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Fusion gene ID: 40464 |
FusionGeneSummary for UBE2N_APPL2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBE2N_APPL2 | Fusion gene ID: 40464 | Hgene | Tgene | Gene symbol | UBE2N | APPL2 | Gene ID | 7334 | 55198 |
| Gene name | ubiquitin conjugating enzyme E2 N | adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 | |
| Synonyms | HEL-S-71|UBC13|UBCHBEN; UBC13|UbcH-ben|UbcH13 | DIP13B | |
| Cytomap | 12q22 | 12q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin-conjugating enzyme E2 NE2 ubiquitin-conjugating enzyme Nbendless-like ubiquitin conjugating enzymeepididymis secretory protein Li 71ubiquitin carrier protein Nubiquitin conjugating enzyme E2Nubiquitin-conjugating enzyme E2N (UBC13 homolog, | DCC-interacting protein 13-betaDIP13 betaadapter protein containing PH domain, PTB domain and leucine zipper motif 2adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P61088 | Q8NEU8 | |
| Ensembl transtripts involved in fusion gene | ENST00000548946, ENST00000318066, ENST00000550657, ENST00000549833, ENST00000552442, | ENST00000258530, ENST00000539978, ENST00000546731, ENST00000551662, ENST00000549573, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 4 X 3=48 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: UBE2N [Title/Abstract] AND APPL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UBE2N | GO:0070534 | protein K63-linked ubiquitination | 16307917|20061386|21512573 |
| Tgene | APPL2 | GO:0008283 | cell proliferation | 15016378 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-YL-A8SP-01B | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000548946 | ENST00000258530 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| intron-5UTR | ENST00000548946 | ENST00000539978 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| intron-intron | ENST00000548946 | ENST00000546731 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| intron-intron | ENST00000548946 | ENST00000551662 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| intron-intron | ENST00000548946 | ENST00000549573 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| In-frame | ENST00000318066 | ENST00000258530 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| 5CDS-5UTR | ENST00000318066 | ENST00000539978 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| 5CDS-intron | ENST00000318066 | ENST00000546731 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| 5CDS-intron | ENST00000318066 | ENST00000551662 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| 5CDS-intron | ENST00000318066 | ENST00000549573 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| In-frame | ENST00000550657 | ENST00000258530 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| 5CDS-5UTR | ENST00000550657 | ENST00000539978 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| 5CDS-intron | ENST00000550657 | ENST00000546731 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| 5CDS-intron | ENST00000550657 | ENST00000551662 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| 5CDS-intron | ENST00000550657 | ENST00000549573 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| intron-3CDS | ENST00000549833 | ENST00000258530 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| intron-5UTR | ENST00000549833 | ENST00000539978 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| intron-intron | ENST00000549833 | ENST00000546731 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| intron-intron | ENST00000549833 | ENST00000551662 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| intron-intron | ENST00000549833 | ENST00000549573 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| In-frame | ENST00000552442 | ENST00000258530 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| 5CDS-5UTR | ENST00000552442 | ENST00000539978 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| 5CDS-intron | ENST00000552442 | ENST00000546731 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| 5CDS-intron | ENST00000552442 | ENST00000551662 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
| 5CDS-intron | ENST00000552442 | ENST00000549573 | UBE2N | chr12 | 93835631 | - | APPL2 | chr12 | 105623001 | - |
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FusionProtFeatures for UBE2N_APPL2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBE2N | APPL2 |
| The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyzethe synthesis of non-canonical 'Lys-63'-linked polyubiquitinchains. This type of polyubiquitination does not lead to proteindegradation by the proteasome. Mediates transcriptional activationof target genes. Plays a role in the control of progress throughthe cell cycle and differentiation. Plays a role in the error-freeDNA repair pathway and contributes to the survival of cells afterDNA damage. Acts together with the E3 ligases, HLTF and SHPRH, inthe 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxicstress, which is required for DNA repair. Appears to act togetherwith E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination ofJKAMP thereby regulating JKAMP function by decreasing itsassociation with components of the proteasome and ERAD. PromotesTRIM5 capsid-specific restriction activity and the UBE2V1-UBE2Nheterodimer acts in concert with TRIM5 to generate 'Lys-63'-linkedpolyubiquitin chains which activate the MAP3K7/TAK1 complex whichin turn results in the induction and expression of NF-kappa-B andMAPK-responsive inflammatory genes. {ECO:0000269|PubMed:10089880,ECO:0000269|PubMed:14562038, ECO:0000269|PubMed:19269966,ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:21512573}. | Required for the regulation of cell proliferation inresponse to extracellular signals mediated by an early endosomalcompartment. Links Rab5 to nuclear signal transduction.{ECO:0000269|PubMed:15016378}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UBE2N_APPL2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_UBE2N_ENST00000318066_chr12_93835631_-_APPL2_ENST00000258530_chr12_105623001_-_657aa MAGLPRRIIKTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLLAYEKQNFALGKGDEEVISTLHYFSKVVDELNL LHTELAKQLADTMVLPIIQFREKDLTEVSTLKDLFGLASNEHDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRKQHLSSLQYYCALNAL QYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVELEAEAEKMRVSQQELLSVDESVYTPDSDVAAPQINRNLI QKAGYLNLRNKTGLVTTTWERLYFFTQGGNLMCQPRGAVAGGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKSGIILQAESRKENEEWIC AINNISRQIYLTDNPEAVAIKLNQTALQAVTPITSFGKKQESSCPSQNLKNSEMENENDKIVPKATASLPEAEELIAPGTPIQFDIVLPA