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Fusion gene ID: 4051 |
FusionGeneSummary for BCL7A_KCNIP3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BCL7A_KCNIP3 | Fusion gene ID: 4051 | Hgene | Tgene | Gene symbol | BCL7A | KCNIP3 | Gene ID | 605 | 30818 |
| Gene name | BCL tumor suppressor 7A | potassium voltage-gated channel interacting protein 3 | |
| Synonyms | BCL7 | CSEN|DREAM|KCHIP3 | |
| Cytomap | 12q24.31 | 2q11.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | B-cell CLL/lymphoma 7 protein family member AB-cell CLL/lymphoma 7AB-cell CLL/lymphoma-7 | calsenilinA-type potassium channel modulatory protein 3DRE-antagonist modulatorKv channel interacting protein 3, calsenilincalsenilin, presenilin-binding protein, EF hand transcription factorkv channel-interacting protein 3potassium channel interact | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q4VC05 | Q9Y2W7 | |
| Ensembl transtripts involved in fusion gene | ENST00000538010, ENST00000261822, | ENST00000295225, ENST00000377181, ENST00000360990, ENST00000468529, | |
| Fusion gene scores | * DoF score | 5 X 4 X 5=100 | 4 X 4 X 3=48 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: BCL7A [Title/Abstract] AND KCNIP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AO-A03U-01B | BCL7A | chr12 | 122473333 | + | KCNIP3 | chr2 | 96040044 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000538010 | ENST00000295225 | BCL7A | chr12 | 122473333 | + | KCNIP3 | chr2 | 96040044 | + |
| 5CDS-3UTR | ENST00000538010 | ENST00000377181 | BCL7A | chr12 | 122473333 | + | KCNIP3 | chr2 | 96040044 | + |
| 5CDS-3UTR | ENST00000538010 | ENST00000360990 | BCL7A | chr12 | 122473333 | + | KCNIP3 | chr2 | 96040044 | + |
| 5CDS-3UTR | ENST00000538010 | ENST00000468529 | BCL7A | chr12 | 122473333 | + | KCNIP3 | chr2 | 96040044 | + |
| In-frame | ENST00000261822 | ENST00000295225 | BCL7A | chr12 | 122473333 | + | KCNIP3 | chr2 | 96040044 | + |
| 5CDS-3UTR | ENST00000261822 | ENST00000377181 | BCL7A | chr12 | 122473333 | + | KCNIP3 | chr2 | 96040044 | + |
| 5CDS-3UTR | ENST00000261822 | ENST00000360990 | BCL7A | chr12 | 122473333 | + | KCNIP3 | chr2 | 96040044 | + |
| 5CDS-3UTR | ENST00000261822 | ENST00000468529 | BCL7A | chr12 | 122473333 | + | KCNIP3 | chr2 | 96040044 | + |
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FusionProtFeatures for BCL7A_KCNIP3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BCL7A | KCNIP3 |
| Calcium-dependent transcriptional repressor that bindsto the DRE element of genes including PDYN and FOS. Affinity forDNA is reduced upon binding to calcium and enhanced by binding tomagnesium. Seems to be involved in nociception (By similarity).{ECO:0000250|UniProtKB:Q9QXT8}. Regulatory subunit of Kv4/D (Shal)-type voltage-gatedrapidly inactivating A-type potassium channels, such asKCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at thecell membrane, gating characteristics, inactivation kinetics andrate of recovery from inactivation in a calcium-dependent andisoform-specific manner. {ECO:0000269|PubMed:10676964,ECO:0000269|PubMed:12829703, ECO:0000269|PubMed:15485870,ECO:0000269|PubMed:16123112, ECO:0000269|PubMed:18957440}. May play a role in the regulation of PSEN2 proteolyticprocessing and apoptosis. Together with PSEN2 involved inmodulation of amyloid-beta formation.{ECO:0000269|PubMed:11259376, ECO:0000269|PubMed:11988022,ECO:0000269|PubMed:9771752}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >KCNIP3 | chr12:122473333 | chr2:96040044 | ENST00000295225 | + | 1 | 9 | 175_186 | 60 | 257 | Calcium binding | 1 |
| Tgene | >KCNIP3 | chr12:122473333 | chr2:96040044 | ENST00000295225 | + | 1 | 9 | 223_234 | 60 | 257 | Calcium binding | 2 |
| Tgene | >KCNIP3 | chr12:122473333 | chr2:96040044 | ENST00000468529 | + | 0 | 8 | 175_186 | 34 | 231 | Calcium binding | 1 |
| Tgene | >KCNIP3 | chr12:122473333 | chr2:96040044 | ENST00000468529 | + | 0 | 8 | 223_234 | 34 | 231 | Calcium binding | 2 |
| Tgene | >KCNIP3 | chr12:122473333 | chr2:96040044 | ENST00000295225 | + | 1 | 9 | 126_161 | 60 | 257 | Domain | EF-hand 2 |
| Tgene | >KCNIP3 | chr12:122473333 | chr2:96040044 | ENST00000295225 | + | 1 | 9 | 162_197 | 60 | 257 | Domain | EF-hand 3 |
| Tgene | >KCNIP3 | chr12:122473333 | chr2:96040044 | ENST00000295225 | + | 1 | 9 | 210_245 | 60 | 257 | Domain | EF-hand 4 |
| Tgene | >KCNIP3 | chr12:122473333 | chr2:96040044 | ENST00000295225 | + | 1 | 9 | 67_123 | 60 | 257 | Domain | EF-hand 1%3B degenerate |
| Tgene | >KCNIP3 | chr12:122473333 | chr2:96040044 | ENST00000468529 | + | 0 | 8 | 126_161 | 34 | 231 | Domain | EF-hand 2 |
| Tgene | >KCNIP3 | chr12:122473333 | chr2:96040044 | ENST00000468529 | + | 0 | 8 | 162_197 | 34 | 231 | Domain | EF-hand 3 |
| Tgene | >KCNIP3 | chr12:122473333 | chr2:96040044 | ENST00000468529 | + | 0 | 8 | 210_245 | 34 | 231 | Domain | EF-hand 4 |
| Tgene | >KCNIP3 | chr12:122473333 | chr2:96040044 | ENST00000468529 | + | 0 | 8 | 67_123 | 34 | 231 | Domain | EF-hand 1%3B degenerate |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BCL7A_KCNIP3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_BCL7A_ENST00000538010_chr12_122473333_+_KCNIP3_ENST00000295225_chr2_96040044_+_287aa MSGRSVRAETRSRAKDDIKRVMAAIEKVRKWEKKWVTVGDTSLRIYKWVPVTEPKVDDKNKNKKKGKDEKCGSEVTTPENSSSPGMMDMH DSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYAQFFPQGDATTYAHFLFNAFDADGNGAIHFED FVVGLSILLRGTVHEKLKWAFNLYDINKDGYITKEEMLAIMKSIYDMMGRHTYPILREDAPAEHVERFFEKMDRNQDGVVTIEEFLEACQ >In-frame_BCL7A_ENST00000261822_chr12_122473333_+_KCNIP3_ENST00000295225_chr2_96040044_+_287aa MSGRSVRAETRSRAKDDIKRVMAAIEKVRKWEKKWVTVGDTSLRIYKWVPVTEPKVDDKNKNKKKGKDEKCGSEVTTPENSSSPGMMDMH DSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYAQFFPQGDATTYAHFLFNAFDADGNGAIHFED FVVGLSILLRGTVHEKLKWAFNLYDINKDGYITKEEMLAIMKSIYDMMGRHTYPILREDAPAEHVERFFEKMDRNQDGVVTIEEFLEACQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_BCL7A_ENST00000538010_chr12_122473333_+_KCNIP3_ENST00000295225_chr2_96040044_+_861nt ATGTCGGGCAGGTCGGTTCGAGCCGAGACGAGGAGCCGGGCCAAAGATGATATCAAGAGGGTCATGGCGGCGATCGAGAAAGTGCGCAAA TGGGAGAAGAAATGGGTGACCGTTGGTGACACATCCCTACGAATCTACAAATGGGTCCCTGTGACGGAGCCCAAGGTTGATGACAAAAAC AAGAATAAGAAAAAAGGCAAGGACGAGAAGTGTGGCTCAGAGGTGACCACTCCGGAGAACAGTTCCTCCCCAGGGATGATGGACATGCAT GATAGCAGCGACAGTGAGCTGGAGCTGTCCACGGTGCGCCACCAGCCAGAGGGGCTGGACCAGCTGCAGGCCCAGACCAAGTTCACCAAG AAGGAGCTGCAGTCTCTCTACAGGGGCTTTAAGAATGAGTGTCCCACGGGCCTGGTGGACGAAGACACCTTCAAACTCATTTACGCGCAG TTCTTCCCTCAGGGAGATGCCACCACCTATGCACACTTCCTCTTCAACGCCTTTGATGCGGACGGGAACGGGGCCATCCACTTTGAGGAC TTTGTGGTTGGCCTCTCCATCCTGCTGCGGGGCACAGTCCACGAGAAGCTCAAGTGGGCCTTTAATCTCTACGACATTAACAAGGATGGC TACATCACCAAAGAGGAGATGCTGGCCATCATGAAGTCCATCTATGACATGATGGGCCGCCACACCTACCCCATCCTGCGGGAGGACGCG CCGGCGGAGCACGTGGAGAGGTTCTTCGAGAAAATGGACCGGAACCAGGATGGGGTAGTGACCATTGAAGAGTTCCTGGAGGCCTGTCAG >In-frame_BCL7A_ENST00000261822_chr12_122473333_+_KCNIP3_ENST00000295225_chr2_96040044_+_861nt ATGTCGGGCAGGTCGGTTCGAGCCGAGACGAGGAGCCGGGCCAAAGATGATATCAAGAGGGTCATGGCGGCGATCGAGAAAGTGCGCAAA TGGGAGAAGAAATGGGTGACCGTTGGTGACACATCCCTACGAATCTACAAATGGGTCCCTGTGACGGAGCCCAAGGTTGATGACAAAAAC AAGAATAAGAAAAAAGGCAAGGACGAGAAGTGTGGCTCAGAGGTGACCACTCCGGAGAACAGTTCCTCCCCAGGGATGATGGACATGCAT GATAGCAGCGACAGTGAGCTGGAGCTGTCCACGGTGCGCCACCAGCCAGAGGGGCTGGACCAGCTGCAGGCCCAGACCAAGTTCACCAAG AAGGAGCTGCAGTCTCTCTACAGGGGCTTTAAGAATGAGTGTCCCACGGGCCTGGTGGACGAAGACACCTTCAAACTCATTTACGCGCAG TTCTTCCCTCAGGGAGATGCCACCACCTATGCACACTTCCTCTTCAACGCCTTTGATGCGGACGGGAACGGGGCCATCCACTTTGAGGAC TTTGTGGTTGGCCTCTCCATCCTGCTGCGGGGCACAGTCCACGAGAAGCTCAAGTGGGCCTTTAATCTCTACGACATTAACAAGGATGGC TACATCACCAAAGAGGAGATGCTGGCCATCATGAAGTCCATCTATGACATGATGGGCCGCCACACCTACCCCATCCTGCGGGAGGACGCG CCGGCGGAGCACGTGGAGAGGTTCTTCGAGAAAATGGACCGGAACCAGGATGGGGTAGTGACCATTGAAGAGTTCCTGGAGGCCTGTCAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_BCL7A_ENST00000538010_chr12_122473333_+_KCNIP3_ENST00000295225_chr2_96040044_+_5559nt CCCAGCCTAGATTTCTTTTTATTATGATCAAATACACATAAAATTGACCATTGTAACCATTTAAAAGTGTACAATTCAGCGTCATTAAGT ACATTCACATTGTTCTGCAACCATCACCACTATCTCATTCCAGAACTTTCCTATCACTCCGAAAGGAAACCCCACATCCGTTAGCAGTCA CTCCTGCTCTCCCTCCCCCTTGCCTCTGGCAACCACCAATCTGATATCTGTCTTTATGGATTCGCCTAGTTGTAGATATCTCCCGCAAAT GGACTTACGCATATTTATCCTTTTGTGACTGGCTTCTTTCACTTAGCGTGTTTCAAGGTTCACCCATGTTGTAGCATGTATTCATTCCCT TTTATGGCTGAATAATATTCCATTGTGTGGATAGACACATTTATCTGTTCCTCAGTCACTATTTGAATTCTGACATAATATTTTCCTATT TTAAATTTTAAGATACATTTTTTTAAAGTTTCATGTGGCCCAAAGCACATACCTATTGATCTCACATATCTCTGTGAGATCTGTTTTATG ACCTGCTGTTGCATATTTTCCCAGAAAATTCTCGGAACGATTCTCTGAAGTCCTTCTTTCTCTTTCTCTTTTTTTTCTTTTTCTTTCTCT CTTTCTTTTTTTGTTTTGTTTTGTTTTATTTTGTTTTGTTTTGTTTTTTTGAGATTCAGTTTTGCTCTGTTGCCCAGGCTGGAGTGCAAT GGCATGATCATTGCACCTCTGCCTCCCAGGTTCAAGCATTTTCCTGCCTCAGCCTCCCGCGTAGCTCAGATTACAGGCCTGCACCACCAC GCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCTCCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCGTGATCTGCCCAC TTCGGCCTCCAAAGTGCTGGGATTACAGGCATGAACCACCGCGCCCGGCCTTTTTTTTTTTTCTGAGACAGGGTCTCACTCTGTCTCCCA GGCTGGAGTGCAGTGGCTGGATCTCTGCTCACTGCAACCTCCGTCTCCCAGGTTCAAGCGAGTCTCCTGCCTCAGACTCCCGAGTAGCTG CGATTACAGGAGCCCACCACCGCGCCCGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCCACCATGTTGGCCAGGCTGGTATC GAACTCTTAACCTCAAGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGTATTACAGGCATGAGCCACCGCGCCCGGCCAGTATTTGTT CTTTTCTTCATTTTTCACGTCAGGAGACTGCGTTTCAGAATAGTAAAAACAAATGCCTAGGAAAAGGCCTGCGGTCTCTCCATTTCCACA GTAGCGTGTTCCCCAAAGACCAAACCCTCAGGGGAAACGTCTAGAATGAGTAACAACTTAAGGCTGCAACCTTAAACTTTCCCAGGACTC AGTTTCCCCAGCTGTGAAATGGCTGCTGTCGGGCTGTCATCTCCAGGCCCGGGGCGCTGACATTTGGGCCACTCTCGGTCTCCCTCTTCA TTCTGGGCGCGCATTAGCTCTGGTCCGGCCGGTTCCGCTGCAGCTGAACAGCAAGATGCGGCACCCAGGTTACCCTGATCATCGCAGATT TCTCCCCGGGGCTCTGTTCTGAGGCCTCAAAAGTGCTCCTTGTAGATGGGACCAGGGGTCATTTGGGCAGTAGCAGCGCCTGGTCTCAGT CTGGTACTGAAGTCAGGAATGGCTTAAGGTGAAATCGTGGTCCTCTGGTGAAGCTCAGCGAAGACCCCCTCGCCTTGTTTATGACAAGAG AACTTCTGGGGGCGGGAGGAAGAGTCCCTGTTACGATGCTGATCATCATTGAGCTTTTGCTGAGCAGAAAACTCTTTAGTACTCAAGGTC GAGAGTCTCTGGTGGTCTGCCTGGCACCAGGCACCTTCCTACAACCCTAGTTTTCCAAAAGGACAAAGCCTGGGGCAGGCGACGTCCTAG CTCGCATTTGAACAGGGCCGCGGGCCAGCAGAGATGCGCGATGCCCAACTCTTTCCAAGAGCACCTCGCGTCCCGAACCGGTGCCTTCAA CTCGGAGAAGTCAAGAGACCCGCAAGAAACTTGCACGACTGCACCCGCCGCCGCGCTCTGGGGGCTGGGCAGGGGCAGCTGGGCTGGCTC CCGGGGAACGCGACCCCCCCGCGCCCCGCAGACCGGCTGTCTCCCATGGACCCCTCGGCACCTGCAGCCTCCGAGGAAGGGTCAGCGCGC GTGTCCGCACGCCCGCCCCCACCGCGCGCCCAGAGCCGGGGGTCGCCGTGCGCCCTTCGCCACCTCCCCAGGAGGGCGTCCGGGGCGTCC CCTCTGGGGGCGCAGGAGGCCCGGGGGCGCTGCCCGGTGGCCGCGGCGCCCGGAGGCCGCACTGCCGGCGGCGGCGGCGGCGCGGCTCCC CCTGCTCTGTGCAGCTGCCGCCCGGCGCTTGCGCACTGGGCCAGGCGCGCGGCGGCCCCGGGCTTTGTGTGTGTGTGTATGTGTGTGTGT GTGTGTGTGTGTGTGTGAGTGTGTGCGTGTGAGAGTGCGAGTGTCTGTGCGCGAGTGAGTGAGCGGCGGGCGGGCGCGAGTGTGGCCGCC GCGGAGCGCGAGCAGGACCCGGCGGGCGCGCTCCCCAGCCTCCGTCTCCCCGCCGGAACCATGTCGGGCAGGTCGGTTCGAGCCGAGACG AGGAGCCGGGCCAAAGATGATATCAAGAGGGTCATGGCGGCGATCGAGAAAGTGCGCAAATGGGAGAAGAAATGGGTGACCGTTGGTGAC ACATCCCTACGAATCTACAAATGGGTCCCTGTGACGGAGCCCAAGGTTGATGACAAAAACAAGAATAAGAAAAAAGGCAAGGACGAGAAG TGTGGCTCAGAGGTGACCACTCCGGAGAACAGTTCCTCCCCAGGGATGATGGACATGCATGATAGCAGCGACAGTGAGCTGGAGCTGTCC ACGGTGCGCCACCAGCCAGAGGGGCTGGACCAGCTGCAGGCCCAGACCAAGTTCACCAAGAAGGAGCTGCAGTCTCTCTACAGGGGCTTT AAGAATGAGTGTCCCACGGGCCTGGTGGACGAAGACACCTTCAAACTCATTTACGCGCAGTTCTTCCCTCAGGGAGATGCCACCACCTAT GCACACTTCCTCTTCAACGCCTTTGATGCGGACGGGAACGGGGCCATCCACTTTGAGGACTTTGTGGTTGGCCTCTCCATCCTGCTGCGG GGCACAGTCCACGAGAAGCTCAAGTGGGCCTTTAATCTCTACGACATTAACAAGGATGGCTACATCACCAAAGAGGAGATGCTGGCCATC ATGAAGTCCATCTATGACATGATGGGCCGCCACACCTACCCCATCCTGCGGGAGGACGCGCCGGCGGAGCACGTGGAGAGGTTCTTCGAG AAAATGGACCGGAACCAGGATGGGGTAGTGACCATTGAAGAGTTCCTGGAGGCCTGTCAGAAGGATGAGAACATCATGAGCTCCATGCAG CTGTTTGAGAATGTCATCTAGGACACGTCCAAAGGAGTGCATGGCCACAGCCACCTCCACCCCCAAGAAACCTCCATCCTGCCAGGAGCA GCCTCCAAGAAACTTTTAAAAAATAGATTTGCAAAAAGTGAACAGATTGCTACACACACACACACACACACACACACACACACACACAGC CATTCATCTGGGCTGGCAGAGGGGACAGAGTTCAGGGAGGGGCTGAGTCTGGCTAGGGGCCGAGTCCAGGAGCCCCAGCCAGCCCTTCCC AGGCCAGCGAGGCGAGGCTGCCTCTGGGTGAGTGGCTGACAGAGCAGGTCTGCAGGCCACCAGCTGCTGGATGTCACCAAGAAGGGGCTC GAGTGCCCCTGCAGGGGAGGGTCCAATCTCCGGTGTGAGCCCACCTCGTCCCGTTCTCCATTCTGCTTTCTTGCCACACAGTGGGCCGGC CCCAGGCTCCCCTGGTCTCCTCCCCGTAGCCACTCTCTGCCCACTACCTATGCTTCTAGAAAGCCCCTCACCTCAGGACCCCAGAGGGAC CAGCTGGGGGGCAGGGGGGAGAGGGGGTAATGGAGGCCAAGCCTGCAGCTTTCTGGAAATTCTTCCCTGGGGGTCCCAGGATCCCCTGCT ACTCCACTGACCTGGAAGAGCTGGGTACCAGGCCACCCACTGTGGGGCAAGCCTGAGTGGTGAGGGGCCACTGGGCCCCATTCTCCCTCC ATGGCAGGAAGGCGGGGGATTTCAAGTTTAGGGATTGGGTCGTGGTGGAGAATCTGAGGGCACTCTCTGCCAGCTCCACAGGGTGGGATG AGCCTCTCCTTGCCCCAGTCCTGGTTCAGTGGGAATGCAGTGGGTGGGGCTGTACACACCCTCCAGCACAGACTGTTCCCTCCAAGGTCC TCTTAGGTCCCGGGAGGAACGTGGTTCAGAGACTGGCAGCCAGGGAGCCCGGGGCAGAGCTCAGAGGAGTCTGGGAAGGGGCGTGTCCCT CCTCTTCCTGTAGTGCCCCTCCCATGGCCCAGCAGCTTGGCTGAGCCCCCTCTCCTGAAGCAGTGTCGCCGTCCCTCTGCCTTGCACAAA AAGCACAAGCATTCCTTAGCAGCTCAGGCGCAGCCCTAGTGGGAGCCCAGCACACTGCTTCTCGGAGGCCAGGCCCTCCTGCTGGCTGAG GCTTGGGCCCAGTAGCCCCAATATGGTGGCCCTGGGGAAGAGGCCTTGGGGGTCTGCTCTGTGCCTGGGATCAGTGGGGCCCCAAAGCCC AGCCCGGCTGACCAACATTCAAAAGCACAAACCCTGGGGACTCTGCTTGGCTGTCCCCTCCATCTGGGGATGGAGAATGCCAGCCCAAAG CTGGAGCCAATGGTGAGGGCTGAGAGGGCTGTGGCTGGGTGGTCAGCAGAAACCCCCAGGAGGAGAGAGATGCTGCTCCCGCCTGATTGG GGCCTCACCCAGAAGGAACCCGGTCCCAGGCCGCATGGCCCCTCCAGGAACATTCCCACATAATACATTCCATCACAGCCAGCCCAGCTC CACTCAGGGCTGGCCCGGGGAGTCCCCGTGTGCCCCAAGAGGCTAGCCCCAGGGTGAGCAGGGCCCTCAGAGGAAAGGCAGTATGGCGGA GGCCATGGGGGCCCCTCGGCATTCACACACAGCCTGGCCTCCCCTGCGGAGCTGCATGGACGCCTGGCTCCAGGCTCCAGGCTGACTGGG GGCCTCTGCCTCCAGGAGGGCATCAGCTTTCCCTGGCTCAGGGATCTTCTCCCTCCCCTCACCCGCTGCCCAGCCCTCCCAGCTGGTGTC ACTCTGCCTCTAAGGCCAAGGCCTCAGGAGAGCATCACCACCACACCCCTGCCGGCCTTGGCCTTGGGGCCAGACTGGCTGCACAGCCCA ACCAGGAGGGGTCTGCCTCCCACGCTGGGACACAGACCGGCCGCATGTCTGCATGGCAGAAGCGTCTCCCTTGGCCACGGCCTGGGAGGG >In-frame_BCL7A_ENST00000261822_chr12_122473333_+_KCNIP3_ENST00000295225_chr2_96040044_+_3095nt ACTGGGCCAGGCGCGCGGCGGCCCCGGGCTTTGTGTGTGTGTGTATGTGTGTGTGTGTGTGTGTGTGTGTGTGAGTGTGTGCGTGTGAGA GTGCGAGTGTCTGTGCGCGAGTGAGTGAGCGGCGGGCGGGCGCGAGTGTGGCCGCCGCGGAGCGCGAGCAGGACCCGGCGGGCGCGCTCC CCAGCCTCCGTCTCCCCGCCGGAACCATGTCGGGCAGGTCGGTTCGAGCCGAGACGAGGAGCCGGGCCAAAGATGATATCAAGAGGGTCA TGGCGGCGATCGAGAAAGTGCGCAAATGGGAGAAGAAATGGGTGACCGTTGGTGACACATCCCTACGAATCTACAAATGGGTCCCTGTGA CGGAGCCCAAGGTTGATGACAAAAACAAGAATAAGAAAAAAGGCAAGGACGAGAAGTGTGGCTCAGAGGTGACCACTCCGGAGAACAGTT CCTCCCCAGGGATGATGGACATGCATGATAGCAGCGACAGTGAGCTGGAGCTGTCCACGGTGCGCCACCAGCCAGAGGGGCTGGACCAGC TGCAGGCCCAGACCAAGTTCACCAAGAAGGAGCTGCAGTCTCTCTACAGGGGCTTTAAGAATGAGTGTCCCACGGGCCTGGTGGACGAAG ACACCTTCAAACTCATTTACGCGCAGTTCTTCCCTCAGGGAGATGCCACCACCTATGCACACTTCCTCTTCAACGCCTTTGATGCGGACG GGAACGGGGCCATCCACTTTGAGGACTTTGTGGTTGGCCTCTCCATCCTGCTGCGGGGCACAGTCCACGAGAAGCTCAAGTGGGCCTTTA ATCTCTACGACATTAACAAGGATGGCTACATCACCAAAGAGGAGATGCTGGCCATCATGAAGTCCATCTATGACATGATGGGCCGCCACA CCTACCCCATCCTGCGGGAGGACGCGCCGGCGGAGCACGTGGAGAGGTTCTTCGAGAAAATGGACCGGAACCAGGATGGGGTAGTGACCA TTGAAGAGTTCCTGGAGGCCTGTCAGAAGGATGAGAACATCATGAGCTCCATGCAGCTGTTTGAGAATGTCATCTAGGACACGTCCAAAG GAGTGCATGGCCACAGCCACCTCCACCCCCAAGAAACCTCCATCCTGCCAGGAGCAGCCTCCAAGAAACTTTTAAAAAATAGATTTGCAA AAAGTGAACAGATTGCTACACACACACACACACACACACACACACACACACACAGCCATTCATCTGGGCTGGCAGAGGGGACAGAGTTCA GGGAGGGGCTGAGTCTGGCTAGGGGCCGAGTCCAGGAGCCCCAGCCAGCCCTTCCCAGGCCAGCGAGGCGAGGCTGCCTCTGGGTGAGTG GCTGACAGAGCAGGTCTGCAGGCCACCAGCTGCTGGATGTCACCAAGAAGGGGCTCGAGTGCCCCTGCAGGGGAGGGTCCAATCTCCGGT GTGAGCCCACCTCGTCCCGTTCTCCATTCTGCTTTCTTGCCACACAGTGGGCCGGCCCCAGGCTCCCCTGGTCTCCTCCCCGTAGCCACT CTCTGCCCACTACCTATGCTTCTAGAAAGCCCCTCACCTCAGGACCCCAGAGGGACCAGCTGGGGGGCAGGGGGGAGAGGGGGTAATGGA GGCCAAGCCTGCAGCTTTCTGGAAATTCTTCCCTGGGGGTCCCAGGATCCCCTGCTACTCCACTGACCTGGAAGAGCTGGGTACCAGGCC ACCCACTGTGGGGCAAGCCTGAGTGGTGAGGGGCCACTGGGCCCCATTCTCCCTCCATGGCAGGAAGGCGGGGGATTTCAAGTTTAGGGA TTGGGTCGTGGTGGAGAATCTGAGGGCACTCTCTGCCAGCTCCACAGGGTGGGATGAGCCTCTCCTTGCCCCAGTCCTGGTTCAGTGGGA ATGCAGTGGGTGGGGCTGTACACACCCTCCAGCACAGACTGTTCCCTCCAAGGTCCTCTTAGGTCCCGGGAGGAACGTGGTTCAGAGACT GGCAGCCAGGGAGCCCGGGGCAGAGCTCAGAGGAGTCTGGGAAGGGGCGTGTCCCTCCTCTTCCTGTAGTGCCCCTCCCATGGCCCAGCA