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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40385

FusionGeneSummary for UBE2C_UBE2C

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE2C_UBE2C
Fusion gene ID: 40385
HgeneTgene
Gene symbol

UBE2C

UBE2C

Gene ID

11065

11065

Gene nameubiquitin conjugating enzyme E2 Cubiquitin conjugating enzyme E2 C
SynonymsUBCH10|dJ447F3.2UBCH10|dJ447F3.2
Cytomap

20q13.12

20q13.12

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-conjugating enzyme E2 C(E3-independent) E2 ubiquitin-conjugating enzyme CE2 ubiquitin-conjugating enzyme Ccyclin-selective ubiquitin carrier proteinmitotic-specific ubiquitin-conjugating enzymeubiquitin conjugating enzyme E2Cubiquitin-protubiquitin-conjugating enzyme E2 C(E3-independent) E2 ubiquitin-conjugating enzyme CE2 ubiquitin-conjugating enzyme Ccyclin-selective ubiquitin carrier proteinmitotic-specific ubiquitin-conjugating enzymeubiquitin conjugating enzyme E2Cubiquitin-prot
Modification date2018052320180523
UniProtAcc

O00762

O00762

Ensembl transtripts involved in fusion geneENST00000356455, ENST00000405520, 
ENST00000335046, ENST00000243893, 
ENST00000352551, ENST00000372568, 
ENST00000496085, 		ENST00000356455, 
ENST00000405520, ENST00000335046, 
ENST00000243893, ENST00000352551, 
ENST00000372568, ENST00000496085, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: UBE2C [Title/Abstract] AND UBE2C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE2C

GO:0006511

ubiquitin-dependent protein catabolic process

9122200|18485873

HgeneUBE2C

GO:0010994

free ubiquitin chain polymerization

19822757

HgeneUBE2C

GO:0016567

protein ubiquitination

9122200

HgeneUBE2C

GO:0031145

anaphase-promoting complex-dependent catabolic process

9122200|19822757

HgeneUBE2C

GO:0070936

protein K48-linked ubiquitination

20061386

HgeneUBE2C

GO:0070979

protein K11-linked ubiquitination

18485873|19822757|20061386

TgeneUBE2C

GO:0006511

ubiquitin-dependent protein catabolic process

9122200|18485873

TgeneUBE2C

GO:0010994

free ubiquitin chain polymerization

19822757

TgeneUBE2C

GO:0016567

protein ubiquitination

9122200

TgeneUBE2C

GO:0031145

anaphase-promoting complex-dependent catabolic process

9122200|19822757

TgeneUBE2C

GO:0070936

protein K48-linked ubiquitination

20061386

TgeneUBE2C

GO:0070979

protein K11-linked ubiquitination

18485873|19822757|20061386


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW404348UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000356455ENST00000356455UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-3CDSENST00000356455ENST00000405520UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-3CDSENST00000356455ENST00000335046UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-intronENST00000356455ENST00000243893UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-intronENST00000356455ENST00000352551UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-intronENST00000356455ENST00000372568UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-3UTRENST00000356455ENST00000496085UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-3CDSENST00000405520ENST00000356455UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-3CDSENST00000405520ENST00000405520UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-3CDSENST00000405520ENST00000335046UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-intronENST00000405520ENST00000243893UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-intronENST00000405520ENST00000352551UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-intronENST00000405520ENST00000372568UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-3UTRENST00000405520ENST00000496085UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-3CDSENST00000335046ENST00000356455UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-3CDSENST00000335046ENST00000405520UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-3CDSENST00000335046ENST00000335046UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-intronENST00000335046ENST00000243893UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-intronENST00000335046ENST00000352551UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-intronENST00000335046ENST00000372568UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-3UTRENST00000335046ENST00000496085UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-3CDSENST00000243893ENST00000356455UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-3CDSENST00000243893ENST00000405520UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-3CDSENST00000243893ENST00000335046UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-intronENST00000243893ENST00000243893UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-intronENST00000243893ENST00000352551UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-intronENST00000243893ENST00000372568UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-3UTRENST00000243893ENST00000496085UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-3CDSENST00000352551ENST00000356455UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-3CDSENST00000352551ENST00000405520UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-3CDSENST00000352551ENST00000335046UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-intronENST00000352551ENST00000243893UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-intronENST00000352551ENST00000352551UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-intronENST00000352551ENST00000372568UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-3UTRENST00000352551ENST00000496085UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-3CDSENST00000372568ENST00000356455UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-3CDSENST00000372568ENST00000405520UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-3CDSENST00000372568ENST00000335046UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-intronENST00000372568ENST00000243893UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-intronENST00000372568ENST00000352551UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-intronENST00000372568ENST00000372568UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
3UTR-3UTRENST00000372568ENST00000496085UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
intron-3CDSENST00000496085ENST00000356455UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
intron-3CDSENST00000496085ENST00000405520UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
intron-3CDSENST00000496085ENST00000335046UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
intron-intronENST00000496085ENST00000243893UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
intron-intronENST00000496085ENST00000352551UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
intron-intronENST00000496085ENST00000372568UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+
intron-3UTRENST00000496085ENST00000496085UBE2Cchr20

44445455

-UBE2Cchr20

44443085

+

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FusionProtFeatures for UBE2C_UBE2C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBE2C

O00762

UBE2C

O00762

Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essentialfactor of the anaphase promoting complex/cyclosome (APC/C), a cellcycle-regulated ubiquitin ligase that controls progression throughmitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chainson APC/C substrates, leading to the degradation of APC/Csubstrates by the proteasome and promoting mitotic exit.{ECO:0000269|PubMed:15558010, ECO:0000269|PubMed:18485873,ECO:0000269|PubMed:19820702, ECO:0000269|PubMed:19822757,ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:27259151}. Accepts ubiquitin from the E1 complex and catalyzes itscovalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essentialfactor of the anaphase promoting complex/cyclosome (APC/C), a cellcycle-regulated ubiquitin ligase that controls progression throughmitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chainson APC/C substrates, leading to the degradation of APC/Csubstrates by the proteasome and promoting mitotic exit.{ECO:0000269|PubMed:15558010, ECO:0000269|PubMed:18485873,ECO:0000269|PubMed:19820702, ECO:0000269|PubMed:19822757,ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:27259151}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBE2C_UBE2C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBE2C_UBE2C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBE2C_UBE2C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBE2C_UBE2C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUBE2CC1458155Mammary Neoplasms1CTD_human
TgeneUBE2CC1458155Mammary Neoplasms1CTD_human