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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40412

FusionGeneSummary for UBE2E3_SREBF1

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE2E3_SREBF1
Fusion gene ID: 40412
HgeneTgene
Gene symbol

UBE2E3

SREBF1

Gene ID

10477

6720

Gene nameubiquitin conjugating enzyme E2 E3sterol regulatory element binding transcription factor 1
SynonymsUBCH9|UbcM2SREBP1|bHLHd1
Cytomap

2q31.3

17p11.2

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-conjugating enzyme E2 E3E2 ubiquitin-conjugating enzyme E3ubiquitin carrier protein E3ubiquitin conjugating enzyme E2E 3ubiquitin-conjugating enzyme E2-23 kDaubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)ubiquitin-conjugating esterol regulatory element-binding protein 1class D basic helix-loop-helix protein 1
Modification date2018052320180522
UniProtAcc

Q969T4

P36956

Ensembl transtripts involved in fusion geneENST00000392415, ENST00000410062, 
ENST00000602710, ENST00000602837, 
ENST00000602959, ENST00000602475, 
ENST00000602632, 
ENST00000338854, 
ENST00000395757, ENST00000355815, 
ENST00000261646, ENST00000435530, 
ENST00000583732, 
Fusion gene scores* DoF score4 X 3 X 4=485 X 4 X 4=80
# samples 45
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UBE2E3 [Title/Abstract] AND SREBF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE2E3

GO:0070534

protein K63-linked ubiquitination

20061386

HgeneUBE2E3

GO:0070936

protein K48-linked ubiquitination

20061386

HgeneUBE2E3

GO:0070979

protein K11-linked ubiquitination

20061386

TgeneSREBF1

GO:0045944

positive regulation of transcription by RNA polymerase II

26437365


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA092279UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000392415ENST00000338854UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000392415ENST00000395757UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000392415ENST00000355815UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000392415ENST00000261646UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000392415ENST00000435530UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-intronENST00000392415ENST00000583732UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-3CDSENST00000410062ENST00000338854UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000410062ENST00000395757UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000410062ENST00000355815UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000410062ENST00000261646UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000410062ENST00000435530UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-intronENST00000410062ENST00000583732UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-3CDSENST00000602710ENST00000338854UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000602710ENST00000395757UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000602710ENST00000355815UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000602710ENST00000261646UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000602710ENST00000435530UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-intronENST00000602710ENST00000583732UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-3CDSENST00000602837ENST00000338854UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000602837ENST00000395757UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000602837ENST00000355815UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000602837ENST00000261646UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000602837ENST00000435530UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-intronENST00000602837ENST00000583732UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-3CDSENST00000602959ENST00000338854UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000602959ENST00000395757UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000602959ENST00000355815UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000602959ENST00000261646UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000602959ENST00000435530UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-intronENST00000602959ENST00000583732UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-3CDSENST00000602475ENST00000338854UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000602475ENST00000395757UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000602475ENST00000355815UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000602475ENST00000261646UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000602475ENST00000435530UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-intronENST00000602475ENST00000583732UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-3CDSENST00000602632ENST00000338854UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000602632ENST00000395757UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000602632ENST00000355815UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000602632ENST00000261646UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-5UTRENST00000602632ENST00000435530UBE2E3chr2

181881928

+SREBF1chr17

17723029

-
intron-intronENST00000602632ENST00000583732UBE2E3chr2

181881928

+SREBF1chr17

17723029

-

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FusionProtFeatures for UBE2E3_SREBF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBE2E3

Q969T4

SREBF1

P36956

Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination.Participates in the regulation of transepithelial sodium transportin renal cells. May be involved in cell growth arrest.{ECO:0000269|PubMed:10343118, ECO:0000269|PubMed:20061386}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBE2E3_SREBF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBE2E3_SREBF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBE2E3_SREBF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBE2E3_SREBF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSREBF1C0011853Diabetes Mellitus, Experimental2CTD_human
TgeneSREBF1C0400966Non-alcoholic Fatty Liver Disease2CTD_human
TgeneSREBF1C2239176Liver carcinoma2CTD_human
TgeneSREBF1C0015695Fatty Liver1CTD_human
TgeneSREBF1C0021655Insulin Resistance1CTD_human
TgeneSREBF1C0022661Kidney Failure, Chronic1CTD_human
TgeneSREBF1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneSREBF1C0028754Obesity1CTD_human
TgeneSREBF1C0036341Schizophrenia1PSYGENET