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Fusion gene ID: 40550 |
FusionGeneSummary for UBL3_FZD5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBL3_FZD5 | Fusion gene ID: 40550 | Hgene | Tgene | Gene symbol | UBL3 | FZD5 | Gene ID | 5412 | 7855 |
| Gene name | ubiquitin like 3 | frizzled class receptor 5 | |
| Synonyms | HCG-1|PNSC1 | C2orf31|HFZ5 | |
| Cytomap | 13q12.3 | 2q33.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin-like protein 3MUBhsMUBmembrane-anchored ubiquitin-fold proteinprotein HCG-1 | frizzled-5Wnt receptorfrizzled 5, seven transmembrane spanning receptorfrizzled family receptor 5fz-5fzE5seven-transmembrane receptor frizzled-5 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | O95164 | Q13467 | |
| Ensembl transtripts involved in fusion gene | ENST00000380680, | ENST00000295417, | |
| Fusion gene scores | * DoF score | 8 X 3 X 4=96 | 1 X 1 X 1=1 |
| # samples | 8 | 1 | |
| ** MAII score | log2(8/96*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: UBL3 [Title/Abstract] AND FZD5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | FZD5 | GO:0000578 | embryonic axis specification | 12121999 |
| Tgene | FZD5 | GO:0002726 | positive regulation of T cell cytokine production | 16601243 |
| Tgene | FZD5 | GO:0008595 | anterior/posterior axis specification, embryo | 9054360 |
| Tgene | FZD5 | GO:0044332 | Wnt signaling pathway involved in dorsal/ventral axis specification | 11029007 |
| Tgene | FZD5 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12857724 |
| Tgene | FZD5 | GO:0060061 | Spemann organizer formation | 9054360 |
| Tgene | FZD5 | GO:0060070 | canonical Wnt signaling pathway | 12121999|12857724|15459103|24080158|28733458 |
| Tgene | FZD5 | GO:0071219 | cellular response to molecule of bacterial origin | 16601243 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BM670781 | UBL3 | chr13 | 30341335 | + | FZD5 | chr2 | 208629266 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000380680 | ENST00000295417 | UBL3 | chr13 | 30341335 | + | FZD5 | chr2 | 208629266 | - |
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FusionProtFeatures for UBL3_FZD5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBL3 | FZD5 |
| Receptor for Wnt proteins (PubMed:9054360,PubMed:10097073, PubMed:20530549). Can activate WNT2, WNT10B,WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation maybe different since not all of these are known to be coexpressed(By similarity). In neurons, activation of WNT7A promotesformation of synapses (PubMed:20530549). Functions in thecanonical Wnt/beta-catenin signaling pathway. The canonicalWnt/beta-catenin signaling pathway leads to the activation ofdisheveled proteins, inhibition of GSK-3 kinase, nuclearaccumulation of beta-catenin and activation of Wnt target genes(By similarity). A second signaling pathway involving PKC andcalcium fluxes has been seen for some family members, but it isnot yet clear if it represents a distinct pathway or if it can beintegrated in the canonical pathway, as PKC seems to be requiredfor Wnt-mediated inactivation of GSK-3 kinase. Both pathways seemto involve interactions with G-proteins. May be involved intransduction and intercellular transmission of polarityinformation during tissue morphogenesis and/or in differentiatedtissues (Probable). Plays a role in yolk sac angiogenesis and inplacental vascularization (By similarity).{ECO:0000250|UniProtKB:Q9EQD0, ECO:0000269|PubMed:10097073,ECO:0000269|PubMed:20530549, ECO:0000269|PubMed:9054360,ECO:0000305}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UBL3_FZD5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UBL3_FZD5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBL3_FZD5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBL3_FZD5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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