TEFLDQNRGSRRTNPFGETEDESFPEAEDSLLQQMFIVRFLGSMAVKTDSTTEVIYEAMRQVLAARAIHNIFRMTESHLMVTSQSLRLID PQTQVSRANFELTSVTQFAAHQENKRLVGFVIRVPESTGEESLSTYIFESNSEGEKICYAINLGKEIIEVQKDPEALAQLMLSIPLTNDG >In-frame_UBE2N_ENST00000550657_chr12_93835631_-_APPL2_ENST00000258530_chr12_105623001_-_657aa MAGLPRRIIKTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLLAYEKQNFALGKGDEEVISTLHYFSKVVDELNL LHTELAKQLADTMVLPIIQFREKDLTEVSTLKDLFGLASNEHDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRKQHLSSLQYYCALNAL QYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVELEAEAEKMRVSQQELLSVDESVYTPDSDVAAPQINRNLI QKAGYLNLRNKTGLVTTTWERLYFFTQGGNLMCQPRGAVAGGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKSGIILQAESRKENEEWIC AINNISRQIYLTDNPEAVAIKLNQTALQAVTPITSFGKKQESSCPSQNLKNSEMENENDKIVPKATASLPEAEELIAPGTPIQFDIVLPA TEFLDQNRGSRRTNPFGETEDESFPEAEDSLLQQMFIVRFLGSMAVKTDSTTEVIYEAMRQVLAARAIHNIFRMTESHLMVTSQSLRLID PQTQVSRANFELTSVTQFAAHQENKRLVGFVIRVPESTGEESLSTYIFESNSEGEKICYAINLGKEIIEVQKDPEALAQLMLSIPLTNDG >In-frame_UBE2N_ENST00000552442_chr12_93835631_-_APPL2_ENST00000258530_chr12_105623001_-_657aa MAGLPRRIIKTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLLAYEKQNFALGKGDEEVISTLHYFSKVVDELNL LHTELAKQLADTMVLPIIQFREKDLTEVSTLKDLFGLASNEHDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRKQHLSSLQYYCALNAL QYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVELEAEAEKMRVSQQELLSVDESVYTPDSDVAAPQINRNLI QKAGYLNLRNKTGLVTTTWERLYFFTQGGNLMCQPRGAVAGGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKSGIILQAESRKENEEWIC AINNISRQIYLTDNPEAVAIKLNQTALQAVTPITSFGKKQESSCPSQNLKNSEMENENDKIVPKATASLPEAEELIAPGTPIQFDIVLPA TEFLDQNRGSRRTNPFGETEDESFPEAEDSLLQQMFIVRFLGSMAVKTDSTTEVIYEAMRQVLAARAIHNIFRMTESHLMVTSQSLRLID PQTQVSRANFELTSVTQFAAHQENKRLVGFVIRVPESTGEESLSTYIFESNSEGEKICYAINLGKEIIEVQKDPEALAQLMLSIPLTNDG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_UBE2N_ENST00000318066_chr12_93835631_-_APPL2_ENST00000258530_chr12_105623001_-_1971nt ATGGCCGGGCTGCCCCGCAGGATCATCAAGACTCGCTCTTTACTGAGCGTGTTTGAAGAAGATGCTGGCACCCTCACAGACTATACCAAC CAGCTGCTCCAGGCAATGCAGCGCGTCTATGGAGCCCAGAATGAGATGTGCCTGGCCACACAACAGCTTTCTAAGCAACTGCTGGCATAT GAAAAACAGAACTTTGCTCTTGGCAAAGGTGATGAAGAAGTAATTTCAACACTCCACTATTTTTCCAAAGTGGTGGATGAGCTTAATCTT CTCCATACAGAGCTGGCTAAACAGTTGGCAGACACAATGGTTCTACCTATCATACAATTCCGAGAAAAGGATCTCACAGAAGTAAGCACT TTAAAGGATCTATTTGGACTCGCTAGCAATGAGCATGACCTCTCAATGGCAAAATACAGCAGGCTGCCTAAGAAAAAGGAGAATGAGAAG GTGAAGACCGAAGTCGGAAAAGAGGTGGCCGCGGCCCGGCGGAAGCAGCACCTCTCCTCCCTTCAGTACTACTGTGCCCTCAACGCGCTG CAGTACAGAAAGCAAATGGCCATGATGGAGCCCATGATAGGCTTTGCCCATGGACAGATTAACTTTTTTAAGAAGGGAGCAGAGATGTTT TCCAAACGTATGGACAGCTTTTTATCCTCCGTTGCAGACATGGTTCAAAGCATTCAGGTAGAACTGGAAGCCGAGGCGGAAAAGATGCGG GTGTCCCAGCAAGAATTACTTTCTGTTGATGAATCTGTTTACACTCCAGACTCTGATGTGGCCGCACCACAGATCAACAGGAACCTCATC CAGAAGGCTGGTTACCTTAATCTTAGAAACAAAACAGGGCTGGTCACCACCACCTGGGAGAGGCTTTATTTCTTCACCCAAGGCGGGAAT CTCATGTGTCAGCCCAGGGGAGCCGTGGCTGGAGGTTTGATCCAGGACCTGGACAACTGCTCAGTGATGGCCGTGGATTGCGAAGACCGG CGCTACTGCTTCCAGATCACCACGCCCAATGGAAAATCGGGAATAATCCTCCAGGCTGAGAGCAGAAAGGAAAATGAAGAGTGGATATGT GCAATAAACAACATCTCCAGACAGATCTACCTGACCGACAACCCTGAGGCAGTCGCGATCAAGTTGAATCAGACCGCTCTGCAAGCAGTG ACTCCCATTACAAGTTTTGGAAAAAAACAAGAAAGCTCATGCCCCAGCCAGAACCTGAAAAATTCAGAGATGGAAAATGAAAATGACAAG ATTGTTCCCAAAGCAACAGCCAGTCTACCTGAAGCAGAGGAGCTGATCGCGCCTGGAACGCCGATTCAATTCGATATTGTGCTTCCTGCT ACAGAATTCCTTGATCAGAACAGAGGGAGCAGGCGTACCAACCCTTTTGGTGAAACTGAGGATGAATCATTTCCAGAAGCAGAAGATTCT