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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40652

FusionGeneSummary for UBXN7_UBXN7

check button Fusion gene summary
Fusion gene informationFusion gene name: UBXN7_UBXN7
Fusion gene ID: 40652
HgeneTgene
Gene symbol

UBXN7

UBXN7

Gene ID

26043

26043

Gene nameUBX domain protein 7UBX domain protein 7
SynonymsUBXD7UBXD7
Cytomap

3q29

3q29

Type of geneprotein-codingprotein-coding
DescriptionUBX domain-containing protein 7UBX domain containing 7UBX domain-containing protein 7UBX domain containing 7
Modification date2018051920180519
UniProtAcc

O94888

O94888

Ensembl transtripts involved in fusion geneENST00000296328, ENST00000428095, 
ENST00000535858, 
ENST00000296328, 
ENST00000428095, ENST00000535858, 
Fusion gene scores* DoF score3 X 3 X 2=183 X 3 X 1=9
# samples 33
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: UBXN7 [Title/Abstract] AND UBXN7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE813748UBXN7chr3

196089181

+UBXN7chr3

196083331

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000296328ENST00000296328UBXN7chr3

196089181

+UBXN7chr3

196083331

-
intron-intronENST00000296328ENST00000428095UBXN7chr3

196089181

+UBXN7chr3

196083331

-
intron-intronENST00000296328ENST00000535858UBXN7chr3

196089181

+UBXN7chr3

196083331

-
intron-3UTRENST00000428095ENST00000296328UBXN7chr3

196089181

+UBXN7chr3

196083331

-
intron-intronENST00000428095ENST00000428095UBXN7chr3

196089181

+UBXN7chr3

196083331

-
intron-intronENST00000428095ENST00000535858UBXN7chr3

196089181

+UBXN7chr3

196083331

-
intron-3UTRENST00000535858ENST00000296328UBXN7chr3

196089181

+UBXN7chr3

196083331

-
intron-intronENST00000535858ENST00000428095UBXN7chr3

196089181

+UBXN7chr3

196083331

-
intron-intronENST00000535858ENST00000535858UBXN7chr3

196089181

+UBXN7chr3

196083331

-

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FusionProtFeatures for UBXN7_UBXN7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBXN7

O94888

UBXN7

O94888

Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, toregulate turnover of their ubiquitination substrates.{ECO:0000269|PubMed:22537386}. Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, toregulate turnover of their ubiquitination substrates.{ECO:0000269|PubMed:22537386}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBXN7_UBXN7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBXN7_UBXN7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBXN7_UBXN7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBXN7_UBXN7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource