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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40430

FusionGeneSummary for UBE2G2_RUNX1

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE2G2_RUNX1
Fusion gene ID: 40430
HgeneTgene
Gene symbol

UBE2G2

RUNX1

Gene ID

7327

861

Gene nameubiquitin conjugating enzyme E2 G2runt related transcription factor 1
SynonymsUBC7AML1|AML1-EVI-1|AMLCR1|CBF2alpha|CBFA2|EVI-1|PEBP2aB|PEBP2alpha
Cytomap

21q22.3

21q22.12

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-conjugating enzyme E2 G2E2 ubiquitin-conjugating enzyme G2ubiquitin carrier protein G2ubiquitin conjugating enzyme 7ubiquitin conjugating enzyme G2ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)ubiquitin-conjugating enzyme E2G 2 (runt-related transcription factor 1AML1-EVI-1 fusion proteinPEA2-alpha BPEBP2-alpha BSL3-3 enhancer factor 1 alpha B subunitSL3/AKV core-binding factor alpha B subunitacute myeloid leukemia 1 proteincore-binding factor, runt domain, alpha subunit 2
Modification date2018052320180527
UniProtAcc

P60604

Q01196

Ensembl transtripts involved in fusion geneENST00000345496, ENST00000477954, 
ENST00000330942, 
ENST00000344691, 
ENST00000325074, ENST00000437180, 
ENST00000300305, ENST00000399240, 
ENST00000486278, ENST00000494829, 
ENST00000358356, 
Fusion gene scores* DoF score6 X 5 X 5=15017 X 29 X 7=3451
# samples 633
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(33/3451*10)=-3.3864765441897
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UBE2G2 [Title/Abstract] AND RUNX1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE2G2

GO:0044257

cellular protein catabolic process

21628527

HgeneUBE2G2

GO:0070936

protein K48-linked ubiquitination

20061386

TgeneRUNX1

GO:0030097

hemopoiesis

21873977

TgeneRUNX1

GO:0045893

positive regulation of transcription, DNA-templated

10207087|14970218

TgeneRUNX1

GO:0045944

positive regulation of transcription by RNA polymerase II

9199349|10207087|14970218|21873977


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AO-A129-01AUBE2G2chr21

46221621

-RUNX1chr21

36171759

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000345496ENST00000344691UBE2G2chr21

