2receptor TAC (IL2R/P55). |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >UCKL1 | chr20:62587613 | chr9:113013742 | ENST00000354216 | - | 1 | 15 | 105_112 | 37 | 549 | Nucleotide binding | ATP |
| Hgene | >UCKL1 | chr20:62587613 | chr9:113013742 | ENST00000358711 | - | 1 | 13 | 105_112 | 37 | 412 | Nucleotide binding | ATP |
| Hgene | >UCKL1 | chr20:62587613 | chr9:113013742 | ENST00000369908 | - | 1 | 15 | 105_112 | -100 | 534 | Nucleotide binding | ATP |
| Tgene | TXN | chr20:62587613 | chr9:113013742 | ENST00000374515 | - | 0 | 4 | 2_105 | 8 | 86 | Domain | Thioredoxin |
| Tgene | TXN | chr20:62587613 | chr9:113013742 | ENST00000374517 | - | 0 | 5 | 2_105 | 8 | 106 | Domain | Thioredoxin |
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FusionGeneSequence for UCKL1_TXN |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_UCKL1_ENST00000354216_chr20_62587613_-_TXN_ENST00000374515_chr9_113013742_-_115aa MAAPPARADADPSPTSPPTARDTPGRQAEKSETACEDRLLFRKPWTLQVINLXXLTSQPRGVGLAKXSSLSFMMLLQSVKSNACQHSSFL >In-frame_UCKL1_ENST00000354216_chr20_62587613_-_TXN_ENST00000374517_chr9_113013742_-_135aa MAAPPARADADPSPTSPPTARDTPGRQAEKSETACEDRLLFRKPWTLQVINLXXLTSQPRGVGLAKXSSLSFIPSLKSIPTXYSLKXMWM >In-frame_UCKL1_ENST00000369892_chr20_62587613_-_TXN_ENST00000374515_chr9_113013742_-_115aa MAAPPARADADPSPTSPPTARDTPGRQAEKSETACEDRLLFRKPWTLQVINLXXLTSQPRGVGLAKXSSLSFMMLLQSVKSNACQHSSFL >In-frame_UCKL1_ENST00000369892_chr20_62587613_-_TXN_ENST00000374517_chr9_113013742_-_135aa MAAPPARADADPSPTSPPTARDTPGRQAEKSETACEDRLLFRKPWTLQVINLXXLTSQPRGVGLAKXSSLSFIPSLKSIPTXYSLKXMWM >In-frame_UCKL1_ENST00000358711_chr20_62587613_-_TXN_ENST00000374515_chr9_113013742_-_115aa MAAPPARADADPSPTSPPTARDTPGRQAEKSETACEDRLLFRKPWTLQVINLXXLTSQPRGVGLAKXSSLSFMMLLQSVKSNACQHSSFL >In-frame_UCKL1_ENST00000358711_chr20_62587613_-_TXN_ENST00000374517_chr9_113013742_-_135aa MAAPPARADADPSPTSPPTARDTPGRQAEKSETACEDRLLFRKPWTLQVINLXXLTSQPRGVGLAKXSSLSFIPSLKSIPTXYSLKXMWM |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_UCKL1_ENST00000354216_chr20_62587613_-_TXN_ENST00000374515_chr9_113013742_-_347nt ATGGCTGCGCCCCCGGCCCGCGCGGACGCTGATCCTTCGCCCACGTCGCCACCTACGGCCCGAGACACACCAGGCCGGCAGGCTGAGAAA AGCGAGACCGCGTGCGAGGACCGACTGCTTTTCAGGAAGCCTTGGACGCTGCAGGTGATAAACTTGTAGTAGTTGACTTCTCAGCCACGT GGTGTGGGCCTTGCAAAATGATCAAGCCTTTCTTTCATGATGTTGCTTCAGAGTGTGAAGTCAAATGCATGCCAACATTCCAGTTTTTTA >In-frame_UCKL1_ENST00000354216_chr20_62587613_-_TXN_ENST00000374517_chr9_113013742_-_407nt ATGGCTGCGCCCCCGGCCCGCGCGGACGCTGATCCTTCGCCCACGTCGCCACCTACGGCCCGAGACACACCAGGCCGGCAGGCTGAGAAA AGCGAGACCGCGTGCGAGGACCGACTGCTTTTCAGGAAGCCTTGGACGCTGCAGGTGATAAACTTGTAGTAGTTGACTTCTCAGCCACGT GGTGTGGGCCTTGCAAAATGATCAAGCCTTTCTTTCATTCCCTCTCTGAAAAGTATTCCAACGTGATATTCCTTGAAGTAGATGTGGATG ACTGTCAGGATGTTGCTTCAGAGTGTGAAGTCAAATGCATGCCAACATTCCAGTTTTTTAAGAAGGGACAAAAGGTGGGTGAATTTTCTG >In-frame_UCKL1_ENST00000369892_chr20_62587613_-_TXN_ENST00000374515_chr9_113013742_-_347nt ATGGCTGCGCCCCCGGCCCGCGCGGACGCTGATCCTTCGCCCACGTCGCCACCTACGGCCCGAGACACACCAGGCCGGCAGGCTGAGAAA AGCGAGACCGCGTGCGAGGACCGACTGCTTTTCAGGAAGCCTTGGACGCTGCAGGTGATAAACTTGTAGTAGTTGACTTCTCAGCCACGT GGTGTGGGCCTTGCAAAATGATCAAGCCTTTCTTTCATGATGTTGCTTCAGAGTGTGAAGTCAAATGCATGCCAACATTCCAGTTTTTTA >In-frame_UCKL1_ENST00000369892_chr20_62587613_-_TXN_ENST00000374517_chr9_113013742_-_407nt ATGGCTGCGCCCCCGGCCCGCGCGGACGCTGATCCTTCGCCCACGTCGCCACCTACGGCCCGAGACACACCAGGCCGGCAGGCTGAGAAA AGCGAGACCGCGTGCGAGGACCGACTGCTTTTCAGGAAGCCTTGGACGCTGCAGGTGATAAACTTGTAGTAGTTGACTTCTCAGCCACGT GGTGTGGGCCTTGCAAAATGATCAAGCCTTTCTTTCATTCCCTCTCTGAAAAGTATTCCAACGTGATATTCCTTGAAGTAGATGTGGATG ACTGTCAGGATGTTGCTTCAGAGTGTGAAGTCAAATGCATGCCAACATTCCAGTTTTTTAAGAAGGGACAAAAGGTGGGTGAATTTTCTG >In-frame_UCKL1_ENST00000358711_chr20_62587613_-_TXN_ENST00000374515_chr9_113013742_-_347nt ATGGCTGCGCCCCCGGCCCGCGCGGACGCTGATCCTTCGCCCACGTCGCCACCTACGGCCCGAGACACACCAGGCCGGCAGGCTGAGAAA AGCGAGACCGCGTGCGAGGACCGACTGCTTTTCAGGAAGCCTTGGACGCTGCAGGTGATAAACTTGTAGTAGTTGACTTCTCAGCCACGT GGTGTGGGCCTTGCAAAATGATCAAGCCTTTCTTTCATGATGTTGCTTCAGAGTGTGAAGTCAAATGCATGCCAACATTCCAGTTTTTTA >In-frame_UCKL1_ENST00000358711_chr20_62587613_-_TXN_ENST00000374517_chr9_113013742_-_407nt ATGGCTGCGCCCCCGGCCCGCGCGGACGCTGATCCTTCGCCCACGTCGCCACCTACGGCCCGAGACACACCAGGCCGGCAGGCTGAGAAA AGCGAGACCGCGTGCGAGGACCGACTGCTTTTCAGGAAGCCTTGGACGCTGCAGGTGATAAACTTGTAGTAGTTGACTTCTCAGCCACGT GGTGTGGGCCTTGCAAAATGATCAAGCCTTTCTTTCATTCCCTCTCTGAAAAGTATTCCAACGTGATATTCCTTGAAGTAGATGTGGATG