CTTTTGCAGCAGATGTTTATAGTTCGGTTTTTGGGATCAATGGCAGTTAAAACAGACAGCACTACTGAAGTGATTTATGAAGCGATGAGA CAAGTATTGGCTGCTCGGGCTATTCATAACATCTTCCGCATGACAGAATCCCATCTGATGGTCACCAGTCAATCTTTGAGGTTGATAGAT CCACAGACTCAAGTATCAAGGGCCAATTTTGAACTTACCAGTGTCACACAATTTGCTGCTCATCAAGAAAACAAGAGACTGGTTGGTTTT GTCATCCGTGTTCCTGAATCCACTGGAGAAGAATCTCTGAGTACATACATTTTTGAAAGCAACTCAGAAGGCGAAAAGATATGTTATGCT ATTAATTTGGGAAAAGAAATTATTGAGGTTCAGAAGGATCCAGAAGCACTGGCTCAATTAATGCTGTCCATACCACTAACCAATGACGGA >In-frame_UBE2N_ENST00000550657_chr12_93835631_-_APPL2_ENST00000258530_chr12_105623001_-_1971nt ATGGCCGGGCTGCCCCGCAGGATCATCAAGACTCGCTCTTTACTGAGCGTGTTTGAAGAAGATGCTGGCACCCTCACAGACTATACCAAC CAGCTGCTCCAGGCAATGCAGCGCGTCTATGGAGCCCAGAATGAGATGTGCCTGGCCACACAACAGCTTTCTAAGCAACTGCTGGCATAT GAAAAACAGAACTTTGCTCTTGGCAAAGGTGATGAAGAAGTAATTTCAACACTCCACTATTTTTCCAAAGTGGTGGATGAGCTTAATCTT CTCCATACAGAGCTGGCTAAACAGTTGGCAGACACAATGGTTCTACCTATCATACAATTCCGAGAAAAGGATCTCACAGAAGTAAGCACT TTAAAGGATCTATTTGGACTCGCTAGCAATGAGCATGACCTCTCAATGGCAAAATACAGCAGGCTGCCTAAGAAAAAGGAGAATGAGAAG GTGAAGACCGAAGTCGGAAAAGAGGTGGCCGCGGCCCGGCGGAAGCAGCACCTCTCCTCCCTTCAGTACTACTGTGCCCTCAACGCGCTG CAGTACAGAAAGCAAATGGCCATGATGGAGCCCATGATAGGCTTTGCCCATGGACAGATTAACTTTTTTAAGAAGGGAGCAGAGATGTTT TCCAAACGTATGGACAGCTTTTTATCCTCCGTTGCAGACATGGTTCAAAGCATTCAGGTAGAACTGGAAGCCGAGGCGGAAAAGATGCGG GTGTCCCAGCAAGAATTACTTTCTGTTGATGAATCTGTTTACACTCCAGACTCTGATGTGGCCGCACCACAGATCAACAGGAACCTCATC CAGAAGGCTGGTTACCTTAATCTTAGAAACAAAACAGGGCTGGTCACCACCACCTGGGAGAGGCTTTATTTCTTCACCCAAGGCGGGAAT CTCATGTGTCAGCCCAGGGGAGCCGTGGCTGGAGGTTTGATCCAGGACCTGGACAACTGCTCAGTGATGGCCGTGGATTGCGAAGACCGG CGCTACTGCTTCCAGATCACCACGCCCAATGGAAAATCGGGAATAATCCTCCAGGCTGAGAGCAGAAAGGAAAATGAAGAGTGGATATGT GCAATAAACAACATCTCCAGACAGATCTACCTGACCGACAACCCTGAGGCAGTCGCGATCAAGTTGAATCAGACCGCTCTGCAAGCAGTG ACTCCCATTACAAGTTTTGGAAAAAAACAAGAAAGCTCATGCCCCAGCCAGAACCTGAAAAATTCAGAGATGGAAAATGAAAATGACAAG ATTGTTCCCAAAGCAACAGCCAGTCTACCTGAAGCAGAGGAGCTGATCGCGCCTGGAACGCCGATTCAATTCGATATTGTGCTTCCTGCT ACAGAATTCCTTGATCAGAACAGAGGGAGCAGGCGTACCAACCCTTTTGGTGAAACTGAGGATGAATCATTTCCAGAAGCAGAAGATTCT CTTTTGCAGCAGATGTTTATAGTTCGGTTTTTGGGATCAATGGCAGTTAAAACAGACAGCACTACTGAAGTGATTTATGAAGCGATGAGA CAAGTATTGGCTGCTCGGGCTATTCATAACATCTTCCGCATGACAGAATCCCATCTGATGGTCACCAGTCAATCTTTGAGGTTGATAGAT CCACAGACTCAAGTATCAAGGGCCAATTTTGAACTTACCAGTGTCACACAATTTGCTGCTCATCAAGAAAACAAGAGACTGGTTGGTTTT GTCATCCGTGTTCCTGAATCCACTGGAGAAGAATCTCTGAGTACATACATTTTTGAAAGCAACTCAGAAGGCGAAAAGATATGTTATGCT ATTAATTTGGGAAAAGAAATTATTGAGGTTCAGAAGGATCCAGAAGCACTGGCTCAATTAATGCTGTCCATACCACTAACCAATGACGGA >In-frame_UBE2N_ENST00000552442_chr12_93835631_-_APPL2_ENST00000258530_chr12_105623001_-_1971nt ATGGCCGGGCTGCCCCGCAGGATCATCAAGACTCGCTCTTTACTGAGCGTGTTTGAAGAAGATGCTGGCACCCTCACAGACTATACCAAC CAGCTGCTCCAGGCAATGCAGCGCGTCTATGGAGCCCAGAATGAGATGTGCCTGGCCACACAACAGCTTTCTAAGCAACTGCTGGCATAT GAAAAACAGAACTTTGCTCTTGGCAAAGGTGATGAAGAAGTAATTTCAACACTCCACTATTTTTCCAAAGTGGTGGATGAGCTTAATCTT CTCCATACAGAGCTGGCTAAACAGTTGGCAGACACAATGGTTCTACCTATCATACAATTCCGAGAAAAGGATCTCACAGAAGTAAGCACT TTAAAGGATCTATTTGGACTCGCTAGCAATGAGCATGACCTCTCAATGGCAAAATACAGCAGGCTGCCTAAGAAAAAGGAGAATGAGAAG GTGAAGACCGAAGTCGGAAAAGAGGTGGCCGCGGCCCGGCGGAAGCAGCACCTCTCCTCCCTTCAGTACTACTGTGCCCTCAACGCGCTG CAGTACAGAAAGCAAATGGCCATGATGGAGCCCATGATAGGCTTTGCCCATGGACAGATTAACTTTTTTAAGAAGGGAGCAGAGATGTTT TCCAAACGTATGGACAGCTTTTTATCCTCCGTTGCAGACATGGTTCAAAGCATTCAGGTAGAACTGGAAGCCGAGGCGGAAAAGATGCGG GTGTCCCAGCAAGAATTACTTTCTGTTGATGAATCTGTTTACACTCCAGACTCTGATGTGGCCGCACCACAGATCAACAGGAACCTCATC CAGAAGGCTGGTTACCTTAATCTTAGAAACAAAACAGGGCTGGTCACCACCACCTGGGAGAGGCTTTATTTCTTCACCCAAGGCGGGAAT CTCATGTGTCAGCCCAGGGGAGCCGTGGCTGGAGGTTTGATCCAGGACCTGGACAACTGCTCAGTGATGGCCGTGGATTGCGAAGACCGG CGCTACTGCTTCCAGATCACCACGCCCAATGGAAAATCGGGAATAATCCTCCAGGCTGAGAGCAGAAAGGAAAATGAAGAGTGGATATGT GCAATAAACAACATCTCCAGACAGATCTACCTGACCGACAACCCTGAGGCAGTCGCGATCAAGTTGAATCAGACCGCTCTGCAAGCAGTG ACTCCCATTACAAGTTTTGGAAAAAAACAAGAAAGCTCATGCCCCAGCCAGAACCTGAAAAATTCAGAGATGGAAAATGAAAATGACAAG ATTGTTCCCAAAGCAACAGCCAGTCTACCTGAAGCAGAGGAGCTGATCGCGCCTGGAACGCCGATTCAATTCGATATTGTGCTTCCTGCT ACAGAATTCCTTGATCAGAACAGAGGGAGCAGGCGTACCAACCCTTTTGGTGAAACTGAGGATGAATCATTTCCAGAAGCAGAAGATTCT CTTTTGCAGCAGATGTTTATAGTTCGGTTTTTGGGATCAATGGCAGTTAAAACAGACAGCACTACTGAAGTGATTTATGAAGCGATGAGA CAAGTATTGGCTGCTCGGGCTATTCATAACATCTTCCGCATGACAGAATCCCATCTGATGGTCACCAGTCAATCTTTGAGGTTGATAGAT CCACAGACTCAAGTATCAAGGGCCAATTTTGAACTTACCAGTGTCACACAATTTGCTGCTCATCAAGAAAACAAGAGACTGGTTGGTTTT GTCATCCGTGTTCCTGAATCCACTGGAGAAGAATCTCTGAGTACATACATTTTTGAAAGCAACTCAGAAGGCGAAAAGATATGTTATGCT ATTAATTTGGGAAAAGAAATTATTGAGGTTCAGAAGGATCCAGAAGCACTGGCTCAATTAATGCTGTCCATACCACTAACCAATGACGGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_UBE2N_ENST00000318066_chr12_93835631_-_APPL2_ENST00000258530_chr12_105623001_-_3367nt GGTTAAGAGAGACGCGCGCGCAGTCGCGCGCGGGTCGTGCCGTACCACCGTCGCGGGCAGGCTCGGCCACGAGCGCCAGAGCCCCGCGCC TCCCCTCGCGGCCTGTCCCAAGTCCCTGCCCCGCAACAGAGCGTCACTTCCGCCATCCCCGGCAGCGGTTGGGGCGGGGCGCACGGGGGA GGGGGCCAGGTCGGAGGGAAGCCCGCCCGTGCCCGAGCCCGCGCCCGAGCAGGGACTACATTTCCCGAGGGGCCTCGGCGGCGGCTGCGG CGACGGGCGCGGCAACGTCCCCCGGAAGTGGAGCCCGGGACTTCCACTCGTGCGTGAGGCGAGAGGAGCCGGAGACGAGACCAGAGGCCG AACTCGGGTTCTGACAAGATGGCCGGGCTGCCCCGCAGGATCATCAAGACTCGCTCTTTACTGAGCGTGTTTGAAGAAGATGCTGGCACC CTCACAGACTATACCAACCAGCTGCTCCAGGCAATGCAGCGCGTCTATGGAGCCCAGAATGAGATGTGCCTGGCCACACAACAGCTTTCT AAGCAACTGCTGGCATATGAAAAACAGAACTTTGCTCTTGGCAAAGGTGATGAAGAAGTAATTTCAACACTCCACTATTTTTCCAAAGTG GTGGATGAGCTTAATCTTCTCCATACAGAGCTGGCTAAACAGTTGGCAGACACAATGGTTCTACCTATCATACAATTCCGAGAAAAGGAT CTCACAGAAGTAAGCACTTTAAAGGATCTATTTGGACTCGCTAGCAATGAGCATGACCTCTCAATGGCAAAATACAGCAGGCTGCCTAAG AAAAAGGAGAATGAGAAGGTGAAGACCGAAGTCGGAAAAGAGGTGGCCGCGGCCCGGCGGAAGCAGCACCTCTCCTCCCTTCAGTACTAC TGTGCCCTCAACGCGCTGCAGTACAGAAAGCAAATGGCCATGATGGAGCCCATGATAGGCTTTGCCCATGGACAGATTAACTTTTTTAAG AAGGGAGCAGAGATGTTTTCCAAACGTATGGACAGCTTTTTATCCTCCGTTGCAGACATGGTTCAAAGCATTCAGGTAGAACTGGAAGCC GAGGCGGAAAAGATGCGGGTGTCCCAGCAAGAATTACTTTCTGTTGATGAATCTGTTTACACTCCAGACTCTGATGTGGCCGCACCACAG ATCAACAGGAACCTCATCCAGAAGGCTGGTTACCTTAATCTTAGAAACAAAACAGGGCTGGTCACCACCACCTGGGAGAGGCTTTATTTC TTCACCCAAGGCGGGAATCTCATGTGTCAGCCCAGGGGAGCCGTGGCTGGAGGTTTGATCCAGGACCTGGACAACTGCTCAGTGATGGCC GTGGATTGCGAAGACCGGCGCTACTGCTTCCAGATCACCACGCCCAATGGAAAATCGGGAATAATCCTCCAGGCTGAGAGCAGAAAGGAA AATGAAGAGTGGATATGTGCAATAAACAACATCTCCAGACAGATCTACCTGACCGACAACCCTGAGGCAGTCGCGATCAAGTTGAATCAG ACCGCTCTGCAAGCAGTGACTCCCATTACAAGTTTTGGAAAAAAACAAGAAAGCTCATGCCCCAGCCAGAACCTGAAAAATTCAGAGATG GAAAATGAAAATGACAAGATTGTTCCCAAAGCAACAGCCAGTCTACCTGAAGCAGAGGAGCTGATCGCGCCTGGAACGCCGATTCAATTC GATATTGTGCTTCCTGCTACAGAATTCCTTGATCAGAACAGAGGGAGCAGGCGTACCAACCCTTTTGGTGAAACTGAGGATGAATCATTT CCAGAAGCAGAAGATTCTCTTTTGCAGCAGATGTTTATAGTTCGGTTTTTGGGATCAATGGCAGTTAAAACAGACAGCACTACTGAAGTG ATTTATGAAGCGATGAGACAAGTATTGGCTGCTCGGGCTATTCATAACATCTTCCGCATGACAGAATCCCATCTGATGGTCACCAGTCAA TCTTTGAGGTTGATAGATCCACAGACTCAAGTATCAAGGGCCAATTTTGAACTTACCAGTGTCACACAATTTGCTGCTCATCAAGAAAAC AAGAGACTGGTTGGTTTTGTCATCCGTGTTCCTGAATCCACTGGAGAAGAATCTCTGAGTACATACATTTTTGAAAGCAACTCAGAAGGC GAAAAGATATGTTATGCTATTAATTTGGGAAAAGAAATTATTGAGGTTCAGAAGGATCCAGAAGCACTGGCTCAATTAATGCTGTCCATA CCACTAACCAATGACGGAAAATATGTACTGTTAAACGATCAACCAGATGACGATGATGGAAATCCAAACGAACATAGAGGCGCAGAATCC GAAGCATAACTCACTTGCGCCTGTGGGGGAAGAGCAAACAGGAAGGAGAGCTACCTCCTAAGGGTTTTAACGTCTCTGACATACAGGCAC ACTGACCTGATTTCCGAAGGCTGACAATCGTTTGTGGAATGTAATCTTGATGCCTTGATACTGAGACTTGGGAGGGAAACTAAGAAATGG TTGACAGCGTTCCCACCCATCTACAATGTTATTTTAGGTGCTTTGTGGTAAGTCTTTTTTCTTAGATTGCGCTAAAATTTCTTAGATTGT TCAGCGCTCAGAACAAAAGTTTGAAAAATGCATTGTTCATATGAATGTCATCTCTTTTCAGTTTCCAGTATCCTTTTTAAAAAATGGCAA AAGCCTAGATTTACAATTTGATGAACACTAAATATTTCTTATTAATATAATCTATTTTTGTATTTTACTTAATGAGCTTTAAGTGCCTGT CGTTCTGAAAATTGTGTATTTATAATTCAGCTTATCTCATAATTGGACCTAATAGCATTTCTTTGTGCAGTTAGGTGATGAGCACTGCTT TGAGGCCCAAGCACTAGTAGAGATGCGCGATACAGGTCTAGTTTCGGTAACTGTTCCAGACATCAAGCAATAAAAAAATGAATACCACAA AAGATGTTTGATTTTACAGTGGAGCCTTACTGAACCAGCATTCAGAAGTTTAAGGTCCTCCTAGGTATGAGTATTTTTAGTAGTGGATCA CTGTGGACAGGGTGCAGCTCTACCAGTTCCTGTTTCTTCTGAGCCAGACCCTCTTCAGGGAAGGGACCAATTAATTTTAAAACTCACTTG AAGCACAGCTGGTCATGGGGCTTGGTATAAAGTTCCTATTTCCACCCTGATACTTCCAATTCCTGGAACCCCAGCCCACTCCCCCATCCC TCCTCCCTATCAAACTAGTATAATGATTTTGAATCGGTACAGTGTGTTTAACTGTAACTAAGTTCAACAGACTATTATTATCTTTGTAAT >In-frame_UBE2N_ENST00000550657_chr12_93835631_-_APPL2_ENST00000258530_chr12_105623001_-_3048nt GTGCGTGAGGCGAGAGGAGCCGGAGACGAGACCAGAGGCCGAACTCGGGTTCTGACAAGATGGCCGGGCTGCCCCGCAGGATCATCAAGA CTCGCTCTTTACTGAGCGTGTTTGAAGAAGATGCTGGCACCCTCACAGACTATACCAACCAGCTGCTCCAGGCAATGCAGCGCGTCTATG GAGCCCAGAATGAGATGTGCCTGGCCACACAACAGCTTTCTAAGCAACTGCTGGCATATGAAAAACAGAACTTTGCTCTTGGCAAAGGTG ATGAAGAAGTAATTTCAACACTCCACTATTTTTCCAAAGTGGTGGATGAGCTTAATCTTCTCCATACAGAGCTGGCTAAACAGTTGGCAG ACACAATGGTTCTACCTATCATACAATTCCGAGAAAAGGATCTCACAGAAGTAAGCACTTTAAAGGATCTATTTGGACTCGCTAGCAATG AGCATGACCTCTCAATGGCAAAATACAGCAGGCTGCCTAAGAAAAAGGAGAATGAGAAGGTGAAGACCGAAGTCGGAAAAGAGGTGGCCG CGGCCCGGCGGAAGCAGCACCTCTCCTCCCTTCAGTACTACTGTGCCCTCAACGCGCTGCAGTACAGAAAGCAAATGGCCATGATGGAGC CCATGATAGGCTTTGCCCATGGACAGATTAACTTTTTTAAGAAGGGAGCAGAGATGTTTTCCAAACGTATGGACAGCTTTTTATCCTCCG TTGCAGACATGGTTCAAAGCATTCAGGTAGAACTGGAAGCCGAGGCGGAAAAGATGCGGGTGTCCCAGCAAGAATTACTTTCTGTTGATG AATCTGTTTACACTCCAGACTCTGATGTGGCCGCACCACAGATCAACAGGAACCTCATCCAGAAGGCTGGTTACCTTAATCTTAGAAACA AAACAGGGCTGGTCACCACCACCTGGGAGAGGCTTTATTTCTTCACCCAAGGCGGGAATCTCATGTGTCAGCCCAGGGGAGCCGTGGCTG GAGGTTTGATCCAGGACCTGGACAACTGCTCAGTGATGGCCGTGGATTGCGAAGACCGGCGCTACTGCTTCCAGATCACCACGCCCAATG GAAAATCGGGAATAATCCTCCAGGCTGAGAGCAGAAAGGAAAATGAAGAGTGGATATGTGCAATAAACAACATCTCCAGACAGATCTACC TGACCGACAACCCTGAGGCAGTCGCGATCAAGTTGAATCAGACCGCTCTGCAAGCAGTGACTCCCATTACAAGTTTTGGAAAAAAACAAG AAAGCTCATGCCCCAGCCAGAACCTGAAAAATTCAGAGATGGAAAATGAAAATGACAAGATTGTTCCCAAAGCAACAGCCAGTCTACCTG AAGCAGAGGAGCTGATCGCGCCTGGAACGCCGATTCAATTCGATATTGTGCTTCCTGCTACAGAATTCCTTGATCAGAACAGAGGGAGCA GGCGTACCAACCCTTTTGGTGAAACTGAGGATGAATCATTTCCAGAAGCAGAAGATTCTCTTTTGCAGCAGATGTTTATAGTTCGGTTTT TGGGATCAATGGCAGTTAAAACAGACAGCACTACTGAAGTGATTTATGAAGCGATGAGACAAGTATTGGCTGCTCGGGCTATTCATAACA TCTTCCGCATGACAGAATCCCATCTGATGGTCACCAGTCAATCTTTGAGGTTGATAGATCCACAGACTCAAGTATCAAGGGCCAATTTTG