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Fusion gene ID: 40489 |
FusionGeneSummary for UBE2R2_PRSS3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBE2R2_PRSS3 | Fusion gene ID: 40489 | Hgene | Tgene | Gene symbol | UBE2R2 | PRSS3 | Gene ID | 54926 | 5646 |
| Gene name | ubiquitin conjugating enzyme E2 R2 | serine protease 3 | |
| Synonyms | CDC34B|E2-CDC34B|UBC3B | MTG|PRSS4|T9|TRY3|TRY4 | |
| Cytomap | 9p13.3 | 9p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin-conjugating enzyme E2 R2E2 ubiquitin-conjugating enzyme R2ubiquitin carrier protein R2ubiquitin conjugating enzyme E2R 2ubiquitin-conjugating enzyme E2-CDC34Bubiquitin-conjugating enzyme UBC3Bubiquitin-protein ligase R2 | trypsin-3brain trypsinogenmesotrypsinmesotrypsinogenpancreatic trypsinogen IIIprotease, serine 3protease, serine, 4 (trypsin 4, brain)trypsin IIItrypsin IVtrypsinogen 4trypsinogen 5trypsinogen IV | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q712K3 | P35030 | |
| Ensembl transtripts involved in fusion gene | ENST00000263228, | ENST00000361005, ENST00000342836, ENST00000429677, ENST00000379405, ENST00000495682, | |
| Fusion gene scores | * DoF score | 9 X 5 X 6=270 | 7 X 2 X 6=84 |
| # samples | 9 | 7 | |
| ** MAII score | log2(9/270*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/84*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: UBE2R2 [Title/Abstract] AND PRSS3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UBE2R2 | GO:0006513 | protein monoubiquitination | 20061386 |
| Hgene | UBE2R2 | GO:0070936 | protein K48-linked ubiquitination | 20061386 |
| Tgene | PRSS3 | GO:0006508 | proteolysis | 6698368 |
| Tgene | PRSS3 | GO:0031638 | zymogen activation | 6698368 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-60-2719-01A | UBE2R2 | chr9 | 33817932 | + | PRSS3 | chr9 | 33796641 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000263228 | ENST00000361005 | UBE2R2 | chr9 | 33817932 | + | PRSS3 | chr9 | 33796641 | + |
| Frame-shift | ENST00000263228 | ENST00000342836 | UBE2R2 | chr9 | 33817932 | + | PRSS3 | chr9 | 33796641 | + |
| Frame-shift | ENST00000263228 | ENST00000429677 | UBE2R2 | chr9 | 33817932 | + | PRSS3 | chr9 | 33796641 | + |
| Frame-shift | ENST00000263228 | ENST00000379405 | UBE2R2 | chr9 | 33817932 | + | PRSS3 | chr9 | 33796641 | + |
| 5CDS-intron | ENST00000263228 | ENST00000495682 | UBE2R2 | chr9 | 33817932 | + | PRSS3 | chr9 | 33796641 | + |
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FusionProtFeatures for UBE2R2_PRSS3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBE2R2 | PRSS3 |
| Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. In vitro catalyzesmonoubiquitination and 'Lys-48'-linked polyubiquitination. May beinvolved in degradation of katenin. {ECO:0000269|PubMed:12037680,ECO:0000269|PubMed:20061386}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UBE2R2_PRSS3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UBE2R2_PRSS3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| UBE2R2 | BTRC, RNF113B, ARIH2, CBLC, DTX3L, DZIP3, INF2, PNPLA2, ARHGDIA, FBXW5, RBX1, C9orf78, NUBP2, RAD23A, SFN, DRG2, EZR, GNPDA1, PAK2, UBR7, WDR4, YWHAE, YWHAG, YWHAH, UBC, UBA1, UBE2R2, MEOX1, APPBP2, FBXW11, UBE2D2, KRAS, CTNNB1, TCEANC2, IRF9, BATF3, MUL1, SIRT7 | PRSS3 | TFPI, HDGF, ALB, RPS6KB2, HNRNPA1, MCM2, SHC1, RC3H1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBE2R2_PRSS3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBE2R2_PRSS3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PRSS3 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
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