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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40500

FusionGeneSummary for UBE2V1_PRKAG1

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE2V1_PRKAG1
Fusion gene ID: 40500
HgeneTgene
Gene symbol

UBE2V1

PRKAG1

Gene ID

7335

5571

Gene nameubiquitin conjugating enzyme E2 V1protein kinase AMP-activated non-catalytic subunit gamma 1
SynonymsCIR1|CROC-1|CROC1|UBE2V|UEV-1|UEV1|UEV1AAMPKG
Cytomap

20q13.13

12q13.12

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-conjugating enzyme E2 variant 1DNA-binding proteinTRAF6-regulated IKK activator 1 beta Uev1A5'-AMP-activated protein kinase subunit gamma-15'-AMP-activated protein kinase, gamma-1 subunitAMPK gamma-1 chainAMPK gamma1protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Modification date2018052320180522
UniProtAcc

Q13404

P54619

Ensembl transtripts involved in fusion geneENST00000371657, ENST00000396059, 
ENST00000371674, ENST00000371677, 
ENST00000340309, ENST00000420027, 
ENST00000415862, 
ENST00000395170, 
ENST00000547306, ENST00000316299, 
ENST00000548065, ENST00000552212, 
Fusion gene scores* DoF score9 X 11 X 2=1987 X 7 X 3=147
# samples 227
** MAII scorelog2(22/198*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UBE2V1 [Title/Abstract] AND PRKAG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE2V1

GO:0070534

protein K63-linked ubiquitination

16307917|21512573

TgenePRKAG1

GO:0006468

protein phosphorylation

17028174

TgenePRKAG1

GO:0010628

positive regulation of gene expression

17028174


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU588474UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000371657ENST00000395170UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000371657ENST00000547306UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000371657ENST00000316299UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000371657ENST00000548065UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-intronENST00000371657ENST00000552212UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000396059ENST00000395170UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000396059ENST00000547306UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000396059ENST00000316299UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000396059ENST00000548065UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-intronENST00000396059ENST00000552212UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000371674ENST00000395170UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000371674ENST00000547306UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000371674ENST00000316299UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000371674ENST00000548065UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-intronENST00000371674ENST00000552212UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000371677ENST00000395170UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000371677ENST00000547306UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000371677ENST00000316299UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000371677ENST00000548065UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-intronENST00000371677ENST00000552212UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000340309ENST00000395170UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000340309ENST00000547306UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000340309ENST00000316299UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000340309ENST00000548065UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-intronENST00000340309ENST00000552212UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000420027ENST00000395170UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000420027ENST00000547306UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000420027ENST00000316299UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000420027ENST00000548065UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-intronENST00000420027ENST00000552212UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000415862ENST00000395170UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000415862ENST00000547306UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000415862ENST00000316299UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-3UTRENST00000415862ENST00000548065UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-
intron-intronENST00000415862ENST00000552212UBE2V1chr20

48713315

-PRKAG1chr12

49396152

-

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FusionProtFeatures for UBE2V1_PRKAG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBE2V1

Q13404

PRKAG1

P54619

AMP/ATP-binding subunit of AMP-activated protein kinase(AMPK), an energy sensor protein kinase that plays a key role inregulating cellular energy metabolism. In response to reduction ofintracellular ATP levels, AMPK activates energy-producing pathwaysand inhibits energy-consuming processes: inhibits protein,carbohydrate and lipid biosynthesis, as well as cell growth andproliferation. AMPK acts via direct phosphorylation of metabolicenzymes, and by longer-term effects via phosphorylation oftranscription regulators. Also acts as a regulator of cellularpolarity by remodeling the actin cytoskeleton; probably byindirectly activating myosin. Gamma non-catalytic subunit mediatesbinding to AMP, ADP and ATP, leading to activate or inhibit AMPK:AMP-binding results in allosteric activation of alpha catalyticsubunit (PRKAA1 or PRKAA2) both by inducing phosphorylation andpreventing dephosphorylation of catalytic subunits. ADP alsostimulates phosphorylation, without stimulating alreadyphosphorylated catalytic subunit. ATP promotes dephosphorylationof catalytic subunit, rendering the AMPK enzyme inactive.{ECO:0000269|PubMed:21680840}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBE2V1_PRKAG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBE2V1_PRKAG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBE2V1_PRKAG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBE2V1_PRKAG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource