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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40389

FusionGeneSummary for UBE2D2_CTNNA1

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE2D2_CTNNA1
Fusion gene ID: 40389
HgeneTgene
Gene symbol

UBE2D2

CTNNA1

Gene ID

7322

1495

Gene nameubiquitin conjugating enzyme E2 D2catenin alpha 1
SynonymsE2(17)KB2|PUBC1|UBC4|UBC4/5|UBCH4|UBCH5BCAP102|MDPT2
Cytomap

5q31.2

5q31.2

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-conjugating enzyme E2 D2(E3-independent) E2 ubiquitin-conjugating enzyme D2E2 ubiquitin-conjugating enzyme D2p53-regulated ubiquitin-conjugating enzyme 1ubiquitin carrier protein D2ubiquitin conjugating enzyme E2D 2ubiquitin-conjugating encatenin alpha-1alpha-E-catenincatenin (cadherin-associated protein), alpha 1, 102kDarenal carcinoma antigen NY-REN-13
Modification date2018052320180522
UniProtAcc

P62837

P35221

Ensembl transtripts involved in fusion geneENST00000511725, ENST00000253815, 
ENST00000398733, ENST00000505548, 
ENST00000355078, ENST00000302763, 
ENST00000518825, ENST00000520400, 
ENST00000540387, 
Fusion gene scores* DoF score9 X 6 X 8=43211 X 13 X 6=858
# samples 1013
** MAII scorelog2(10/432*10)=-2.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/858*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UBE2D2 [Title/Abstract] AND CTNNA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE2D2

GO:0000209

protein polyubiquitination

15247280

HgeneUBE2D2

GO:0016567

protein ubiquitination

9990509|14593114

HgeneUBE2D2

GO:0051865

protein autoubiquitination

21068390

HgeneUBE2D2

GO:0070936

protein K48-linked ubiquitination

20061386

TgeneCTNNA1

GO:0071681

cellular response to indole-3-methanol

10868478


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-EP-A2KA-01AUBE2D2chr5

138980020

+CTNNA1chr5

138221901

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000511725ENST00000355078UBE2D2chr5

138980020

+CTNNA1chr5

138221901

+
Frame-shiftENST00000511725ENST00000302763UBE2D2chr5

138980020

+CTNNA1chr5

138221901

+
Frame-shiftENST00000511725ENST00000518825UBE2D2chr5

138980020

+CTNNA1chr5

138221901

+
5CDS-3UTRENST00000511725ENST00000520400UBE2D2chr5

138980020

+CTNNA1chr5

138221901

+
5CDS-5UTRENST00000511725ENST00000540387UBE2D2chr5

138980020

+CTNNA1chr5

138221901

+
Frame-shiftENST00000253815ENST00000355078UBE2D2chr5

138980020

+CTNNA1chr5

138221901

+
Frame-shiftENST00000253815ENST00000302763UBE2D2chr5

138980020

+CTNNA1chr5

138221901

+
Frame-shiftENST00000253815ENST00000518825UBE2D2chr5

138980020

+CTNNA1chr5

138221901

+
5CDS-3UTRENST00000253815ENST00000520400UBE2D2chr5

138980020

+CTNNA1chr5

138221901

+
5CDS-5UTRENST00000253815ENST00000540387UBE2D2chr5

138980020

+CTNNA1chr5

138221901

+
Frame-shiftENST00000398733ENST00000355078UBE2D2chr5

138980020

+CTNNA1chr5

138221901

+
Frame-shiftENST00000398733ENST00000302763UBE2D2chr5

138980020

+CTNNA1chr5

138221901

+
Frame-shiftENST00000398733ENST00000518825UBE2D2chr5

138980020

+CTNNA1chr5

138221901

+
5CDS-3UTRENST00000398733ENST00000520400UBE2D2chr5

138980020

+CTNNA1chr5

138221901

+
5CDS-5UTRENST00000398733ENST00000540387UBE2D2chr5

138980020

+CTNNA1chr5

138221901

+
Frame-shiftENST00000505548ENST00000355078UBE2D2chr5

138980020

+CTNNA1chr5

138221901

+
Frame-shiftENST00000505548ENST00000302763UBE2D2chr5

138980020

+CTNNA1chr5

138221901

+
Frame-shiftENST00000505548ENST00000518825UBE2D2chr5

138980020

+CTNNA1chr5

138221901

+
5CDS-3UTRENST00000505548ENST00000520400UBE2D2chr5

138980020

+CTNNA1chr5

138221901

+
5CDS-5UTRENST00000505548ENST00000540387UBE2D2chr5

138980020

+CTNNA1chr5

138221901

+

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FusionProtFeatures for UBE2D2_CTNNA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBE2D2

P62837

CTNNA1

P35221

Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradationof short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination ofPEX5 and autoubiquitination of STUB1 and TRAF6. Involved in thesignal-induced conjugation and subsequent degradation of NFKBIA,FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependentdegradation of p53/TP53 and the activation of MAVS in themitochondria by DDX58/RIG-I in response to viral infection.Essential for viral activation of IRF3.{ECO:0000269|PubMed:10329681, ECO:0000269|PubMed:15280377,ECO:0000269|PubMed:18042044, ECO:0000269|PubMed:18359941,ECO:0000269|PubMed:18703417, ECO:0000269|PubMed:19854139,ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20403326,ECO:0000269|PubMed:20525694}. Associates with the cytoplasmic domain of a variety ofcadherins. The association of catenins to cadherins produces acomplex which is linked to the actin filament network, and whichseems to be of primary importance for cadherins cell-adhesionproperties. Can associate with both E- and N-cadherins. Originallybelieved to be a stable component of E-cadherin/catenin adhesioncomplexes and to mediate the linkage of cadherins to the actincytoskeleton at adherens junctions. In contrast, cortical actinwas found to be much more dynamic than E-cadherin/catenincomplexes and CTNNA1 was shown not to bind to F-actin whenassembled in the complex suggesting a different linkage betweenactin and adherens junctions components. The homodimeric form mayregulate actin filament assembly and inhibit actin branching bycompeting with the Arp2/3 complex for binding to actin filaments.May play a crucial role in cell differentiation.{ECO:0000269|PubMed:25653389}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBE2D2_CTNNA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBE2D2_CTNNA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UBE2D2NEDD4, BARD1, DTX3L, UBE3A, RNF2, CBL, BTRC, FBXW2, FBXO7, FBXL3, FBXO4, RAF1, STUB1, PJA2, PJA1, CDKN1B, BIRC3, DDX58, STAM2, EPS15, POLM, POLL, UBASH3B, UBA6, PDZRN3, OTUB1, ING4, UFM1, AMFR, MUL1, CADPS2, CNOT4, DTX1, UBE4A, RNF103, RNF181, MAP3K1, MIB1, RFWD3, RMND5B, RNF11, RNF111, RNF13, RNF130, RNF150, RNF165, RNF167, RNF186, RNF25, RNF26, RNF43, SIAH1, RNF4, TOPORS, UHRF2, LTN1, RNF115, ZNRF1, ZNRF2, ZNRF4, XIAP, RNF125, RNF126, UBOX5, RNF5, RING1, DTX3, RNF14, RNF114, TRIM8, DZIP3, MID1, MKRN3, TRIM39, TRIM27, RNF10, RNF166, RNF185, TRIM43, TRAF6, BIRC8, RNF138, BFAR, TRAF7, MARCH3, RSPRY1, RLIM, LRSAM1, CHFR, ARIH2, MGRN1, TRIM55, RNF38, RNF7, TRIM17, TRIM2, TRIM25, TRIM26, TRIM31, TRIM35, TRIM5, UBE4B, BIRC2, BIRC7, BRCA1, MAPT, NFKBIA, MID2, TRIM10, TRIM11, TRIM50, TRIM7, TRIM37, TRIM38, TRIM45, TRIM32, UBC, UBA1, QSOX1, UBE2D2, RELA, STK11, NEDD4L, NEDD8, MDM2, MDM4, CUL3, CBLB, RAG1, SOCS6, RCHY1, PARK2, VPS18, UBR5, TRIM41, TRIM28, TRIM23, MYLIP, SIAH2, VPRBP, FBXO2, LNX1, HUWE1, CBLC, RBX1, RFWD2, TRIM21, ANAPC11, MARCH5, TRIM13, TRIM63, TRAIP, TRIM36, RNF122, SYVN1, HERC4, WWP2, ITCH, PELI1, TTC3, NSMCE1, RNF151, UBE2D1, UBQLN1, UBE2L3, SSSCA1, AHCYL1, TAX1BP3, UBE2M, UBXN7, ZPR1, UBE2V1, USP9X, TIAL1, TTC1, TXN, HSP90AA4P, RFFL, UBTD1, RNF135, KCMF1, MARCH7, RNF146, CCNB1, RNF34, MARCH6, UBE3C, VHL, RBCK1, RNF31, ANAPC2, ARL6IP6, THAP8, FCGR2A, FSD1, NFYA, NKD2, OR5F1, RDH12, SPRY2, UBB, ACOX1, AASDHPPT, CCDC58, MTAP, UBE2I, UBE2K, UBE2R2, UBE2F, LNX2, RC3H2, RC3H1, AREL1, SMURF1, SMURF2, WWP1, HECW1, TRIM62, MCM2, SPOP, RNF170, F12, NAT10, TRIM3, PLEC, AAK1, SEC24B, CCDC88A, EYA4, DVL3, PPIP5K2, QSER1, LUZP1, WSB1, F3CTNNA1APC, CTNNB1, CDH1, CTNNA1, JUP, CDH3, CDH5, CTNND1, CDH2, CA9, PTPN14, MLLT4, VEZT, MYO7A, TJP2, PSEN1, ACTN1, VCL, DLG1, SPTBN1, FAM84B, RNF219, ZGPAT, RYK, CTBP1, ARRB2, SIRT7, ARMC8, COPS5, APP, VCP, CTNNA3, GARS, OSBP, SEC23A, USP11, XRCC6, CTTN, CUL2, EIF4B, HSPH1, PRMT3, XPO7, FBXW11, OBSL1, CCDC8, UBE2I, ARAF, ILK, BTRC, UNK, DMD, NTRK1, HERC2, GSK3A, HSPA5, AXIN1, MAPRE1, EGFR, MCM2, CDC5L, C21orf59, IQSEC1, CSNK2A1, CTDSPL, CDH8, CTNNBIP1, SAPCD1, SLAMF7, NEK4, SLC9A3R2, MTNR1A, MTNR1B, DLD, HSD17B10, PDHA1, TRIM25, UBE2A, BRCA1, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBE2D2_CTNNA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBE2D2_CTNNA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCTNNA1C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneCTNNA1C1837029Macular Dystrophy, Butterfly-Shaped Pigmentary, 21UNIPROT
TgeneCTNNA1C1868569Patterned dystrophy of retinal pigment epithelium1CTD_human
TgeneCTNNA1C3463824MYELODYSPLASTIC SYNDROME1CTD_human