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Fusion gene ID: 4047 |
FusionGeneSummary for BCL6_IGHG1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BCL6_IGHG1 | Fusion gene ID: 4047 | Hgene | Tgene | Gene symbol | BCL6 | IGHG1 | Gene ID | 604 | 3500 |
| Gene name | B cell CLL/lymphoma 6 | immunoglobulin heavy constant gamma 1 (G1m marker) | |
| Synonyms | BCL5|BCL6A|LAZ3|ZBTB27|ZNF51 | - | |
| Cytomap | 3q27.3 | 14q32.33 | |
| Type of gene | protein-coding | other | |
| Description | B-cell lymphoma 6 proteinB-cell lymphoma 5 proteinB-cell lymphoma 6 protein transcriptBCL-5BCL-6cys-his2 zinc finger transcription factorlymphoma-associated zinc finger gene on chromosome 3protein LAZ-3zinc finger and BTB domain-containing protein | constant region of heavy chain of IgG1immunoglobulin gamma 1 (Gm marker) | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P41182 | P01857 | |
| Ensembl transtripts involved in fusion gene | ENST00000406870, ENST00000232014, ENST00000450123, ENST00000496823, | ENST00000390548, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 32 X 42 X 3=4032 |
| # samples | 4 | 46 | |
| ** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(46/4032*10)=-3.13178987255554 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: BCL6 [Title/Abstract] AND IGHG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BCL6 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 11929873|15577913 |
| Hgene | BCL6 | GO:0006974 | cellular response to DNA damage stimulus | 15577913 |
| Hgene | BCL6 | GO:0030308 | negative regulation of cell growth | 10490843 |
| Hgene | BCL6 | GO:0043065 | positive regulation of apoptotic process | 10490843 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | DLBC | TCGA-GS-A9TY-01A | BCL6 | chr3 | 187463198 | - | IGHG1 | chr14 | 106209407 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000406870 | ENST00000390548 | BCL6 | chr3 | 187463198 | - | IGHG1 | chr14 | 106209407 | - |
| intron-3CDS | ENST00000232014 | ENST00000390548 | BCL6 | chr3 | 187463198 | - | IGHG1 | chr14 | 106209407 | - |
| intron-3CDS | ENST00000450123 | ENST00000390548 | BCL6 | chr3 | 187463198 | - | IGHG1 | chr14 | 106209407 | - |
| 5UTR-3CDS | ENST00000496823 | ENST00000390548 | BCL6 | chr3 | 187463198 | - | IGHG1 | chr14 | 106209407 | - |
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FusionProtFeatures for BCL6_IGHG1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BCL6 | IGHG1 |
| Transcriptional repressor mainly required for germinalcenter (GC) formation and antibody affinity maturation which hasdifferent mechanisms of action specific to the lineage andbiological functions. Forms complexes with different corepressorsand histone deacetylases to repress the transcriptional expressionof different subsets of target genes. Represses its target genesby binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptionalactivity of transcription factors. In GC B-cells, represses genesthat function in differentiation, inflammation, apoptosis and cellcycle control, also autoregulates its transcriptional expressionand up-regulates, indirectly, the expression of some genesimportant for GC reactions, such as AICDA, through the repressionof microRNAs expression, like miR155. An important function is toallow GC B-cells to proliferate very rapidly in response to T-celldependent antigens and tolerate the physiological DNA breaksrequired for immunglobulin class switch recombination and somatichypermutation without inducing a p53/TP53-dependent apoptoticresponse. In follicular helper CD4(+) T-cells (T(FH) cells),promotes the expression of T(FH)-related genes but inhibits thedifferentiation of T(H)1, T(H)2 and T(H)17 cells. Also requiredfor the establishment and maintenance of immunological memory forboth T- and B-cells. Suppresses macrophage proliferation throughcompetition with STAT5 for STAT-binding motifs binding on certaintarget genes, such as CCL2 and CCND2. In response to genotoxicstress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controlsneurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets,such as HES5, including the recruitment of the deacetylase SIRT1and resulting in an epigenetic silencing leading to neuronaldifferentiation. {ECO:0000269|PubMed:10981963,ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12414651,ECO:0000269|PubMed:12504096, ECO:0000269|PubMed:15454082,ECO:0000269|PubMed:15577913, ECO:0000269|PubMed:16142238,ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:18212045,ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:22113614,ECO:0000269|PubMed:23166356, ECO:0000269|PubMed:23911289,ECO:0000269|PubMed:9649500}. | Constant region of immunoglobulin heavy chains.Immunoglobulins, also known as antibodies, are membrane-bound orsecreted glycoproteins produced by B lymphocytes. In therecognition phase of humoral immunity, the membrane-boundimmunoglobulins serve as receptors which, upon binding of aspecific antigen, trigger the clonal expansion and differentiationof B lymphocytes into immunoglobulins-secreting plasma cells.Secreted immunoglobulins mediate the effector phase of humoralimmunity, which results in the elimination of bound antigens(PubMed:22158414, PubMed:20176268). The antigen binding site isformed by the variable domain of one heavy chain, together withthat of its associated light chain. Thus, each immunoglobulin hastwo antigen binding sites with remarkable affinity for aparticular antigen. The variable domains are assembled by aprocess called V-(D)-J rearrangement and can then be subjected tosomatic hypermutations which, after exposure to antigen andselection, allow affinity maturation for a particular antigen(PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170,ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BCL6_IGHG1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BCL6_IGHG1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| BCL6 | HDAC5, HDAC4, HDAC7, BCOR, NCOR2, NCOR1, HDAC1, IRF4, SIN3A, JUN, JUND, JUNB, ZBTB7A, PML, ZBTB16, BACH2, SPI1, BCL6B, EP300, HDAC2, MTA3, MBD3, CHD3, CREBBP, EBF1, HDAC9, PPARGC1A, HNF1A, YY1, E2F3, BCL11A, ATF7, POU2F3, SMARCA4, HELZ2, KDM2A, KMT2B, TRAF3IP3, ZNF443, ZMYND8, SAE1, DDX6, ERCC5, PARP12, LSM1, OSBPL1A, MAPK8IP3, MED23, WNT16, TNFRSF8, ARNT2, LPAR2, EPHB6, NKRF, SMO, LPAR4, PRKD3, PIKFYVE, EIF2AK3, DROSHA, EHMT1, IDI2, TRIB3, SPTLC2, PCDH9, PANX3, CSMD1, ARHGAP35, PPAP2B, SENP7, EIF4ENIF1, CACNA1A, WNK4, DNAH9, KIF13B, HSF4, WDR35, UTP6, OLA1, FBXO11, CDK19, CDK8, MED6, MED17, FOXM1, PIN1, HBEGF, HSP90AA1, NACC1, BCL6, PATZ1, RUNX1T1, CTBP1, RAF1, CUL3, PELI1, AES, KIFC3, SIAH1, TRAF1, BLZF1, ZBTB7B, CUTC, LIMS3, TP53, TWIST1, CTNNB1, IL32, PRKCE, ZBTB17, USP7, HDAC3, CARKD | IGHG1 | FCGR3B, UCHL5, TRIM21, SHC1, ALB, VCAM1, PHB, EGFR, YWHAE, IQCB1, PARK2, CUL7, OBSL1, EED, SUSD3, HSD17B10, CA8, GDPD1, FAM175B, ASCC1, DDX19B, AGA, CCDC51, TFG, UGT1A10, ICE2, ZSCAN20, ALDH2, RBM24, MCM2, PDE4DIP, CDK15, CYP3A5, DDX31, ZNF354C, ALDH3A1, SNX27, TBC1D22B, CYLD, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BCL6_IGHG1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BCL6_IGHG1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | BCL6 | C0024305 | Lymphoma, Non-Hodgkin | 1 | CTD_human |
| Hgene | BCL6 | C0079772 | T-Cell Lymphoma | 1 | CTD_human |
| Tgene | IGHG1 | C0027121 | Myositis | 1 | CTD_human |
| Tgene | IGHG1 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
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