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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40403

FusionGeneSummary for UBE2E1_UBE2E1

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE2E1_UBE2E1
Fusion gene ID: 40403
HgeneTgene
Gene symbol

UBE2E1

UBE2E1

Gene ID

7324

7324

Gene nameubiquitin conjugating enzyme E2 E1ubiquitin conjugating enzyme E2 E1
SynonymsUBCH6UBCH6
Cytomap

3p24.2

3p24.2

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-conjugating enzyme E2 E1(E3-independent) E2 ubiquitin-conjugating enzyme E1E2 ubiquitin-conjugating enzyme E1ubiquitin carrier protein E1ubiquitin conjugating enzyme E2E 1ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)ubiquitin-ubiquitin-conjugating enzyme E2 E1(E3-independent) E2 ubiquitin-conjugating enzyme E1E2 ubiquitin-conjugating enzyme E1ubiquitin carrier protein E1ubiquitin conjugating enzyme E2E 1ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)ubiquitin-
Modification date2018052320180523
UniProtAcc

P51965

P51965

Ensembl transtripts involved in fusion geneENST00000306627, ENST00000346855, 
ENST00000467766, ENST00000424381, 
ENST00000475680, 		ENST00000306627, 
ENST00000346855, ENST00000467766, 
ENST00000424381, ENST00000475680, 
Fusion gene scores* DoF score5 X 6 X 4=1201 X 2 X 1=2
# samples 62
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/2*10)=3.32192809488736
Context

PubMed: UBE2E1 [Title/Abstract] AND UBE2E1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE2E1

GO:0000209

protein polyubiquitination

15247280|16522193

HgeneUBE2E1

GO:0010390

histone monoubiquitination

16307923

HgeneUBE2E1

GO:0016567

protein ubiquitination

9990509

HgeneUBE2E1

GO:0032020

ISG15-protein conjugation

16428300

HgeneUBE2E1

GO:0033523

histone H2B ubiquitination

16307923

HgeneUBE2E1

GO:0070936

protein K48-linked ubiquitination

20061386

TgeneUBE2E1

GO:0000209

protein polyubiquitination

15247280|16522193

TgeneUBE2E1

GO:0010390

histone monoubiquitination

16307923

TgeneUBE2E1

GO:0016567

protein ubiquitination

9990509

TgeneUBE2E1

GO:0032020

ISG15-protein conjugation

16428300

TgeneUBE2E1

GO:0033523

histone H2B ubiquitination

16307923

TgeneUBE2E1

GO:0070936

protein K48-linked ubiquitination

20061386


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK022062UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
ChiTaRS3.1BU675579UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000306627ENST00000306627UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
intron-intronENST00000306627ENST00000346855UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
intron-intronENST00000306627ENST00000467766UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
intron-intronENST00000306627ENST00000424381UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
intron-intronENST00000306627ENST00000475680UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
intron-intronENST00000346855ENST00000306627UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
intron-intronENST00000346855ENST00000346855UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
intron-intronENST00000346855ENST00000467766UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
intron-intronENST00000346855ENST00000424381UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
intron-intronENST00000346855ENST00000475680UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
intron-intronENST00000467766ENST00000306627UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
intron-intronENST00000467766ENST00000346855UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
intron-intronENST00000467766ENST00000467766UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
intron-intronENST00000467766ENST00000424381UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
intron-intronENST00000467766ENST00000475680UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
intron-intronENST00000424381ENST00000306627UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
intron-intronENST00000424381ENST00000346855UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
intron-intronENST00000424381ENST00000467766UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
intron-intronENST00000424381ENST00000424381UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
intron-intronENST00000424381ENST00000475680UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
intron-intronENST00000475680ENST00000306627UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
intron-intronENST00000475680ENST00000346855UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
intron-intronENST00000475680ENST00000467766UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
intron-intronENST00000475680ENST00000424381UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
intron-intronENST00000475680ENST00000475680UBE2E1chr3

23903708

+UBE2E1chr3

23898916

+
3UTR-3UTRENST00000306627ENST00000306627UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
3UTR-3UTRENST00000306627ENST00000346855UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
3UTR-intronENST00000306627ENST00000467766UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
3UTR-3UTRENST00000306627ENST00000424381UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
3UTR-intronENST00000306627ENST00000475680UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
3UTR-3UTRENST00000346855ENST00000306627UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
3UTR-3UTRENST00000346855ENST00000346855UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
3UTR-intronENST00000346855ENST00000467766UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
3UTR-3UTRENST00000346855ENST00000424381UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
3UTR-intronENST00000346855ENST00000475680UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
intron-3UTRENST00000467766ENST00000306627UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
intron-3UTRENST00000467766ENST00000346855UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
intron-intronENST00000467766ENST00000467766UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
intron-3UTRENST00000467766ENST00000424381UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
intron-intronENST00000467766ENST00000475680UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
3UTR-3UTRENST00000424381ENST00000306627UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
3UTR-3UTRENST00000424381ENST00000346855UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
3UTR-intronENST00000424381ENST00000467766UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
3UTR-3UTRENST00000424381ENST00000424381UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
3UTR-intronENST00000424381ENST00000475680UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
intron-3UTRENST00000475680ENST00000306627UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
intron-3UTRENST00000475680ENST00000346855UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
intron-intronENST00000475680ENST00000467766UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
intron-3UTRENST00000475680ENST00000424381UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+
intron-intronENST00000475680ENST00000475680UBE2E1chr3

23932727

-UBE2E1chr3

23932617

+

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FusionProtFeatures for UBE2E1_UBE2E1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBE2E1

P51965

UBE2E1

P51965

Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. Catalyzes the covalentattachment of ISG15 to other proteins. Mediates the selectivedegradation of short-lived and abnormal proteins. In vitro alsocatalyzes 'Lys-48'-linked polyubiquitination.{ECO:0000269|PubMed:16428300, ECO:0000269|PubMed:20061386}. Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. Catalyzes the covalentattachment of ISG15 to other proteins. Mediates the selectivedegradation of short-lived and abnormal proteins. In vitro alsocatalyzes 'Lys-48'-linked polyubiquitination.{ECO:0000269|PubMed:16428300, ECO:0000269|PubMed:20061386}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBE2E1_UBE2E1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBE2E1_UBE2E1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBE2E1_UBE2E1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBE2E1_UBE2E1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUBE2E1C0037274Dermatologic disorders1CTD_human
HgeneUBE2E1C0311375Arsenic Poisoning1CTD_human
HgeneUBE2E1C3495559Juvenile arthritis1CTD_human
TgeneUBE2E1C0037274Dermatologic disorders1CTD_human
TgeneUBE2E1C0311375Arsenic Poisoning1CTD_human
TgeneUBE2E1C3495559Juvenile arthritis1CTD_human