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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40388

FusionGeneSummary for UBE2D2_C9orf3

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE2D2_C9orf3
Fusion gene ID: 40388
HgeneTgene
Gene symbol

UBE2D2

C9orf3

Gene ID

7322

84909

Gene nameubiquitin conjugating enzyme E2 D2chromosome 9 open reading frame 3
SynonymsE2(17)KB2|PUBC1|UBC4|UBC4/5|UBCH4|UBCH5BAOPEP|AP-O|APO|C90RF3|ONPEP
Cytomap

5q31.2

9q22.32

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-conjugating enzyme E2 D2(E3-independent) E2 ubiquitin-conjugating enzyme D2E2 ubiquitin-conjugating enzyme D2p53-regulated ubiquitin-conjugating enzyme 1ubiquitin carrier protein D2ubiquitin conjugating enzyme E2D 2ubiquitin-conjugating enaminopeptidase O
Modification date2018052320180523
UniProtAcc

P62837

Ensembl transtripts involved in fusion geneENST00000511725, ENST00000253815, 
ENST00000398733, ENST00000505548, 
ENST00000277198, ENST00000297979, 
ENST00000375315, ENST00000395357, 
ENST00000425634, ENST00000433691, 
ENST00000473778, 
Fusion gene scores* DoF score9 X 6 X 8=4328 X 4 X 7=224
# samples 108
** MAII scorelog2(10/432*10)=-2.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UBE2D2 [Title/Abstract] AND C9orf3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE2D2

GO:0000209

protein polyubiquitination

15247280

HgeneUBE2D2

GO:0016567

protein ubiquitination

9990509|14593114

HgeneUBE2D2

GO:0051865

protein autoubiquitination

21068390

HgeneUBE2D2

GO:0070936

protein K48-linked ubiquitination

20061386

TgeneC9orf3

GO:0006508

proteolysis

15687497


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCESCTCGA-DS-A0VL-01AUBE2D2chr5

138906197

+C9orf3chr9

97848964

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000511725ENST00000277198UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
5UTR-3UTRENST00000511725ENST00000297979UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
5UTR-3UTRENST00000511725ENST00000375315UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
5UTR-intronENST00000511725ENST00000395357UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
5UTR-intronENST00000511725ENST00000425634UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
5UTR-intronENST00000511725ENST00000433691UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
5UTR-intronENST00000511725ENST00000473778UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
intron-intronENST00000253815ENST00000277198UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
intron-3UTRENST00000253815ENST00000297979UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
intron-3UTRENST00000253815ENST00000375315UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
intron-intronENST00000253815ENST00000395357UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
intron-intronENST00000253815ENST00000425634UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
intron-intronENST00000253815ENST00000433691UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
intron-intronENST00000253815ENST00000473778UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
intron-intronENST00000398733ENST00000277198UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
intron-3UTRENST00000398733ENST00000297979UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
intron-3UTRENST00000398733ENST00000375315UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
intron-intronENST00000398733ENST00000395357UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
intron-intronENST00000398733ENST00000425634UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
intron-intronENST00000398733ENST00000433691UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
intron-intronENST00000398733ENST00000473778UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
intron-intronENST00000505548ENST00000277198UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
intron-3UTRENST00000505548ENST00000297979UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
intron-3UTRENST00000505548ENST00000375315UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
intron-intronENST00000505548ENST00000395357UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
intron-intronENST00000505548ENST00000425634UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
intron-intronENST00000505548ENST00000433691UBE2D2chr5

138906197

+C9orf3chr9

97848964

+
intron-intronENST00000505548ENST00000473778UBE2D2chr5

138906197

+C9orf3chr9

97848964

+

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FusionProtFeatures for UBE2D2_C9orf3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBE2D2

