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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40498

FusionGeneSummary for UBE2V1_PAAF1

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE2V1_PAAF1
Fusion gene ID: 40498
HgeneTgene
Gene symbol

UBE2V1

PAAF1

Gene ID

7335

80227

Gene nameubiquitin conjugating enzyme E2 V1proteasomal ATPase associated factor 1
SynonymsCIR1|CROC-1|CROC1|UBE2V|UEV-1|UEV1|UEV1APAAF|Rpn14|WDR71
Cytomap

20q13.13

11q13.4

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-conjugating enzyme E2 variant 1DNA-binding proteinTRAF6-regulated IKK activator 1 beta Uev1Aproteasomal ATPase-associated factor 1WD repeat domain 71WD repeat-containing protein 71
Modification date2018052320180525
UniProtAcc

Q13404

Q9BRP4

Ensembl transtripts involved in fusion geneENST00000371657, ENST00000396059, 
ENST00000371674, ENST00000371677, 
ENST00000340309, ENST00000420027, 
ENST00000415862, 		ENST00000541951, 
ENST00000310571, ENST00000535604, 
ENST00000536003, ENST00000544552, 
ENST00000376384, ENST00000543079, 
ENST00000544909, 
Fusion gene scores* DoF score9 X 11 X 2=1986 X 5 X 5=150
# samples 226
** MAII scorelog2(22/198*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UBE2V1 [Title/Abstract] AND PAAF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE2V1

GO:0070534

protein K63-linked ubiquitination

16307917|21512573


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-YG-AA3P-06AUBE2V1chr20

48713209

-PAAF1chr11

73610191

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000371657ENST00000541951UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-5UTRENST00000371657ENST00000310571UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-5UTRENST00000371657ENST00000535604UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-5UTRENST00000371657ENST00000536003UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-5UTRENST00000371657ENST00000544552UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-5UTRENST00000371657ENST00000376384UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-3UTRENST00000371657ENST00000543079UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-3UTRENST00000371657ENST00000544909UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
intron-5UTRENST00000396059ENST00000541951UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
intron-5UTRENST00000396059ENST00000310571UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
intron-5UTRENST00000396059ENST00000535604UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
intron-5UTRENST00000396059ENST00000536003UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
intron-5UTRENST00000396059ENST00000544552UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
intron-5UTRENST00000396059ENST00000376384UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
intron-3UTRENST00000396059ENST00000543079UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
intron-3UTRENST00000396059ENST00000544909UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-5UTRENST00000371674ENST00000541951UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-5UTRENST00000371674ENST00000310571UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-5UTRENST00000371674ENST00000535604UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-5UTRENST00000371674ENST00000536003UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-5UTRENST00000371674ENST00000544552UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-5UTRENST00000371674ENST00000376384UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-3UTRENST00000371674ENST00000543079UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-3UTRENST00000371674ENST00000544909UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-5UTRENST00000371677ENST00000541951UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-5UTRENST00000371677ENST00000310571UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-5UTRENST00000371677ENST00000535604UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-5UTRENST00000371677ENST00000536003UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-5UTRENST00000371677ENST00000544552UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-5UTRENST00000371677ENST00000376384UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-3UTRENST00000371677ENST00000543079UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-3UTRENST00000371677ENST00000544909UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-5UTRENST00000340309ENST00000541951UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-5UTRENST00000340309ENST00000310571UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-5UTRENST00000340309ENST00000535604UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-5UTRENST00000340309ENST00000536003UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-5UTRENST00000340309ENST00000544552UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-5UTRENST00000340309ENST00000376384UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-3UTRENST00000340309ENST00000543079UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
5CDS-3UTRENST00000340309ENST00000544909UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
intron-5UTRENST00000420027ENST00000541951UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
intron-5UTRENST00000420027ENST00000310571UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
intron-5UTRENST00000420027ENST00000535604UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
intron-5UTRENST00000420027ENST00000536003UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
intron-5UTRENST00000420027ENST00000544552UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
intron-5UTRENST00000420027ENST00000376384UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
intron-3UTRENST00000420027ENST00000543079UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
intron-3UTRENST00000420027ENST00000544909UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
intron-5UTRENST00000415862ENST00000541951UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
intron-5UTRENST00000415862ENST00000310571UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
intron-5UTRENST00000415862ENST00000535604UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
intron-5UTRENST00000415862ENST00000536003UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
intron-5UTRENST00000415862ENST00000544552UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
intron-5UTRENST00000415862ENST00000376384UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
intron-3UTRENST00000415862ENST00000543079UBE2V1chr20

48713209

-PAAF1chr11

73610191

+
intron-3UTRENST00000415862ENST00000544909UBE2V1chr20

48713209

-PAAF1chr11

73610191

+

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FusionProtFeatures for UBE2V1_PAAF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBE2V1

Q13404

PAAF1

Q9BRP4


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBE2V1_PAAF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBE2V1_PAAF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UBE2V1UBE2N, TRAF6, TRAF2, UBOX5, RNF14, ZNRF1, TRIM8, MID1, XIAP, BIRC8, RNF5, DTX3, ARIH2, DZIP3, MKRN3, TRIM39, RNF10, RNF111, RNF144A, RNF185, RNF2, TRIM32, TRIM5, STUB1, UBC, BIRC2, BIRC3, PARK2, PELI1, UBE2V2, UBE2B, AHCYL1, USP34, UGDH, UBE2A, UCHL3, UBXN7, UBE2D2, TXN, ATP6V1F, SSSCA1, UBE4B, ZYX, POMP, ULK4, TTC9C, ATP6V1B2, PSMB1, UBE2C, ATP6V1G1, PELI3, IQCB1, G6PD, LDHB, SFN, TGM2, TXNDC5, ECHS1, YWHAG, YWHAQ, YWHAZ, TRAF3IP2, FAM168A, UBQLN1, MAP3K1, CHORDC1, RAB7A, TAGLN2, UBE2K, GMPPB, HINT1, ITPA, NME1-NME2, NME2, SOD1, YKT6, RC3H1, RC3H2, SMURF1, TRIM25, HSD17B10, RHBDF2PAAF1PSMD2, PSMD3, PSMC5, PSMC1, ALDH16A1, PSMD1, DERA, PSMC4, PSMC3, PSMD14, PSMD7, PSMD10, PSMD12, PSMD11, PSMD8, FADS1, PSMD6, PSMC2, PSMC6, UCHL5, TK1, ANXA7, PSMA1, SUPT6H, PSMA2, PARK2, CCDC6, ELP2, FAM21A, GPHN, HDAC1, MON2, POLR2E, PPP4R2, VASP, SHFM1, ZFAND2B, ADRM1, PSMD5, UBLCP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBE2V1_PAAF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBE2V1_PAAF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource