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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40405

FusionGeneSummary for UBE2E2_BRPF3

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE2E2_BRPF3
Fusion gene ID: 40405
HgeneTgene
Gene symbol

UBE2E2

BRPF3

Gene ID

7325

27154

Gene nameubiquitin conjugating enzyme E2 E2bromodomain and PHD finger containing 3
SynonymsUBCH8-
Cytomap

3p24.3

6p21.31

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-conjugating enzyme E2 E2E2 ubiquitin-conjugating enzyme E2ubiquitin carrier protein E2ubiquitin conjugating enzyme E2E 2ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)ubiquitin-conjugating enzyme E2E 2 (homologous to yeast UBC4/5bromodomain and PHD finger-containing protein 3
Modification date2018052320180519
UniProtAcc

Q96LR5

Q9ULD4

Ensembl transtripts involved in fusion geneENST00000425792, ENST00000396703, 
ENST00000357641, ENST00000339717, 
ENST00000534694, ENST00000543502, 
ENST00000443324, ENST00000534400, 
Fusion gene scores* DoF score6 X 4 X 4=963 X 3 X 2=18
# samples 73
** MAII scorelog2(7/96*10)=-0.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: UBE2E2 [Title/Abstract] AND BRPF3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE2E2

GO:0032020

ISG15-protein conjugation

16428300

HgeneUBE2E2

GO:0070534

protein K63-linked ubiquitination

20061386

HgeneUBE2E2

GO:0070936

protein K48-linked ubiquitination

20061386

HgeneUBE2E2

GO:0070979

protein K11-linked ubiquitination

20061386

TgeneBRPF3

GO:0043966

histone H3 acetylation

16387653


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ375843UBE2E2chr3

23631661

+BRPF3chr6

36200148

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000425792ENST00000357641UBE2E2chr3

23631661

+BRPF3chr6

36200148

+
3UTR-3UTRENST00000425792ENST00000339717UBE2E2chr3

23631661

+BRPF3chr6

36200148

+
3UTR-3UTRENST00000425792ENST00000534694UBE2E2chr3

23631661

+BRPF3chr6

36200148

+
3UTR-3UTRENST00000425792ENST00000543502UBE2E2chr3

23631661

+BRPF3chr6

36200148

+
3UTR-3UTRENST00000425792ENST00000443324UBE2E2chr3

23631661

+BRPF3chr6

36200148

+
3UTR-intronENST00000425792ENST00000534400UBE2E2chr3

23631661

+BRPF3chr6

36200148

+
3UTR-3UTRENST00000396703ENST00000357641UBE2E2chr3

23631661

+BRPF3chr6

36200148

+
3UTR-3UTRENST00000396703ENST00000339717UBE2E2chr3

23631661

+BRPF3chr6

36200148

+
3UTR-3UTRENST00000396703ENST00000534694UBE2E2chr3

23631661

+BRPF3chr6

36200148

+
3UTR-3UTRENST00000396703ENST00000543502UBE2E2chr3

23631661

+BRPF3chr6

36200148

+
3UTR-3UTRENST00000396703ENST00000443324UBE2E2chr3

23631661

+BRPF3chr6

36200148

+
3UTR-intronENST00000396703ENST00000534400UBE2E2chr3

23631661

+BRPF3chr6

36200148

+

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FusionProtFeatures for UBE2E2_BRPF3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBE2E2

Q96LR5

BRPF3

Q9ULD4

Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination.Catalyzes the ISGylation of influenza A virus NS1 protein.{ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20133869,ECO:0000269|PubMed:9371400}. Component of the MOZ/MORF complex which has a histone H3acetyltransferase activity. {ECO:0000269|PubMed:16387653}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBE2E2_BRPF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBE2E2_BRPF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBE2E2_BRPF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBE2E2_BRPF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUBE2E2C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human