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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40665

FusionGeneSummary for UCK2_MRPL9

check button Fusion gene summary
Fusion gene informationFusion gene name: UCK2_MRPL9
Fusion gene ID: 40665
HgeneTgene
Gene symbol

UCK2

MRPL9

Gene ID

7371

65005

Gene nameuridine-cytidine kinase 2mitochondrial ribosomal protein L9
SynonymsTSA903|UK|UMPKL9mt
Cytomap

1q24.1

1q21.3

Type of geneprotein-codingprotein-coding
Descriptionuridine-cytidine kinase 2cytidine monophosphokinase 2testis-specific protein TSA903uridine kinaseuridine monophosphate kinaseuridine monophosphokinase 239S ribosomal protein L9, mitochondrialmitochondrial large ribosomal subunit protein bL9m
Modification date2018052520180523
UniProtAcc

Q9BZX2

Q9BYD2

Ensembl transtripts involved in fusion geneENST00000367879, ENST00000372212, 
ENST00000462329, ENST00000469256, 
ENST00000470820, 		ENST00000368830, 
ENST00000467306, ENST00000368829, 
Fusion gene scores* DoF score11 X 5 X 7=3854 X 4 X 2=32
# samples 124
** MAII scorelog2(12/385*10)=-1.68182403997375
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: UCK2 [Title/Abstract] AND MRPL9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-GU-A764-01AUCK2chr1

165797169

+MRPL9chr1

151734976

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000367879ENST00000368830UCK2chr1

165797169

+MRPL9chr1

151734976

-
5CDS-5UTRENST00000367879ENST00000467306UCK2chr1

165797169

+MRPL9chr1

151734976

-
5CDS-5UTRENST00000367879ENST00000368829UCK2chr1

165797169

+MRPL9chr1

151734976

-
Frame-shiftENST00000372212ENST00000368830UCK2chr1

165797169

+MRPL9chr1

151734976

-
5CDS-5UTRENST00000372212ENST00000467306UCK2chr1

165797169

+MRPL9chr1

151734976

-
5CDS-5UTRENST00000372212ENST00000368829UCK2chr1

165797169

+MRPL9chr1

151734976

-
intron-3CDSENST00000462329ENST00000368830UCK2chr1

165797169

+MRPL9chr1

151734976

-
intron-5UTRENST00000462329ENST00000467306UCK2chr1

165797169

+MRPL9chr1

151734976

-
intron-5UTRENST00000462329ENST00000368829UCK2chr1

165797169

+MRPL9chr1

151734976

-
intron-3CDSENST00000469256ENST00000368830UCK2chr1

165797169

+MRPL9chr1

151734976

-
intron-5UTRENST00000469256ENST00000467306UCK2chr1

165797169

+MRPL9chr1

151734976

-
intron-5UTRENST00000469256ENST00000368829UCK2chr1

165797169

+MRPL9chr1

151734976

-
intron-3CDSENST00000470820ENST00000368830UCK2chr1

165797169

+MRPL9chr1

151734976

-
intron-5UTRENST00000470820ENST00000467306UCK2chr1

165797169

+MRPL9chr1

151734976

-
intron-5UTRENST00000470820ENST00000368829UCK2chr1

165797169

+MRPL9chr1

151734976

-

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FusionProtFeatures for UCK2_MRPL9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UCK2

Q9BZX2

MRPL9

Q9BYD2

Phosphorylates uridine and cytidine to uridinemonophosphate and cytidine monophosphate. Does not phosphorylatedeoxyribonucleosides or purine ribonucleosides. Can use ATP or GTPas a phosphate donor. Can also phosphorylate cytidine and uridinenucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UCK2_MRPL9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UCK2_MRPL9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UCK2UBC, UPP1, FBXO6, EGFR, CCDC8, UPRT, UCK1, UCKL1, IAH1, VARS2, RMND5B, DLD, TRIM25MRPL9ICT1, CAND1, MRPL15, MRPL37, MRPL3, MRPL44, MRPL39, MRPL38, MRPL19, MRPL2, MRPL45, MRPL40, MRPL55, MRPL11, MRPL13, MRPL32, MRPL23, MRPL12, MRPL28, TMEM177, ILF3, DDX28, SLC25A3, PLP2, EIF4H, SAT1, SOX2, FAM9B, EGFR, RPL13, ZNF22, RBMS3, RPL6, ZC3H3, RPS8, MRPL4, HNRNPA1, MRPS30, MRPL47, GAA, MRPL17, MRPL18, MRPL46, MRPL48, DLD, GANAB, MRPL24, NSF, SCFD1, PLBD2, MRPL49, SLC25A10, EIF4G1, JUP, TK2, MRPL33, MRPL42, MRPL22, ITSN2, MRPL51, MRPL30, MRPL27, MRPL35, MRPL50, MRPL16, MRPL20, MRPS18A, NLN, MRPL14, MRPL41, MRPL34, MRPL1, THAP9, MRPL43, MICALL1, GADD45GIP1, MRPL53, MRPL54, MRPL52, MRPL10, TMEM92, MRPL21, NANOG, POU5F1, C6orf203


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UCK2_MRPL9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneUCK2Q9BZX2DB04272Citric AcidUridine-cytidine kinase 2small moleculeapproved|nutraceutical|vet_approved

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RelatedDiseases for UCK2_MRPL9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUCK2C0033578Prostatic Neoplasms1CTD_human
TgeneMRPL9C1458155Mammary Neoplasms1CTD_human