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Fusion gene ID: 40459 |
FusionGeneSummary for UBE2L3_LLGL2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBE2L3_LLGL2 | Fusion gene ID: 40459 | Hgene | Tgene | Gene symbol | UBE2L3 | LLGL2 | Gene ID | 7332 | 3993 |
| Gene name | ubiquitin conjugating enzyme E2 L3 | LLGL2, scribble cell polarity complex component | |
| Synonyms | E2-F1|L-UBC|UBCH7|UbcM4 | HGL|Hugl-2|LGL2 | |
| Cytomap | 22q11.21 | 17q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin-conjugating enzyme E2 L3E2 ubiquitin-conjugating enzyme L3ubiquitin carrier protein L3ubiquitin conjugating enzyme E2L 3ubiquitin-conjugating enzyme E2-F1ubiquitin-conjugating enzyme UBCH7ubiquitin-protein ligase L3 | lethal(2) giant larvae protein homolog 2human giant larvae homologlethal giant larvae homolog 2, scribble cell polarity complex component | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P68036 | Q6P1M3 | |
| Ensembl transtripts involved in fusion gene | ENST00000458578, ENST00000342192, ENST00000545681, | ENST00000167462, ENST00000375227, ENST00000392550, ENST00000578363, ENST00000577200, | |
| Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 6 X 5 X 5=150 |
| # samples | 4 | 8 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/150*10)=-0.906890595608519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: UBE2L3 [Title/Abstract] AND LLGL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | UBE2L3 | GO:0000209 | protein polyubiquitination | 10888878|14765125 |
| Hgene | UBE2L3 | GO:0006355 | regulation of transcription, DNA-templated | 17003263 |
| Hgene | UBE2L3 | GO:0016567 | protein ubiquitination | 9990509|21532592 |
| Hgene | UBE2L3 | GO:0070979 | protein K11-linked ubiquitination | 20061386 |
| Hgene | UBE2L3 | GO:0071385 | cellular response to glucocorticoid stimulus | 17003263 |
| Tgene | LLGL2 | GO:0032878 | regulation of establishment or maintenance of cell polarity | 12725730 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCEC | TCGA-AJ-A6NU-01A | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000458578 | ENST00000167462 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| intron-5UTR | ENST00000458578 | ENST00000375227 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| intron-5UTR | ENST00000458578 | ENST00000392550 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| intron-5UTR | ENST00000458578 | ENST00000578363 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| intron-5UTR | ENST00000458578 | ENST00000577200 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| 5CDS-5UTR | ENST00000342192 | ENST00000167462 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| 5CDS-5UTR | ENST00000342192 | ENST00000375227 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| 5CDS-5UTR | ENST00000342192 | ENST00000392550 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| 5CDS-5UTR | ENST00000342192 | ENST00000578363 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| 5CDS-5UTR | ENST00000342192 | ENST00000577200 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| 5CDS-5UTR | ENST00000545681 | ENST00000167462 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| 5CDS-5UTR | ENST00000545681 | ENST00000375227 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| 5CDS-5UTR | ENST00000545681 | ENST00000392550 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| 5CDS-5UTR | ENST00000545681 | ENST00000578363 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
| 5CDS-5UTR | ENST00000545681 | ENST00000577200 | UBE2L3 | chr22 | 21922060 | + | LLGL2 | chr17 | 73539478 | + |
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FusionProtFeatures for UBE2L3_LLGL2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBE2L3 | LLGL2 |
| Ubiquitin-conjugating enzyme E2 that specifically actswith HECT-type and RBR family E3 ubiquitin-protein ligases. Doesnot function with most RING-containing E3 ubiquitin-proteinligases because it lacks intrinsic E3-independent reactivity withlysine: in contrast, it has activity with the RBR family E3enzymes, such as PRKN and ARIH1, that function like function likeRING-HECT hybrids. Accepts ubiquitin from the E1 complex andcatalyzes its covalent attachment to other proteins. In vitrocatalyzes 'Lys-11'-linked polyubiquitination. Involved in theselective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression throughthe cell cycle. Regulates nuclear hormone receptorstranscriptional activity. May play a role in myelopoiesis.{ECO:0000269|PubMed:10888878, ECO:0000269|PubMed:15367689,ECO:0000269|PubMed:17003263, ECO:0000269|PubMed:18946090,ECO:0000269|PubMed:19340006, ECO:0000269|PubMed:20061386,ECO:0000269|PubMed:21532592}. | Part of a complex with GPSM2/LGN, PRKCI/aPKC andPARD6B/Par-6, which may ensure the correct organization andorientation of bipolar spindles for normal cell division. Thiscomplex plays roles in the initial phase of the establishment ofepithelial cell polarity. {ECO:0000269|PubMed:15632202}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UBE2L3_LLGL2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for UBE2L3_LLGL2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| UBE2L3 | UBOX5, AURKA, BRCA1, RNF216, EIF4E2, ARIH1, PTEN, NEDD4, UBE3A, ARIH2, CUL9, CBL, RNF19A, POLR2A, SMURF2, ITCH, WWP2, UBASH3A, RNF125, RNF144B, RNF113B, RNF144A, RBCK1, TRAF7, DTX3, CBLC, MID1, MKRN3, TRIM39, RNF19B, BIRC2, BIRC3, XIAP, PARK2, MYC, MAPK6, ATXN3, ELAVL1, NFKBIA, FOS, NCOA1, UBA1, RELA, SMAD7, RNF103, NR3C1, HACE1, HUWE1, TRIM28, PJA1, TRAF6, NEDD4L, TRIM21, MDM2, STUB1, FBXO2, RNF2, UBE3C, HERC3, TRIP12, WWP1, UBE2D2, AHCYL1, NDUFA7, USP9X, USP34, ZPR1, C12orf5, UBE2B, USP26, SRPRB, UBXN7, TSNAXIP1, UBE2V2, SF1, MRPL53, YAP1, UCHL3, VDAC2, PSMD2, SUGP1, PSMA5, UBE4B, UBXN1, LIG4, FN1, CCNB1IP1, RBX1, AICDA, HSPA4, BAG3, MAP1LC3B, CACNA1B, UBR5, SMURF1, UBA6, UBC, UBE2L3, MUL1, TP53BP1, UBA7, RNF20, HECW2, RNF31, HSPE1, RAB10, SNX12, SNX3, ACAT2, DAZAP1, HEBP1, MDH2, MMACHC, MSI2, PCK2, PIR, PITPNA, PTRHD1, SOD1, UBE2A, UFM1, NDFIP1, AREL1, CACNA1A, RC3H1, HECW1, MCM2, OTUB1, HERC4, HERC6, DUSP4, DUSP8, DNM1L, TRIM25 | LLGL2 | PARD6B, PARD6G, PARD6A, PRKCI, LLGL2, PRKCZ, IFI30, BAG5, STUB1, DNAJA1, DNAJA2, DNAJB1, KBTBD7, NUDC, RAD18, SQSTM1, SUGT1, TIMM13, PTEN, CCNB1, LYST, ATF2, BPTF, MTOR, MAP3K1, ALDH18A1, RBBP6, ST5, SVIL, TAF9, SF1, BAG6, MKNK1, EXO1, NOLC1, ZNHIT3, VPRBP, HMGXB4, DNM1L, ABCA7, CASC3, PALLD, ZC3H3, KIAA0556, DAPK2, ATP5S, ECSIT, PHF21A, EPB41L4B, C11orf57, IMP3, IMPACT, IWS1, RNF20, BIRC6, PLEKHG1, RBM26, PHACTR4, BHLHE41, GCC1, ZNF668, KIAA1715, FIP1L1, CD99L2, ZNF707, FMN1, BRWD3, ZMYND8, GSE1, ZNF592, TOPORS, CACTIN, ZNF687, PPFIA1, DDA1, TRIM26, C1QBP, HMG20A, UBE2O, C18orf25, NKTR, HMG20B, NKAP, RCOR3, CSNK2A1, KBTBD6, UBE2A, RAB30, NEK7, RCOR1, GTPBP4, THRAP3, DIEXF |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBE2L3_LLGL2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBE2L3_LLGL2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | UBE2L3 | C0524909 | Hepatitis B, Chronic | 1 | CTD_human |
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