AACTTACCAGTGTCACACAATTTGCTGCTCATCAAGAAAACAAGAGACTGGTTGGTTTTGTCATCCGTGTTCCTGAATCCACTGGAGAAG AATCTCTGAGTACATACATTTTTGAAAGCAACTCAGAAGGCGAAAAGATATGTTATGCTATTAATTTGGGAAAAGAAATTATTGAGGTTC AGAAGGATCCAGAAGCACTGGCTCAATTAATGCTGTCCATACCACTAACCAATGACGGAAAATATGTACTGTTAAACGATCAACCAGATG ACGATGATGGAAATCCAAACGAACATAGAGGCGCAGAATCCGAAGCATAACTCACTTGCGCCTGTGGGGGAAGAGCAAACAGGAAGGAGA GCTACCTCCTAAGGGTTTTAACGTCTCTGACATACAGGCACACTGACCTGATTTCCGAAGGCTGACAATCGTTTGTGGAATGTAATCTTG ATGCCTTGATACTGAGACTTGGGAGGGAAACTAAGAAATGGTTGACAGCGTTCCCACCCATCTACAATGTTATTTTAGGTGCTTTGTGGT AAGTCTTTTTTCTTAGATTGCGCTAAAATTTCTTAGATTGTTCAGCGCTCAGAACAAAAGTTTGAAAAATGCATTGTTCATATGAATGTC ATCTCTTTTCAGTTTCCAGTATCCTTTTTAAAAAATGGCAAAAGCCTAGATTTACAATTTGATGAACACTAAATATTTCTTATTAATATA ATCTATTTTTGTATTTTACTTAATGAGCTTTAAGTGCCTGTCGTTCTGAAAATTGTGTATTTATAATTCAGCTTATCTCATAATTGGACC TAATAGCATTTCTTTGTGCAGTTAGGTGATGAGCACTGCTTTGAGGCCCAAGCACTAGTAGAGATGCGCGATACAGGTCTAGTTTCGGTA ACTGTTCCAGACATCAAGCAATAAAAAAATGAATACCACAAAAGATGTTTGATTTTACAGTGGAGCCTTACTGAACCAGCATTCAGAAGT TTAAGGTCCTCCTAGGTATGAGTATTTTTAGTAGTGGATCACTGTGGACAGGGTGCAGCTCTACCAGTTCCTGTTTCTTCTGAGCCAGAC CCTCTTCAGGGAAGGGACCAATTAATTTTAAAACTCACTTGAAGCACAGCTGGTCATGGGGCTTGGTATAAAGTTCCTATTTCCACCCTG ATACTTCCAATTCCTGGAACCCCAGCCCACTCCCCCATCCCTCCTCCCTATCAAACTAGTATAATGATTTTGAATCGGTACAGTGTGTTT >In-frame_UBE2N_ENST00000552442_chr12_93835631_-_APPL2_ENST00000258530_chr12_105623001_-_3040nt GGCGAGAGGAGCCGGAGACGAGACCAGAGGCCGAACTCGGGTTCTGACAAGATGGCCGGGCTGCCCCGCAGGATCATCAAGACTCGCTCT TTACTGAGCGTGTTTGAAGAAGATGCTGGCACCCTCACAGACTATACCAACCAGCTGCTCCAGGCAATGCAGCGCGTCTATGGAGCCCAG AATGAGATGTGCCTGGCCACACAACAGCTTTCTAAGCAACTGCTGGCATATGAAAAACAGAACTTTGCTCTTGGCAAAGGTGATGAAGAA GTAATTTCAACACTCCACTATTTTTCCAAAGTGGTGGATGAGCTTAATCTTCTCCATACAGAGCTGGCTAAACAGTTGGCAGACACAATG GTTCTACCTATCATACAATTCCGAGAAAAGGATCTCACAGAAGTAAGCACTTTAAAGGATCTATTTGGACTCGCTAGCAATGAGCATGAC CTCTCAATGGCAAAATACAGCAGGCTGCCTAAGAAAAAGGAGAATGAGAAGGTGAAGACCGAAGTCGGAAAAGAGGTGGCCGCGGCCCGG CGGAAGCAGCACCTCTCCTCCCTTCAGTACTACTGTGCCCTCAACGCGCTGCAGTACAGAAAGCAAATGGCCATGATGGAGCCCATGATA GGCTTTGCCCATGGACAGATTAACTTTTTTAAGAAGGGAGCAGAGATGTTTTCCAAACGTATGGACAGCTTTTTATCCTCCGTTGCAGAC ATGGTTCAAAGCATTCAGGTAGAACTGGAAGCCGAGGCGGAAAAGATGCGGGTGTCCCAGCAAGAATTACTTTCTGTTGATGAATCTGTT TACACTCCAGACTCTGATGTGGCCGCACCACAGATCAACAGGAACCTCATCCAGAAGGCTGGTTACCTTAATCTTAGAAACAAAACAGGG CTGGTCACCACCACCTGGGAGAGGCTTTATTTCTTCACCCAAGGCGGGAATCTCATGTGTCAGCCCAGGGGAGCCGTGGCTGGAGGTTTG ATCCAGGACCTGGACAACTGCTCAGTGATGGCCGTGGATTGCGAAGACCGGCGCTACTGCTTCCAGATCACCACGCCCAATGGAAAATCG GGAATAATCCTCCAGGCTGAGAGCAGAAAGGAAAATGAAGAGTGGATATGTGCAATAAACAACATCTCCAGACAGATCTACCTGACCGAC AACCCTGAGGCAGTCGCGATCAAGTTGAATCAGACCGCTCTGCAAGCAGTGACTCCCATTACAAGTTTTGGAAAAAAACAAGAAAGCTCA TGCCCCAGCCAGAACCTGAAAAATTCAGAGATGGAAAATGAAAATGACAAGATTGTTCCCAAAGCAACAGCCAGTCTACCTGAAGCAGAG GAGCTGATCGCGCCTGGAACGCCGATTCAATTCGATATTGTGCTTCCTGCTACAGAATTCCTTGATCAGAACAGAGGGAGCAGGCGTACC AACCCTTTTGGTGAAACTGAGGATGAATCATTTCCAGAAGCAGAAGATTCTCTTTTGCAGCAGATGTTTATAGTTCGGTTTTTGGGATCA ATGGCAGTTAAAACAGACAGCACTACTGAAGTGATTTATGAAGCGATGAGACAAGTATTGGCTGCTCGGGCTATTCATAACATCTTCCGC ATGACAGAATCCCATCTGATGGTCACCAGTCAATCTTTGAGGTTGATAGATCCACAGACTCAAGTATCAAGGGCCAATTTTGAACTTACC AGTGTCACACAATTTGCTGCTCATCAAGAAAACAAGAGACTGGTTGGTTTTGTCATCCGTGTTCCTGAATCCACTGGAGAAGAATCTCTG AGTACATACATTTTTGAAAGCAACTCAGAAGGCGAAAAGATATGTTATGCTATTAATTTGGGAAAAGAAATTATTGAGGTTCAGAAGGAT CCAGAAGCACTGGCTCAATTAATGCTGTCCATACCACTAACCAATGACGGAAAATATGTACTGTTAAACGATCAACCAGATGACGATGAT