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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40408

FusionGeneSummary for UBE2E2_SRSF3

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE2E2_SRSF3
Fusion gene ID: 40408
HgeneTgene
Gene symbol

UBE2E2

SRSF3

Gene ID

7325

6428

Gene nameubiquitin conjugating enzyme E2 E2serine and arginine rich splicing factor 3
SynonymsUBCH8SFRS3|SRp20
Cytomap

3p24.3

6p21.31-p21.2

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-conjugating enzyme E2 E2E2 ubiquitin-conjugating enzyme E2ubiquitin carrier protein E2ubiquitin conjugating enzyme E2E 2ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)ubiquitin-conjugating enzyme E2E 2 (homologous to yeast UBC4/5serine/arginine-rich splicing factor 3pre-mRNA splicing factor SRp20pre-mRNA-splicing factor SRP20splicing factor, arginine/serine-rich 3splicing factor, arginine/serine-rich, 20-kD
Modification date2018052320180523
UniProtAcc

Q96LR5

P84103

Ensembl transtripts involved in fusion geneENST00000425792, ENST00000396703, 
ENST00000373715, ENST00000339436, 
Fusion gene scores* DoF score6 X 4 X 4=965 X 6 X 2=60
# samples 76
** MAII scorelog2(7/96*10)=-0.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/60*10)=0
Context

PubMed: UBE2E2 [Title/Abstract] AND SRSF3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE2E2

GO:0032020

ISG15-protein conjugation

16428300

HgeneUBE2E2

GO:0070534

protein K63-linked ubiquitination

20061386

HgeneUBE2E2

GO:0070936

protein K48-linked ubiquitination

20061386

HgeneUBE2E2

GO:0070979

protein K11-linked ubiquitination

20061386

TgeneSRSF3

GO:0048024

regulation of mRNA splicing, via spliceosome

26876937


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF173958UBE2E2chr3

23306906

+SRSF3chr6

36571114

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000425792ENST00000373715UBE2E2chr3

23306906

+SRSF3chr6

36571114

+
intron-intronENST00000425792ENST00000339436UBE2E2chr3

23306906

+SRSF3chr6

36571114

+
intron-3UTRENST00000396703ENST00000373715UBE2E2chr3

23306906

+SRSF3chr6

36571114

+
intron-intronENST00000396703ENST00000339436UBE2E2chr3

23306906

+SRSF3chr6

36571114

+

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FusionProtFeatures for UBE2E2_SRSF3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBE2E2

Q96LR5

SRSF3

P84103

Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination.Catalyzes the ISGylation of influenza A virus NS1 protein.{ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20133869,ECO:0000269|PubMed:9371400}. Splicing factor that specifically promotes exon-inclusion during alternative splicing (PubMed:26876937).Interaction with YTHDC1, a RNA-binding protein that recognizes andbinds N6-methyladenosine (m6A)-containing RNAs, promotesrecruitment of SRSF3 to its mRNA-binding elements adjacent to m6Asites, leading to exon-inclusion during alternative splicing(PubMed:26876937). Also functions as export adapter involved inmRNA nuclear export (PubMed:11336712, PubMed:18364396,PubMed:28984244). Binds mRNA which is thought to be transferred tothe NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhancesNXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396).Involved in nuclear export of m6A-containing mRNAs via interactionwith YTHDC1: interaction with YTHDC1 facilitates m6A-containingmRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export(PubMed:28984244). RNA-binding is semi-sequence specific(PubMed:17036044). {ECO:0000269|PubMed:11336712,ECO:0000269|PubMed:17036044, ECO:0000269|PubMed:18364396,ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:28984244}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBE2E2_SRSF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBE2E2_SRSF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBE2E2_SRSF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBE2E2_SRSF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUBE2E2C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneSRSF3C0005586Bipolar Disorder1PSYGENET