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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40628

FusionGeneSummary for UBTF_FOXP1

check button Fusion gene summary
Fusion gene informationFusion gene name: UBTF_FOXP1
Fusion gene ID: 40628
HgeneTgene
Gene symbol

UBTF

FOXP1

Gene ID

7343

27086

Gene nameupstream binding transcription factorforkhead box P1
SynonymsCONDBA|NOR-90|UBF|UBF-1|UBF1|UBF212CC4|HSPC215|MFH|QRF1|hFKH1B
Cytomap

17q21.31

3p13

Type of geneprotein-codingprotein-coding
Descriptionnucleolar transcription factor 190-kDa nucleolus organizer region autoantigenautoantigen NOR-90upstream binding transcription factor, RNA polymerase Iforkhead box protein P1fork head-related protein like Bglutamine-rich factor 1mac-1-regulated forkhead
Modification date2018052220180522
UniProtAcc

P17480

Q9H334

Ensembl transtripts involved in fusion geneENST00000343638, ENST00000302904, 
ENST00000527034, ENST00000533177, 
ENST00000436088, ENST00000393606, 
ENST00000529383, ENST00000526094, 
ENST00000537550, 
ENST00000318789, 
ENST00000475937, ENST00000493089, 
ENST00000484350, ENST00000318779, 
ENST00000491238, ENST00000498215, 
ENST00000468577, ENST00000472382, 
Fusion gene scores* DoF score9 X 10 X 6=54037 X 16 X 17=10064
# samples 1840
** MAII scorelog2(18/540*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(40/10064*10)=-4.65306001710456
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UBTF [Title/Abstract] AND FOXP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBTF

GO:1902659

regulation of glucose mediated signaling pathway

22368283

TgeneFOXP1

GO:0002903

negative regulation of B cell apoptotic process

25267198

TgeneFOXP1

GO:0030316

osteoclast differentiation

18799727

TgeneFOXP1

GO:0032496

response to lipopolysaccharide

18799727

TgeneFOXP1

GO:0032680

regulation of tumor necrosis factor production

18799727

TgeneFOXP1

GO:0035926

chemokine (C-C motif) ligand 2 secretion

18799727

TgeneFOXP1

GO:0036035

osteoclast development

18799727

TgeneFOXP1

GO:0042116

macrophage activation

18799727

TgeneFOXP1

GO:0042117

monocyte activation

18799727

TgeneFOXP1

GO:0045655

regulation of monocyte differentiation

15286807

TgeneFOXP1

GO:0045892

negative regulation of transcription, DNA-templated

20950788

TgeneFOXP1

GO:0050706

regulation of interleukin-1 beta secretion

18799727

TgeneFOXP1

GO:0050727

regulation of inflammatory response

18799727

TgeneFOXP1

GO:0060766

negative regulation of androgen receptor signaling pathway

18640093

TgeneFOXP1

GO:1900424

regulation of defense response to bacterium

18799727

TgeneFOXP1

GO:1901256

regulation of macrophage colony-stimulating factor production

18799727

TgeneFOXP1

GO:2001182

regulation of interleukin-12 secretion

18799727


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A48P-01AUBTFchr17

42283962

-FOXP1chr3

71007472

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000343638ENST00000318789UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-3UTRENST00000343638ENST00000475937UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000343638ENST00000493089UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000343638ENST00000484350UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000343638ENST00000318779UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000343638ENST00000491238UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000343638ENST00000498215UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000343638ENST00000468577UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000343638ENST00000472382UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-3UTRENST00000302904ENST00000318789UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-3UTRENST00000302904ENST00000475937UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000302904ENST00000493089UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000302904ENST00000484350UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000302904ENST00000318779UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000302904ENST00000491238UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000302904ENST00000498215UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000302904ENST00000468577UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000302904ENST00000472382UBTFchr17

42283962

-FOXP1chr3

71007472

-
5CDS-3UTRENST00000527034ENST00000318789UBTFchr17

42283962

-FOXP1chr3

71007472

-
5CDS-3UTRENST00000527034ENST00000475937UBTFchr17

42283962

-FOXP1chr3

71007472

-
5CDS-intronENST00000527034ENST00000493089UBTFchr17

42283962

-FOXP1chr3

71007472

-
5CDS-intronENST00000527034ENST00000484350UBTFchr17

42283962

-FOXP1chr3

71007472

-
5CDS-intronENST00000527034ENST00000318779UBTFchr17

42283962

-FOXP1chr3

71007472

-
5CDS-intronENST00000527034ENST00000491238UBTFchr17

42283962

-FOXP1chr3

71007472

-
5CDS-intronENST00000527034ENST00000498215UBTFchr17

42283962

-FOXP1chr3

71007472

-
5CDS-intronENST00000527034ENST00000468577UBTFchr17

42283962

-FOXP1chr3

71007472

-
5CDS-intronENST00000527034ENST00000472382UBTFchr17

42283962

-FOXP1chr3

71007472

-
5CDS-3UTRENST00000533177ENST00000318789UBTFchr17

42283962

-FOXP1chr3

71007472

-
5CDS-3UTRENST00000533177ENST00000475937UBTFchr17

42283962

-FOXP1chr3

71007472

-
5CDS-intronENST00000533177ENST00000493089UBTFchr17

42283962

-FOXP1chr3

71007472

-
5CDS-intronENST00000533177ENST00000484350UBTFchr17

42283962

-FOXP1chr3

71007472

-
5CDS-intronENST00000533177ENST00000318779UBTFchr17

42283962

-FOXP1chr3

71007472

-
5CDS-intronENST00000533177ENST00000491238UBTFchr17

42283962

-FOXP1chr3

71007472

-
5CDS-intronENST00000533177ENST00000498215UBTFchr17

42283962

-FOXP1chr3

71007472

-
5CDS-intronENST00000533177ENST00000468577UBTFchr17

42283962

-FOXP1chr3

71007472

-
5CDS-intronENST00000533177ENST00000472382UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-3UTRENST00000436088ENST00000318789UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-3UTRENST00000436088ENST00000475937UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000436088ENST00000493089UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000436088ENST00000484350UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000436088ENST00000318779UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000436088ENST00000491238UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000436088ENST00000498215UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000436088ENST00000468577UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000436088ENST00000472382UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-3UTRENST00000393606ENST00000318789UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-3UTRENST00000393606ENST00000475937UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000393606ENST00000493089UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000393606ENST00000484350UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000393606ENST00000318779UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000393606ENST00000491238UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000393606ENST00000498215UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000393606ENST00000468577UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000393606ENST00000472382UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-3UTRENST00000529383ENST00000318789UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-3UTRENST00000529383ENST00000475937UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000529383ENST00000493089UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000529383ENST00000484350UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000529383ENST00000318779UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000529383ENST00000491238UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000529383ENST00000498215UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000529383ENST00000468577UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000529383ENST00000472382UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-3UTRENST00000526094ENST00000318789UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-3UTRENST00000526094ENST00000475937UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000526094ENST00000493089UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000526094ENST00000484350UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000526094ENST00000318779UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000526094ENST00000491238UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000526094ENST00000498215UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000526094ENST00000468577UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000526094ENST00000472382UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-3UTRENST00000537550ENST00000318789UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-3UTRENST00000537550ENST00000475937UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000537550ENST00000493089UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000537550ENST00000484350UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000537550ENST00000318779UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000537550ENST00000491238UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000537550ENST00000498215UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000537550ENST00000468577UBTFchr17

42283962

-FOXP1chr3

71007472

-
intron-intronENST00000537550ENST00000472382UBTFchr17

42283962

-FOXP1chr3

71007472

-

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FusionProtFeatures for UBTF_FOXP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBTF

P17480

FOXP1

Q9H334

Recognizes the ribosomal RNA gene promoter and activatestranscription mediated by RNA polymerase I through cooperativeinteractions with the transcription factor SL1/TIF-IB complex. Itbinds specifically to the upstream control element.{ECO:0000269|PubMed:28777933, ECO:0000269|PubMed:7982918}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBTF_FOXP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBTF_FOXP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UBTFTAF1, POLR1E, LEF1, CSNK2A1, TBP, TAF1C, CD3EAP, RRN3, RB1, TAF1A, TAF1B, CENPC, IRS1, IRS2, ZMYM2, ACTN4, TLE1, SIRT7, MCRS1, TAF1D, PIK3CA, MAPK1, MAPK3, CHD4, POLR1A, MYBBP1A, SMARCA5, KAT5, HDAC1, RUNX2, GRK5, WDR70, YEATS4, CDK4, CCND1, CDK2, CCNE1, ESR1, KAT2B, CUL7, OBSL1, RNF2, VTI1B, CTDSP2, EDA, PTGER3, AP3M1, RTF1, NTRK1, KRAS, IFI16, EWSR1, MDM2, AHSA1, DAXX, HNRNPU, RPL10, TMPO, VIM, NOP56, CNOT1, MPHOSPH8, KCNA3, SENP3, AURKA, BRCA1, CDC14B, PIP4K2A, CAMKV, RAP1GDS1, PES1, MDK, CPNE7, C11orf57, HIST1H1E, RSBN1, KNOP1, SHPRH, FOXA1, TRIM25, LMNAFOXP1CTBP1, FOXP1, FOXP2, FOXP4, GATAD2B, MTA1, NCOR2, ELAVL1, MYC, IL3RA, CCDC183, UNK, RCC1, HOXD13, QSER1, SATB1, SATB2, CTBP2, MYH10, LIG3, C10orf2, CUX1, VRK3, XRCC1, CHD1L, RPA2, BLM, MRE11A, MYL12B, TBP, TP53, TTF2, ZBTB10, MYL9, RPA3, TFCP2, TOP2A, UBP1, FOXP3, AURKA, SNRNP70


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBTF_FOXP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBTF_FOXP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFOXP1C0024232Lymphatic Metastasis1CTD_human
TgeneFOXP1C0027626Neoplasm Invasiveness1CTD_human
TgeneFOXP1C0030297Pancreatic Neoplasm1CTD_human
TgeneFOXP1C0042900Vitiligo1CTD_human
TgeneFOXP1C0279628Adenocarcinoma Of Esophagus1CTD_human
TgeneFOXP1C1510586Autism Spectrum Disorders1CTD_human
TgeneFOXP1C3495559Juvenile arthritis1CTD_human
TgeneFOXP1C4013764MENTAL RETARDATION WITH LANGUAGE IMPAIRMENT AND WITH OR WITHOUT AUTISTIC FEATURES1CTD_human;ORPHANET;UNIPROT