GCTTGGCTGAGCCCCCTCTCCTGAAGCAGTGTCGCCGTCCCTCTGCCTTGCACAAAAAGCACAAGCATTCCTTAGCAGCTCAGGCGCAGC CCTAGTGGGAGCCCAGCACACTGCTTCTCGGAGGCCAGGCCCTCCTGCTGGCTGAGGCTTGGGCCCAGTAGCCCCAATATGGTGGCCCTG GGGAAGAGGCCTTGGGGGTCTGCTCTGTGCCTGGGATCAGTGGGGCCCCAAAGCCCAGCCCGGCTGACCAACATTCAAAAGCACAAACCC TGGGGACTCTGCTTGGCTGTCCCCTCCATCTGGGGATGGAGAATGCCAGCCCAAAGCTGGAGCCAATGGTGAGGGCTGAGAGGGCTGTGG CTGGGTGGTCAGCAGAAACCCCCAGGAGGAGAGAGATGCTGCTCCCGCCTGATTGGGGCCTCACCCAGAAGGAACCCGGTCCCAGGCCGC ATGGCCCCTCCAGGAACATTCCCACATAATACATTCCATCACAGCCAGCCCAGCTCCACTCAGGGCTGGCCCGGGGAGTCCCCGTGTGCC CCAAGAGGCTAGCCCCAGGGTGAGCAGGGCCCTCAGAGGAAAGGCAGTATGGCGGAGGCCATGGGGGCCCCTCGGCATTCACACACAGCC TGGCCTCCCCTGCGGAGCTGCATGGACGCCTGGCTCCAGGCTCCAGGCTGACTGGGGGCCTCTGCCTCCAGGAGGGCATCAGCTTTCCCT GGCTCAGGGATCTTCTCCCTCCCCTCACCCGCTGCCCAGCCCTCCCAGCTGGTGTCACTCTGCCTCTAAGGCCAAGGCCTCAGGAGAGCA TCACCACCACACCCCTGCCGGCCTTGGCCTTGGGGCCAGACTGGCTGCACAGCCCAACCAGGAGGGGTCTGCCTCCCACGCTGGGACACA GACCGGCCGCATGTCTGCATGGCAGAAGCGTCTCCCTTGGCCACGGCCTGGGAGGGTGGTTCCTGTTCTCAGCATCCACTAATATTCAGT 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FusionGenePPI for BCL7A_KCNIP3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| BCL7A | RELB, SMARCA2, SMARCA4, WHSC1L1, CUL3, CBX5, ALAS1, DPF3, DPF2, SS18, SMARCD1, ARID1A, ARID1B, SMARCB1, SMARCD2, SMARCD3, SMARCC1, SMARCC2, MAPK8, POTEJ, SPIRE1, PHACTR4, SPIRE2, PHACTR2, BRD9, MKL2, GLTSCR1, GLTSCR1L, MKL1, DPF1, BRD7, PBRM1, SCIN, CAP2, ARID2, ACTR8, GSN, INO80, PHF10, WDR54, INO80C, CAP1, INO80E, ACTL6B, BCL7C, KLHL23, SMARCE1, TWF2, EMC8, MYO1B, ACTBL2, ACTL6A | KCNIP3 | PSEN2, CD177, PSEN1, CREM, CREB1, TARBP2, PCBD2, UBE2I, GRK6, ADRBK1, PPP3CA, KCNIP3, CLN3, CALM2, KCND2, IGF1R, IL6ST, IGLV3-25, MAVS, CTBP1, CTBP2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | KCNIP3 | chr12:122473333 | chr2:96040044 | ENST00000295225 | + | 1 | 9 | 243_256 | 60 | 257 | KCND2 |
| Tgene | KCNIP3 | chr12:122473333 | chr2:96040044 | ENST00000468529 | + | 0 | 8 | 243_256 | 34 | 231 | KCND2 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BCL7A_KCNIP3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BCL7A_KCNIP3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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