P62837

C9orf3

Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradationof short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination ofPEX5 and autoubiquitination of STUB1 and TRAF6. Involved in thesignal-induced conjugation and subsequent degradation of NFKBIA,FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependentdegradation of p53/TP53 and the activation of MAVS in themitochondria by DDX58/RIG-I in response to viral infection.Essential for viral activation of IRF3.{ECO:0000269|PubMed:10329681, ECO:0000269|PubMed:15280377,ECO:0000269|PubMed:18042044, ECO:0000269|PubMed:18359941,ECO:0000269|PubMed:18703417, ECO:0000269|PubMed:19854139,ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20403326,ECO:0000269|PubMed:20525694}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBE2D2_C9orf3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBE2D2_C9orf3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UBE2D2NEDD4, BARD1, DTX3L, UBE3A, RNF2, CBL, BTRC, FBXW2, FBXO7, FBXL3, FBXO4, RAF1, STUB1, PJA2, PJA1, CDKN1B, BIRC3, DDX58, STAM2, EPS15, POLM, POLL, UBASH3B, UBA6, PDZRN3, OTUB1, ING4, UFM1, AMFR, MUL1, CADPS2, CNOT4, DTX1, UBE4A, RNF103, RNF181, MAP3K1, MIB1, RFWD3, RMND5B, RNF11, RNF111, RNF13, RNF130, RNF150, RNF165, RNF167, RNF186, RNF25, RNF26, RNF43, SIAH1, RNF4, TOPORS, UHRF2, LTN1, RNF115, ZNRF1, ZNRF2, ZNRF4, XIAP, RNF125, RNF126, UBOX5, RNF5, RING1, DTX3, RNF14, RNF114, TRIM8, DZIP3, MID1, MKRN3, TRIM39, TRIM27, RNF10, RNF166, RNF185, TRIM43, TRAF6, BIRC8, RNF138, BFAR, TRAF7, MARCH3, RSPRY1, RLIM, LRSAM1, CHFR, ARIH2, MGRN1, TRIM55, RNF38, RNF7, TRIM17, TRIM2, TRIM25, TRIM26, TRIM31, TRIM35, TRIM5, UBE4B, BIRC2, BIRC7, BRCA1, MAPT, NFKBIA, MID2, TRIM10, TRIM11, TRIM50, TRIM7, TRIM37, TRIM38, TRIM45, TRIM32, UBC, UBA1, QSOX1, UBE2D2, RELA, STK11, NEDD4L, NEDD8, MDM2, MDM4, CUL3, CBLB, RAG1, SOCS6, RCHY1, PARK2, VPS18, UBR5, TRIM41, TRIM28, TRIM23, MYLIP, SIAH2, VPRBP, FBXO2, LNX1, HUWE1, CBLC, RBX1, RFWD2, TRIM21, ANAPC11, MARCH5, TRIM13, TRIM63, TRAIP, TRIM36, RNF122, SYVN1, HERC4, WWP2, ITCH, PELI1, TTC3, NSMCE1, RNF151, UBE2D1, UBQLN1, UBE2L3, SSSCA1, AHCYL1, TAX1BP3, UBE2M, UBXN7, ZPR1, UBE2V1, USP9X, TIAL1, TTC1, TXN, HSP90AA4P, RFFL, UBTD1, RNF135, KCMF1, MARCH7, RNF146, CCNB1, RNF34, MARCH6, UBE3C, VHL, RBCK1, RNF31, ANAPC2, ARL6IP6, THAP8, FCGR2A, FSD1, NFYA, NKD2, OR5F1, RDH12, SPRY2, UBB, ACOX1, AASDHPPT, CCDC58, MTAP, UBE2I, UBE2K, UBE2R2, UBE2F, LNX2, RC3H2, RC3H1, AREL1, SMURF1, SMURF2, WWP1, HECW1, TRIM62, MCM2, SPOP, RNF170, F12, NAT10, TRIM3, PLEC, AAK1, SEC24B, CCDC88A, EYA4, DVL3, PPIP5K2, QSER1, LUZP1, WSB1, F3C9orf3SUN2, LRRC40, ZDHHC17, TUBA4A, SUZ12, TUBB3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBE2D2_C9orf3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBE2D2_C9orf3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC9orf3C0004238Atrial Fibrillation1CTD_human
TgeneC9orf3C0032927Precancerous Conditions1CTD_human
TgeneC9orf3C3495559Juvenile arthritis1CTD_human