GGAAATCCAAACGAACATAGAGGCGCAGAATCCGAAGCATAACTCACTTGCGCCTGTGGGGGAAGAGCAAACAGGAAGGAGAGCTACCTC CTAAGGGTTTTAACGTCTCTGACATACAGGCACACTGACCTGATTTCCGAAGGCTGACAATCGTTTGTGGAATGTAATCTTGATGCCTTG ATACTGAGACTTGGGAGGGAAACTAAGAAATGGTTGACAGCGTTCCCACCCATCTACAATGTTATTTTAGGTGCTTTGTGGTAAGTCTTT TTTCTTAGATTGCGCTAAAATTTCTTAGATTGTTCAGCGCTCAGAACAAAAGTTTGAAAAATGCATTGTTCATATGAATGTCATCTCTTT TCAGTTTCCAGTATCCTTTTTAAAAAATGGCAAAAGCCTAGATTTACAATTTGATGAACACTAAATATTTCTTATTAATATAATCTATTT TTGTATTTTACTTAATGAGCTTTAAGTGCCTGTCGTTCTGAAAATTGTGTATTTATAATTCAGCTTATCTCATAATTGGACCTAATAGCA TTTCTTTGTGCAGTTAGGTGATGAGCACTGCTTTGAGGCCCAAGCACTAGTAGAGATGCGCGATACAGGTCTAGTTTCGGTAACTGTTCC AGACATCAAGCAATAAAAAAATGAATACCACAAAAGATGTTTGATTTTACAGTGGAGCCTTACTGAACCAGCATTCAGAAGTTTAAGGTC CTCCTAGGTATGAGTATTTTTAGTAGTGGATCACTGTGGACAGGGTGCAGCTCTACCAGTTCCTGTTTCTTCTGAGCCAGACCCTCTTCA GGGAAGGGACCAATTAATTTTAAAACTCACTTGAAGCACAGCTGGTCATGGGGCTTGGTATAAAGTTCCTATTTCCACCCTGATACTTCC AATTCCTGGAACCCCAGCCCACTCCCCCATCCCTCCTCCCTATCAAACTAGTATAATGATTTTGAATCGGTACAGTGTGTTTAACTGTAA |
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FusionGenePPI for UBE2N_APPL2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| UBE2N | AURKA, RNF128, UBE2V1, CHUK, IL1B, TNF, TRAF6, TRAF2, HLTF, TRIM32, OTUB1, STAMBPL1, TP53, AMFR, BIRC3, CADPS2, CNOT4, DTX1, RNF103, LRSAM1, MIB1, MID2, NEURL1, NFX1, PJA2, RNF11, RNF13, RNF130, RNF152, RNF165, RNF167, RNF182, RNF43, SH3RF2, TOPORS, ZNRF1, ZNRF2, ZNRF3, ZNRF4, XIAP, SIAH1, DZIP3, MID1, MKRN3, RC3H2, RNF8, RBCK1, BIRC8, RNF125, MARCH7, CHFR, MARCH5, RFWD3, TRIM25, TRIM5, STUB1, HSP90AA1, UBE2V2, TMEM189, OTUB2, RNF168, UBC, HERC2, BRCA1, ELAVL1, RAD23A, SLC2A4, SHPRH, TRIM11, TRIM50, TRIM27, ISG15, CDK2, RIPK1, UBA1, PC, PCCA, ACACA, PCCB, ARIH2, PARK2, TRIM28, MIB2, MYLIP, TNFAIP3, PELI1, SH3RF1, RNF122, TRIM17, TRIM39, RNF5, BARD1, ATP6V1H, VPS33B, ZDHHC5, TXNDC17, SARDH, UFD1L, VASP, USP14, ACTR2, NBN, RNF126, RNF115, FN1, VCAM1, RNF111, BAG3, PELI3, TRIM72, NEDD4L, ARIH1, MFN2, UBE2N, TRIM33, BFAR, BCL10, MALT1, RHNO1, MDM2, DTL, ATP2B3, GNPNAT1, ACOT13, ARF4, ASPDH, CAB39, FH, HADH, HNRNPA3, HSPB1, IDH3A, LDHAL6A, LDHB, LDHC, LGALS1, PHGDH, RAD23B, SF1, UBE2K, TMEM189-UBE2V1, UBL5, KIF1C, PPIA, RC3H1, CNEP1R1, RNF181, RNF4, SNW1, CDC5L, EPM2A, NHLRC1, F12, TRIM69, TRIM63, DERL1, PA2G4, ANXA5, GPI, NANS, TRAP1, PLS3, SND1, SNRPB2, PPA1, HPRT1, EIF5B, IDH2, PDIA3, MRPL12, CRNN, ZNF207, CHIC2, MED15, CPNE3, CS, PYGL, SF3A3, DNAJC8, CPSF6, SF3A1, ECHS1, SRP68, MYL12B, AIMP1, CBS, HMGB1, ARPC4, GARS, ATP5E, ADRM1, ZYX, VCL, PRKACA, CYCS, EIF3M, SDCCAG8, MNS1, VIM, CALM1, PRPF31, FEN1, DLD, SOD1, TRIM23, BIRC2, RHBDF2, MUL1 | APPL2 | APPL1, RAB22A, RUVBL2, RAB5A, RBBP7, MTA2, TINF2, POT1, FSHR, SUV39H2, ABI2, FAM65A, TPM1, RAB5C, CRADD, NTRK1, MLST8, LGALS9C, LIX1, KMT2C, MAPRE3, C17orf82, DOK3, LDHAL6B, PINK1, RBP7, ATF3, CRBN, CRLF3, LECT1, RAI2, TSC1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBE2N_APPL2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBE2N_APPL2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | UBE2N | C0752351 | Embryo Loss | 1 | CTD_human |
| Tgene | APPL2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | APPL2 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
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