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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40614

FusionGeneSummary for UBR5_SSTR5

check button Fusion gene summary
Fusion gene informationFusion gene name: UBR5_SSTR5
Fusion gene ID: 40614
HgeneTgene
Gene symbol

UBR5

SSTR5

Gene ID

51366

6755

Gene nameubiquitin protein ligase E3 component n-recognin 5somatostatin receptor 5
SynonymsDD5|EDD|EDD1|HYDSS-5-R
Cytomap

8q22.3

16p13.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase UBR5E3 identified by differential displayE3 ubiquitin-protein ligase, HECT domain-containing 1HECT-type E3 ubiquitin transferase UBR5hyperplastic discs protein homologprogestin-induced proteinsomatostatin receptor type 5somatostatin receptor subtype 5
Modification date2018052320180523
UniProtAcc

O95071

P35346

Ensembl transtripts involved in fusion geneENST00000520539, ENST00000220959, 
ENST00000518205, ENST00000521922, 
ENST00000519528, 
ENST00000397547, 
ENST00000293897, ENST00000562758, 
Fusion gene scores* DoF score12 X 9 X 7=7561 X 1 X 1=1
# samples 151
** MAII scorelog2(15/756*10)=-2.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: UBR5 [Title/Abstract] AND SSTR5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBR5

GO:0000209

protein polyubiquitination

21118991|28689657

HgeneUBR5

GO:0006974

cellular response to DNA damage stimulus

12011095

HgeneUBR5

GO:0010628

positive regulation of gene expression

18076571

HgeneUBR5

GO:0050847

progesterone receptor signaling pathway

12011095

HgeneUBR5

GO:0070936

protein K48-linked ubiquitination

28689657


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-D8-A27L-01AUBR5chr8

103424401

-SSTR5chr16

1128842

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000520539ENST00000397547UBR5chr8

103424401

-SSTR5chr16

1128842

+
5CDS-5UTRENST00000520539ENST00000293897UBR5chr8

103424401

-SSTR5chr16

1128842

+
5CDS-intronENST00000520539ENST00000562758UBR5chr8

103424401

-SSTR5chr16

1128842

+
5CDS-5UTRENST00000220959ENST00000397547UBR5chr8

103424401

-SSTR5chr16

1128842

+
5CDS-5UTRENST00000220959ENST00000293897UBR5chr8

103424401

-SSTR5chr16

1128842

+
5CDS-intronENST00000220959ENST00000562758UBR5chr8

103424401

-SSTR5chr16

1128842

+
intron-5UTRENST00000518205ENST00000397547UBR5chr8

103424401

-SSTR5chr16

1128842

+
intron-5UTRENST00000518205ENST00000293897UBR5chr8

103424401

-SSTR5chr16

1128842

+
intron-intronENST00000518205ENST00000562758UBR5chr8

103424401

-SSTR5chr16

1128842

+
5CDS-5UTRENST00000521922ENST00000397547UBR5chr8

103424401

-SSTR5chr16

1128842

+
5CDS-5UTRENST00000521922ENST00000293897UBR5chr8

103424401

-SSTR5chr16

1128842

+
5CDS-intronENST00000521922ENST00000562758UBR5chr8

103424401

-SSTR5chr16

1128842

+
intron-5UTRENST00000519528ENST00000397547UBR5chr8

103424401

-SSTR5chr16

1128842

+
intron-5UTRENST00000519528ENST00000293897UBR5chr8

103424401

-SSTR5chr16

1128842

+
intron-intronENST00000519528ENST00000562758UBR5chr8

103424401

-SSTR5chr16

1128842

+

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FusionProtFeatures for UBR5_SSTR5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBR5

O95071

SSTR5

P35346

E3 ubiquitin-protein ligase which is a component of theN-end rule pathway. Recognizes and binds to proteins bearingspecific N-terminal residues that are destabilizing according tothe N-end rule, leading to their ubiquitination and subsequentdegradation (By similarity). Involved in maturation and/ortranscriptional regulation of mRNA by activating CDK9 bypolyubiquitination. May play a role in control of cell cycleprogression. May have tumor suppressor function. Regulates DNAtopoisomerase II binding protein (TopBP1) in the DNA damageresponse. Plays an essential role in extraembryonic development.Ubiquitinates acetylated PCK1. Also acts as a regulator of DNAdamage response by acting as a suppressor of RNF168, an E3ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting asa guard against excessive spreading of ubiquitinated chromatin atdamaged chromosomes. {ECO:0000250, ECO:0000269|PubMed:21127351,ECO:0000269|PubMed:21726808, ECO:0000269|PubMed:22884692}. Receptor for somatostatin 28 and to a lesser extent forsomatostatin-14. The activity of this receptor is mediated by Gproteins which inhibit adenylyl cyclase. Increases cell growthinhibition activity of SSTR2 following heterodimerization.{ECO:0000269|PubMed:12072395, ECO:0000269|PubMed:7908405,ECO:0000269|PubMed:8078491, ECO:0000269|PubMed:8373420}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBR5_SSTR5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBR5_SSTR5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UBR5MCRS1, MAGED1, MAPK1, MAPK3, TOPBP1, KPNA1, PGR, CIB1, RECQL5, USP49, WDR48, TCEA1, GTF2E2, PMS2, PMS1, PAIP2, CEBPD, SATB1, TP53, SNW1, NCOA2, UBXN7, FAF2, UBXN1, DYRK2, DDB1, VPRBP, KATNA1, BUB1, GSK3B, CDK9, PCK1, VHL, ARRB2, SIRT7, TNRC6A, TXN2, PAIP1, GSPT1, GSPT2, TOB1, TOB2, IGBP1, UBC, CALM1, PABPC1, CUL3, UBR5, CHEK2, UBE2D2, UBE2D3, UTP15, WDR43, UBE2D1, MRPS18B, ATP6V1F, BARD1, VCP, TERT, RNF168, SMAD2, BIRC2, SOX2, HDAC11, ANKRD28, NR1I2, UBE2A, UBE2B, UBE2L3, SHFM1, SPRTN, AURKB, CDKN1A, CEP250, TUBG1, TUBGCP3, ATMIN, CCDC8, SIRT6, MRPL4, CALR3, MRS2, C1QBP, BUB3, XPNPEP3, BUB1B, CDC20, FBXW11, ACTR1A, EIF3I, GTF2F2, RANGAP1, SET, SRSF1, TPD52L1, CAD, EEF1A1, PSMC2, UQCRC2, NCOA1, XPO1, JAK3, KIF2A, XRCC3, NES, GEMIN5, DSN1, FOXB1, FOXG1, FOXJ2, NLRP3, CRY2, ZNF207, DPPA4, POU5F1, BAG6, GKN1, ATOH1, MOAP1, DPF3, RING1, RNF2, BMI1, UBAP2L, SUPT16H, SSRP1, SUB1, SUPT5H, NONO, APC, ZNF746, DUSP26, PDGFD, P4HA3, DDX28, F9, LYZL1, PRMT2, PRSS37, STX11, PPAN, HNRNPLL, POGLUT1, ERG, TRIM25, CEP78, CCP110, C2orf40SSTR5CORT, SSTR5, GOPC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBR5_SSTR5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSSTR5P35346DB06663PasireotideSomatostatin receptor type 5small moleculeapproved
TgeneSSTR5P35346DB06791LanreotideSomatostatin receptor type 5small moleculeapproved
TgeneSSTR5P35346DB00104OctreotideSomatostatin receptor type 5small moleculeapproved|investigational
TgeneSSTR5P35346DB04894VapreotideSomatostatin receptor type 5small moleculeapproved|investigational

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RelatedDiseases for UBR5_SSTR5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSSTR5C0005586Bipolar Disorder2PSYGENET
TgeneSSTR5C0038220Status Epilepticus1CTD_human
TgeneSSTR5C0041696Unipolar Depression1PSYGENET
TgeneSSTR5C1269683Major Depressive Disorder1PSYGENET