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Fusion gene ID: 40367 |
FusionGeneSummary for UBAP2_NCF4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: UBAP2_NCF4 | Fusion gene ID: 40367 | Hgene | Tgene | Gene symbol | UBAP2 | NCF4 | Gene ID | 55833 | 4689 |
| Gene name | ubiquitin associated protein 2 | neutrophil cytosolic factor 4 | |
| Synonyms | UBAP-2 | CGD3|NCF|P40PHOX|SH3PXD4 | |
| Cytomap | 9p13.3 | 22q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ubiquitin-associated protein 2AD-012 protein | neutrophil cytosol factor 4NCF-4SH3 and PX domain-containing protein 4neutrophil NADPH oxidase factor 4neutrophil cytosolic factor 4, 40kDap40-phox | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q5T6F2 | Q15080 | |
| Ensembl transtripts involved in fusion gene | ENST00000449054, ENST00000379238, ENST00000360802, ENST00000379239, ENST00000539807, ENST00000418786, ENST00000379225, ENST00000379235, ENST00000480885, | ENST00000248899, ENST00000397147, | |
| Fusion gene scores | * DoF score | 13 X 10 X 8=1040 | 3 X 3 X 3=27 |
| # samples | 13 | 3 | |
| ** MAII score | log2(13/1040*10)=-3 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: UBAP2 [Title/Abstract] AND NCF4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-19-2625-01A | UBAP2 | chr9 | 33986758 | - | NCF4 | chr22 | 37271695 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000449054 | ENST00000248899 | UBAP2 | chr9 | 33986758 | - | NCF4 | chr22 | 37271695 | + |
| Frame-shift | ENST00000449054 | ENST00000397147 | UBAP2 | chr9 | 33986758 | - | NCF4 | chr22 | 37271695 | + |
| Frame-shift | ENST00000379238 | ENST00000248899 | UBAP2 | chr9 | 33986758 | - | NCF4 | chr22 | 37271695 | + |
| Frame-shift | ENST00000379238 | ENST00000397147 | UBAP2 | chr9 | 33986758 | - | NCF4 | chr22 | 37271695 | + |
| Frame-shift | ENST00000360802 | ENST00000248899 | UBAP2 | chr9 | 33986758 | - | NCF4 | chr22 | 37271695 | + |
| In-frame | ENST00000360802 | ENST00000397147 | UBAP2 | chr9 | 33986758 | - | NCF4 | chr22 | 37271695 | + |
| 5UTR-3CDS | ENST00000379239 | ENST00000248899 | UBAP2 | chr9 | 33986758 | - | NCF4 | chr22 | 37271695 | + |
| 5UTR-3CDS | ENST00000379239 | ENST00000397147 | UBAP2 | chr9 | 33986758 | - | NCF4 | chr22 | 37271695 | + |
| intron-3CDS | ENST00000539807 | ENST00000248899 | UBAP2 | chr9 | 33986758 | - | NCF4 | chr22 | 37271695 | + |
| intron-3CDS | ENST00000539807 | ENST00000397147 | UBAP2 | chr9 | 33986758 | - | NCF4 | chr22 | 37271695 | + |
| Frame-shift | ENST00000418786 | ENST00000248899 | UBAP2 | chr9 | 33986758 | - | NCF4 | chr22 | 37271695 | + |
| In-frame | ENST00000418786 | ENST00000397147 | UBAP2 | chr9 | 33986758 | - | NCF4 | chr22 | 37271695 | + |
| intron-3CDS | ENST00000379225 | ENST00000248899 | UBAP2 | chr9 | 33986758 | - | NCF4 | chr22 | 37271695 | + |
| intron-3CDS | ENST00000379225 | ENST00000397147 | UBAP2 | chr9 | 33986758 | - | NCF4 | chr22 | 37271695 | + |
| intron-3CDS | ENST00000379235 | ENST00000248899 | UBAP2 | chr9 | 33986758 | - | NCF4 | chr22 | 37271695 | + |
| intron-3CDS | ENST00000379235 | ENST00000397147 | UBAP2 | chr9 | 33986758 | - | NCF4 | chr22 | 37271695 | + |
| intron-3CDS | ENST00000480885 | ENST00000248899 | UBAP2 | chr9 | 33986758 | - | NCF4 | chr22 | 37271695 | + |
| intron-3CDS | ENST00000480885 | ENST00000397147 | UBAP2 | chr9 | 33986758 | - | NCF4 | chr22 | 37271695 | + |
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FusionProtFeatures for UBAP2_NCF4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| UBAP2 | NCF4 |
| Component of the NADPH-oxidase, a multicomponent enzymesystem responsible for the oxidative burst in which electrons aretransported from NADPH to molecular oxygen, generating reactiveoxidant intermediates. It may be important for the assembly and/oractivation of the NADPH-oxidase complex.{ECO:0000269|PubMed:8280052}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for UBAP2_NCF4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_UBAP2_ENST00000360802_chr9_33986758_-_NCF4_ENST00000397147_chr22_37271695_+_313aa MMTSVSSDHCRGAREKPQISAAQSTQPQKQVVQATAEQMRLAQVIFDKNDSDFEAKVKQLMEVTGKNQDECIVALHDCNGDVNKAINILL EGNSDTTSWETVGCKKKNFAKENSENKENREKKSEKESSRGRGNNNRKGRGGNRGREFRGEENGIDCNQVDKPSDRGKRARGRGHCPGSH GHLPSLLREDPQRLPXGGRPHQLAALLLLRRHHQHHQVCGLGGRGLSSLPAIPTTTAPHITFSWVPLPLQSPQWLPDEPQCCNKPSTSRV >In-frame_UBAP2_ENST00000418786_chr9_33986758_-_NCF4_ENST00000397147_chr22_37271695_+_313aa MMTSVSSDHCRGAREKPQISAAQSTQPQKQVVQATAEQMRLAQVIFDKNDSDFEAKVKQLMEVTGKNQDECIVALHDCNGDVNKAINILL EGNSDTTSWETVGCKKKNFAKENSENKENREKKSEKESSRGRGNNNRKGRGGNRGREFRGEENGIDCNQVDKPSDRGKRARGRGHCPGSH GHLPSLLREDPQRLPXGGRPHQLAALLLLRRHHQHHQVCGLGGRGLSSLPAIPTTTAPHITFSWVPLPLQSPQWLPDEPQCCNKPSTSRV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_UBAP2_ENST00000360802_chr9_33986758_-_NCF4_ENST00000397147_chr22_37271695_+_940nt ATGATGACTTCAGTGAGCAGTGACCATTGTCGAGGTGCTCGGGAAAAACCACAGATTTCAGCAGCACAATCAACGCAACCACAGAAACAA GTGGTACAGGCAACAGCTGAACAGATGCGTCTCGCTCAAGTGATCTTTGATAAGAATGATTCAGATTTTGAAGCTAAAGTTAAGCAGCTT ATGGAAGTGACAGGGAAAAATCAGGATGAATGCATAGTGGCCCTACATGATTGTAATGGAGATGTGAACAAAGCTATCAATATATTGCTG GAAGGGAATTCAGACACAACTTCATGGGAGACTGTAGGGTGTAAGAAAAAGAATTTTGCAAAAGAAAATTCAGAAAACAAAGAGAATAGA GAGAAGAAAAGCGAGAAAGAATCGAGTCGTGGACGTGGAAACAACAACCGGAAAGGAAGAGGCGGCAATCGTGGCAGAGAATTTAGAGGT GAAGAAAATGGAATTGATTGCAATCAAGTGGACAAACCTTCAGATCGTGGCAAGCGAGCCCGGGGTAGAGGGCACTGTCCGGGGAGCCAC GGGCATCTTCCCTCTCTCCTTCGTGAAGATCCTCAAAGACTTCCCTGAGGAGGACGACCCCACCAACTGGCTGCGTTGCTACTACTACGA