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Fusion gene ID: 40560 |
FusionGeneSummary for UBN1_BLNK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBN1_BLNK | Fusion gene ID: 40560 | Hgene | Tgene | Gene symbol | UBN1 | BLNK | Gene ID | 29855 | 29760 |
| Gene name | ubinuclein 1 | B cell linker | |
| Synonyms | VT|VT4 | AGM4|BASH|BLNK-S|LY57|SLP-65|SLP65|bca | |
| Cytomap | 16p13.3 | 10q24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubinuclein-1HIRA-binding proteinubiquitously expressed nuclear protein | B-cell linker proteinB cell adaptor containing SH2 domainB-cell activationB-cell adapter containing a SH2 domain proteinB-cell adapter containing a Src homology 2 domain proteinSrc homology 2 domain-containing leukocyte protein of 65 kDaSrc homology | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9NPG3 | Q8WV28 | |
| Ensembl transtripts involved in fusion gene | ENST00000262376, ENST00000545171, ENST00000590769, ENST00000396658, ENST00000585857, | ENST00000224337, ENST00000371176, ENST00000427367, ENST00000413476, ENST00000495266, | |
| Fusion gene scores | * DoF score | 4 X 5 X 5=100 | 1 X 1 X 1=1 |
| # samples | 6 | 1 | |
| ** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: UBN1 [Title/Abstract] AND BLNK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UBN1 | GO:0006336 | DNA replication-independent nucleosome assembly | 14718166 |
| Tgene | BLNK | GO:0035556 | intracellular signal transduction | 9341187 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-EB-A42Z-01A | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000262376 | ENST00000224337 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| Frame-shift | ENST00000262376 | ENST00000371176 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| Frame-shift | ENST00000262376 | ENST00000427367 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| Frame-shift | ENST00000262376 | ENST00000413476 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| Frame-shift | ENST00000262376 | ENST00000495266 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| intron-3CDS | ENST00000545171 | ENST00000224337 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| intron-3CDS | ENST00000545171 | ENST00000371176 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| intron-3CDS | ENST00000545171 | ENST00000427367 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| intron-3CDS | ENST00000545171 | ENST00000413476 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| intron-3CDS | ENST00000545171 | ENST00000495266 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| intron-3CDS | ENST00000590769 | ENST00000224337 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| intron-3CDS | ENST00000590769 | ENST00000371176 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| intron-3CDS | ENST00000590769 | ENST00000427367 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| intron-3CDS | ENST00000590769 | ENST00000413476 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| intron-3CDS | ENST00000590769 | ENST00000495266 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| Frame-shift | ENST00000396658 | ENST00000224337 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| Frame-shift | ENST00000396658 | ENST00000371176 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| Frame-shift | ENST00000396658 | ENST00000427367 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| Frame-shift | ENST00000396658 | ENST00000413476 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| Frame-shift | ENST00000396658 | ENST00000495266 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| intron-3CDS | ENST00000585857 | ENST00000224337 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| intron-3CDS | ENST00000585857 | ENST00000371176 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| intron-3CDS | ENST00000585857 | ENST00000427367 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| intron-3CDS | ENST00000585857 | ENST00000413476 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
| intron-3CDS | ENST00000585857 | ENST00000495266 | UBN1 | chr16 | 4927475 | + | BLNK | chr10 | 98006805 | - |
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FusionProtFeatures for UBN1_BLNK |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBN1 | BLNK |
| Acts as a novel regulator of senescence. Involved in theformation of senescence-associated heterochromatin foci (SAHF),which represses expression of proliferation-promoting genes. Bindsto proliferation-promoting genes. May be required for replication-independent chromatin assembly. {ECO:0000269|PubMed:14718166,ECO:0000269|PubMed:19029251}. | Functions as a central linker protein, downstream of theB-cell receptor (BCR), bridging the SYK kinase to a multitude ofsignaling pathways and regulating biological outcomes of B-cellfunction and development. Plays a role in the activation ofERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation.Important for the activation of NF-kappa-B and NFAT. Plays animportant role in BCR-mediated PLCG1 and PLCG2 activation andCa(2+) mobilization and is required for trafficking of the BCR tolate endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3(PI3) kinase signaling. May be required for the RAC1-JNK pathway.Plays a critical role in orchestrating the pro-B cell to pre-Bcell transition. May play an important role in BCR-induced B-cellapoptosis. {ECO:0000269|PubMed:10583958,ECO:0000269|PubMed:15270728, ECO:0000269|PubMed:16912232,ECO:0000269|PubMed:9697839}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UBN1_BLNK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UBN1_BLNK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| UBN1 | H3F3A, CABIN1, HIRA, POLR2A, ASF1A, ZNF606, WDR36, TJP2, HIST1H3A, MASTL, CDC5L, ASF1B | BLNK | NCK1, VAV1, GRB2, MAP4K1, SH3KBP1, CD79A, CRKL, BTK, CD72, PTPN6, CD2AP, CAPZA1, CAPZA2, CAPZB, HSPA4, HSPH1, MYBPC3, CLEC17A, DOK3, NCK2, TLN1, LYN, SYK, PLCG2, VAV3, MAP2K4, PPP2R2C, AIFM1, WDR81, CBL, PLCG1, GRAP2, ERBB2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBN1_BLNK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBN1_BLNK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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