ACTGTCAGGATGTTGCTTCAGAGTGTGAAGTCAAATGCATGCCAACATTCCAGTTTTTTAAGAAGGGACAAAAGGTGGGTGAATTTTCTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_UCKL1_ENST00000354216_chr20_62587613_-_TXN_ENST00000374515_chr9_113013742_-_736nt TGCGCGCCGCCCGGCCAGGCCCGCAAAGAGGCCTCCGAGCGCCATGGCTGCGCCCCCGGCCCGCGCGGACGCTGATCCTTCGCCCACGTC GCCACCTACGGCCCGAGACACACCAGGCCGGCAGGCTGAGAAAAGCGAGACCGCGTGCGAGGACCGACTGCTTTTCAGGAAGCCTTGGAC GCTGCAGGTGATAAACTTGTAGTAGTTGACTTCTCAGCCACGTGGTGTGGGCCTTGCAAAATGATCAAGCCTTTCTTTCATGATGTTGCT TCAGAGTGTGAAGTCAAATGCATGCCAACATTCCAGTTTTTTAAGAAGGGACAAAAGGTGGGTGAATTTTCTGGAGCCAATAAGGAAAAG CTTGAAGCCACCATTAATGAATTAGTCTAATCATGTTTTCTGAAAATATAACCAGCCATTGGCTATTTAAAACTTGTAATTTTTTTAATT TACAAAAATATAAAATATGAAGACATAAACCCAGTTGCCATCTGCGTGACAATAAAACATTAATGCTAACACTTTTTAAAACCGTCTCAT GTCTGAATAGCTTTCAAAATAAATGTGAAATGGTCATTTAATGTATTTTCCTATATTCTCAATCACTTTTTAGTAACCTTGTAGGCCACT GATTATTTTAAGATTTTAAAAATTATTATTGCTACCTTAATGTATTGCTACAAAAATCTCTTGTTGGGGGCAATGCAGGTAATAAAGTAG >In-frame_UCKL1_ENST00000354216_chr20_62587613_-_TXN_ENST00000374517_chr9_113013742_-_796nt TGCGCGCCGCCCGGCCAGGCCCGCAAAGAGGCCTCCGAGCGCCATGGCTGCGCCCCCGGCCCGCGCGGACGCTGATCCTTCGCCCACGTC GCCACCTACGGCCCGAGACACACCAGGCCGGCAGGCTGAGAAAAGCGAGACCGCGTGCGAGGACCGACTGCTTTTCAGGAAGCCTTGGAC GCTGCAGGTGATAAACTTGTAGTAGTTGACTTCTCAGCCACGTGGTGTGGGCCTTGCAAAATGATCAAGCCTTTCTTTCATTCCCTCTCT GAAAAGTATTCCAACGTGATATTCCTTGAAGTAGATGTGGATGACTGTCAGGATGTTGCTTCAGAGTGTGAAGTCAAATGCATGCCAACA TTCCAGTTTTTTAAGAAGGGACAAAAGGTGGGTGAATTTTCTGGAGCCAATAAGGAAAAGCTTGAAGCCACCATTAATGAATTAGTCTAA TCATGTTTTCTGAAAATATAACCAGCCATTGGCTATTTAAAACTTGTAATTTTTTTAATTTACAAAAATATAAAATATGAAGACATAAAC CCAGTTGCCATCTGCGTGACAATAAAACATTAATGCTAACACTTTTTAAAACCGTCTCATGTCTGAATAGCTTTCAAAATAAATGTGAAA TGGTCATTTAATGTATTTTCCTATATTCTCAATCACTTTTTAGTAACCTTGTAGGCCACTGATTATTTTAAGATTTTAAAAATTATTATT >In-frame_UCKL1_ENST00000369892_chr20_62587613_-_TXN_ENST00000374515_chr9_113013742_-_737nt ATGCGCGCCGCCCGGCCAGGCCCGCAAAGAGGCCTCCGAGCGCCATGGCTGCGCCCCCGGCCCGCGCGGACGCTGATCCTTCGCCCACGT CGCCACCTACGGCCCGAGACACACCAGGCCGGCAGGCTGAGAAAAGCGAGACCGCGTGCGAGGACCGACTGCTTTTCAGGAAGCCTTGGA CGCTGCAGGTGATAAACTTGTAGTAGTTGACTTCTCAGCCACGTGGTGTGGGCCTTGCAAAATGATCAAGCCTTTCTTTCATGATGTTGC TTCAGAGTGTGAAGTCAAATGCATGCCAACATTCCAGTTTTTTAAGAAGGGACAAAAGGTGGGTGAATTTTCTGGAGCCAATAAGGAAAA GCTTGAAGCCACCATTAATGAATTAGTCTAATCATGTTTTCTGAAAATATAACCAGCCATTGGCTATTTAAAACTTGTAATTTTTTTAAT TTACAAAAATATAAAATATGAAGACATAAACCCAGTTGCCATCTGCGTGACAATAAAACATTAATGCTAACACTTTTTAAAACCGTCTCA TGTCTGAATAGCTTTCAAAATAAATGTGAAATGGTCATTTAATGTATTTTCCTATATTCTCAATCACTTTTTAGTAACCTTGTAGGCCAC TGATTATTTTAAGATTTTAAAAATTATTATTGCTACCTTAATGTATTGCTACAAAAATCTCTTGTTGGGGGCAATGCAGGTAATAAAGTA >In-frame_UCKL1_ENST00000369892_chr20_62587613_-_TXN_ENST00000374517_chr9_113013742_-_797nt ATGCGCGCCGCCCGGCCAGGCCCGCAAAGAGGCCTCCGAGCGCCATGGCTGCGCCCCCGGCCCGCGCGGACGCTGATCCTTCGCCCACGT CGCCACCTACGGCCCGAGACACACCAGGCCGGCAGGCTGAGAAAAGCGAGACCGCGTGCGAGGACCGACTGCTTTTCAGGAAGCCTTGGA CGCTGCAGGTGATAAACTTGTAGTAGTTGACTTCTCAGCCACGTGGTGTGGGCCTTGCAAAATGATCAAGCCTTTCTTTCATTCCCTCTC TGAAAAGTATTCCAACGTGATATTCCTTGAAGTAGATGTGGATGACTGTCAGGATGTTGCTTCAGAGTGTGAAGTCAAATGCATGCCAAC ATTCCAGTTTTTTAAGAAGGGACAAAAGGTGGGTGAATTTTCTGGAGCCAATAAGGAAAAGCTTGAAGCCACCATTAATGAATTAGTCTA ATCATGTTTTCTGAAAATATAACCAGCCATTGGCTATTTAAAACTTGTAATTTTTTTAATTTACAAAAATATAAAATATGAAGACATAAA CCCAGTTGCCATCTGCGTGACAATAAAACATTAATGCTAACACTTTTTAAAACCGTCTCATGTCTGAATAGCTTTCAAAATAAATGTGAA ATGGTCATTTAATGTATTTTCCTATATTCTCAATCACTTTTTAGTAACCTTGTAGGCCACTGATTATTTTAAGATTTTAAAAATTATTAT >In-frame_UCKL1_ENST00000358711_chr20_62587613_-_TXN_ENST00000374515_chr9_113013742_-_737nt ATGCGCGCCGCCCGGCCAGGCCCGCAAAGAGGCCTCCGAGCGCCATGGCTGCGCCCCCGGCCCGCGCGGACGCTGATCCTTCGCCCACGT CGCCACCTACGGCCCGAGACACACCAGGCCGGCAGGCTGAGAAAAGCGAGACCGCGTGCGAGGACCGACTGCTTTTCAGGAAGCCTTGGA CGCTGCAGGTGATAAACTTGTAGTAGTTGACTTCTCAGCCACGTGGTGTGGGCCTTGCAAAATGATCAAGCCTTTCTTTCATGATGTTGC TTCAGAGTGTGAAGTCAAATGCATGCCAACATTCCAGTTTTTTAAGAAGGGACAAAAGGTGGGTGAATTTTCTGGAGCCAATAAGGAAAA GCTTGAAGCCACCATTAATGAATTAGTCTAATCATGTTTTCTGAAAATATAACCAGCCATTGGCTATTTAAAACTTGTAATTTTTTTAAT TTACAAAAATATAAAATATGAAGACATAAACCCAGTTGCCATCTGCGTGACAATAAAACATTAATGCTAACACTTTTTAAAACCGTCTCA TGTCTGAATAGCTTTCAAAATAAATGTGAAATGGTCATTTAATGTATTTTCCTATATTCTCAATCACTTTTTAGTAACCTTGTAGGCCAC TGATTATTTTAAGATTTTAAAAATTATTATTGCTACCTTAATGTATTGCTACAAAAATCTCTTGTTGGGGGCAATGCAGGTAATAAAGTA >In-frame_UCKL1_ENST00000358711_chr20_62587613_-_TXN_ENST00000374517_chr9_113013742_-_797nt ATGCGCGCCGCCCGGCCAGGCCCGCAAAGAGGCCTCCGAGCGCCATGGCTGCGCCCCCGGCCCGCGCGGACGCTGATCCTTCGCCCACGT CGCCACCTACGGCCCGAGACACACCAGGCCGGCAGGCTGAGAAAAGCGAGACCGCGTGCGAGGACCGACTGCTTTTCAGGAAGCCTTGGA CGCTGCAGGTGATAAACTTGTAGTAGTTGACTTCTCAGCCACGTGGTGTGGGCCTTGCAAAATGATCAAGCCTTTCTTTCATTCCCTCTC TGAAAAGTATTCCAACGTGATATTCCTTGAAGTAGATGTGGATGACTGTCAGGATGTTGCTTCAGAGTGTGAAGTCAAATGCATGCCAAC ATTCCAGTTTTTTAAGAAGGGACAAAAGGTGGGTGAATTTTCTGGAGCCAATAAGGAAAAGCTTGAAGCCACCATTAATGAATTAGTCTA ATCATGTTTTCTGAAAATATAACCAGCCATTGGCTATTTAAAACTTGTAATTTTTTTAATTTACAAAAATATAAAATATGAAGACATAAA CCCAGTTGCCATCTGCGTGACAATAAAACATTAATGCTAACACTTTTTAAAACCGTCTCATGTCTGAATAGCTTTCAAAATAAATGTGAA ATGGTCATTTAATGTATTTTCCTATATTCTCAATCACTTTTTAGTAACCTTGTAGGCCACTGATTATTTTAAGATTTTAAAAATTATTAT |
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FusionGenePPI for UCKL1_TXN |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| UCKL1 | CIAO1, UPRT, MPPED1, SKAP1, KAT5, BCS1L, UCK2, KLHL2, LAMP3, VWA5A, IL13RA2, CD70 | TXN | COL1A1, NCF4, PINX1, VHL, CD40, GAPDH, NR3C1, FST, VIM, TXNIP, MAP3K5, NFKB1, TP53, UCHL5, CUL4B, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, PTPN6, WDR1, UBQLN4, AHCYL1, UBE2V1, SSSCA1, ATP6V1F, SFPQ, SFXN1, UBL5, UBE2D2, SYNCRIP, ATIC, UBE2K, TAX1BP3, PRDX1, MYC, IFIT3, UBL4A, PAN2, NPM1, MYD88, GPRASP2, DYNLT1, CDKN1A, MLH1, NFE2, SIAH1, ACTN4, PARK2, APEX1, SRP9, GPX1, UNK, NTRK1, AKR7A2, ARHGDIA, CCS, EEF2, EIF4EBP2, GLOD4, GSTO1, HINT1, HSPE1, IMPA2, PDCD6, PRDX2, RAB1A, SOD1, STIP1, TAGLN2, TAGLN3, ASS1, C4orf27, ENO1, ENO2, ENO3, FKBP1A, FKBP2, GLRX5, GSTO2, HSPA5, IMPA1, LGALS3, MAP2K2, PGAM1, PGAM2, PSMD14, RAE1, TMX1, TXN2, TYMS, REV3L, PTEN, EWSR1, SRPK2, GEMIN5, TOR1AIP1, EGFR, CRY1, MCM2, OTUB1, PCGF1, DPPA4, NANOG, POU5F1, CRBN, DUSP13, CDK1, COQ2, COX15, DLD, DNM1L, PARK7, SOAT1, VDAC1, G3BP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UCKL1_TXN |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UCKL1_TXN |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | TXN | C0006287 | Bronchopulmonary Dysplasia | 1 | CTD_human |
| Tgene | TXN | C0011616 | Contact Dermatitis | 1 | CTD_human |
| Tgene | TXN | C0023895 | Liver diseases | 1 | CTD_human |
| Tgene | TXN | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Tgene | TXN | C0242488 | Acute Lung Injury | 1 | CTD_human |
| Tgene | TXN | C0345967 | Malignant mesothelioma | 1 | CTD_human |
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