AGACACCATCAGCACCATCAAGTCTGTGGCCTGGGAGGGAGGGGCCTGTCCAGCCTTCCTGCCATCCCTACGACCACTGCCCCTCACATC ACCTTCTCATGGGTCCCTCTCCCACTCCAAAGCCCCCAGTGGCTCCCAGATGAGCCACAATGCTGTAACAAGCCATCAACGTCCAGGGTG GCCTGGCCAGCCTCATTCCCCTTTCCCCCACCCCACACCCCACTTCCAGCCTGATGCCTCCTTACTCCAGCCTGTCACCCCCTTAGGGAC >In-frame_UBAP2_ENST00000418786_chr9_33986758_-_NCF4_ENST00000397147_chr22_37271695_+_940nt ATGATGACTTCAGTGAGCAGTGACCATTGTCGAGGTGCTCGGGAAAAACCACAGATTTCAGCAGCACAATCAACGCAACCACAGAAACAA GTGGTACAGGCAACAGCTGAACAGATGCGTCTCGCTCAAGTGATCTTTGATAAGAATGATTCAGATTTTGAAGCTAAAGTTAAGCAGCTT ATGGAAGTGACAGGGAAAAATCAGGATGAATGCATAGTGGCCCTACATGATTGTAATGGAGATGTGAACAAAGCTATCAATATATTGCTG GAAGGGAATTCAGACACAACTTCATGGGAGACTGTAGGGTGTAAGAAAAAGAATTTTGCAAAAGAAAATTCAGAAAACAAAGAGAATAGA GAGAAGAAAAGCGAGAAAGAATCGAGTCGTGGACGTGGAAACAACAACCGGAAAGGAAGAGGCGGCAATCGTGGCAGAGAATTTAGAGGT GAAGAAAATGGAATTGATTGCAATCAAGTGGACAAACCTTCAGATCGTGGCAAGCGAGCCCGGGGTAGAGGGCACTGTCCGGGGAGCCAC GGGCATCTTCCCTCTCTCCTTCGTGAAGATCCTCAAAGACTTCCCTGAGGAGGACGACCCCACCAACTGGCTGCGTTGCTACTACTACGA AGACACCATCAGCACCATCAAGTCTGTGGCCTGGGAGGGAGGGGCCTGTCCAGCCTTCCTGCCATCCCTACGACCACTGCCCCTCACATC ACCTTCTCATGGGTCCCTCTCCCACTCCAAAGCCCCCAGTGGCTCCCAGATGAGCCACAATGCTGTAACAAGCCATCAACGTCCAGGGTG GCCTGGCCAGCCTCATTCCCCTTTCCCCCACCCCACACCCCACTTCCAGCCTGATGCCTCCTTACTCCAGCCTGTCACCCCCTTAGGGAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_UBAP2_ENST00000360802_chr9_33986758_-_NCF4_ENST00000397147_chr22_37271695_+_1463nt GTGACGCGAGGTCACGTGACGGGTTGGGCAGCCTGTGCCGCCGCCGCCGCTTTGTAAGAGGCACATTGGCAGATTTTCTATTTTGTACAT ACATTATTTTGTATATACTGTATATGATGACTTCAGTGAGCAGTGACCATTGTCGAGGTGCTCGGGAAAAACCACAGATTTCAGCAGCAC AATCAACGCAACCACAGAAACAAGTGGTACAGGCAACAGCTGAACAGATGCGTCTCGCTCAAGTGATCTTTGATAAGAATGATTCAGATT TTGAAGCTAAAGTTAAGCAGCTTATGGAAGTGACAGGGAAAAATCAGGATGAATGCATAGTGGCCCTACATGATTGTAATGGAGATGTGA ACAAAGCTATCAATATATTGCTGGAAGGGAATTCAGACACAACTTCATGGGAGACTGTAGGGTGTAAGAAAAAGAATTTTGCAAAAGAAA ATTCAGAAAACAAAGAGAATAGAGAGAAGAAAAGCGAGAAAGAATCGAGTCGTGGACGTGGAAACAACAACCGGAAAGGAAGAGGCGGCA ATCGTGGCAGAGAATTTAGAGGTGAAGAAAATGGAATTGATTGCAATCAAGTGGACAAACCTTCAGATCGTGGCAAGCGAGCCCGGGGTA GAGGGCACTGTCCGGGGAGCCACGGGCATCTTCCCTCTCTCCTTCGTGAAGATCCTCAAAGACTTCCCTGAGGAGGACGACCCCACCAAC TGGCTGCGTTGCTACTACTACGAAGACACCATCAGCACCATCAAGTCTGTGGCCTGGGAGGGAGGGGCCTGTCCAGCCTTCCTGCCATCC CTACGACCACTGCCCCTCACATCACCTTCTCATGGGTCCCTCTCCCACTCCAAAGCCCCCAGTGGCTCCCAGATGAGCCACAATGCTGTA ACAAGCCATCAACGTCCAGGGTGGCCTGGCCAGCCTCATTCCCCTTTCCCCCACCCCACACCCCACTTCCAGCCTGATGCCTCCTTACTC CAGCCTGTCACCCCCTTAGGGACATCGCGGTGGAGGAAGATCTCAGCAGCACTCCCCTATTGAAAGACCTGCTGGAGCTCACAAGGCGGG AGTTCCAGAGAGAGGACATAGCTCTGAATTACCGGGACGCTGAGGGGGATCTGGTTCGGCTGCTGTCGGATGAGGACGTAGCGCTCATGG TGCGGCAGGCTCGTGGCCTCCCCTCCCAGAAGCGCCTCTTCCCCTGGAAGCTGCACATCACGCAGAAGGACAACTACAGGGTCTACAACA CGATGCCATGAGCTGACGGTGTCCCTGGAGCAGTGAGGGGACACCAGCAAAAACCTTCAGCTCTCAGAGGAGATTGGGACCAGGAAAACC TGGGAGGATGGGCAGACTTCCTGTCTTTGAGGCTAATGGACCCGTGGGGCTTGTAATCTGTCTCTTTCTACTATTTACATCTGATTTAAA >In-frame_UBAP2_ENST00000418786_chr9_33986758_-_NCF4_ENST00000397147_chr22_37271695_+_1443nt GGGTTGGGCAGCCTGTGCCGCCGCCGCCGCTTTGTAAGAGGCACATTGGCAGATTTTCTATTTTGTACATACATTATTTTGTATATACTG TATATGATGACTTCAGTGAGCAGTGACCATTGTCGAGGTGCTCGGGAAAAACCACAGATTTCAGCAGCACAATCAACGCAACCACAGAAA CAAGTGGTACAGGCAACAGCTGAACAGATGCGTCTCGCTCAAGTGATCTTTGATAAGAATGATTCAGATTTTGAAGCTAAAGTTAAGCAG CTTATGGAAGTGACAGGGAAAAATCAGGATGAATGCATAGTGGCCCTACATGATTGTAATGGAGATGTGAACAAAGCTATCAATATATTG CTGGAAGGGAATTCAGACACAACTTCATGGGAGACTGTAGGGTGTAAGAAAAAGAATTTTGCAAAAGAAAATTCAGAAAACAAAGAGAAT AGAGAGAAGAAAAGCGAGAAAGAATCGAGTCGTGGACGTGGAAACAACAACCGGAAAGGAAGAGGCGGCAATCGTGGCAGAGAATTTAGA GGTGAAGAAAATGGAATTGATTGCAATCAAGTGGACAAACCTTCAGATCGTGGCAAGCGAGCCCGGGGTAGAGGGCACTGTCCGGGGAGC CACGGGCATCTTCCCTCTCTCCTTCGTGAAGATCCTCAAAGACTTCCCTGAGGAGGACGACCCCACCAACTGGCTGCGTTGCTACTACTA CGAAGACACCATCAGCACCATCAAGTCTGTGGCCTGGGAGGGAGGGGCCTGTCCAGCCTTCCTGCCATCCCTACGACCACTGCCCCTCAC ATCACCTTCTCATGGGTCCCTCTCCCACTCCAAAGCCCCCAGTGGCTCCCAGATGAGCCACAATGCTGTAACAAGCCATCAACGTCCAGG GTGGCCTGGCCAGCCTCATTCCCCTTTCCCCCACCCCACACCCCACTTCCAGCCTGATGCCTCCTTACTCCAGCCTGTCACCCCCTTAGG GACATCGCGGTGGAGGAAGATCTCAGCAGCACTCCCCTATTGAAAGACCTGCTGGAGCTCACAAGGCGGGAGTTCCAGAGAGAGGACATA GCTCTGAATTACCGGGACGCTGAGGGGGATCTGGTTCGGCTGCTGTCGGATGAGGACGTAGCGCTCATGGTGCGGCAGGCTCGTGGCCTC CCCTCCCAGAAGCGCCTCTTCCCCTGGAAGCTGCACATCACGCAGAAGGACAACTACAGGGTCTACAACACGATGCCATGAGCTGACGGT GTCCCTGGAGCAGTGAGGGGACACCAGCAAAAACCTTCAGCTCTCAGAGGAGATTGGGACCAGGAAAACCTGGGAGGATGGGCAGACTTC CTGTCTTTGAGGCTAATGGACCCGTGGGGCTTGTAATCTGTCTCTTTCTACTATTTACATCTGATTTAAATAAACCATTCCATCTGAAAG |
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FusionGenePPI for UBAP2_NCF4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| UBAP2 | G3BP2, CUL3, UBAP2L, DLD, NUP50, VDAC1, TOMM40, PRDX5, ZFR, VPS29, THY1, S100A10, ZC3H14, ITCH, WWOX, FXR1, FUS, KLHL20, GLUL, QPCT, RBFOX2, CDKL5, NTRK1, CDH1, HSPBP1, HAO2, GORASP2, RAVER1, SCYL2, TRIM25, G3BP1, BRCA1 | NCF4 | XRCC6, TXN, NCF2, NCF1, MSN, PRKDC |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for UBAP2_NCF4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBAP2_NCF4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | UBAP2 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Tgene | NCF4 | C0010346 | Crohn Disease | 1 | CTD_human |
| Tgene | NCF4 | C0018799 | Heart Diseases | 1 | CTD_human |
| Tgene | NCF4 | C3151409 | GRANULOMATOUS DISEASE, CHRONIC, AUTOSOMAL RECESSIVE, CYTOCHROME b-POSITIVE, TYPE III | 1 | UNIPROT |
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