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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40631

FusionGeneSummary for UBTF_PYY

check button Fusion gene summary
Fusion gene informationFusion gene name: UBTF_PYY
Fusion gene ID: 40631
HgeneTgene
Gene symbol

UBTF

PYY

Gene ID

7343

5697

Gene nameupstream binding transcription factorpeptide YY
SynonymsCONDBA|NOR-90|UBF|UBF-1|UBF1|UBF2PYY-I|PYY1
Cytomap

17q21.31

17q21.31

Type of geneprotein-codingprotein-coding
Descriptionnucleolar transcription factor 190-kDa nucleolus organizer region autoantigenautoantigen NOR-90upstream binding transcription factor, RNA polymerase Ipeptide YYpeptide tyrosine tyrosineprepro-PYY
Modification date2018052220180523
UniProtAcc

P17480

P10082

Ensembl transtripts involved in fusion geneENST00000343638, ENST00000302904, 
ENST00000527034, ENST00000533177, 
ENST00000436088, ENST00000393606, 
ENST00000529383, ENST00000526094, 
ENST00000537550, 
ENST00000360085, 
ENST00000592796, 
Fusion gene scores* DoF score9 X 10 X 6=5403 X 1 X 2=6
# samples 183
** MAII scorelog2(18/540*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/6*10)=2.32192809488736
Context

PubMed: UBTF [Title/Abstract] AND PYY [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBTF

GO:1902659

regulation of glucose mediated signaling pathway

22368283


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-VQ-A928-01AUBTFchr17

42295540

-PYYchr17

42043900

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000343638ENST00000360085UBTFchr17

42295540

-PYYchr17

42043900

-
5CDS-intronENST00000343638ENST00000592796UBTFchr17

42295540

-PYYchr17

42043900

-
5CDS-5UTRENST00000302904ENST00000360085UBTFchr17

42295540

-PYYchr17

42043900

-
5CDS-intronENST00000302904ENST00000592796UBTFchr17

42295540

-PYYchr17

42043900

-
5CDS-5UTRENST00000527034ENST00000360085UBTFchr17

42295540

-PYYchr17

42043900

-
5CDS-intronENST00000527034ENST00000592796UBTFchr17

42295540

-PYYchr17

42043900

-
5CDS-5UTRENST00000533177ENST00000360085UBTFchr17

42295540

-PYYchr17

42043900

-
5CDS-intronENST00000533177ENST00000592796UBTFchr17

42295540

-PYYchr17

42043900

-
5CDS-5UTRENST00000436088ENST00000360085UBTFchr17

42295540

-PYYchr17

42043900

-
5CDS-intronENST00000436088ENST00000592796UBTFchr17

42295540

-PYYchr17

42043900

-
5CDS-5UTRENST00000393606ENST00000360085UBTFchr17

42295540

-PYYchr17

42043900

-
5CDS-intronENST00000393606ENST00000592796UBTFchr17

42295540

-PYYchr17

42043900

-
5CDS-5UTRENST00000529383ENST00000360085UBTFchr17

42295540

-PYYchr17

42043900

-
5CDS-intronENST00000529383ENST00000592796UBTFchr17

42295540

-PYYchr17

42043900

-
5CDS-5UTRENST00000526094ENST00000360085UBTFchr17

42295540

-PYYchr17

42043900

-
5CDS-intronENST00000526094ENST00000592796UBTFchr17

42295540

-PYYchr17

42043900

-
5UTR-5UTRENST00000537550ENST00000360085UBTFchr17

42295540

-PYYchr17

42043900

-
5UTR-intronENST00000537550ENST00000592796UBTFchr17

42295540

-PYYchr17

42043900

-

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FusionProtFeatures for UBTF_PYY


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBTF

P17480

PYY

P10082

Recognizes the ribosomal RNA gene promoter and activatestranscription mediated by RNA polymerase I through cooperativeinteractions with the transcription factor SL1/TIF-IB complex. Itbinds specifically to the upstream control element.{ECO:0000269|PubMed:28777933, ECO:0000269|PubMed:7982918}. This gut peptide inhibits exocrine pancreatic secretion,has a vasoconstrictory action and inhibitis jejunal and colonicmobility.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBTF_PYY


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBTF_PYY


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UBTFTAF1, POLR1E, LEF1, CSNK2A1, TBP, TAF1C, CD3EAP, RRN3, RB1, TAF1A, TAF1B, CENPC, IRS1, IRS2, ZMYM2, ACTN4, TLE1, SIRT7, MCRS1, TAF1D, PIK3CA, MAPK1, MAPK3, CHD4, POLR1A, MYBBP1A, SMARCA5, KAT5, HDAC1, RUNX2, GRK5, WDR70, YEATS4, CDK4, CCND1, CDK2, CCNE1, ESR1, KAT2B, CUL7, OBSL1, RNF2, VTI1B, CTDSP2, EDA, PTGER3, AP3M1, RTF1, NTRK1, KRAS, IFI16, EWSR1, MDM2, AHSA1, DAXX, HNRNPU, RPL10, TMPO, VIM, NOP56, CNOT1, MPHOSPH8, KCNA3, SENP3, AURKA, BRCA1, CDC14B, PIP4K2A, CAMKV, RAP1GDS1, PES1, MDK, CPNE7, C11orf57, HIST1H1E, RSBN1, KNOP1, SHPRH, FOXA1, TRIM25, LMNAPYYMEP1B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBTF_PYY


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBTF_PYY


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePYYC0011570Mental Depression2PSYGENET
TgenePYYC0011581Depressive disorder2PSYGENET
TgenePYYC0002395Alzheimer's Disease1CTD_human
TgenePYYC0003123Anorexia1CTD_human
TgenePYYC0011991Diarrhea1CTD_human
TgenePYYC0027794Neural Tube Defects1CTD_human
TgenePYYC0028754Obesity1CTD_human