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Fusion gene ID: 40585 |
FusionGeneSummary for UBR2_ARL15 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBR2_ARL15 | Fusion gene ID: 40585 | Hgene | Tgene | Gene symbol | UBR2 | ARL15 | Gene ID | 23304 | 54622 |
| Gene name | ubiquitin protein ligase E3 component n-recognin 2 | ADP ribosylation factor like GTPase 15 | |
| Synonyms | C6orf133|bA49A4.1|dJ242G1.1|dJ392M17.3 | ARFRP2 | |
| Cytomap | 6p21.1 | 5q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase UBR2RING-type E3 ubiquitin transferase UBR2ubiquitin-protein ligase E3-alpha-2ubiquitin-protein ligase E3-alpha-II | ADP-ribosylation factor-like protein 15ADP-ribosylation factor-like 15ADP-ribosylation factor-related protein 2ARF-related protein 2 | |
| Modification date | 20180529 | 20180519 | |
| UniProtAcc | Q8IWV8 | Q9NXU5 | |
| Ensembl transtripts involved in fusion gene | ENST00000372899, ENST00000372901, ENST00000372883, ENST00000372903, | ENST00000502271, ENST00000504924, ENST00000510591, ENST00000507646, | |
| Fusion gene scores | * DoF score | 9 X 9 X 6=486 | 8 X 7 X 4=224 |
| # samples | 9 | 8 | |
| ** MAII score | log2(9/486*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: UBR2 [Title/Abstract] AND ARL15 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UBR2 | GO:0071233 | cellular response to leucine | 20298436 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE708433 | UBR2 | chr6 | 42630894 | + | ARL15 | chr5 | 53472665 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000372899 | ENST00000502271 | UBR2 | chr6 | 42630894 | + | ARL15 | chr5 | 53472665 | + |
| intron-intron | ENST00000372899 | ENST00000504924 | UBR2 | chr6 | 42630894 | + | ARL15 | chr5 | 53472665 | + |
| intron-intron | ENST00000372899 | ENST00000510591 | UBR2 | chr6 | 42630894 | + | ARL15 | chr5 | 53472665 | + |
| intron-intron | ENST00000372899 | ENST00000507646 | UBR2 | chr6 | 42630894 | + | ARL15 | chr5 | 53472665 | + |
| intron-intron | ENST00000372901 | ENST00000502271 | UBR2 | chr6 | 42630894 | + | ARL15 | chr5 | 53472665 | + |
| intron-intron | ENST00000372901 | ENST00000504924 | UBR2 | chr6 | 42630894 | + | ARL15 | chr5 | 53472665 | + |
| intron-intron | ENST00000372901 | ENST00000510591 | UBR2 | chr6 | 42630894 | + | ARL15 | chr5 | 53472665 | + |
| intron-intron | ENST00000372901 | ENST00000507646 | UBR2 | chr6 | 42630894 | + | ARL15 | chr5 | 53472665 | + |
| intron-intron | ENST00000372883 | ENST00000502271 | UBR2 | chr6 | 42630894 | + | ARL15 | chr5 | 53472665 | + |
| intron-intron | ENST00000372883 | ENST00000504924 | UBR2 | chr6 | 42630894 | + | ARL15 | chr5 | 53472665 | + |
| intron-intron | ENST00000372883 | ENST00000510591 | UBR2 | chr6 | 42630894 | + | ARL15 | chr5 | 53472665 | + |
| intron-intron | ENST00000372883 | ENST00000507646 | UBR2 | chr6 | 42630894 | + | ARL15 | chr5 | 53472665 | + |
| intron-intron | ENST00000372903 | ENST00000502271 | UBR2 | chr6 | 42630894 | + | ARL15 | chr5 | 53472665 | + |
| intron-intron | ENST00000372903 | ENST00000504924 | UBR2 | chr6 | 42630894 | + | ARL15 | chr5 | 53472665 | + |
| intron-intron | ENST00000372903 | ENST00000510591 | UBR2 | chr6 | 42630894 | + | ARL15 | chr5 | 53472665 | + |
| intron-intron | ENST00000372903 | ENST00000507646 | UBR2 | chr6 | 42630894 | + | ARL15 | chr5 | 53472665 | + |
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FusionProtFeatures for UBR2_ARL15 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBR2 | ARL15 |
| E3 ubiquitin-protein ligase which is a component of theN-end rule pathway. Recognizes and binds to proteins bearingspecific N-terminal residues that are destabilizing according tothe N-end rule, leading to their ubiquitination and subsequentdegradation. Plays a critical role in chromatin inactivation andchromosome-wide transcriptional silencing during meiosis viaubiquitination of histone H2A. Binds leucine and is a negativeregulator of the leucine-mTOR signaling pathway, therebycontrolling cell growth. Required for spermatogenesis, promotes,with Tex19.1, SPO11-dependent recombination foci to accumulate anddrive robust homologous chromosome synapsis (By similarity).Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, whichinduces degradation, inhibiting LINE-1 retranstoposon mobilization(By similarity). {ECO:0000250|UniProtKB:Q6WKZ8,ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:20298436,ECO:0000269|PubMed:20835242}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UBR2_ARL15 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UBR2_ARL15 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBR2_ARL15 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBR2_ARL15 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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