46221621

-RUNX1chr21

36171759

-
Frame-shitENST00000345496ENST00000325074UBE2G2chr21

46221621

-RUNX1chr21

36171759

-
Frame-shitENST00000345496ENST00000437180UBE2G2chr21

46221621

-RUNX1chr21

36171759

-
Frame-shitENST00000345496ENST00000300305UBE2G2chr21

46221621

-RUNX1chr21

36171759

-
Frame-shitENST00000345496ENST00000399240UBE2G2chr21

46221621

-RUNX1chr21

36171759

-
5CDS-intronENST00000345496ENST00000486278UBE2G2chr21

46221621

-RUNX1chr21

36171759

-
5CDS-intronENST00000345496ENST00000494829UBE2G2chr21

46221621

-RUNX1chr21

36171759

-
5CDS-intronENST00000345496ENST00000358356UBE2G2chr21

46221621

-RUNX1chr21

36171759

-
5UTR-3CDSENST00000477954ENST00000344691UBE2G2chr21

46221621

-RUNX1chr21

36171759

-
5UTR-3CDSENST00000477954ENST00000325074UBE2G2chr21

46221621

-RUNX1chr21

36171759

-
5UTR-3CDSENST00000477954ENST00000437180UBE2G2chr21

46221621

-RUNX1chr21

36171759

-
5UTR-3CDSENST00000477954ENST00000300305UBE2G2chr21

46221621

-RUNX1chr21

36171759

-
5UTR-3CDSENST00000477954ENST00000399240UBE2G2chr21

46221621

-RUNX1chr21

36171759

-
5UTR-intronENST00000477954ENST00000486278UBE2G2chr21

46221621

-RUNX1chr21

36171759

-
5UTR-intronENST00000477954ENST00000494829UBE2G2chr21

46221621

-RUNX1chr21

36171759

-
5UTR-intronENST00000477954ENST00000358356UBE2G2chr21

46221621

-RUNX1chr21

36171759

-
5UTR-3CDSENST00000330942ENST00000344691UBE2G2chr21

46221621

-RUNX1chr21

36171759

-
5UTR-3CDSENST00000330942ENST00000325074UBE2G2chr21

46221621

-RUNX1chr21

36171759

-
5UTR-3CDSENST00000330942ENST00000437180UBE2G2chr21

46221621

-RUNX1chr21

36171759

-
5UTR-3CDSENST00000330942ENST00000300305UBE2G2chr21

46221621

-RUNX1chr21

36171759

-
5UTR-3CDSENST00000330942ENST00000399240UBE2G2chr21

46221621

-RUNX1chr21

36171759

-
5UTR-intronENST00000330942ENST00000486278UBE2G2chr21

46221621

-RUNX1chr21

36171759

-
5UTR-intronENST00000330942ENST00000494829UBE2G2chr21

46221621

-RUNX1chr21

36171759

-
5UTR-intronENST00000330942ENST00000358356UBE2G2chr21

46221621

-RUNX1chr21

36171759

-

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FusionProtFeatures for UBE2G2_RUNX1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBE2G2

P60604

RUNX1

Q01196

Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). {ECO:0000269|PubMed:20061386,ECO:0000269|PubMed:22607976}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBE2G2_RUNX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBE2G2_RUNX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UBE2G2AMFR, USP15, AUP1, MALT1, CORO1A, BIRC8, MDM2, MGRN1, RFFL, RNF111, RNF146, RNF157, RNF168, RNF26, TRIM3, TRIM43, ZNRF4, TRIM9, UBC, KIAA0368, PARK2, RNF5, RNF139, RBX1, UBL4A, BAG3, HBS1L, CPOX, MLLT6, NDUFS4, VAMP8, FARP2, POLR3F, KDM2A, CNNM3, ARL14, TMEM45B, UBE2G2, SHFM1, EGFR, UBA1, UBA6, MUL1, ERLEC1, FBXW11, HNRNPAB, HNRNPD, HNRNPDL, TMEM216, RC3H2, RC3H1, OTUB1, DUSP6, PTPRO, TRIM25RUNX1SUV39H1, KAT6B, CBFB, AES, PAX5, YAP1, JUN, FOS, SMAD3, SMAD1, SMAD2, SMAD5, VDR, ELF4, ELF2, CEBPB, TLE1, CBFA2T2, TRAF6, FHL2, MYOD1, HIPK2, EP300, HDAC1, HDAC3, KAT6A, TCF12, TCF3, RUNX1T1, NCOR1, SIAH1, UBE2L6, RUNX1, PML, RARA, HDAC2, SIN3A, NR4A2, TRIM33, STUB1, SMARCA4, SMARCB1, SMARCC1, CDK1, TAL1, COPRS, KMT2A, RBM14, SPEN, DNMT1, ELAVL1, CBFA2T3, PRMT1, HLA-DMA, CREBBP, UXT, CTBP2, NOTCH1, MYC, NCOR2, FOXP3, SOX2, CTBP1, HDAC11, RAG1, SPI1, ELF1, CDK6, KLF6, NFATC1, NFATC2, ZNF131, BRCA1, CDK9, FANCD2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBE2G2_RUNX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBE2G2_RUNX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRUNX1C0023467Leukemia, Myelocytic, Acute2CTD_human;HPO
TgeneRUNX1C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma2CTD_human
TgeneRUNX1C0003873Rheumatoid Arthritis1CTD_human
TgeneRUNX1C0017636Glioblastoma1CTD_human
TgeneRUNX1C0033578Prostatic Neoplasms1CTD_human
TgeneRUNX1C0349639Juvenile Myelomonocytic Leukemia1CTD_human
TgeneRUNX1C1832388Platelet Disorder, Familial, with Associated Myeloid Malignancy1CTD_human;ORPHANET;UNIPROT
TgeneRUNX1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human